acibro 100mg capsule - Acebrophylline (100mg) medicine

AB Phylline Capsule (Acebrophylline 100mg): Complete Guide

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🏭 Synokem Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 20, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate
Reviewed by
SaathiMed Expert Panel | Sep 20, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is acibro 100mg capsule used for?

This medicine is a bronchodilator and mucolytic used to treat asthma and COPD. It works by relaxing airway muscles and thinning mucus, making breathing easier. The usual adult dose is 100 mg once or twice daily, as prescribed by a doctor.

  • Generic Name: Acebrophylline
  • Manufacturer: Synokem Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 acibro 100mg capsule के बारे में (Hindi Summary)

उपयोग: यह दवा एसिब्रोफाइलिन 100 मिलीग्राम कैप्सूल है, जिसका उपयोग अस्थमा और क्रॉनिक ऑब्सट्रक्टिव पल्मोनरी डिजीज (सीओपीडी) जैसी श्वसन संबंधी बीमारियों के इलाज के लिए किया जाता है। यह श्वास नलियों को फैलाकर और बलगम को पतला करके सांस लेने में आसानी प्रदान करती है। यह दवा सूजन को कम करने और खांसी को कम करने में भी मदद करती है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में परेशानी, सिरदर्द और बेचैनी शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको दिल की धड़कन तेज होना, दौरा पड़ना या गंभीर एलर्जी हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। कैप्सूल को चबाएं नहीं, पूरा निगल लें। इसे भोजन के साथ लेने से पेट की परेशानी कम हो सकती है। इस दवा के सेवन के दौरान शराब न पिएं। यदि आपको हृदय, यकृत या गुर्दे की बीमारी है तो डॉक्टर को बताएं। दवा बंद करने से पहले डॉक्टर से सलाह लें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 acibro 100mg capsule Uses & Benefits

[{"condition":"Bronchial asthma","description":"Helps relieve bronchospasm and reduces mucus viscosity, improving breathing.","evidence":"Well-established"},{"condition":"Chronic obstructive pulmonary disease (COPD)","description":"Used as a bronchodilator and mucolytic to ease symptoms and improve lung function.","evidence":"Well-established"},{"condition":"Chronic bronchitis","description":"Helps in thinning mucus and easing cough, making it easier to expel sputum.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Sinusitis","description":"Sometimes prescribed off-label to help reduce mucus thickness in sinusitis.","evidence":"Limited"}]

Primary treatment for: Bronchial asthma

Also treats: Chronic obstructive pulmonary disease (COPD), Chronic bronchitis

📋 Drug Information

Generic Name(s)Acebrophylline
Brand NameAb Phylline
ManufacturerSynokem Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassTheophylline & its derivatives
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Stay well hydrated throughout the day to help thin mucus.
3
Avoid alcohol while taking this medicine.
4
Do not take more than the prescribed dose.
5
Consult your doctor if symptoms persist beyond 7 days.
6
Report any unusual heart palpitations or restlessness immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Wheezing
This medicine is commonly prescribed for this.
Likely Use
Chest tightness
This medicine helps relieve bronchospasm.
Likely Use
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAcebrophylline is rapidly absorbed from the gastrointestinal tract after oral administration. The presence of food does not significantly affect the extent of absorption.
DistributionIt is widely distributed throughout the body, with a volume of distribution that suggests extensive tissue penetration, including the lungs.
Protein BindingNot established from the available information.
MetabolismAcebrophylline is metabolized in the liver, primarily by oxidation and conjugation reactions. The metabolites include ambroxol and theophylline derivatives.
Half-LifeThe elimination half-life of acebrophylline is approximately 3 to 4 hours in healthy adults.
ExcretionMetabolites are excreted mainly via the kidneys in urine, with a small fraction eliminated in feces.
BioavailabilityThe oral bioavailability of acebrophylline is approximately 90%.
Onset of ActionThe onset of bronchodilator effect is typically within 30 to 60 minutes after oral administration.
Peak Plasma TimePeak plasma concentrations are reached about 1 to 2 hours after oral intake.
Duration of ActionThe therapeutic effect lasts for approximately 8 to 12 hours, depending on the individual.

How It Works

Acebrophylline is a xanthine derivative that combines the bronchodilator properties of theophylline with the mucolytic action of ambroxol. It works by inhibiting phosphodiesterase enzymes, leading to increased cyclic AMP levels, which relaxes bronchial smooth muscle and widens the airways. Additionally, it reduces the viscosity of mucus by altering its composition, making it easier to cough out. It also has anti-inflammatory effects that help reduce airway inflammation.

Mechanism Steps

1
Phosphodiesterase inhibition: Acebrophylline inhibits phosphodiesterase enzymes in bronchial smooth muscle cells, preventing the breakdown of cyclic AMP.
2
Increased cyclic AMP: Elevated cyclic AMP levels lead to relaxation of bronchial smooth muscle, resulting in bronchodilation.
3
Mucolytic action: The ambroxol component of acebrophylline reduces mucus viscosity by breaking down mucopolysaccharide fibers, facilitating expectoration.
4
Anti-inflammatory effect: Acebrophylline reduces the release of inflammatory mediators from mast cells and other immune cells, decreasing airway inflammation.

💡 How to Take acibro 100mg capsule

Strength: Acebrophylline 100 mg immediate-release capsule

1Swallow the capsule whole with a glass of water.
2Do not crush, chew, or open the capsule.
3Take with or without food, but preferably with food to reduce stomach upset.
4Take at the same time each day to maintain consistent levels.
5If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 100 mg taken orally once or twice daily, or as directed by your physician. The dose may be adjusted based on your condition and response to treatment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine. Dose adjustment may be necessary based on renal and hepatic function. Consult your doctor.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be required. Consult your doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be required. Consult your doctor.
Maximum Daily DoseThe maximum recommended daily dose is 200 mg, but this may vary based on clinical judgment.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Caffeine
Limit
May increase stimulant effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of acibro 100mg capsule

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food to reduce nausea. If it persists, consult your doctor.
Vomiting (Common (5-10%))
Stay hydrated and avoid heavy meals. Consult doctor if severe.
Stomach discomfort (Common (5-10%))
Take with a meal or snack. If pain persists, seek medical advice.
Headache (Common (5-10%))
Rest and stay hydrated. If headache is severe or persistent, consult your doctor.
Restlessness (Uncommon (1-5%))
Avoid caffeine. If it interferes with daily activities, inform your doctor.

🚨 Serious Side Effects

Palpitations (Rare (<0.1%))
Seek immediate medical attention if you experience rapid or irregular heartbeat.
Seizures (Rare (<0.1%))
Call emergency services if seizures occur.
Severe allergic reactions (Rare (<0.1%))
Get emergency help if you notice rash, swelling, or difficulty breathing.

⚠️ Rare Side Effects

Hypokalemia
Report muscle weakness or cramps to your doctor.
Hyperglycemia
Monitor blood sugar if diabetic and inform your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ciprofloxacin Major
Erythromycin Major
Beta-blockers Moderate
Diuretics Moderate
Cimetidine Minor

🚨 Major Interactions

  • Ciprofloxacin
  • Erythromycin

⚡ Moderate Interactions

  • Beta-blockers
  • Diuretics

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine as it may increase the risk of side effects such as dizziness and drowsiness.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to acebrophylline or any component of the formulation","Severe cardiac arrhythmias","Acute porphyria","Severe hepatic impairment","Severe renal impairment","Peptic ulcer disease"]

⚠️ Warnings & Precautions

["Use with caution in patients with cardiovascular disease.","Avoid in patients with seizure disorders.","Monitor liver and kidney function during prolonged use.","May impair ability to drive or operate machinery; avoid until you know how it affects you.","Do not exceed the recommended dose."]

🤱 Lactation Safety

It is not known whether acebrophylline passes into breast milk. Consult your doctor before breastfeeding.

💊 Overdose Management

Overdose may cause severe nausea, vomiting, tachycardia, seizures, and cardiac arrhythmias. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not crush or chew the capsule; swallow it whole with a glass of water. It can be taken with or without food, but taking it with food may reduce stomach upset. Avoid consuming alcohol while on this medicine as it may increase the risk of side effects. Inform your doctor if you have a history of heart disease, liver or kidney problems, or peptic ulcers. Do not stop taking this medicine abruptly without consulting your doctor. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects of this medicine, especially cardiac effects. Dose adjustment may be needed based on kidney and liver function.

🤰 Pregnancy Planning (TTC)

Consult your doctor if you are planning to become pregnant or are pregnant. The safety of this medicine during pregnancy is not well established.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with certain anesthetic agents.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine. It may cause dry mouth, which can affect dental health.

💚 Lifestyle Tips for Better Results

🏃
Avoid smoking and exposure to secondhand smoke.
🥗
Use a humidifier to keep airways moist.
😴
Practice deep breathing exercises.
💧
Stay up to date with vaccinations (flu, pneumonia).
🧘
Maintain a healthy weight to reduce breathing effort.

🏋️ Exercise Considerations

Avoid strenuous exercise if you have breathing difficulties. Consult your doctor before starting any exercise program. Gentle activities like walking or swimming may be beneficial.

🥗 Diet Recommendations

Include plenty of fluids to help thin mucus.
Eat a balanced diet rich in fruits and vegetables.
Avoid foods that trigger allergies or asthma symptoms.
Limit caffeine intake as it may increase restlessness.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or restlessness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It should not significantly impact your ability to work if you follow your doctor's advice.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your condition worsens, contact your healthcare provider immediately.

📅 Long-Term Use Effects

Long-term use of this medicine may require periodic monitoring of liver and kidney function, as well as heart rate. It is generally well-tolerated, but prolonged use should be under medical supervision. Do not stop abruptly without consulting your doctor.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Inhaled bronchodilators

Fast-acting inhalers can provide quick relief from acute symptoms.

Evidence: Well-established
Inhaled corticosteroids

Reduce airway inflammation and prevent exacerbations.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Ensure you are up to date with influenza and pneumococcal vaccinations, as respiratory infections can worsen asthma and COPD.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing times gradually as advised by your doctor. Keep enough supply for the entire trip. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic asthma
Started this medicine as prescribed for asthma. Within a week noticed significant improvement in breathing and reduced cough. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 60-year-old retired teacher with COPD
Was prescribed this medicine for COPD. After two weeks, experienced easier breathing and less mucus production. Noted that skipping doses led to return of symptoms.
💡 Lesson: Regular adherence to the prescribed schedule is key to managing chronic respiratory conditions.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30 to 60 minutes after oral intake, with peak effects in 1 to 2 hours.

Q: Can I take it with food?

A: Yes, it can be taken with or without food, but taking it with food may reduce stomach upset.

Q: What are the common side effects?

A: Common side effects include nausea, vomiting, stomach discomfort, headache, and restlessness.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for acibro 100mg capsule

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure asthma permanently.
    Fact: This medicine helps control symptoms but does not cure asthma. It should be used as part of a comprehensive treatment plan.
  • Myth: It is safe to take extra doses if you feel breathless.
    Fact: Taking more than the prescribed dose can be dangerous and may cause serious side effects. Always follow your doctor's instructions.

🔄 Alternative Options

Generic Alternatives

  • Acebrophylline 100 mg capsules

📊 Comparison with Similar Medicines

[{"medicine":"Acebrophylline","class":"Xanthine derivative with mucolytic","primary_use":"Asthma, COPD","route":"Oral"},{"medicine":"Theophylline","class":"Xanthine bronchodilator","primary_use":"Asthma, COPD","route":"Oral, IV"},{"medicine":"Ambroxol","class":"Mucolytic","primary_use":"Productive cough","route":"Oral"}]

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