acibro plus tablet sr - Acebrophylline (200mg) + Montelukast (10mg) medicine

Acibro Plus Tablet SR: Complete Medicine Guide

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🏭 Synokem Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 20, 2026
⚠️ Hepatotoxicity Risk 🤰 Pregnancy Category Not classified under the older letter-category system. Montelukast is generally considered acceptable when clearly needed during pregnancy after weighing benefits and risks, while safety data for Acebrophylline in pregnancy are limited. This medicine should be used in pregnancy only when a qualified clinician decides that the benefit outweighs the potential risk. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for the individual components in airway disease; limited for the fixed-dose combination as a single product.
Reviewed by
SaathiMed Expert Panel | Sep 20, 2026

When to Call Your Doctor IMMEDIATELY

  • Swelling of the face, lips, tongue, or throat with difficulty breathing
  • Severe chest pain, fainting, or very fast irregular heartbeat
  • Yellowing of the eyes or skin, dark urine, or persistent vomiting
  • Severe abdominal pain radiating to the back with vomiting
  • New agitation, depression, or thoughts of self-harm
  • Unusual bruising, bleeding gums, or tiny red spots on the skin
  • Seizure or loss of consciousness

If experiencing severe symptoms, call emergency services immediately.

What is acibro plus tablet sr used for?

This medicine is an oral sustained-release tablet combining Acebrophylline 200 mg and Montelukast 10 mg. It is used in adults to help control asthma and other chronic airway conditions by opening the airways, thinning mucus, and reducing inflammation. It is not a rescue medicine for sudden severe breathing attacks and should be taken only as prescribed by a doctor.

  • Generic Name: Acebrophylline + Montelukast
  • Manufacturer: Synokem Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 acibro plus tablet sr के बारे में (Hindi Summary)

उपयोग: यह दवा एसिब्रोफिलिन 200 मिलीग्राम और मॉन्टेलुकास्ट 10 मिलीग्राम का संयोजन है, जो मुख्य रूप से दमा और पुरानी श्वसन नली की बीमारियों में सांस की तकलीफ, घरघराहट और बलगम की समस्या को कम करने के लिए दी जाती है। यह दवा श्वसन नलियों को खोलने, बलगम को पतला करने और फेफड़ों की सूजन कम करने में मदद करती है। यह तुरंत असर करने वाली दवा नहीं है, इसलिए अचानक तेज दमे के दौरे में इसका उपयोग न करें। इसे डॉक्टर की सलाह के अनुसार ही लें और बीच में अपने आप बंद न करें।

साइड इफेक्ट्स: इस दवा से आमतौर पर सिरदर्द, जी मिचलाना, पेट में हल्की गड़बड़, दस्त, मुँह सूखना और हल्की नींद आना जैसी शिकायतें हो सकती हैं। कुछ लोगों को धड़कन तेज होना, घबराहट या कंपन महसूस हो सकता है, खासकर अगर ज्यादा चाय-कॉफी या एनर्जी ड्रिंक ली जाए। मॉन्टेलुकास्ट कभी-कभी मूड में बदलाव, नींद की गड़बड़ी या बुरे सपने पैदा कर सकता है। अगर चेहरे या गले में सूजन, सांस लेने में तकलीफ, पीलिया, गहरे रंग का पेशाब या त्वचा पर गंभीर दाने दिखें तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर द्वारा बताई गई मात्रा में ही लें और रोज एक ही समय पर लेने की कोशिश करें। गोली को चबाएं या तोड़ें नहीं, पूरा निगल लें। अचानक तेज दमे के दौरे के लिए इस दवा पर निर्भर न रहें, अपना रेस्क्यू इनहेलर हमेशा साथ रखें। शराब से बचें और चाय, कॉफी तथा एनर्जी ड्रिंक कम करें। गर्भावस्था, स्तनपान, किडनी या लिवर की बीमारी में डॉक्टर से सलाह लें। कोई भी नई दवा शुरू करने से पहले अपने डॉक्टर को बताएं।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 acibro plus tablet sr Uses & Benefits

[{"condition":"Bronchial asthma","description":"Used in adults as add-on maintenance therapy to reduce airway inflammation and bronchospasm when inhaled corticosteroids or other controllers are not enough.","evidence":"Moderate"},{"condition":"Chronic obstructive pulmonary disease (COPD)","description":"Sometimes prescribed to help loosen mucus and ease breathlessness in selected patients with chronic bronchitis-type COPD.","evidence":"Limited"},{"condition":"Allergic rhinitis with asthma","description":"Montelukast component helps nasal allergy symptoms that often accompany asthma, while Acebrophylline supports airway clearance.","evidence":"Moderate"},{"condition":"Exercise-induced bronchoconstriction","description":"Montelukast may reduce narrowing of airways triggered by exercise in some patients, but this medicine is not a substitute for a rescue inhaler.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Chronic cough with mucus","description":"Occasionally prescribed off-label when a clinician judges that mucus thickening and mild airway narrowing are contributing to persistent cough.","evidence":"Limited"},{"condition":"Post-infectious airway hyperreactivity","description":"Sometimes used short-term after a severe respiratory infection when cough and wheeze persist, but good trial evidence is lacking.","evidence":"Limited"}]

Primary treatment for: Bronchial asthma

Also treats: Chronic obstructive pulmonary disease, Allergic rhinitis, Exercise-induced bronchoconstriction

📋 Drug Information

Generic Name(s)Acebrophylline + Montelukast
Brand NameAbiways-M Tablet SR
ManufacturerSynokem Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassRespiratory
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and moisture. Keep the tablets in the original blister pack or container until use.
Shelf LifeTypically 24 months from the date of manufacture, but always check the expiry date printed on the pack. Do not use the medicine after the expiry date.
WHO GuidelineNot established from the available information for this specific fixed-dose combination. International asthma guidelines generally recommend inhaled corticosteroids as the foundation of asthma control, with leukotriene receptor antagonists such as Montelukast used as add-on therapy in selected patients.
ICMR GuidelineNot established from the available information for this specific fixed-dose combination. Patients should follow the prescribing advice of their treating clinician and national asthma management guidance.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at night to reduce daytime drowsiness and to match the body's natural overnight airway inflammation cycle.
2
Swallow the sustained-release tablet whole; crushing or chewing can cause a sudden release of the medicine and increase side effects.
3
Keep your rescue inhaler with you at all times because this medicine does not relieve a sudden severe asthma attack.
4
Limit coffee, strong tea, and energy drinks, as caffeine can add to the heart-rate and tremor effects of Acebrophylline.
5
Report any new mood changes, sleep problems, or unusual dreams to your doctor, as Montelukast can occasionally affect mental well-being.
6
Do not stop this medicine on your own when you feel better; sudden withdrawal can lead to loss of asthma control.
7
Ask your doctor about periodic liver function tests if you need this medicine for several months.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Wheezing and chest tightness
This medicine is commonly prescribed as maintenance therapy for asthma and chronic airway narrowing.
Likely Use
✅
Thick sticky mucus with cough
The Acebrophylline component helps thin mucus and improve clearance.
Likely Use
✅
Sneezing and runny nose with asthma
The Montelukast component can help allergic rhinitis symptoms that accompany asthma.
Likely Use
❌
Sudden severe breathlessness at rest
This medicine is not a rescue treatment. Seek emergency care and use your rescue inhaler.
Not Primary
❌
Fever with body ache
This medicine is not a fever reducer or general painkiller.
Not Primary
❌
Chest pain with sweating
This is a red flag symptom and requires immediate emergency evaluation.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAcebrophylline is absorbed from the gastrointestinal tract after oral administration, and the sustained-release tablet is designed to release the drug gradually. Montelukast is also absorbed orally and reaches peak blood levels within a few hours. Food does not meaningfully change the total absorption of Montelukast, but taking the tablet with a meal may reduce stomach upset.
DistributionBoth components distribute into body tissues, including the lungs. Montelukast is highly bound to plasma proteins, while Acebrophylline and its metabolites are distributed in extracellular and intracellular fluid. Specific volume-of-distribution values are not established from the available information for this fixed-dose combination.
Protein BindingMontelukast is extensively bound to plasma proteins, mainly albumin, at more than 99 percent. Protein binding data for Acebrophylline in this combination are not established from the available information.
MetabolismMontelukast is metabolized in the liver primarily by cytochrome P450 enzymes, including CYP2C8 and CYP3A4. Acebrophylline undergoes hepatic metabolism through xanthine-related pathways. Because both components depend on liver enzymes, liver impairment or enzyme-altering drugs can change their blood levels.
Half-LifeThe elimination half-life of Montelukast is approximately 2.7 to 5.5 hours in healthy adults. The elimination half-life of Acebrophylline in this combination is not established from the available information.
ExcretionMontelukast and its metabolites are excreted mainly in bile and feces, with a smaller amount in urine. Acebrophylline metabolites are excreted through urine and bile. Specific excretion percentages for this combination are not established from the available information.
BioavailabilityThe oral bioavailability of Montelukast is approximately 64 percent in adults when taken without food. The oral bioavailability of Acebrophylline in this sustained-release combination is not established from the available information.
Onset of ActionMontelukast begins to produce measurable effects within a few hours of the first dose, but meaningful clinical improvement in asthma control usually takes several days to a few weeks of regular use. Acebrophylline may loosen mucus and ease breathing within hours in some patients. This medicine is not intended for immediate relief of an acute attack.
Peak Plasma TimeMontelukast reaches peak plasma concentration about 3 to 4 hours after oral administration in adults. The peak plasma time for Acebrophylline in this sustained-release tablet is not established from the available information.
Duration of ActionMontelukast provides receptor blockade that lasts beyond 24 hours, which supports once-daily dosing. The duration of bronchodilator and mucolytic action of Acebrophylline in this formulation is not established from the available information.

How It Works

This medicine works through two complementary mechanisms. Acebrophylline is a xanthine derivative that relaxes bronchial smooth muscle, improves mucociliary clearance, and reduces mucus viscosity, making it easier to cough out sticky secretions. Montelukast selectively blocks cysteinyl leukotriene type 1 receptors in the airways, which reduces leukotriene-driven bronchoconstriction, mucus secretion, and eosinophilic inflammation. The combined effect is better airway opening and less ongoing inflammation than either component alone in selected patients.

Mechanism Steps

1
Acebrophylline relaxes airway smooth muscle: Acebrophylline inhibits phosphodiesterase and blocks adenosine receptors in bronchial smooth muscle, which raises cyclic AMP levels and causes the muscle to relax.
2
Acebrophylline thins mucus: The xanthine component improves mucociliary transport and reduces the thickness of respiratory secretions, so mucus is cleared more easily.
3
Montelukast blocks leukotriene receptors: Montelukast occupies cysteinyl leukotriene type 1 receptors on airway smooth muscle and inflammatory cells, preventing leukotrienes from triggering narrowing and swelling.
4
Combined anti-inflammatory and bronchodilator effect: The two actions together reduce both immediate bronchospasm and the ongoing inflammatory cycle that makes airways sensitive.

💡 How to Take acibro plus tablet sr

Strength: Sustained-release tablet containing Acebrophylline 200 mg and Montelukast 10 mg.

1Take the tablet at the same time each day, preferably in the evening or at night.
2Swallow the sustained-release tablet whole with a glass of water.
3Do not crush, chew, or break the tablet because this can release the medicine too quickly.
4You may take it with or without food, but a light snack may reduce stomach upset.
5Avoid taking it with grapefruit juice, alcohol, or large amounts of caffeine.
6If you also take antacids, separate them by at least two hours.
7Keep a record of any side effects and share them with your doctor at follow-up.

Dosage Information

Adult DosageThe usual adult dose of this fixed-dose combination is one tablet taken orally once daily, preferably at night, with or without food. Some clinicians may advise taking it in the evening to reduce daytime drowsiness. The exact dose and duration must be individualized by a qualified clinician based on the indication, age, weight, kidney function, liver function, and response to treatment. Do not increase or decrease the dose on your own.
Pediatric DosagePediatric dosing for this fixed-dose combination is not established from available information. Consult a pediatrician for appropriate evaluation and treatment.
Elderly DosageElderly patients above 65 years may be more sensitive to the heart-rate and nervous-system effects of Acebrophylline. A qualified clinician should assess kidney and liver function and may choose a lower dose or a different formulation. Regular monitoring of heart rate, blood pressure, and mental status is advised.
Renal ImpairmentPatients with mild kidney impairment usually do not need a dose change, but those with moderate to severe impairment may require adjustment or closer monitoring because Acebrophylline metabolites are partly cleared by the kidneys. Dose must be individualized by a qualified clinician based on measured kidney function.
Hepatic ImpairmentPatients with mild to moderate liver impairment should be monitored closely, and those with severe liver disease should generally avoid this medicine unless a specialist decides otherwise. Dose reduction or alternative therapy may be needed, and liver function should be checked periodically.
Maximum Daily DoseThe maximum recommended daily dose for this fixed-dose combination is generally one tablet containing Acebrophylline 200 mg and Montelukast 10 mg. Higher doses should not be taken unless specifically directed by a qualified clinician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

Light meal or snack
Can be taken with or without food
A light snack may reduce stomach upset.
Grapefruit and grapefruit juice
Avoid large amounts
Grapefruit can inhibit CYP3A4 and may increase Montelukast levels.
Coffee, strong tea, and energy drinks
Limit intake
Caffeine can add to the stimulating effects of Acebrophylline.
Alcohol
Avoid
Alcohol can increase drowsiness, dizziness, and stomach irritation.
Antacids
Separate by at least two hours
Antacids may reduce absorption if taken at the same time.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.
📌 You are unsure or have missed more than one dose
→ Contact your doctor or pharmacist for advice.
💡 Do not take extra tablets on your own.

⚠️ Side Effects of acibro plus tablet sr

✅ Common Side Effects

Headache (Common (5-10%))
Rest, stay hydrated, and take paracetamol only if your doctor approves. Consult the doctor if headaches are severe or persistent.
Nausea or stomach discomfort (Common (5-10%))
Take the tablet with a light meal or snack and avoid lying down immediately after taking it.
Loose motions (Common (5-10%))
Drink plenty of fluids and avoid very spicy or oily food. Seek advice if diarrhea lasts more than two days.
Dry mouth (Common (5-10%))
Sip water frequently and chew sugar-free gum if needed. Report persistent dryness to the doctor.
Mild drowsiness or dizziness (Uncommon (1-5%))
Avoid driving or operating heavy machinery until you know how this medicine affects you.
Increased heart rate or palpitations (Uncommon (1-5%))
Reduce tea, coffee, and energy drinks. If palpitations are frequent or associated with chest discomfort, contact the doctor.

🚨 Serious Side Effects

Severe allergic reaction with facial or throat swelling (Rare (<0.1%))
Stop the medicine and seek emergency medical care immediately if you have swelling of the lips, tongue, or throat, or difficulty breathing.
Liver injury with jaundice (Rare (<0.1%))
Report yellowing of eyes or skin, dark urine, or persistent vomiting to a doctor urgently for liver tests.
Severe skin reaction (Very rare (<0.01%))
Stop the medicine and get immediate medical help if a painful spreading rash, blisters, or peeling skin develops.
Serious heart rhythm disturbance (Rare (<0.1%))
Seek emergency care for fainting, severe palpitations, or chest pain.
Blood abnormality such as low platelet count (Very rare (<0.01%))
Report unusual bruising, bleeding gums, or tiny red spots on the skin to the doctor promptly.

⚠️ Rare Side Effects

Mood changes or agitation
Inform the doctor if you feel unusually anxious, irritable, or depressed, as Montelukast can occasionally affect mood.
Sleep disturbance or vivid dreams
Discuss with the doctor if sleep problems persist, as timing of the dose may need adjustment.
Seizure
Seek emergency care for any seizure-like activity, especially in patients with a history of seizures.
Pancreatitis
Go to the emergency department for severe upper abdominal pain radiating to the back, with vomiting.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Clarithromycin Major
Rifampicin Major
Amiodarone Major
Salbutamol Moderate
Theophylline Moderate
Prednisolone Moderate
Furosemide Moderate
Caffeine Minor
Antacids Minor

🚨 Major Interactions

  • Strong CYP3A4 inhibitors such as ketoconazole, itraconazole, clarithromycin, and ritonavir
  • Drugs that prolong the QT interval such as amiodarone, sotalol, and some antipsychotics
  • Phenobarbital and rifampicin

⚡ Moderate Interactions

  • Beta-2 agonists such as salbutamol
  • Theophylline or aminophylline
  • Corticosteroids such as prednisolone
  • Diuretics such as furosemide

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine. It can increase drowsiness, dizziness, and stomach irritation, and it may add to the heart-rate effects of Acebrophylline. If you drink regularly, discuss this openly with your doctor so that your treatment can be adjusted safely.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity or allergy to Acebrophylline, Montelukast, or any component of the tablet","Active peptic ulcer or a history of recurrent gastrointestinal bleeding","Severe liver impairment or active liver disease","Uncontrolled cardiac arrhythmias or severe heart disease without specialist supervision","Children below the age for which this fixed-dose combination is approved","Acute severe asthma attack requiring emergency treatment"]

⚠️ Warnings & Precautions

["This medicine is not a rescue medicine and must not be used to treat a sudden severe asthma attack.","Do not crush, chew, or break the sustained-release tablet, as this can release the drug too quickly.","Use with caution in patients with heart disease, high blood pressure, or thyroid disorders because Acebrophylline can increase heart rate.","Montelukast has been associated with mood and behavior changes; report any new agitation, depression, or sleep problems to the doctor.","Avoid alcohol and limit caffeine-containing drinks during treatment.","Inform your doctor about all other medicines, including herbal products, before starting this medicine.","Patients with liver or kidney disease may need dose adjustment and closer monitoring.","Do not stop this medicine suddenly without medical advice, especially if you have been using it regularly for asthma control."]

🤱 Lactation Safety

Montelukast is present in breast milk in small amounts and is generally considered compatible with breastfeeding when prescribed. Data on Acebrophylline transfer into breast milk are limited. Breastfeeding mothers should consult their doctor before using this medicine and watch the infant for unusual drowsiness, irritability, or feeding difficulty.

💊 Overdose Management

Overdose with this medicine may cause nausea, vomiting, restlessness, palpitations, rapid heart rate, and in severe cases seizures or irregular heart rhythm. If an overdose is suspected, contact emergency medical services or a poison control center immediately. Do not try to induce vomiting unless instructed by a healthcare professional. Treatment is supportive and may include monitoring of heart rhythm, blood pressure, and electrolytes in a hospital setting.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember, provided there is still a long time before the next scheduled dose. If the next dose is due soon, skip the missed dose and continue with your regular schedule. Never take two doses at the same time to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed, preferably at the same time each day, and swallow the sustained-release tablet whole without crushing, chewing, or breaking it. Do not use this medicine to relieve a sudden asthma attack; keep your rescue inhaler with you at all times. Avoid alcohol and reduce excess tea, coffee, and energy drinks because caffeine-like substances can add to the stimulating effects of Acebrophylline. Tell your doctor about all other medicines you take, especially antibiotics, antifungal drugs, heart medicines, and blood thinners, because some can change how this medicine behaves in the body. Do not start or stop any other medicine without informing your clinician. If you are pregnant, planning pregnancy, or breastfeeding, speak to your doctor before continuing this medicine. Keep all follow-up appointments so that your breathing control, liver health, and heart rate can be monitored when needed.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Patients above 65 years may be more sensitive to the heart-rate and nervous-system effects of Acebrophylline. Kidney and liver function should be assessed before and during treatment, and the dose may need adjustment. Elderly patients should also be monitored for dizziness and falls, especially if they take other medicines that affect blood pressure or alertness.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, discuss this medicine with your doctor before conception. Montelukast is generally considered acceptable when clearly needed, but data on Acebrophylline in pregnancy are limited. Your clinician may adjust or change your treatment to ensure the safest option for both mother and baby.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. Acebrophylline can affect heart rate, and Montelukast may interact with other medicines used during anesthesia. Your doctor may advise temporary adjustment or monitoring around the time of surgery.

🦷 Dental Procedures

Tell your dentist that you are taking this medicine before any dental procedure. There is no major direct interaction with common dental anesthetics, but the xanthine component can increase heart rate, and some dental medicines may interact with liver enzymes. If you have severe asthma, ensure your rescue inhaler is available during dental visits.

💚 Lifestyle Tips for Better Results

🏃
Avoid known asthma triggers such as dust, smoke, strong perfumes, and cold air.
🥗
Keep your home well ventilated and use allergen-proof covers on bedding if you are allergic to dust mites.
😴
Maintain a healthy weight, as excess weight can worsen breathlessness and asthma control.
💧
Practice breathing exercises such as pursed-lip breathing and diaphragmatic breathing as advised by your doctor.
🧘
Get adequate sleep and keep a regular bedtime routine to support lung health.
🌞
Wash your hands frequently and stay up to date with recommended vaccinations to prevent respiratory infections.
🚭
Keep a symptom diary to track triggers, rescue inhaler use, and response to treatment.

🏋️ Exercise Considerations

Regular physical activity is encouraged, but exercise can sometimes trigger bronchoconstriction in people with asthma. Warm up gradually, keep your rescue inhaler nearby, and avoid exercising in very cold, dry, or polluted air. If your doctor has advised a pre-exercise dose of a reliever inhaler, follow that plan. Stop exercising and seek medical help if you develop chest pain, severe breathlessness, or dizziness.

🥗 Diet Recommendations

Eat a balanced diet rich in fruits and vegetables to support overall lung health.
Include omega-3 rich foods such as flaxseed, walnuts, and fatty fish if suitable for you.
Stay well hydrated to help keep respiratory secretions thin.
Limit processed foods, excess salt, and sugary drinks.
Avoid foods that you know trigger your allergy or asthma symptoms.
Limit caffeine-containing drinks because they can add to the stimulating effects of this medicine.

💼 Impact on Daily Work & Life

This medicine may cause mild drowsiness or dizziness in some people, especially during the first few days. Avoid driving, operating heavy machinery, or working at heights until you know how it affects you. Most people can continue their usual office or household work, but those in safety-sensitive jobs should discuss timing of the dose with their doctor. Keeping the rescue inhaler at the workplace is strongly advised.

🛑 When to Stop This Medicine

Do not stop this medicine on your own, especially if you have been using it regularly for asthma control. Sudden withdrawal can lead to worsening symptoms. If you experience a serious side effect such as a severe allergic reaction, liver symptoms, or mood changes, stop the medicine and contact your doctor immediately. Otherwise, any decision to stop or change the dose should be made by your treating clinician after reviewing your condition.

📅 Long-Term Use Effects

Long-term use of this medicine may be appropriate for some patients with chronic asthma or COPD, but it requires regular medical review. Possible long-term concerns include liver enzyme changes, mood or sleep disturbances from Montelukast, and heart-rate effects from Acebrophylline. Periodic monitoring of liver function, heart rate, blood pressure, and symptom control is advised. The dose should be reassessed regularly, and the medicine should be continued only as long as the clinician judges that the benefits outweigh the risks.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Inhaled corticosteroids

The foundation of long-term asthma control and often used alongside or instead of oral controller medicines.

Evidence: Well-established
Inhaled bronchodilators

Provide rapid relief of acute breathlessness and are essential rescue therapy for asthma.

Evidence: Well-established
Allergen avoidance and environmental control

Reducing exposure to dust mites, pollen, smoke, and other triggers can improve symptoms and reduce medicine needs.

Evidence: Well-established
Pulmonary rehabilitation

Structured exercise and breathing training can improve quality of life in chronic lung disease.

Evidence: Moderate
Vaccination against influenza and pneumococcus

Reduces the risk of respiratory infections that can trigger asthma and COPD flare-ups.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There is no known direct interaction between this medicine and routine vaccines. However, patients with chronic lung disease are generally advised to stay up to date with influenza and pneumococcal vaccinations as recommended by their doctor. If you are acutely unwell with fever or a severe asthma flare-up, vaccination may be deferred until you recover.

📦 Storage Guide

✅ DO

Store at room temperature between 15°C and 30°C

❌ DON'T

Do not refrigerate unless specifically instructed

✅ DO

Keep the tablets in the original blister pack or container

❌ DON'T

Do not transfer them to unmarked containers

✅ DO

Keep away from direct sunlight and moisture

❌ DON'T

Do not store in the bathroom cabinet

✅ DO

Check the expiry date before use

❌ DON'T

Do not use expired tablets

✅ DO

Keep out of reach of children and pets

❌ DON'T

Do not leave loose tablets within easy reach

✈️ Traveling with This Medicine

Carry this medicine in its original blister pack or container with the prescription label visible. Keep a copy of your prescription and a doctor&#039;s note with you, especially for international travel, because some countries may ask about prescription medicines. Store the tablets in hand luggage rather than checked baggage to avoid extreme temperatures. If you are crossing time zones, take the tablet at your usual bedtime in the new time zone and do not double the dose. Carry enough supply for the entire trip plus a few extra days in case of delays. Keep your rescue inhaler easily accessible at all times.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 42-year-old man with moderate persistent asthma and frequent morning cough
He was prescribed this medicine once daily at night along with his inhaled corticosteroid. After three weeks he noticed less morning cough and fewer episodes of breathlessness during his morning walk. He initially felt mildly sleepy in the first few days, which settled after he shifted the dose to bedtime.
💡 Lesson: Taking this medicine at night can improve tolerability and may better match overnight airway inflammation.
👤 A 58-year-old woman with COPD and thick mucus who also drank several cups of strong coffee daily
She started this medicine as prescribed but soon complained of palpitations and shakiness. On review, her doctor advised her to cut down coffee and energy drinks. Her symptoms improved within a week without changing the medicine dose.
💡 Lesson: Caffeine can amplify the stimulating effects of Acebrophylline, so reducing tea, coffee, and energy drinks is an important part of safe use.
👤 A 35-year-old woman with allergic asthma who developed irritability and poor sleep
She had good asthma control on this medicine but reported feeling unusually irritable and having vivid dreams. Her doctor recognized these as possible Montelukast-related neuropsychiatric effects and adjusted her treatment plan after discussion.
💡 Lesson: Mood and sleep changes should never be ignored; they may be medicine-related and need prompt medical review.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Some people notice easier mucus clearance within a few hours, but meaningful improvement in asthma control usually takes several days to a few weeks of regular use. This medicine is not for immediate relief of an acute attack.

Q: Can I take this medicine at night?

A: Yes, many doctors recommend taking it at night because it may reduce daytime drowsiness and may better match overnight airway inflammation. Follow your prescriber's specific instruction.

Q: Is this medicine safe for long-term use?

A: It can be used long-term when prescribed and monitored by a doctor. Periodic review of liver function, heart rate, and symptom control may be needed, especially if you have other health conditions.

Q: Does this medicine cause drowsiness?

A: Mild drowsiness or dizziness can occur in some people. Avoid driving or operating heavy machinery until you know how this medicine affects you.

Q: Can I take this medicine with coffee?

A: It is best to limit coffee, strong tea, and energy drinks because caffeine can add to the heart-rate and tremor effects of Acebrophylline.

Q: What should I do if I miss a dose?

A: If you remember soon after the missed time, take it as soon as you can. If the next dose is near, skip the missed dose and continue your regular schedule. Never double the dose.

Q: Can this medicine be used during pregnancy?

A: It should be used during pregnancy only when a qualified clinician decides that the benefit outweighs the potential risk. Do not start or stop it without medical advice.

Q: Does this medicine cure asthma permanently?

A: No, this medicine helps control symptoms and reduce flare-ups but does not cure asthma. Long-term management usually includes inhaled medicines, trigger avoidance, and regular follow-up.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my liver or kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Will this medicine make me sleepy?
  • Can I take it with my other asthma inhalers?

🔄 Substitutes for acibro plus tablet sr

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can replace a rescue inhaler during an asthma attack.
    Fact: This medicine is a maintenance therapy and does not provide immediate relief during a sudden severe attack. A rescue inhaler must always be kept available.
  • Myth: Once symptoms improve, the medicine can be stopped without telling the doctor.
    Fact: Stopping suddenly can lead to loss of asthma control. Any change should be discussed with the treating clinician.
  • Myth: This medicine is safe for children in the same dose as adults.
    Fact: Pediatric dosing for this fixed-dose combination is not established. A pediatrician must decide appropriate treatment.
  • Myth: Taking extra tablets will make breathing better faster.
    Fact: Taking more than the prescribed dose increases the risk of palpitations, nausea, and other side effects without giving extra benefit.

🔄 Alternative Options

Generic Alternatives

  • Acebrophylline 200 mg + Montelukast 10 mg sustained-release tablet

Brand Alternatives

  • Acibro Plus Tablet SR

📊 Comparison with Similar Medicines

[{"feature":"Active ingredients","this_medicine":"Acebrophylline 200 mg + Montelukast 10 mg","montelukast_alone":"Montelukast 10 mg","acebrophylline_alone":"Acebrophylline 200 mg"},{"feature":"Main action","this_medicine":"Bronchodilation, mucus thinning, and anti-inflammatory effect","montelukast_alone":"Anti-inflammatory leukotriene blockade","acebrophylline_alone":"Bronchodilation and mucus clearance"},{"feature":"Typical use","this_medicine":"Asthma and chronic airway disease maintenance","montelukast_alone":"Asthma and allergic rhinitis maintenance","acebrophylline_alone":"Chronic bronchitis and mucus-heavy airway disease"},{"feature":"Dosing","this_medicine":"Usually once daily","montelukast_alone":"Usually once daily at night","acebrophylline_alone":"Usually once or twice daily as prescribed"}]

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