Mabtas RA 500mg Injection (Rituximab): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat during or after infusion
- Severe rash with blistering or peeling skin
- High fever with chills or persistent cough
- Confusion, dizziness, loss of balance, or vision problems
- Yellowing of the eyes or skin, dark urine, or severe abdominal pain
- Chest pain, palpitations, or shortness of breath
- Decreased urine output or swelling in the legs
If experiencing severe symptoms, call emergency services immediately.
What is x mab 500mg injection used for?
This medicine is a prescription-only intravenous infusion containing rituximab 500 mg. It is used to treat certain cancers and autoimmune diseases by targeting CD20-positive B-cells. It is given by a healthcare professional and requires close monitoring.
- Generic Name: Rituximab (500mg)
- Manufacturer: RPG Life Sciences Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 x mab 500mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा रिटक्सीमैब 500 मिलीग्राम इंजेक्शन के रूप में उपलब्ध है। यह कुछ प्रकार के कैंसर जैसे नॉन-हॉजकिन लिंफोमा और क्रोनिक लिम्फोसाइटिक ल्यूकेमिया के इलाज में उपयोग की जाती है। इसके अलावा, यह रूमेटॉइड आर्थराइटिस, ग्रैनुलोमैटोसिस विद पोलिएंजाइटिस और पेम्फिगस वल्गारिस जैसी ऑटोइम्यून बीमारियों के इलाज में भी प्रयोग की जाती है। यह दवा केवल डॉक्टर की देखरेख में अस्पताल या क्लिनिक में इंट्रावेनस इन्फ्यूजन द्वारा दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में बुखार, ठंड लगना, दाने, और निम्न रक्तचाप शामिल हैं, जो आमतौर पर पहले इन्फ्यूजन के दौरान होते हैं। अन्य सामान्य दुष्प्रभावों में थकान, सिरदर्द और मतली शामिल हैं। गंभीर दुष्प्रभावों में गंभीर संक्रमण, प्रोग्रेसिव मल्टीफोकल ल्यूकोएन्सेफैलोपैथी, हेपेटाइटिस बी का पुनः सक्रिय होना, और गंभीर त्वचा प्रतिक्रियाएं शामिल हैं।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा प्रशासित की जानी चाहिए। इन्फ्यूजन के दौरान और बाद में रोगी की निगरानी की जानी चाहिए। यदि आपको बुखार, ठंड लगना, दाने, सांस लेने में कठिनाई, या संक्रमण के कोई भी लक्षण महसूस हों तो तुरंत अपने डॉक्टर को सूचित करें। इस दवा के सेवन के दौरान जीवित टीके न लगवाएं। गर्भवती महिलाओं और स्तनपान कराने वाली महिलाओं को यह दवा नहीं दी जानी चाहिए।
💊 x mab 500mg injection Uses & Benefits
[{"condition":"Non-Hodgkin Lymphoma","description":"Used as part of combination therapy for CD20-positive B-cell non-Hodgkin lymphoma, including follicular lymphoma and diffuse large B-cell lymphoma.","evidence":"Well-established"},{"condition":"Chronic Lymphocytic Leukemia","description":"Used in combination with other agents for the treatment of CD20-positive chronic lymphocytic leukemia.","evidence":"Well-established"},{"condition":"Rheumatoid Arthritis","description":"Used in combination with methotrexate for moderately to severely active rheumatoid arthritis in patients who have had an inadequate response to other therapies.","evidence":"Well-established"},{"condition":"Granulomatosis with Polyangiitis and Microscopic Polyangiitis","description":"Used in combination with glucocorticoids for the treatment of these two types of ANCA-associated vasculitis.","evidence":"Well-established"},{"condition":"Pemphigus Vulgaris","description":"Used for the treatment of moderate to severe pemphigus vulgaris.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Multiple Sclerosis","description":"Sometimes used off-label for certain forms of multiple sclerosis, but evidence is limited and it is not a standard treatment.","evidence":"Limited"},{"condition":"Systemic Lupus Erythematosus","description":"Occasionally used off-label for severe lupus, but its role is not firmly established.","evidence":"Limited"}]
Primary treatment for: Non-Hodgkin Lymphoma
Also treats: Chronic Lymphocytic Leukemia, Rheumatoid Arthritis, Granulomatosis with Polyangiitis, Microscopic Polyangiitis, Pemphigus Vulgaris
📋 Drug Information
| Generic Name(s) | Rituximab (500mg) |
| Brand Name | x mab 500mg injection |
| Manufacturer | RPG Life Sciences Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | CD 20 Inhibitor |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store vials in a refrigerator at 2°C to 8°C. Do not freeze. Keep vials in the original carton to protect from light. Do not shake. |
| Shelf Life | Refer to the expiry date on the vial or carton. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding specifically to the CD20 antigen on the surface of B-cells. This binding leads to B-cell destruction through various mechanisms, including complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis. By depleting B-cells, it helps to reduce the abnormal immune response in autoimmune diseases and targets malignant B-cells in lymphomas and leukemias.
Mechanism Steps
💡 How to Take x mab 500mg injection
Strength: 500 mg injection (vial for intravenous infusion)
Dosage Information
| Adult Dosage | The dose of this medicine is individualized based on the condition being treated, the patient's body surface area, and other factors. For rheumatoid arthritis, a common regimen is two 1000 mg intravenous infusions separated by two weeks. For non-Hodgkin lymphoma, the dose is typically 375 mg/m² given weekly for several weeks. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients based on age alone. However, elderly patients may be more susceptible to infections and should be monitored closely. |
| Renal Impairment | No dose adjustment is required for renal impairment. However, monitor renal function closely due to risk of tumor lysis syndrome. |
| Hepatic Impairment | No dose adjustment is required for hepatic impairment. However, caution is advised in patients with hepatitis B infection due to risk of reactivation. |
| Maximum Daily Dose | Not applicable as this medicine is given as a single infusion, not daily. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of x mab 500mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Live vaccines | Major | |
| Methotrexate | Major | |
| Antihypertensives | Moderate | |
| NSAIDs | Moderate |
🚨 Major Interactions
- Live vaccines
- Other immunosuppressants (e.g., methotrexate, azathioprine)
⚡ Moderate Interactions
- Antihypertensives
- Nephrotoxic drugs (e.g., NSAIDs, aminoglycosides)
🍷 Alcohol Interaction
There is no known direct interaction between alcohol and this medicine. However, alcohol may worsen certain side effects such as fatigue or nausea, and it can also suppress the immune system. It is advisable to avoid or limit alcohol consumption while receiving this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to rituximab or any component of the product","Active severe infections","Severe heart failure (NYHA class IV)"]
⚠️ Warnings & Precautions
["Infusion reactions: May be severe and require immediate medical intervention.","Tumor lysis syndrome: Risk in patients with high tumor burden; ensure adequate hydration and monitor electrolytes.","Infections: May increase risk of serious infections; monitor and treat promptly.","Hepatitis B reactivation: Screen all patients before treatment; monitor during and after therapy.","Progressive multifocal leukoencephalopathy: Report any new neurological symptoms.","Vaccination: Avoid live vaccines during treatment."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants, women should not breastfeed during treatment and for several months after the last dose.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of overdose, patients should be monitored closely for any adverse effects, and supportive care should be provided as needed.
⏰ Missed Dose
This medicine is administered by a healthcare professional. If you miss an appointment for your infusion, contact your doctor or clinic as soon as possible to reschedule. Do not attempt to self-administer.
Additional Safety Advice
This medicine must be administered by a qualified healthcare professional in a setting equipped to manage infusion reactions. Patients should be monitored closely during and after the infusion. Inform your doctor immediately if you experience fever, chills, rash, difficulty breathing, or any signs of infection. Avoid live vaccines while on this medicine. Women of childbearing potential should use effective contraception during treatment and for several months after the last dose. Do not breastfeed while receiving this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to infections and should be monitored closely. No specific dose adjustment is required based on age alone.
🤰 Pregnancy Planning (TTC)
This medicine may cause fetal harm. Women of childbearing potential should use effective contraception during treatment and for 12 months after the last dose. If you are planning pregnancy, consult your doctor before stopping contraception.
🏥 Post-Surgery Considerations
This medicine may increase the risk of bleeding and infection after surgery. Inform your surgeon that you are receiving this medicine. Your doctor may advise delaying surgery until your immune system recovers.
🦷 Dental Procedures
Inform your dentist that you are receiving this medicine. You may be at increased risk of infection and bleeding. Your dentist may recommend antibiotics before dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but listen to your body. Avoid strenuous activity if you feel fatigued or unwell. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue or dizziness, which can affect your ability to drive or operate machinery. Plan your work schedule around infusion appointments. You may need to take time off for infusions and recovery.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will determine the duration of treatment based on your condition and response. If you experience severe side effects, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to prolonged immunosuppression, increasing the risk of infections. Regular monitoring of blood counts, liver function, and signs of infection is necessary. B-cell levels typically recover within 6 to 12 months after stopping treatment. There is also a risk of late-onset neutropenia and hypogammaglobulinemia.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For rheumatoid arthritis, other biologics may be used if this medicine is not suitable.
Evidence: Well-establishedFor lymphoma, alternative chemotherapy regimens may be considered.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should not be administered during treatment with this medicine. Non-live vaccines may be given, but their effectiveness may be reduced. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep vials in the original carton to protect from light
❌ DON'T
Do not shake the vial
✅ DO
Use before the expiry date
❌ DON'T
Do not use if the solution is discolored or contains particles
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting, so travel planning should revolve around scheduled infusions. If you need to travel, carry a copy of your prescription and a letter from your doctor explaining your treatment. Keep the medicine in its original packaging and store it in a refrigerator (2°C to 8°C) during travel if you are carrying it. However, it is typically supplied and administered by the clinic. Check with your doctor about timing of infusions if you are traveling across time zones.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The onset of action varies depending on the condition being treated. For lymphoma, effects may be seen within weeks. For rheumatoid arthritis, improvement may take several weeks to months.
A: This medicine is given as an intravenous infusion by a healthcare professional in a clinic or hospital setting.
A: Avoid live vaccines and close contact with people who have infections. Use effective contraception if you are of childbearing potential.
🤔 Common Patient Concerns
🔄 Substitutes for x mab 500mg injection
View AllAlternative brands with exact same active ingredient:
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lupiximab 500mg injectionLupin Ltd ₹13,771.41 56.7% CHEAPER
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maball 500mg injectionHetero Drugs Ltd ₹28,392.00 10.7% CHEAPER
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vortuxi solution for infusionZydus Cadila ₹33,750.00 6.1% COSTLIER
-
mabtas n 500mg injectionIntas Pharmaceuticals Ltd ₹34,412.00 8.2% COSTLIER
-
ikgdar 500mg injectionCipla Ltd ₹35,667.19 12.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be self-administered at home.
Fact: This medicine must be given by a healthcare professional in a clinical setting due to the risk of serious infusion reactions. - Myth: This medicine weakens the immune system permanently.
Fact: B-cell depletion is temporary, and B-cell levels typically recover within 6 to 12 months after stopping treatment.