x tus d syrup - Menthol (1mg) + Chlorpheniramine Maleate (2mg) medicine

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🏭 Jollen Medicare Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for individual components; limited for the fixed-dose combination.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or swelling of face, lips, or throat
  • Severe drowsiness or confusion
  • Irregular or rapid heartbeat
  • Inability to urinate or severe lower abdominal pain
  • Blood in vomit or stool
  • Yellowing of skin or eyes
  • Seizures or severe headache

If experiencing severe symptoms, call emergency services immediately.

What is x tus d syrup used for?

This medicine is a combination of Menthol and Chlorpheniramine Maleate used to relieve cough and allergic symptoms such as runny nose and sneezing. It works by soothing the throat and blocking histamine. It may cause drowsiness, so avoid driving. Do not use for more than 7 days without consulting a doctor.

  • Generic Name: Menthol (1mg) + Chlorpheniramine Maleate (2mg)
  • Manufacturer: Jollen Medicare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 x tus d syrup के बारे में (Hindi Summary)

उपयोग: यह दवा मेंथॉल और क्लोरफेनिरामाइन मेलिएट का संयोजन है, जिसका उपयोग खांसी, गले में खराश, नाक बहना और छींक जैसे एलर्जी के लक्षणों से राहत दिलाने के लिए किया जाता है। मेंथॉल गले को ठंडक पहुंचाकर आराम देता है और क्लोरफेनिरामाइन एलर्जी को कम करता है। यह दवा नींद ला सकती है, इसलिए वाहन चलाने से बचें।

साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, मुंह सूखना, चक्कर आना, जी मिचलाना और धुंधली दृष्टि शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि सांस लेने में कठिनाई, चेहरे या गले में सूजन, या दिल की धड़कन अनियमित हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर की सलाह के अनुसार ही लें। निर्धारित मात्रा से अधिक न लें। शराब का सेवन न करें क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से परामर्श करें। 7 दिनों से अधिक उपयोग न करें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 x tus d syrup Uses & Benefits

[{"condition":"Cough associated with upper respiratory tract infections","description":"Provides symptomatic relief by loosening mucus and reducing throat irritation.","evidence":"Well-established for menthol as an expectorant; chlorpheniramine for allergic component."},{"condition":"Allergic rhinitis with cough","description":"Chlorpheniramine reduces sneezing, runny nose, and watery eyes; menthol soothes throat.","evidence":"Well-established for antihistamine effect."},{"condition":"Common cold with mild cough","description":"Helps manage cough and nasal symptoms, but does not shorten the duration of the cold.","evidence":"Supportive care; evidence for combination is limited."}]

Off-label uses: [{"condition":"Pruritus (itching) due to mild allergic reactions","description":"Chlorpheniramine may be used off-label for its sedative and antipruritic effects.","evidence":"Limited"}]

Primary treatment for: Cough and allergic rhinitis

Also treats: Common cold, Upper respiratory tract infection, Allergic cough

📋 Drug Information

Generic Name(s)Menthol (1mg) + Chlorpheniramine Maleate (2mg)
Brand Namex tus d syrup
ManufacturerJollen Medicare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep the container tightly closed.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Avoid driving or operating machinery until you know how it affects you.
3
Do not drink alcohol while taking this medicine.
4
Do not exceed the recommended dose or frequency.
5
Consult your doctor if symptoms persist beyond 7 days.
6
Report any unusual drowsiness, confusion, or difficulty urinating.
7
Keep out of reach of children and store in a cool, dry place.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Cough
This medicine is commonly prescribed for cough.
Likely Use
✅
Runny nose
Chlorpheniramine helps reduce runny nose.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
✅
Sneezing
Antihistamine component helps with sneezing.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMenthol is rapidly absorbed through the oral and pharyngeal mucosa and from the gastrointestinal tract after swallowing. Chlorpheniramine maleate is well absorbed from the gastrointestinal tract, with peak plasma concentrations typically reached within 2 to 3 hours after oral administration.
DistributionMenthol distributes widely into tissues, including the respiratory tract. Chlorpheniramine is widely distributed throughout the body, including the central nervous system, and crosses the placenta and is excreted in breast milk.
Protein BindingChlorpheniramine is approximately 70% bound to plasma proteins. Menthol's protein binding is not well established.
MetabolismMenthol undergoes hepatic metabolism via glucuronidation and oxidation. Chlorpheniramine is extensively metabolized in the liver, primarily by CYP2D6 and CYP3A4 enzymes, to inactive metabolites.
Half-LifeThe elimination half-life of chlorpheniramine is approximately 12 to 43 hours in adults, with considerable interindividual variability. Menthol's half-life is not well established.
ExcretionMenthol metabolites are excreted mainly in urine and bile. Chlorpheniramine and its metabolites are excreted primarily in urine, with small amounts in feces.
BioavailabilityChlorpheniramine oral bioavailability is approximately 25% to 50% due to first-pass metabolism. Menthol bioavailability is not well established.
Onset of ActionMenthol's cooling effect begins within minutes of oral administration. Chlorpheniramine's antihistamine effects start within 30 to 60 minutes after ingestion.
Peak Plasma TimeChlorpheniramine reaches peak plasma concentration in about 2 to 3 hours. Menthol's peak plasma time is not well established.
Duration of ActionChlorpheniramine's effects last approximately 4 to 6 hours, but sedation may persist longer. Menthol's soothing effect lasts 1 to 2 hours.

How It Works

Menthol stimulates cold-sensitive TRPM8 receptors in the oral and pharyngeal mucosa, producing a cooling sensation and a mild local anesthetic effect that temporarily relieves throat irritation. It also acts as a mild expectorant by increasing respiratory tract fluid secretion, which helps thin mucus and makes cough more productive. Chlorpheniramine maleate is a first-generation H1-receptor antagonist that competitively blocks histamine at H1 receptors on effector cells, thereby reducing allergic symptoms such as sneezing, rhinorrhea, and lacrimation. Its anticholinergic properties contribute to drying of respiratory secretions and reduction of cough reflex sensitivity.

Mechanism Steps

1
Menthol activates TRPM8 receptors: Menthol binds to and activates TRPM8 receptors on sensory nerve endings in the throat, generating a cooling sensation that masks irritation and reduces the urge to cough.
2
Menthol stimulates respiratory secretions: Menthol increases the volume of respiratory tract fluids, which helps thin bronchial mucus and facilitates its expulsion through coughing.
3
Chlorpheniramine blocks H1 receptors: Chlorpheniramine competitively antagonizes histamine at H1 receptors on endothelial cells, smooth muscle, and nerve endings, preventing histamine-mediated allergic responses such as vasodilation, edema, and itching.
4
Anticholinergic action reduces secretions: Chlorpheniramine's anticholinergic properties decrease serous and mucous secretions in the respiratory tract, reducing runny nose and postnasal drip that can trigger cough.
5
Central sedative effect: Chlorpheniramine crosses the blood-brain barrier and blocks central H1 receptors, leading to drowsiness, which may further reduce cough reflex sensitivity.

💡 How to Take x tus d syrup

Strength: Each 5 mL contains Menthol 1 mg and Chlorpheniramine Maleate 2 mg.

1Shake the bottle well before each use.
2Use a measuring cup or spoon to measure the exact dose.
3Take orally with or without food.
4Follow the prescribed dosing schedule.
5Do not exceed the recommended dose.
6If symptoms persist beyond 7 days, consult a doctor.

Dosage Information

Adult DosageThe usual adult dose is 5 to 10 mL (1 to 2 teaspoons) orally every 4 to 6 hours as needed, not to exceed 6 doses in 24 hours. However, dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician. This medicine is generally not recommended for children under 6 years of age unless prescribed by a doctor.
Elderly DosageElderly patients (above 65 years) are more sensitive to the sedative and anticholinergic effects of chlorpheniramine. Use with caution and consider a lower dose as individualized by a clinician.
Renal ImpairmentDose adjustment may be required in patients with renal impairment. Consult a clinician for individualized dosing.
Hepatic ImpairmentDose adjustment may be required in patients with hepatic impairment. Consult a clinician for individualized dosing.
Maximum Daily DoseThe maximum daily dose for adults is 60 mL (12 teaspoons) in 24 hours, not to exceed 6 doses. Do not exceed the recommended dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid large amounts
May increase drug levels.
Alcohol
Avoid
Increases drowsiness and CNS depression.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of x tus d syrup

✅ Common Side Effects

Drowsiness (Common (10-20%))
Avoid driving or operating machinery. If persistent, consult your doctor.
Dry mouth (Common (5-15%))
Sip water frequently or chew sugar-free gum. Consult if severe.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying positions. Avoid alcohol.
Nausea (Uncommon (1-5%))
Take with food or milk to reduce stomach upset.
Blurred vision (Uncommon (1-5%))
Avoid tasks requiring clear vision. Consult if persistent.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek emergency medical help immediately if you experience swelling of face, lips, tongue, or throat, difficulty breathing, or severe rash.
Urinary retention (Rare (<0.1%))
Consult a doctor immediately if you are unable to urinate or have severe lower abdominal pain.
Irregular heartbeat (arrhythmia) (Rare (<0.1%))
Seek immediate medical attention if you feel palpitations, chest pain, or shortness of breath.
Severe drowsiness or confusion (Rare (<0.1%))
Do not drive or operate machinery. Contact your doctor if confusion or excessive sedation occurs.

⚠️ Rare Side Effects

Blood dyscrasias (e.g., agranulocytosis, thrombocytopenia)
Report unusual bruising, bleeding, or signs of infection to your doctor immediately.
Hepatotoxicity
Seek medical attention if you notice yellowing of skin or eyes, dark urine, or severe abdominal pain.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAO inhibitors Major
CNS depressants Major
Anticholinergics Moderate
CYP2D6 inhibitors Moderate
CYP3A4 inhibitors Moderate
Antihypertensives Minor
Levodopa Minor

🚨 Major Interactions

  • MAO inhibitors (e.g., phenelzine, tranylcypromine)
  • CNS depressants (e.g., alcohol, benzodiazepines, opioids, barbiturates)

⚡ Moderate Interactions

  • Anticholinergic drugs (e.g., atropine, benztropine, tricyclic antidepressants)
  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, grapefruit juice)

🍷 Alcohol Interaction

Alcohol should be strictly avoided while taking this medicine because it can significantly increase drowsiness, dizziness, and impairment of motor skills, and may lead to respiratory depression.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to menthol, chlorpheniramine, or any component of the formulation","Narrow-angle glaucoma","Urinary retention or prostatic hypertrophy","Severe liver disease","MAO inhibitor therapy within the last 14 days","Children under 6 years of age (unless directed by a physician)"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol and other CNS depressants.","Use with caution in patients with asthma, COPD, or sleep apnea.","May cause dry mouth, constipation, and urinary retention due to anticholinergic effects.","Do not use for chronic cough or cough with excessive secretions without medical advice.","Consult a doctor if symptoms persist beyond 7 days or worsen.","Elderly patients are more sensitive to anticholinergic and sedative effects."]

🤱 Lactation Safety

Chlorpheniramine is excreted in breast milk and may cause drowsiness in nursing infants. Menthol may also pass into breast milk. Breastfeeding mothers should consult their doctor before use; alternative antihistamines may be preferred.

💊 Overdose Management

Overdose may cause severe drowsiness, confusion, hallucinations, seizures, respiratory depression, and cardiac arrhythmias. Seek emergency medical attention immediately. Treatment is supportive and symptomatic, including gastric lavage if within 1-2 hours of ingestion, activated charcoal, and monitoring of vital signs. There is no specific antidote. Physostigmine may be considered for severe anticholinergic toxicity but should be used with caution.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Do not exceed the recommended dose. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not drink alcohol while taking this medicine, as it can increase drowsiness. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Keep out of reach of children. Do not use for more than 7 days without consulting a doctor. If you have glaucoma, prostate enlargement, or difficulty urinating, consult your doctor before use.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more susceptible to anticholinergic effects such as confusion, dry mouth, constipation, and urinary retention. Use with caution and consider lower doses as advised by a clinician.

🤰 Pregnancy Planning (TTC)

Consult your doctor before taking this medicine if you are pregnant, planning to become pregnant, or breastfeeding. Alternative treatments may be safer.

🏥 Post-Surgery Considerations

Consult your surgeon or anesthesiologist before taking this medicine after surgery, as it may interact with anesthetic agents and other medications.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may cause dry mouth and interact with other medications used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help thin mucus.
🥗
Use a humidifier to ease throat irritation.
😴
Avoid smoking and exposure to secondhand smoke.
💧
Get plenty of rest to support recovery.
🧘
Gargle with warm salt water to soothe your throat.
🌞
Avoid allergens that trigger your symptoms.

🏋️ Exercise Considerations

Avoid strenuous exercise while taking this medicine, especially if you feel drowsy or dizzy. Light activity is fine if you feel well.

🥗 Diet Recommendations

Drink warm fluids like herbal tea or soup.
Include vitamin C-rich fruits and vegetables.
Avoid cold and sugary drinks that can irritate the throat.
Eat soft, easy-to-swallow foods if you have a sore throat.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness, which may affect your ability to drive, operate machinery, or perform tasks requiring alertness. Avoid these activities until you know how it affects you. It may also cause dry mouth and dizziness.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects such as difficulty breathing, severe drowsiness, or urinary retention.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended. Prolonged use of chlorpheniramine may lead to tolerance, dependence, and anticholinergic side effects. Regular monitoring of liver and kidney function may be advised if used for extended periods. Consult your doctor if you need to use it for more than 7 days.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Helps loosen mucus and soothe throat irritation.

Evidence: Well-established for symptomatic relief.
Honey and warm water

Soothes cough and throat irritation.

Evidence: Traditional remedy with some evidence.
Saline nasal spray

Helps clear nasal congestion.

Evidence: Well-established for nasal hygiene.

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No known interactions with vaccines. However, if you are acutely ill with fever, consult your doctor before vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from light. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying medications. Do not leave in a hot car.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with seasonal allergies and cough
She was prescribed this medicine for her cough and runny nose. She took it as directed and noticed relief within a few hours. She experienced mild drowsiness, so she avoided driving. She stopped after 5 days when symptoms resolved.
💡 Lesson: This medicine effectively relieves cough and allergy symptoms but can cause drowsiness; avoid driving until you know its effect.
👤 A 60-year-old man with a cold and persistent cough
He took this medicine for his cough but continued to feel drowsy and had difficulty urinating. He consulted his doctor, who advised him to stop the medicine due to its anticholinergic effects and prescribed an alternative.
💡 Lesson: Elderly patients are more sensitive to anticholinergic side effects; consult a doctor if you experience urinary retention or excessive drowsiness.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Menthol provides a cooling effect within minutes, while chlorpheniramine starts working within 30 to 60 minutes.

Q: Can I take this medicine at night?

A: Yes, but it may cause drowsiness, which can be beneficial at night. Avoid driving or operating machinery.

Q: Is it safe for children?

A: Consult a pediatrician. It is generally not recommended for children under 6 years unless prescribed.

Q: Can I take it with other cold medicines?

A: Consult your doctor or pharmacist to avoid duplicate ingredients and interactions.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for x tus d syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure the common cold.
    Fact: This medicine only relieves symptoms; it does not cure or shorten the duration of a cold.
  • Myth: It is safe to take this medicine with alcohol.
    Fact: Alcohol increases drowsiness and CNS depression; it should be avoided.
  • Myth: More medicine means faster relief.
    Fact: Taking more than the recommended dose can cause serious side effects and does not improve efficacy.

🔄 Alternative Options

Generic Alternatives

  • Menthol + Chlorpheniramine Maleate oral solution

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Menthol 1mg + Chlorpheniramine 2mg","primary_use":"Cough and allergy","sedation":"Moderate"},{"medicine":"Dextromethorphan + Chlorpheniramine","composition":"Dextromethorphan 10mg + Chlorpheniramine 2mg","primary_use":"Dry cough and allergy","sedation":"Moderate"},{"medicine":"Guaifenesin + Chlorpheniramine","composition":"Guaifenesin 100mg + Chlorpheniramine 2mg","primary_use":"Productive cough and allergy","sedation":"Moderate"}]

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