acnecure gel - Clarithromycin (1% w/w) medicine

Acnesol CL Gel: A Complete Guide to Uses, Side Effects, and Safety

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🏭 Torque Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 20, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Moderate for topical clarithromycin in acne; supported by clinical studies.
Reviewed by
SaathiMed Expert Panel | Sep 20, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe allergic reaction: swelling of face, lips, or throat, difficulty breathing.
  • Severe skin reaction: blistering, peeling, or sores in the mouth or eyes.
  • Signs of secondary infection: increased redness, pus, or pain.
  • No improvement after 8 weeks of use.
  • Worsening of acne despite treatment.
  • Development of new skin lesions or rashes.

If experiencing severe symptoms, call emergency services immediately.

What is acnecure gel used for?

Acnesol CL Gel is a topical antibiotic gel containing clarithromycin 1% w/w. It is used to treat inflammatory acne by reducing the bacteria that cause pimples. Apply a thin layer to the affected area once or twice daily as prescribed by your doctor.

  • Generic Name: Clarithromycin
  • Manufacturer: Torque Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 acnecure gel के बारे में (Hindi Summary)

उपयोग: यह दवा एक टॉपिकल जेल है जिसमें क्लैरिथ्रोमाइसिन 1% w/w होता है। यह मुँहासे (एक्ने) के इलाज के लिए इस्तेमाल की जाती है। यह त्वचा पर मौजूद बैक्टीरिया को मारती है जो मुँहासे पैदा करते हैं। यह लाल, सूजे हुए दानों को कम करने में मदद करती है। इसे डॉक्टर की सलाह पर ही लगाएं। इसे आंखों, होंठों और म्यूकस मेम्ब्रेन से दूर रखें।

साइड इफेक्ट्स: आम साइड इफेक्ट्स में त्वचा का सूखना, पपड़ी बनना, खुजली, जलन और लालिमा शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर साइड इफेक्ट्स दुर्लभ हैं, लेकिन अगर सांस लेने में तकलीफ, चेहरे या गले में सूजन, या त्वचा पर छाले पड़ें तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को केवल त्वचा पर ही लगाएं, मुँह से न लें। आंखों, होंठों और म्यूकस मेम्ब्रेन से बचाएं। टूटी या कटी त्वचा पर न लगाएं। डॉक्टर के बताए अनुसार ही इस्तेमाल करें। ज्यादा मात्रा में या लंबे समय तक बिना सलाह के न लगाएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 acnecure gel Uses & Benefits

[{"condition":"Inflammatory acne vulgaris","description":"This medicine is used to treat mild to moderate inflammatory acne by reducing the bacteria that cause inflammation and pimples.","evidence":"Well-established"},{"condition":"Acne with sensitive skin","description":"May be prescribed for patients who cannot tolerate other topical antibiotics like erythromycin or clindamycin.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Rosacea","description":"Sometimes used off-label to reduce inflammation in rosacea, though evidence is limited.","evidence":"Limited"},{"condition":"Perioral dermatitis","description":"Rarely used off-label for perioral dermatitis, but not a standard treatment.","evidence":"Limited"}]

Primary treatment for: Acne vulgaris

Also treats: Inflammatory acne, Comedonal acne

📋 Drug Information

Generic Name(s)Clarithromycin
Brand NameAcnesol CL Gel
ManufacturerTorque Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassMacrolides
Route of AdministrationTopical
StorageStore at room temperature (15-30°C). Protect from light and moisture. Keep away from direct sunlight. Do not freeze.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Apply a thin layer of this medicine to the affected area only, avoiding healthy skin.
2
Use a gentle, non-comedogenic cleanser before applying the gel.
3
Moisturize regularly to prevent dryness and peeling.
4
Avoid using other topical acne products unless advised by your doctor.
5
Be patient; it may take several weeks to see improvement.
6
Do not stop using this medicine abruptly without consulting your doctor.
7
Use sunscreen daily as this medicine may increase sun sensitivity.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Inflammatory acne
This medicine is commonly prescribed for this.
Likely Use
Blackheads and whiteheads
This medicine is not a primary treatment for comedonal acne.
Not Primary
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionSystemic absorption of clarithromycin after topical application is minimal. Only a small fraction of the applied dose is absorbed through intact skin, and therefore systemic effects are unlikely.
DistributionNot established from the available information.
Protein BindingNot established from the available information.
MetabolismNot established from the available information.
Half-LifeNot established from the available information.
ExcretionNot established from the available information.
BioavailabilityNot established from the available information.
Onset of ActionImprovement in acne lesions may be noticed within 2 to 4 weeks of regular use, but full effects may take 6 to 8 weeks.
Peak Plasma TimeNot established from the available information.
Duration of ActionThe effect lasts as long as the medicine is used regularly. Once discontinued, acne may recur.

How It Works

Clarithromycin works by binding to the 50S ribosomal subunit of susceptible bacteria, thereby inhibiting protein synthesis. This action is primarily bacteriostatic, but it can be bactericidal at higher concentrations. In acne, it reduces the population of Cutibacterium acnes (formerly Propionibacterium acnes) on the skin, which helps to decrease inflammation and prevent the formation of new comedones and papules.

Mechanism Steps

1
Penetration into skin: After application, clarithromycin penetrates the stratum corneum and reaches the pilosebaceous units where Cutibacterium acnes resides.
2
Binding to ribosomes: Clarithromycin binds reversibly to the 50S ribosomal subunit of the bacteria, blocking the translocation step of protein synthesis.
3
Inhibition of protein synthesis: This binding prevents the elongation of polypeptide chains, thereby inhibiting bacterial protein synthesis and stopping bacterial growth.
4
Reduction of inflammation: By reducing bacterial numbers, the inflammatory response in the skin is diminished, leading to fewer acne lesions.

💡 How to Take acnecure gel

Strength: Topical gel containing clarithromycin 1% w/w.

1Wash your hands thoroughly before applying the gel.
2Clean and dry the affected area gently with a mild cleanser.
3Apply a thin layer of the gel to the affected area, avoiding the eyes, lips, and mucous membranes.
4Rub it in gently until it disappears.
5Wash your hands after application.
6Use as directed by your doctor, usually once or twice daily.
7Do not cover the treated area with tight dressings unless instructed.

Dosage Information

Adult DosageApply a thin layer of this medicine to the affected area once or twice daily, or as directed by your doctor. Clean and dry the skin before application. The dose must be individualized by a qualified clinician based on the severity of acne, skin sensitivity, and response to treatment. Do not use more than the prescribed amount or frequency.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dose adjustments are required for elderly patients. However, use with caution and monitor for skin irritation.
Renal ImpairmentNo dose adjustment is required for renal impairment due to minimal systemic absorption.
Hepatic ImpairmentNo dose adjustment is required for hepatic impairment due to minimal systemic absorption.
Maximum Daily DoseNot established from the available information. Use only as prescribed by a doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Apply the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not apply a double dose to catch up.

⚠️ Side Effects of acnecure gel

✅ Common Side Effects

Skin dryness (Common (5-10%))
Apply a moisturizer if needed. Consult doctor if severe.
Peeling (Common (5-10%))
Reduce frequency of application or use a gentle cleanser. Consult doctor if persists.
Itching (Common (5-10%))
Avoid scratching. Consult doctor if itching is severe or accompanied by rash.
Burning sensation (Common (5-10%))
Usually subsides with continued use. If severe, discontinue and consult doctor.
Redness (Common (5-10%))
May be temporary. If redness worsens, consult doctor.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience swelling of face, lips, throat, difficulty breathing, or severe rash.
Severe skin reactions (e.g., Stevens-Johnson syndrome) (Rare (<0.1%))
Stop use and seek immediate medical attention if you notice blistering, peeling, or sores in the mouth or eyes.
Secondary infection (Rare (<0.1%))
Consult doctor if you develop new or worsening skin infections, such as fungal infections.

⚠️ Rare Side Effects

Contact dermatitis
Discontinue use and consult a doctor. May require topical steroid treatment.
Photosensitivity
Use sunscreen and avoid excessive sun exposure. Consult doctor if reaction occurs.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Clindamycin topical Moderate
Tretinoin topical Moderate
Benzoyl peroxide Minor
Oral clarithromycin Minor
Warfarin Minor

🚨 Major Interactions

  • Other topical antibiotics (e.g., clindamycin, erythromycin)
  • Topical retinoids (e.g., tretinoin, adapalene)

⚡ Moderate Interactions

  • Oral clarithromycin
  • Warfarin

🍷 Alcohol Interaction

No known interaction with alcohol when used topically. However, alcohol consumption may worsen acne and should be limited.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to clarithromycin or other macrolide antibiotics","Known allergy to any component of the gel","Use in children under 12 years without medical advice"]

⚠️ Warnings & Precautions

["For external use only. Do not ingest.","Avoid contact with eyes, lips, and mucous membranes.","Do not apply to large areas of broken skin.","Discontinue if severe irritation or allergic reaction occurs.","Prolonged use may lead to bacterial resistance.","Use with caution in patients with a history of sensitive skin.","Inform your doctor if you are pregnant or breastfeeding."]

🤱 Lactation Safety

It is not known whether clarithromycin is excreted in breast milk after topical application. However, systemic absorption is minimal. Consult your doctor before using while breastfeeding. Avoid applying to the breast area to prevent infant exposure.

💊 Overdose Management

Overdose with topical clarithromycin is unlikely due to minimal systemic absorption. If accidental ingestion occurs, seek medical attention immediately. Symptoms of oral overdose may include nausea, vomiting, diarrhea, and abdominal pain. Treatment is supportive and symptomatic.

⏰ Missed Dose

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.

Additional Safety Advice

General Safety

For external use only. Avoid contact with eyes, lips, and mucous membranes. If accidental contact occurs, rinse thoroughly with water. Do not apply to broken or irritated skin. Use this medicine exactly as prescribed. Do not use more often or for longer than recommended, as this can increase the risk of side effects and antibiotic resistance. Wash your hands before and after applying the gel. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not use this medicine without a prescription. Keep out of reach of children. If your acne does not improve after 6 to 8 weeks of use, consult your doctor. Do not share this medicine with others, even if they have the same symptoms.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may have thinner skin and be more prone to irritation. Use with caution and monitor for adverse effects. No specific dose adjustment is required.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before using this medicine. Topical clarithromycin is generally considered low risk, but it is best to discuss with your healthcare provider.

🏥 Post-Surgery Considerations

If you have recently had surgery, consult your doctor before applying this medicine to the surgical area. Avoid applying to healing wounds unless instructed.

🦷 Dental Procedures

No specific precautions for dental procedures. Inform your dentist about all medications you are using.

💚 Lifestyle Tips for Better Results

🏃
Cleanse your face gently twice daily with a mild cleanser.
🥗
Avoid picking or squeezing pimples to prevent scarring.
😴
Use oil-free, non-comedogenic skincare and makeup products.
💧
Manage stress as it can worsen acne.
🧘
Get adequate sleep and maintain a balanced diet.
🌞
Stay hydrated by drinking plenty of water.

🏋️ Exercise Considerations

Exercise is generally safe while using this medicine. However, sweat may irritate the skin, so wash your face gently after exercising. Avoid sharing towels or equipment that may come into contact with the treated area.

🥗 Diet Recommendations

Include fruits and vegetables rich in antioxidants.
Limit high-glycemic foods that may worsen acne.
Reduce dairy intake if you notice it triggers your acne.
Stay hydrated by drinking water throughout the day.

💼 Impact on Daily Work & Life

This medicine is applied topically and is unlikely to affect your ability to drive or operate machinery. You can continue your normal daily activities. However, if you experience skin irritation, you may want to avoid activities that cause excessive sweating or friction on the treated area.

🛑 When to Stop This Medicine

Do not stop using this medicine without consulting your doctor. If you experience severe side effects or allergic reactions, stop immediately and seek medical advice. Your doctor will determine the appropriate duration of treatment based on your response.

📅 Long-Term Use Effects

Long-term use of topical antibiotics like this medicine can lead to bacterial resistance. It is generally recommended to use it for a limited duration, often in combination with other treatments. Regular follow-up with your doctor is important to assess effectiveness and adjust treatment. Prolonged use may also increase the risk of skin irritation and secondary infections.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Benzoyl peroxide

An alternative topical treatment for acne that kills bacteria and reduces inflammation.

Evidence: Well-established
Retinoids

Topical retinoids like adapalene help unclog pores and prevent new acne.

Evidence: Well-established
Oral antibiotics

For severe acne, oral antibiotics may be prescribed by a doctor.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No known interactions with vaccines. Continue with your regular vaccination schedule.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling with this medicine, keep it in its original packaging and carry a copy of your prescription. Store it at room temperature and protect it from extreme heat or cold. If you are crossing time zones, continue applying it as prescribed; there is no need for time zone adjustment for topical medications. Declare it at customs if required. Always pack it in your carry-on luggage to avoid loss.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 22-year-old college student with moderate acne on the face.
She was prescribed this medicine to apply twice daily. After 4 weeks, she noticed a significant reduction in pimples and redness. She experienced mild dryness, which was managed with a moisturizer. She emphasized the importance of consistency and not skipping doses.
💡 Lesson: Regular use and proper skin care can lead to good results with this medicine.
👤 A 30-year-old woman with sensitive skin and acne.
She was initially hesitant to use a topical antibiotic due to past irritation with other products. Her doctor recommended this medicine once daily. She tolerated it well with minimal irritation and saw improvement in her acne over 6 weeks. She advises patch testing before full application.
💡 Lesson: This medicine can be a good option for sensitive skin when used as directed.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start seeing improvement in 2 to 4 weeks, but it can take up to 8 weeks for full effects.

Q: Can I use it on my back?

A: Yes, it can be used on the back if prescribed by your doctor for acne in that area.

Q: Is it safe to use with other acne products?

A: Consult your doctor before combining with other acne treatments, as it may increase irritation.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I use this medicine long-term?
  • Will it make my skin dry?
  • Can I wear makeup while using this medicine?
  • Does it interact with my other acne treatments?
  • What if I miss a dose?
  • Can I use it during pregnancy?

🔄 Substitutes for acnecure gel

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Acnesol CL Gel can cure acne permanently.
    Fact: It helps control acne but does not cure it. Acne may recur after stopping treatment.
  • Myth: More gel means faster results.
    Fact: Using more than prescribed can increase irritation and does not speed up results.
  • Myth: You can stop using it as soon as acne clears.
    Fact: Stopping too early may lead to recurrence. Follow your doctor's advice on duration.

🔄 Alternative Options

Generic Alternatives

  • Clarithromycin 1% w/w topical gel (generic)

Brand Alternatives

  • Acnesol CL Gel

📊 Comparison with Similar Medicines

[{"medicine":"Acnesol CL Gel","active_ingredient":"Clarithromycin 1%","class":"Macrolide antibiotic","route":"Topical","primary_use":"Inflammatory acne"},{"medicine":"Clindamycin gel","active_ingredient":"Clindamycin 1%","class":"Lincosamide antibiotic","route":"Topical","primary_use":"Inflammatory acne"},{"medicine":"Erythromycin gel","active_ingredient":"Erythromycin 2%","class":"Macrolide antibiotic","route":"Topical","primary_use":"Inflammatory acne"}]

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