aceclomac plus 50mg/5ml/125mg/5ml syrup - Aceclofenac (50mg/5ml) + Paracetamol (125mg/5ml) medicine

aceclomac plus 50mg/5ml/125mg/5ml syrup

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🏭 Torque Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 21, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

What is aceclomac plus 50mg/5ml/125mg/5ml syrup used for?

This medicine contains Aceclofenac (50mg/5ml) + Paracetamol (125mg/5ml) and is used to treat PAIN ANALGESICS. Aceclofenac inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Paracetamol inhibits COX in . Always consult your doctor before use.

  • Generic Name: Aceclofenac + Paracetamol
  • Manufacturer: Torque Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 aceclomac plus 50mg/5ml/125mg/5ml syrup Uses & Benefits

Pain and inflammation in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, dental pain, dysmenorrhea, fever.

Off-label uses: Postoperative pain, migraine (limited evidence).

📋 Drug Information

Generic Name(s)Aceclofenac + Paracetamol
Brand NameAldigesic P
ManufacturerTorque Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNSAID + Analgesic/Antipyretic
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionWell absorbed orally
DistributionDistributes widely in tissues
Protein BindingAceclofenac: >99%; Paracetamol: 10-25%
MetabolismAceclofenac: hepatic via CYP2C9; Paracetamol: hepatic via glucuronidation and sulfation
Half-LifeAceclofenac: 4-5 h; Paracetamol: 2-3 h
ExcretionRenal (primarily urine)
BioavailabilityAceclofenac: ~100%; Paracetamol: ~88%
Onset of Action30-60 minutes
Peak Plasma TimeAceclofenac: 1-3 h; Paracetamol: 0.5-2 h
Duration of Action4-6 hours

How It Works

Aceclofenac inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Paracetamol inhibits COX in the CNS, elevating pain threshold and acting on hypothalamic heat-regulating center.

Mechanism Steps

1Aceclofenac inhibits COX-1 and COX-2, decreasing prostaglandin synthesis.
2Reduced prostaglandins lead to decreased inflammation and pain.
3Paracetamol inhibits COX in the CNS, reducing pain signal transmission.
4Paracetamol acts on hypothalamic heat-regulating center to reduce fever.
5Combined effect provides enhanced analgesia and antipyresis.

💡 How to Take aceclomac plus 50mg/5ml/125mg/5ml syrup

Follow your doctor's prescription exactly.

⚠️ Side Effects of aceclomac plus 50mg/5ml/125mg/5ml syrup

✅ Common Side Effects

Nausea
Dizziness
Drowsiness
Rash
GI upset

🚨 Serious Side Effects

GI bleeding
Hepatotoxicity
Renal failure
Stevens-Johnson syndrome

⚠️ Rare Side Effects

Blood dyscrasias
Anaphylaxis
Pancreatitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased bleeding risk
Methotrexate Major Increased methotrexate toxicity
Lithium Major Increased lithium levels
Aspirin Major Increased risk of GI ulceration
ACE inhibitors Moderate Reduced antihypertensive effect
Diuretics Moderate Reduced diuretic efficacy
Anticoagulants Moderate Increased INR
SSRIs Moderate Increased bleeding risk
Antacids Minor Reduced absorption of aceclofenac
Cholestyramine Minor Reduced absorption of paracetamol

🚨 Major Interactions

  • Warfarin
  • Methotrexate
  • Lithium
  • Aspirin

⚡ Moderate Interactions

  • ACE inhibitors
  • Diuretics
  • Anticoagulants
  • SSRIs

🍷 Alcohol Interaction

Increased risk of hepatotoxicity (paracetamol) and GI bleeding (aceclofenac).

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity, active peptic ulcer, severe hepatic/renal impairment, third trimester pregnancy, history of asthma with NSAIDs.

🤱 Lactation Safety

Caution; paracetamol is safe, aceclofenac may be excreted in small amounts.

💊 Overdose Management

Activated charcoal, N-acetylcysteine for paracetamol overdose; supportive care for aceclofenac.

⏰ Missed Dose

Take as soon as remembered; skip if near next dose; do not double dose.

🔄 Substitutes for aceclomac plus 50mg/5ml/125mg/5ml syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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