Sinate-OD Tablet: Complete Guide to Uses, Dosage, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction: rash, itching, swelling of face, lips, or throat, difficulty breathing.
- Seizures or convulsions.
- Unusual bruising or bleeding.
- Yellowing of skin or eyes (jaundice).
- Severe abdominal pain or persistent vomiting.
- Irregular or rapid heartbeat.
- Difficulty urinating or no urine output.
- Extreme drowsiness or confusion.
If experiencing severe symptoms, call emergency services immediately.
What is vomidox od 20mg/20mg/5mg tablet used for?
This medicine is a combination of Doxylamine and Vitamin B6 used to treat nausea and vomiting during pregnancy. It works by blocking histamine receptors in the brain and supplementing Vitamin B6 to reduce nausea. It is usually taken at bedtime to minimize drowsiness.
- Generic Name: Doxylamine (20mg) + Vitamin B6 (Pyridoxine) (20mg)
- Manufacturer: Healsure Lifesciences Pvt. Ltd.
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 vomidox od 20mg/20mg/5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डॉक्सिलामाइन और विटामिन बी6 का संयोजन है, जिसका उपयोग गर्भावस्था के दौरान मतली और उल्टी (मॉर्निंग सिकनेस) के इलाज के लिए किया जाता है। यह मतली और उल्टी को कम करने में मदद करती है और गर्भवती महिलाओं को राहत प्रदान करती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना, धुंधली दृष्टि और कब्ज शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, दौरे, या रक्त विकार हो सकते हैं। किसी भी असामान्य लक्षण के लिए डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी चिकित्सीय स्थिति के बारे में बताएं। गाड़ी चलाने या मशीनरी चलाने से बचें क्योंकि यह नींद का कारण बन सकती है। शराब का सेवन न करें। गर्भावस्था में डॉक्टर की सलाह के बिना न लें। निर्धारित खुराक से अधिक न लें।
💊 vomidox od 20mg/20mg/5mg tablet Uses & Benefits
- [{"condition":"Nausea and vomiting of pregnancy (morning sickness)","description":"This medicine is used to treat nausea and vomiting in pregnant women who do not respond to conservative management.
- It helps reduce the frequency and severity of nausea and vomiting, improving quality of life.","evidence":"Well-established"},{"condition":"Nausea and vomiting due to other causes","description":"In some cases, this medicine may be used off-label for nausea and vomiting from other causes, such as motion sickness or vertigo, but this is not its primary approved use.","evidence":"Limited"}]
Off-label uses: [{"condition":"Insomnia","description":"Doxylamine, a component of this medicine, is sometimes used alone as a sleep aid. However, the combination with Vitamin B6 is not typically used for insomnia.","evidence":"Limited"},{"condition":"Motion sickness","description":"Antihistamines like doxylamine can be used for motion sickness, but this specific combination is not standard for that purpose.","evidence":"Limited"}]
Primary treatment for: Nausea and vomiting of pregnancy
Also treats: Motion sickness, Vertigo, Insomnia (off-label)
📋 Drug Information
| Generic Name(s) | Doxylamine (20mg) + Vitamin B6 (Pyridoxine) (20mg) |
| Brand Name | vomidox od 20mg/20mg/5mg tablet |
| Manufacturer | Healsure Lifesciences Pvt. Ltd. |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization (WHO) does not have specific guidelines for this combination, but doxylamine-pyridoxine is recommended by the American College of Obstetricians and Gynecologists (ACOG) for nausea and vomiting of pregnancy. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) does not have specific guidelines for this combination. However, it is commonly prescribed in India for morning sickness. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Doxylamine is a first-generation antihistamine that works by competitively blocking histamine H1 receptors in the brain. The exact mechanism by which it reduces nausea and vomiting is not fully understood, but it is thought to involve the chemoreceptor trigger zone in the medulla oblongata. Vitamin B6 (Pyridoxine) is a water-soluble vitamin that is converted to pyridoxal phosphate, a coenzyme involved in many metabolic reactions, including the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA). It is believed that Vitamin B6 helps alleviate nausea by modulating these neurotransmitter pathways. Together, they provide a synergistic effect in reducing nausea and vomiting.
Mechanism Steps
💡 How to Take vomidox od 20mg/20mg/5mg tablet
Strength: Each tablet contains Doxylamine 20 mg and Vitamin B6 (Pyridoxine) 20 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally at bedtime. Some patients may require one tablet in the morning and one at bedtime. The maximum recommended dose is two tablets per day. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially drowsiness and anticholinergic effects. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with severe renal impairment, dose adjustment may be necessary. Consult a healthcare provider for individualized dosing. |
| Hepatic Impairment | In patients with severe hepatic impairment, dose adjustment may be necessary. Consult a healthcare provider for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is 2 tablets (40 mg doxylamine and 40 mg Vitamin B6). Do not exceed this dose unless directed by a doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of vomidox od 20mg/20mg/5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | |
| Opioids | Major | |
| Benzodiazepines | Major | |
| MAOIs | Major | |
| Tricyclic antidepressants | Moderate | |
| SSRIs (fluoxetine, paroxetine) | Moderate | |
| Anticholinergics | Moderate | |
| Levodopa | Minor | |
| Hydralazine | Minor | |
| Isoniazid | Minor |
🚨 Major Interactions
- Central nervous system depressants (e.g., alcohol, opioids, benzodiazepines, barbiturates)
- Monoamine oxidase inhibitors (MAOIs)
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., atropine, scopolamine, tricyclic antidepressants)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can significantly increase drowsiness, dizziness, and impairment of judgment and motor skills. Combined use may also increase the risk of respiratory depression.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to doxylamine, Vitamin B6, or any component of the formulation","Concurrent use with monoamine oxidase inhibitors (MAOIs)","Narrow-angle glaucoma","Urinary retention","Severe liver disease","Asthma (due to anticholinergic effects)","Breastfeeding without medical advice"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol and other CNS depressants.","Use with caution in patients with asthma, glaucoma, or urinary retention.","Not recommended for children under 12 years unless prescribed.","Elderly patients may be more sensitive to side effects.","Do not exceed the recommended dose.","Consult your doctor if symptoms persist or worsen."]
🤱 Lactation Safety
Doxylamine is excreted in breast milk and may cause drowsiness in the nursing infant. Vitamin B6 is also excreted in breast milk and is considered safe. This medicine should be used with caution during breastfeeding, and only if the potential benefit justifies the potential risk to the infant. Consult your doctor.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, seizures, respiratory depression, and anticholinergic effects. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Before taking this medicine, inform your doctor if you have a history of asthma, glaucoma, increased intraocular pressure, urinary retention, or prostate problems. This medicine can cause drowsiness, so avoid driving or operating heavy machinery until you know how it affects you. Do not drink alcohol while taking this medicine, as it can increase drowsiness and impair your ability to think clearly. If you are pregnant, this medicine should only be used under the supervision of a healthcare provider. Do not take more than the prescribed dose. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. Store this medicine at room temperature, away from moisture and heat. Keep out of reach of children. If you experience any severe side effects, contact your doctor immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the anticholinergic and sedative effects of this medicine. Use with caution and start with a lower dose. Monitor for confusion, falls, and urinary retention.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is considered safe for use during pregnancy when prescribed, but always discuss the risks and benefits with your healthcare provider.
🏥 Post-Surgery Considerations
This medicine may interact with anesthetics and other medications used during surgery. Inform your surgeon and anesthesiologist that you are taking this medicine before any surgical procedure.
🦷 Dental Procedures
This medicine can cause dry mouth, which may increase the risk of dental problems. Inform your dentist that you are taking this medicine before any dental procedure. Maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, which may affect your ability to exercise safely. Avoid activities that require balance or coordination, such as cycling or swimming, until you know how the medicine affects you. Light walking may be beneficial, but consult your doctor before starting any exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause significant drowsiness, which may impair your ability to work, drive, or operate machinery. It is best to take it at bedtime to minimize daytime sedation. If you still feel drowsy during the day, avoid driving and inform your employer if your job requires alertness. Adjust your schedule as needed.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If your symptoms resolve, your doctor may advise tapering or stopping. If you experience severe side effects, seek medical advice immediately. Abrupt discontinuation may lead to withdrawal symptoms if used for a long time.
📅 Long-Term Use Effects
Long-term use of this medicine should be under medical supervision. There is a risk of tolerance and dependence with prolonged use of doxylamine. Regular monitoring of liver and kidney function may be advised. Do not use for longer than prescribed without consulting your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Eating small, frequent meals and avoiding trigger foods can help reduce nausea.
Evidence: Well-establishedGinger has been shown to reduce nausea and vomiting in pregnancy.
Evidence: ModerateWristbands that apply pressure to the P6 acupoint may help some women.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider that you are taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from extreme heat or cold. If crossing time zones, continue taking your doses at the same intervals as prescribed; adjust timing gradually. Keep it in your carry-on luggage to avoid loss. Check customs regulations for prescription medications in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 1 to 2 hours after taking it. However, it may take a few days to achieve full effect.
A: This medicine is primarily approved for nausea and vomiting of pregnancy. It may be used off-label for other conditions, but only under medical supervision.
A: Doxylamine passes into breast milk and may cause drowsiness in the infant. Consult your doctor before breastfeeding while on this medicine.
A: Seek emergency medical attention immediately. Overdose can cause severe drowsiness, seizures, and respiratory depression.
🤔 Common Patient Concerns
🔄 Substitutes for vomidox od 20mg/20mg/5mg tablet
View AllAlternative brands with exact same active ingredient:
-
doxylam 20mg/20mg/5mg tabletEuro Organics ₹18.75 71.2% CHEAPER
-
dom forte tabletEdmund Healthcare ₹25.31 61.1% CHEAPER
-
medfol-plus tabletAbia Pharmaceuticals Pvt. Ltd. ₹27.19 58.2% CHEAPER
-
doxyfem b6 tabletDabur India Ltd ₹28.85 55.6% CHEAPER
-
doxipreg od 20mg/20mg tabletBewell Labs Pvt Ltd ₹29.77 54.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe for everyone.
Fact: This medicine is not safe for everyone. It should be avoided in certain conditions like glaucoma, urinary retention, and asthma. Always consult a doctor. - Myth: This medicine can be taken without a prescription.
Fact: This medicine is a prescription drug in many countries. It should only be taken under medical supervision. - Myth: This medicine is completely free of side effects.
Fact: This medicine can cause drowsiness, dizziness, dry mouth, and other side effects. Report any unusual symptoms to your doctor.
🔄 Alternative Options
Generic Alternatives
- Doxylamine + Pyridoxine combination generics
Brand Alternatives
- Doxylamine Succinate + Pyridoxine Hydrochloride tablets (various manufacturers)