Gudfyl 2.5 mg/500 mg Tablet: Complete Information
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is zandril 2.5mg/500mg/5mg tablet used for?
This medicine is a combination of Chlorpheniramine Maleate (an antihistamine) and Paracetamol (a pain reliever and fever reducer). It is used to treat symptoms of allergies and the common cold, such as runny nose, sneezing, and mild fever. It works by blocking histamine and reducing pain and fever. It should be taken as prescribed, usually 1 tablet every 6-8 hours, not exceeding 4 tablets in 24 hours.
- Generic Name: Chlorpheniramine Maleate (2.5mg) + Paracetamol (500mg)
- Manufacturer: Simpson Brawn Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 zandril 2.5mg/500mg/5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एलर्जी और सर्दी-जुकाम के लक्षणों जैसे नाक बहना, छींक आना, आंखों में पानी आना, खुजली, हल्का बुखार और शरीर दर्द में राहत देने के लिए इस्तेमाल की जाती है। इसमें क्लोरफेनिरामाइन मेलिएट और पैरासिटामोल होते हैं। यह दवा डॉक्टर के परामर्श से ही लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, धुंधली दृष्टि और पेट में गड़बड़ी शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, यकृत की समस्या या रक्त विकार हो सकते हैं। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसकी मात्रा न बढ़ाएं। इस दवा को लेने के बाद वाहन चलाने या मशीनरी चलाने से बचें क्योंकि इससे नींद आ सकती है। शराब का सेवन न करें। यदि आपको यकृत या गुर्दे की बीमारी, ग्लूकोमा, प्रोस्टेट की समस्या या अस्थमा है तो डॉक्टर को बताएं। 7 दिनों से अधिक इस दवा का उपयोग बिना डॉक्टर की सलाह के न करें।
💊 zandril 2.5mg/500mg/5mg tablet Uses & Benefits
[{"condition":"Allergic rhinitis","description":"Relieves sneezing, runny nose, itching, and watery eyes associated with seasonal or perennial allergies.","evidence":"Well-established"},{"condition":"Urticaria","description":"Reduces itching and skin rash due to allergic reactions.","evidence":"Well-established"},{"condition":"Common cold","description":"Provides symptomatic relief from runny nose, sneezing, and mild fever or body ache.","evidence":"Well-established"},{"condition":"Allergic conjunctivitis","description":"Helps reduce eye itching and redness due to allergies.","evidence":"Limited"}]
Off-label uses: [{"condition":"Insomnia","description":"Sometimes used off-label for its sedative effect to promote sleep, but not recommended due to side effects.","evidence":"Limited"},{"condition":"Motion sickness","description":"May be used off-label to prevent nausea and vomiting associated with motion sickness.","evidence":"Limited"}]
Primary treatment for: Allergic rhinitis
Also treats: Urticaria, Common cold, Allergic conjunctivitis
📋 Drug Information
| Generic Name(s) | Chlorpheniramine Maleate (2.5mg) + Paracetamol (500mg) |
| Brand Name | zandril 2.5mg/500mg/5mg tablet |
| Manufacturer | Simpson Brawn Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Chlorpheniramine Maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors on effector cells, thereby preventing histamine-mediated allergic responses such as vasodilation, increased vascular permeability, and sensory nerve stimulation. Paracetamol (acetaminophen) acts primarily in the central nervous system by inhibiting prostaglandin synthesis, which results in antipyretic and analgesic effects. The exact mechanism of Paracetamol is not fully understood but is thought to involve inhibition of cyclooxygenase (COX) enzymes, particularly COX-2, in the brain.
Mechanism Steps
💡 How to Take zandril 2.5mg/500mg/5mg tablet
Strength: Tablet containing Chlorpheniramine Maleate 2.5 mg and Paracetamol 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1 tablet taken orally every 6 to 8 hours as needed for symptoms, not to exceed 4 tablets in 24 hours. However, the dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose due to the risk of liver toxicity from Paracetamol. This medicine is intended for short-term use only. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the anticholinergic and sedative effects of Chlorpheniramine. Use with caution and consider dose reduction. Consult a doctor for appropriate dosing. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a doctor for guidance. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction or avoidance may be necessary due to the risk of Paracetamol-induced hepatotoxicity. Consult a doctor for guidance. |
| Maximum Daily Dose | Maximum daily dose: 4 tablets in 24 hours. Do not exceed. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of zandril 2.5mg/500mg/5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Alcohol | Major | |
| Warfarin | Major | |
| Anticholinergics | Moderate | |
| CYP2D6 inhibitors | Moderate | |
| CYP3A4 inducers | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Alcohol and CNS depressants
- Warfarin
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
- CYP2D6 inhibitors (e.g., fluoxetine, quinidine)
- CYP3A4 inducers (e.g., rifampicin, carbamazepine)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase drowsiness and dizziness caused by Chlorpheniramine, and it can also increase the risk of liver damage from Paracetamol. Consuming alcohol may also worsen the sedative effects and impair your ability to drive or operate machinery.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to Chlorpheniramine Maleate, Paracetamol, or any component of the formulation","Newborns and premature infants","Nursing mothers","Severe liver disease or severe renal impairment","Patients taking MAOIs or within 14 days of stopping MAOIs","Narrow-angle glaucoma","Prostatic hypertrophy with urinary retention","Asthma or severe respiratory disease"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery.","Avoid alcohol and other CNS depressants.","Do not exceed recommended dose due to risk of liver toxicity.","Use with caution in patients with liver or kidney disease.","Use with caution in elderly patients due to increased risk of anticholinergic effects.","May cause paradoxical excitation in children.","Consult doctor if symptoms persist beyond 7 days.","Do not use for self-medication in children under 12 years without medical advice."]
🤱 Lactation Safety
Chlorpheniramine Maleate and Paracetamol are excreted in breast milk. This medicine is not recommended during breastfeeding due to potential risk of drowsiness and other side effects in the infant. Consult your doctor for alternative options.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, seizures, respiratory depression, and hepatotoxicity from Paracetamol. If overdose is suspected, seek immediate medical attention. Treatment includes gastric lavage if within 1-2 hours, administration of activated charcoal, and acetylcysteine for Paracetamol toxicity. Supportive care for CNS and respiratory depression may be required.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid driving or operating heavy machinery after taking this medicine because it can cause drowsiness. Avoid consuming alcohol or other central nervous system depressants while on this medicine. Inform your doctor if you have liver or kidney disease, glaucoma, prostate enlargement, or breathing problems such as asthma. Do not use this medicine for more than 7 days without consulting a doctor. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more susceptible to the anticholinergic and sedative effects of Chlorpheniramine, such as confusion, dry mouth, urinary retention, and falls. Use with caution and consider lower doses. Consult a doctor for appropriate dosing.
🤰 Pregnancy Planning (TTC)
Consult your doctor before taking this medicine if you are pregnant, planning to become pregnant, or breastfeeding. The safety of this medicine during pregnancy is not well established.
🏥 Post-Surgery Considerations
Consult your doctor before taking this medicine after surgery, as it may interact with other medications or affect recovery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may cause dry mouth and increase the risk of dental problems. It may also interact with medications used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities requiring mental alertness until you know how this medicine affects you, as it can cause drowsiness and dizziness.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, which may affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is advisable to avoid such activities until you know how the medicine affects you. Inform your employer if your work involves such tasks.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects. Do not stop abruptly if you have been taking it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of liver toxicity from Paracetamol and anticholinergic side effects from Chlorpheniramine. Prolonged use may lead to tolerance, dependence, and other health issues. Regular monitoring of liver and kidney function may be required if used for extended periods. Consult your doctor for alternative treatments if symptoms persist.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps clear nasal passages and reduce congestion without medication.
Evidence: Well-establishedCan help relieve nasal congestion and soothe irritated airways.
Evidence: LimitedReducing exposure to allergens can prevent allergy symptoms.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Consult your doctor regarding vaccination while taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, adjust the dosing schedule as advised by your doctor. Check customs regulations for carrying medications. Do not leave it in a hot car or checked luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30-60 minutes after oral administration.
A: It can be taken with or without food, but taking it with food may reduce stomach upset.
A: Consult your doctor before taking other cold medicines, as they may contain Paracetamol or antihistamines, leading to overdose or increased side effects.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for zandril 2.5mg/500mg/5mg tablet
View AllAlternative brands with exact same active ingredient:
-
gudfyl 2.5 mg/500 mg/5 mg tabletTrends Pharma Pvt Ltd ₹26.25 24.3% CHEAPER
-
coryl suspensionOmega Pharmaceuticals Pvt Ltd ₹32.81 5.4% CHEAPER
-
zandril 2.5mg/500mg/5mg syrupSimpson Brawn Pharmaceuticals ₹49.50 42.7% COSTLIER
-
alerfri oral dropsNavil Laboratories Pvt Ltd ₹53.44 54.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure allergies permanently.
Fact: This medicine only provides symptomatic relief and does not cure the underlying allergy. - Myth: It is safe to take this medicine with alcohol.
Fact: Alcohol increases the risk of drowsiness and liver toxicity; it should be avoided. - Myth: This medicine is safe for children under 2 years.
Fact: It is not recommended for children under 2 years due to risk of serious side effects.
🔄 Alternative Options
Generic Alternatives
- Chlorpheniramine Maleate + Paracetamol tablet