acelive d 80mg/100mg tablet - Drotaverine (80mg) + Aceclofenac (100mg) medicine

Aceclo Spas Tablet: Comprehensive Guide to Uses, Side Effects, and Safety

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🏭 Yodley Life Sciences Private Limited 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Use only if clearly needed and prescribed by a doctor. Avoid in the third trimester due to risk of premature closure of ductus arteriosus and other complications. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate to well-established for individual components; combination evidence is limited.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bruising or bleeding

If experiencing severe symptoms, call emergency services immediately.

What is acelive d 80mg/100mg tablet used for?

This medicine is a combination of Drotaverine (80 mg) and Aceclofenac (100 mg) used to relieve pain and smooth muscle spasm in conditions like abdominal cramps, biliary colic, renal colic, and menstrual cramps. It works by relaxing smooth muscles and reducing inflammation. It should be taken with food and only under medical supervision.

  • Generic Name: Drotaverine + Aceclofenac
  • Manufacturer: Yodley Life Sciences Private Limited
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 acelive d 80mg/100mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा ड्रोटावेरिन 80 मिलीग्राम और एसिटोक्लोफेनाक 100 मिलीग्राम का संयोजन है। इसका उपयोग पेट की ऐंठन, पित्ताशय की ऐंठन, गुर्दे की ऐंठन और मासिक धर्म के दर्द में किया जाता है। यह मांसपेशियों की ऐंठन को कम करती है और दर्द व सूजन को कम करती है। इसे डॉक्टर की सलाह के अनुसार ही लें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, दस्त, कब्ज, सिरदर्द, चक्कर आना और मुंह सूखना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, अल्सर, गुर्दे की समस्या, यकृत की समस्या और एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। इसे भोजन या दूध के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब न लें। यदि आपको चक्कर आते हैं तो वाहन न चलाएं। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 acelive d 80mg/100mg tablet Uses & Benefits

[{"condition":"Abdominal cramps associated with smooth muscle spasm","description":"Relieves pain and spasm in the gastrointestinal tract, often due to irritable bowel syndrome or gastroenteritis.","evidence":"Well-established"},{"condition":"Biliary colic","description":"Helps relieve pain and spasm in the biliary tract, often associated with gallstones.","evidence":"Well-established"},{"condition":"Renal colic","description":"Provides relief from pain and spasm in the urinary tract, commonly due to kidney stones.","evidence":"Well-established"},{"condition":"Primary dysmenorrhea","description":"Reduces menstrual cramps and associated pain by relaxing uterine smooth muscle and reducing inflammation.","evidence":"Well-established"},{"condition":"Post-operative pain with spasm","description":"Used to manage pain and smooth muscle spasm following certain surgical procedures.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Tension-type headache","description":"Sometimes prescribed off-label for tension headaches with associated muscle spasm.","evidence":"Limited"},{"condition":"Cervical spondylosis with muscle spasm","description":"May be used off-label for pain and spasm in cervical spondylosis.","evidence":"Limited"}]

Primary treatment for: Pain and smooth muscle spasm associated with gastrointestinal, biliary, and genitourinary conditions.

Also treats: Irritable bowel syndrome, Gallstones, Kidney stones, Primary dysmenorrhea, Post-operative spasm

📋 Drug Information

Generic Name(s)Drotaverine + Aceclofenac
Brand NameAceclo Spas Tablet
ManufacturerYodley Life Sciences Private Limited
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassAntispasmodic + NSAID
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always prescribe this medicine with food or milk to minimize gastrointestinal irritation.
2
Assess renal and hepatic function before starting and during prolonged therapy.
3
Avoid concurrent use with other NSAIDs or anticoagulants to prevent bleeding risk.
4
Counsel patients to avoid alcohol while taking this medicine.
5
Use the lowest effective dose for the shortest duration necessary.
6
Monitor elderly patients closely for gastrointestinal and renal side effects.
7
Instruct patients to report any signs of gastrointestinal bleeding immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Abdominal cramps
This medicine is commonly prescribed for this.
Likely Use
Biliary colic
This medicine is commonly prescribed for this.
Likely Use
Renal colic
This medicine is commonly prescribed for this.
Likely Use
Menstrual cramps
This medicine is commonly prescribed for this.
Likely Use
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDrotaverine is rapidly absorbed after oral administration. Aceclofenac is also rapidly absorbed from the gastrointestinal tract. Food may delay absorption of aceclofenac but does not significantly affect the extent of absorption.
DistributionDrotaverine is widely distributed in tissues, including smooth muscle. Aceclofenac is highly protein-bound and distributes into synovial fluid, which is relevant for its anti-inflammatory action in joints.
Protein BindingAceclofenac is approximately 99% bound to plasma proteins, primarily albumin. Drotaverine is also highly protein-bound. Not established from the available information for drotaverine exact percentage.
MetabolismDrotaverine is extensively metabolized in the liver. Aceclofenac is metabolized in the liver, primarily by cytochrome P450 2C9, to its major metabolite 4'-hydroxyaceclofenac and other metabolites.
Half-LifeThe elimination half-life of aceclofenac is approximately 4 hours. The elimination half-life of drotaverine is not established from the available information.
ExcretionAceclofenac and its metabolites are excreted primarily in urine and to a lesser extent in feces. Drotaverine is excreted mainly in urine as metabolites.
BioavailabilityThe oral bioavailability of aceclofenac is approximately 80-100%. The oral bioavailability of drotaverine is not established from the available information.
Onset of ActionThe onset of action for drotaverine is typically within 30 minutes to 1 hour. Aceclofenac onset of analgesia is usually within 30-60 minutes.
Peak Plasma TimePeak plasma concentration of aceclofenac is reached approximately 1.5 to 3 hours after oral administration. Peak plasma time for drotaverine is not established from the available information.
Duration of ActionThe duration of action for aceclofenac is approximately 4 to 6 hours. The duration of action for drotaverine is not established from the available information.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Drotaverine is a selective phosphodiesterase-4 inhibitor that increases cyclic adenosine monophosphate levels in smooth muscle cells, leading to relaxation and relief of spasm. Aceclofenac is a nonsteroidal anti-inflammatory drug that inhibits cyclooxygenase enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. The combination provides both smooth muscle relaxation and anti-inflammatory analgesia.

Mechanism Steps

1
Drotaverine inhibits phosphodiesterase-4: Drotaverine selectively inhibits phosphodiesterase-4 in smooth muscle cells, preventing the breakdown of cyclic adenosine monophosphate.
2
Increased cyclic adenosine monophosphate: Elevated cyclic adenosine monophosphate levels lead to reduced intracellular calcium and relaxation of smooth muscle.
3
Aceclofenac inhibits cyclooxygenase: Aceclofenac inhibits cyclooxygenase-1 and cyclooxygenase-2 enzymes, reducing prostaglandin synthesis.
4
Reduced prostaglandins: Lower prostaglandin levels decrease pain, inflammation, and fever.
5
Combined effect: The combination provides both smooth muscle relaxation and anti-inflammatory analgesia, addressing both spasm and pain.

💡 How to Take acelive d 80mg/100mg tablet

Strength: Tablet containing Drotaverine 80 mg and Aceclofenac 100 mg.

1Take the tablet with a full glass of water.
2Take it with food or milk to reduce stomach upset.
3Swallow the tablet whole. Do not crush, chew, or break it.
4Take at the same time each day to maintain consistent levels.
5Do not lie down immediately after taking the tablet; stay upright for at least 30 minutes.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally one to three times daily, depending on the severity of the condition and the prescribing doctor's judgment. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the maximum recommended daily dose. Take with food or milk to reduce stomach upset.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine, especially gastrointestinal and renal side effects. Use with caution and consider lower doses. Dose must be individualized by a qualified clinician based on renal and hepatic function.
Renal ImpairmentUse with caution in patients with renal impairment. Dose reduction may be necessary. Avoid in severe renal impairment (creatinine clearance <30 mL/min). Consult a doctor for individualized dosing.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose reduction may be necessary. Avoid in severe hepatic impairment. Consult a doctor for individualized dosing.
Maximum Daily DoseThe maximum recommended daily dose is not established from the available information. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of gastrointestinal bleeding and liver toxicity.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of acelive d 80mg/100mg tablet

✅ Common Side Effects

Nausea (Common (1-10%))
Take with food or milk. If persistent, consult your doctor.
Abdominal pain (Common (1-10%))
Usually temporary. If severe or persistent, contact your doctor.
Indigestion (Common (1-10%))
Avoid spicy foods. Take with meals. Consult doctor if it continues.
Headache (Common (1-10%))
Rest and stay hydrated. If severe, consult your doctor.
Dizziness (Common (1-10%))
Avoid driving or operating machinery until you feel normal.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black or tarry stools, vomiting blood, or severe abdominal pain.
Peptic ulcer (Rare (<0.1%))
Report persistent stomach pain or heartburn to your doctor immediately.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek emergency help if you experience swelling of face, lips, tongue, or throat, difficulty breathing, or rash.
Kidney impairment (Rare (<0.1%))
Report decreased urine output, swelling in legs, or fatigue to your doctor.
Liver toxicity (Rare (<0.1%))
Seek medical attention if you notice yellowing of skin or eyes, dark urine, or severe fatigue.

⚠️ Rare Side Effects

Agranulocytosis
Report sudden fever, sore throat, or mouth ulcers to your doctor immediately.
Thrombocytopenia
Report unusual bruising or bleeding to your doctor.
Aplastic anemia
Seek medical attention for persistent fatigue, pallor, or shortness of breath.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Corticosteroids Major
Methotrexate Major
Lithium Major
ACE inhibitors Moderate
SSRIs Moderate
Cyclosporine Moderate
Digoxin Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., ibuprofen, naproxen)
  • Corticosteroids
  • Methotrexate
  • Lithium

⚡ Moderate Interactions

  • Antihypertensives (e.g., ACE inhibitors, ARBs, diuretics)
  • Selective serotonin reuptake inhibitors (SSRIs)
  • Cyclosporine
  • Digoxin

🍷 Alcohol Interaction

Avoid alcohol consumption while taking this medicine. Alcohol can increase the risk of gastrointestinal bleeding, ulceration, and liver toxicity. It may also enhance drowsiness and dizziness.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to drotaverine, aceclofenac, or any component of the formulation","Active peptic ulcer or history of recurrent peptic ulcer","Severe heart failure","Severe renal impairment (creatinine clearance

⚠️ Warnings & Precautions

["Take with food to minimize gastrointestinal irritation.","Avoid alcohol consumption.","Use with caution in elderly patients due to increased risk of side effects.","Monitor for signs of gastrointestinal bleeding, especially with long-term use.","Use with caution in patients with cardiovascular risk factors.","Do not exceed the recommended dose.","Consult your doctor if symptoms persist or worsen.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding."]

🤱 Lactation Safety

Not established from the available information. Aceclofenac and drotaverine may pass into breast milk. Consult your doctor before use if you are breastfeeding.

💊 Overdose Management

Overdose may cause nausea, vomiting, abdominal pain, dizziness, drowsiness, and in severe cases, gastrointestinal bleeding, kidney failure, or liver damage. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs, renal and hepatic function, and electrolyte levels.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Always take this medicine exactly as prescribed by your doctor. Take it with food or milk to reduce the risk of stomach upset. Do not crush, chew, or break the tablet unless instructed. Avoid alcohol consumption while taking this medicine as it can increase the risk of gastrointestinal bleeding. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart failure, or asthma. Do not take other pain relievers or anti-inflammatory drugs without consulting your doctor. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medicine. Keep out of reach of children. Store at room temperature away from moisture and heat.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use with caution, at the lowest effective dose, and monitor renal and hepatic function regularly.

🤰 Pregnancy Planning (TTC)

Consult your doctor before taking this medicine if you are planning to become pregnant. It is generally avoided during pregnancy, especially in the third trimester, due to potential risks to the fetus.

🏥 Post-Surgery Considerations

This medicine may be used for post-operative pain and spasm, but it should be prescribed by a doctor. It may increase the risk of bleeding, so inform your surgeon if you are taking it before surgery.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure, as it may increase the risk of bleeding. Your dentist may advise you to stop it temporarily.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints and muscles.
🥗
Stay well hydrated to support kidney function.
😴
Avoid alcohol and smoking.
💧
Practice relaxation techniques to reduce muscle tension.
🧘
Get adequate rest and sleep.
🌞
Include anti-inflammatory foods in your diet.

🏋️ Exercise Considerations

Avoid strenuous exercise or heavy lifting while taking this medicine, especially if you experience dizziness or fatigue. Gentle stretching and low-impact activities may be beneficial. Consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseeds.
Reduce intake of processed and spicy foods.
Stay well hydrated.
Eat small, frequent meals to avoid stomach upset.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food. Inform your employer if your work involves operating machinery.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if you experience severe side effects such as gastrointestinal bleeding, allergic reactions, or kidney problems. Do not stop abruptly if you are on long-term therapy without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney impairment, liver toxicity, and cardiovascular events. Regular monitoring of renal and hepatic function, complete blood count, and blood pressure is recommended. Use the lowest effective dose for the shortest duration possible.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain and spasm.

Evidence: Well-established
Heat therapy

Applying heat to the affected area can help relax muscles and relieve spasm.

Evidence: Moderate
Relaxation techniques

Deep breathing and meditation can help reduce muscle tension.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Not established from the available information. There are no known interactions between this medicine and vaccines. Consult your doctor for specific advice.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing schedule as advised by your doctor. Declare it to customs if required. Keep it in your carry-on luggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with severe menstrual cramps
She was prescribed this medicine for primary dysmenorrhea. She took it with food as directed and experienced significant relief within an hour. She was advised to avoid alcohol and to take it only during her periods.
💡 Lesson: Taking the medicine with food and adhering to the prescribed dose provides effective relief with minimal side effects.
👤 A 50-year-old man with renal colic due to a kidney stone
He received this medicine for severe flank pain. It helped relieve the spasm and pain, but he experienced mild nausea. His doctor advised him to take it with food and to stay hydrated.
💡 Lesson: This medicine can effectively manage renal colic pain, but patients should be monitored for side effects and hydration status.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain and spasm within 30 minutes to 1 hour after taking it.

Q: Can I take it on an empty stomach?

A: It is best taken with food or milk to reduce the risk of stomach upset.

Q: Is it safe to take with other painkillers?

A: Do not take other NSAIDs or painkillers without consulting your doctor, as it may increase the risk of side effects.

Q: Can I take it if I am pregnant?

A: Consult your doctor before taking this medicine if you are pregnant or planning to become pregnant. It is generally avoided in the third trimester.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for acelive d 80mg/100mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken for any type of pain.
    Fact: This medicine is specifically for pain associated with smooth muscle spasm. It is not a general pain reliever for all types of pain.
  • Myth: It is safe to take this medicine for long periods without monitoring.
    Fact: Long-term use requires monitoring of kidney and liver function and may increase the risk of gastrointestinal bleeding.
  • Myth: This medicine is safe to take during pregnancy.
    Fact: It should be avoided during pregnancy, especially in the third trimester, unless prescribed by a doctor.

🔄 Alternative Options

Generic Alternatives

  • Drotaverine + Aceclofenac combination generics available

Brand Alternatives

  • Aceclo Spas Tablet
  • Drotin-A Tablet
  • Aceclofenac + Drotaverine Tablet

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Drotaverine 80 mg + Aceclofenac 100 mg","uses":"Pain with smooth muscle spasm","notes":"Combination provides both spasm relief and anti-inflammatory action."},{"medicine":"Drotaverine alone","composition":"Drotaverine 80 mg","uses":"Smooth muscle spasm","notes":"No anti-inflammatory component."},{"medicine":"Aceclofenac alone","composition":"Aceclofenac 100 mg","uses":"Pain and inflammation","notes":"No smooth muscle relaxant effect."}]

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