Nuflam TH 200mg/16mg Tablet: Comprehensive Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain or persistent indigestion
- Chest pain, shortness of breath, or difficulty breathing
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes (jaundice)
- Decreased urine output or swelling in legs
- Severe headache with visual changes
- Unusual bruising or bleeding
- High fever with rash or confusion
If experiencing severe symptoms, call emergency services immediately.
What is zerodol th od 200 mg/16 mg capsule sr used for?
This medicine is a combination of Aceclofenac (an NSAID) and Thiocolchicoside (a muscle relaxant) used for short-term relief of acute musculoskeletal pain and muscle spasm. It works by reducing inflammation and relaxing muscles. It should be taken with food and only as prescribed.
- Generic Name: Aceclofenac (200mg) + Thiocolchicoside (16mg)
- Manufacturer: Ipca Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 zerodol th od 200 mg/16 mg capsule sr के बारे में (Hindi Summary)
उपयोग: यह दवा एसिफेनाक और थायोकोल्चिकोसाइड का संयोजन है, जिसका उपयोग मांसपेशियों में ऐंठन और दर्द के इलाज के लिए किया जाता है। यह तीव्र मस्कुलोस्केलेटल दर्द, जैसे कमर दर्द, गर्दन दर्द, और चोट के बाद होने वाले दर्द में राहत देती है। यह सूजन को कम करती है और मांसपेशियों को आराम देती है। इसका उपयोग केवल डॉक्टर के परामर्श से ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन पेट में रक्तस्राव, एलर्जी, गुर्दे या यकृत की समस्या हो सकती है। यदि आपको काला मल, खून की उल्टी, त्वचा या आंखों का पीलापन, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। शराब का सेवन न करें। यदि आपको चक्कर या नींद आती है, तो वाहन न चलाएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से परामर्श करें। दवा को बच्चों की पहुंच से दूर रखें।
💊 zerodol th od 200 mg/16 mg capsule sr Uses & Benefits
[{"condition":"Acute musculoskeletal pain with muscle spasm","description":"This medicine is used for short-term relief of acute pain and spasm in conditions such as low back pain, neck pain, and myofascial pain syndrome.","evidence":"Well-established for short-term use"},{"condition":"Post-operative pain and inflammation","description":"It helps manage pain and swelling after orthopedic surgeries or trauma, reducing the need for stronger painkillers.","evidence":"Moderate evidence"},{"condition":"Osteoarthritis flare-ups","description":"Provides symptomatic relief during acute exacerbations of osteoarthritis, improving joint mobility and reducing pain.","evidence":"Moderate evidence"},{"condition":"Rheumatoid arthritis","description":"May be used as an adjunct for short-term symptom relief during flares, but not as a disease-modifying therapy.","evidence":"Limited evidence"},{"condition":"Ankylosing spondylitis","description":"Can help relieve pain and stiffness in the short term, but long-term management requires other therapies.","evidence":"Limited evidence"}]
Off-label uses: [{"condition":"Tension-type headache","description":"Sometimes prescribed off-label for tension headaches associated with muscle tightness, but evidence is limited.","evidence":"Limited"},{"condition":"Fibromyalgia","description":"Occasionally used for short-term symptom relief in fibromyalgia, but not a standard treatment.","evidence":"Limited"}]
Primary treatment for: Acute musculoskeletal pain with muscle spasm
Also treats: Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, Post-operative pain, Low back pain, Neck pain
📋 Drug Information
| Generic Name(s) | Aceclofenac (200mg) + Thiocolchicoside (16mg) |
| Brand Name | zerodol th od 200 mg/16 mg capsule sr |
| Manufacturer | Ipca Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container, tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Aceclofenac is a non-steroidal anti-inflammatory drug that inhibits the cyclooxygenase (COX) enzymes, particularly COX-2, thereby reducing the production of prostaglandins, which are mediators of pain, inflammation, and fever. Thiocolchicoside is a centrally acting muscle relaxant that acts as a GABA-A receptor agonist, enhancing inhibitory neurotransmission in the spinal cord and brainstem, which reduces muscle spasm and tone. Together, they provide both anti-inflammatory and muscle-relaxant effects, addressing both the inflammatory component and the muscle spasm that often accompany acute musculoskeletal pain.
Mechanism Steps
💡 How to Take zerodol th od 200 mg/16 mg capsule sr
Strength: Tablet containing Aceclofenac 200 mg and Thiocolchicoside 16 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally once or twice daily, as prescribed by your doctor. The exact dose and duration depend on the condition being treated, its severity, and your response to therapy. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the effects of this medicine, especially gastrointestinal, renal, and cardiovascular side effects. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with mild to moderate renal impairment. Dose reduction may be necessary. This medicine is contraindicated in severe renal impairment (creatinine clearance <30 mL/min). Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | Use with caution in patients with mild to moderate hepatic impairment. Dose reduction may be necessary. This medicine is contraindicated in severe hepatic impairment. Dose must be individualized by a qualified clinician based on hepatic function. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet twice daily (Aceclofenac 400 mg + Thiocolchicoside 32 mg). Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of zerodol th od 200 mg/16 mg capsule sr
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ibuprofen | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Moderate | |
| SSRIs | Moderate | |
| Oral hypoglycemics | Moderate | |
| Cyclosporine | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Other NSAIDs (e.g., ibuprofen, naproxen)
- Corticosteroids
- Methotrexate
- Lithium
⚡ Moderate Interactions
- Antihypertensives (e.g., ACE inhibitors, ARBs, diuretics)
- SSRIs
- Oral hypoglycemics
- Cyclosporine
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the risk of stomach bleeding, ulcers, and liver damage. It may also enhance drowsiness and dizziness, making it unsafe to drive or operate machinery.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to Aceclofenac, Thiocolchicoside, or any component of the formulation.","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.","Active or history of recurrent peptic ulcer or gastrointestinal bleeding.","Severe heart failure, ischemic heart disease, or peripheral arterial disease.","Severe liver impairment or active liver disease.","Severe kidney impairment (e.g., creatinine clearance
⚠️ Warnings & Precautions
["Take with food or milk to minimize gastrointestinal irritation.","Avoid concurrent use with other NSAIDs or corticosteroids.","Use with caution in elderly patients, who are at higher risk of side effects.","Do not drive or operate machinery if you experience dizziness or drowsiness.","Avoid alcohol consumption during treatment.","Inform your doctor if you have a history of kidney or liver disease, heart failure, or hypertension.","Do not use for longer than prescribed; prolonged use increases the risk of serious side effects.","Report any signs of bleeding, such as black stools or blood in vomit, immediately.","This medicine may mask signs of infection; consult a doctor if you develop a fever.","Keep out of reach of children."]
🤱 Lactation Safety
Not established from the available information. It is not known whether this medicine passes into breast milk. Breastfeeding women should consult their doctor before using this medicine.
💊 Overdose Management
Overdose of this medicine may cause severe nausea, vomiting, abdominal pain, gastrointestinal bleeding, drowsiness, and kidney or liver damage. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic, including gastric lavage if appropriate, activated charcoal, and monitoring of vital signs and organ function. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not increase the dose or take it for longer than recommended. Take it with food or milk to reduce stomach upset. Swallow the tablet whole with a glass of water; do not crush or chew it. Avoid alcohol while taking this medicine, as it can increase the risk of stomach bleeding and liver problems. Do not drive or operate heavy machinery if you feel dizzy or drowsy after taking this medicine. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart problems, asthma, or bleeding disorders. Also tell your doctor about all other medicines you are taking, including over-the-counter drugs, supplements, and herbal products, as this medicine can interact with many of them. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medicine. Do not share this medicine with others, even if they have similar symptoms. Store it at room temperature, away from moisture and direct sunlight, and keep it out of reach of children. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events when taking NSAIDs like Aceclofenac. They may also be more sensitive to the central nervous system effects of Thiocolchicoside, such as drowsiness and dizziness. Use the lowest effective dose for the shortest duration, and monitor renal and hepatic function regularly.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy, especially in the third trimester, as it may harm the fetus. If you are planning to become pregnant or are pregnant, consult your doctor for safer alternatives for pain relief. Do not take this medicine without medical advice.
🏥 Post-Surgery Considerations
This medicine may be prescribed after surgery to manage pain and muscle spasm. However, it should be used with caution due to the risk of bleeding and impaired wound healing. Follow your surgeon's instructions carefully, and inform them if you experience any unusual symptoms. Do not use it for prolonged periods after surgery without medical supervision.
🦷 Dental Procedures
If you are scheduled for dental surgery or procedures, inform your dentist that you are taking this medicine. NSAIDs can increase the risk of bleeding during and after dental procedures. Your dentist may advise you to stop the medicine temporarily or take precautions. Do not stop the medicine without consulting your prescribing doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness or drowsiness. Avoid activities that require full alertness, such as driving or operating heavy machinery, until you know how the medicine affects you. Gentle stretching and low-impact exercises may be beneficial, but avoid strenuous activities that could worsen your condition. Consult your doctor or physiotherapist before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, drowsiness, or blurred vision in some people. If you experience these effects, avoid driving, operating machinery, or performing tasks that require mental alertness. It is advisable to inform your employer if your job involves such activities. Most people can continue their normal daily activities with caution, but listen to your body and rest when needed.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor immediately if you experience any serious side effects such as black stools, vomiting blood, severe abdominal pain, allergic reactions, or signs of kidney or liver problems. Do not stop taking this medicine abruptly without consulting your doctor, especially if you have been on it for more than a few days. Your doctor will advise you on the appropriate duration of treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of serious side effects. Prolonged use of Aceclofenac can lead to gastrointestinal ulcers and bleeding, kidney impairment, liver toxicity, and increased cardiovascular risk. Thiocolchicoside may cause liver enzyme elevations. Regular monitoring of liver and kidney function is advised if extended use is necessary. Always consult your doctor before using this medicine for more than a few days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve muscle strength and flexibility.
Evidence: Well-establishedApplying heat or cold packs can help relieve muscle spasm and pain.
Evidence: Moderate evidenceMay provide pain relief for some musculoskeletal conditions.
Evidence: Limited evidenceYoga, meditation, and relaxation techniques can help manage chronic pain.
Evidence: Moderate evidence💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a vaccine, inform your healthcare provider that you are taking this medicine. It is generally safe to receive vaccines while on this medicine, but your doctor will advise based on your overall health.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking it at the same intervals as prescribed; consult your doctor for specific advice. Keep it in your carry-on luggage to avoid loss. Check local customs regulations regarding prescription medicines before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it. However, the full effect may take a few hours.
A: It is best to take this medicine with food or milk to reduce the risk of stomach upset. Taking it on an empty stomach may increase the chance of gastrointestinal side effects.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: No, you should avoid alcohol while taking this medicine as it can increase the risk of stomach bleeding and liver damage.
A: This medicine is intended for short-term use only. Prolonged use can increase the risk of serious side effects such as gastrointestinal bleeding, kidney damage, and cardiovascular events. Consult your doctor if you need pain relief for more than a few days.
🤔 Common Patient Concerns
🔄 Substitutes for zerodol th od 200 mg/16 mg capsule sr
View AllAlternative brands with exact same active ingredient:
-
Thioceclo 200mg/16mg Tablet SRAristo Pharmaceuticals Pvt Ltd ₹159.38 12.8% CHEAPER
-
Thiox OD 16mg Capsule SRWallace Pharmaceuticals Pvt Ltd ₹179.67 1.7% CHEAPER
-
nuflam th 200mg/16mg tabletCadila Pharmaceuticals Ltd ₹179.72 1.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken long-term for chronic pain.
Fact: This medicine is intended for short-term use only. Prolonged use increases the risk of serious side effects such as gastrointestinal bleeding, kidney damage, and cardiovascular events. - Myth: It is safe to take this medicine without a prescription.
Fact: This is a prescription medicine. It should only be taken under the supervision of a qualified doctor. - Myth: Taking this medicine with alcohol is safe.
Fact: Alcohol increases the risk of stomach bleeding and liver damage. Avoid alcohol while taking this medicine. - Myth: This medicine can cure arthritis.
Fact: This medicine provides symptomatic relief but does not cure arthritis. Long-term management requires a comprehensive treatment plan.
🔄 Alternative Options
Generic Alternatives
- Aceclofenac 200 mg + Thiocolchicoside 16 mg tablet (generic versions available)
Brand Alternatives
- Nuflam TH 200mg/16mg tablet