Eurepa-V 0.5/0.3 Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Severe hypoglycemia with confusion, unconsciousness, or seizures
- Swelling of the face, lips, tongue, or throat, or difficulty breathing
- Yellowing of the skin or eyes, dark urine, or persistent right upper abdominal pain
- Severe abdominal pain, vomiting, or inability to pass stool or gas
- Unusual bruising or bleeding
- Persistent diarrhea leading to dehydration
- Chest pain, palpitations, or shortness of breath
- Sudden severe headache with visual changes
If experiencing severe symptoms, call emergency services immediately.
What is voglimac r hd 0.5mg/0.3mg tablet used for?
This medicine is a prescription oral antidiabetic combination of repaglinide 0.5 mg and voglibose 0.3 mg used to improve blood sugar control in adults with type 2 diabetes. It works by increasing insulin release around meals and slowing carbohydrate digestion. It must be taken just before meals and can cause low blood sugar, so dose and monitoring must be individualized by a doctor.
- Generic Name: Repaglinide (0.5mg) + Voglibose (0.3mg)
- Manufacturer: Macleods Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 voglimac r hd 0.5mg/0.3mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा टाइप 2 डायबिटीज वाले वयस्कों में खून में शुगर को नियंत्रित करने के लिए इस्तेमाल की जाती है। इसमें रेपाग्लिनाइड और वोग्लिबोज दो सक्रिय तत्व हैं। रेपाग्लिनाइड खाने के बाद पैंक्रियाज से इंसुलिन निकलने में मदद करता है, जबकि वोग्लिबोज आंत में कार्बोहाइड्रेट के पाचन को धीमा करता है जिससे खाने के बाद शुगर तेजी से नहीं बढ़ती। यह दवा डॉक्टर की सलाह पर ही लेनी चाहिए और खाने से ठीक पहले लेनी चाहिए। यह दवा डायबिटीज को पूरी तरह ठीक नहीं करती, बल्कि शुगर को नियंत्रित रखने में मदद करती है। इसे डाइट और एक्सरसाइज के साथ ही लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सबसे आम साइड इफेक्ट्स में शुगर कम होना (हाइपोग्लाइसीमिया), पेट में गैस, सूजन, दस्त, जी मिचलाना और वजन बढ़ना शामिल हैं। शुगर कम होने पर कंपकंपी, पसीना, भूख लगना, घबराहट और चक्कर आ सकते हैं। अगर ऐसा हो तो तुरंत ग्लूकोज या मीठी चीज लें और डॉक्टर को बताएं। कुछ लोगों को त्वचा पर रैश या लिवर से जुड़ी समस्या भी हो सकती है। गंभीर लक्षण जैसे बेहोशी, सांस लेने में तकलीफ, चेहरे या गले में सूजन हो तो तुरंत मेडिकल हेल्प लें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार खाने से ठीक पहले लें। खाना नहीं खा रहे हैं तो दवा न लें, वरना शुगर कम हो सकती है। शुगर कम होने के लक्षण पहचानें और अपने पास ग्लूकोज या मीठी चीज हमेशा रखें। शराब न पिएं क्योंकि इससे शुगर कम होने का खतरा बढ़ता है। अपनी शुगर नियमित रूप से जांचें और रिकॉर्ड रखें। किडनी या लिवर की बीमारी हो तो डॉक्टर को जरूर बताएं। गर्भवती होने या ब्रेस्टफीडिंग कराने से पहले डॉक्टर से सलाह लें। दवा अपने आप बंद या शुरू न करें।
💊 voglimac r hd 0.5mg/0.3mg tablet Uses & Benefits
[{"condition":"Type 2 diabetes mellitus","description":"Used as an add-on or combination oral therapy to improve glycemic control in adults whose blood sugar is not adequately controlled by diet, exercise, and a single oral antidiabetic agent.","evidence":"Well-established"},{"condition":"Postprandial hyperglycemia","description":"The voglibose component specifically targets the rise in blood glucose after meals by delaying carbohydrate digestion and absorption.","evidence":"Well-established"},{"condition":"Type 2 diabetes with inadequate control on monotherapy","description":"Combining a meglitinide with an alpha-glucosidase inhibitor can lower both fasting and post-meal glucose when one agent alone is insufficient.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Prediabetes","description":"Alpha-glucosidase inhibitors have been studied for delaying progression of prediabetes to diabetes, but this combination is not approved for that purpose.","evidence":"Limited"},{"condition":"Gestational diabetes","description":"Not recommended for routine use in pregnancy; specialist care and safer alternatives are preferred.","evidence":"Limited"}]
Primary treatment for: Type 2 diabetes mellitus
Also treats: Postprandial hyperglycemia, Metabolic syndrome, Obesity-related diabetes
📋 Drug Information
| Generic Name(s) | Repaglinide (0.5mg) + Voglibose (0.3mg) |
| Brand Name | voglimac r hd 0.5mg/0.3mg tablet |
| Manufacturer | Macleods Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C in a dry place. Keep it in the original container, tightly closed, away from direct sunlight and moisture. Do not refrigerate unless the label specifically says so. Keep out of reach of children and pets. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture, but the exact expiry date is printed on the pack. Do not use this medicine after the expiry date. Check the pack for the specific shelf life of your batch. |
| WHO Guideline | Not established from the available information. Guidelines generally recommend individualized therapy for type 2 diabetes, but this specific combination is not universally endorsed by WHO. |
| ICMR Guideline | Not established from the available information. ICMR guidelines recommend individualized treatment for type 2 diabetes, and the choice of oral agents depends on patient-specific factors. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two oral antidiabetic agents with complementary mechanisms. Repaglinide closes ATP-sensitive potassium channels on pancreatic beta cells, which depolarizes the cell membrane, opens voltage-gated calcium channels, and triggers insulin release. Because it acts quickly and is short-lived, it mainly boosts insulin secretion around meals. Voglibose inhibits alpha-glucosidase enzymes in the small intestine, delaying the breakdown of complex carbohydrates into glucose and slowing glucose absorption into the bloodstream. The result is a lower and more gradual rise in blood glucose after eating. Together, the two ingredients reduce postprandial glucose excursions and help improve overall glycemic control when used with diet and exercise.
Mechanism Steps
💡 How to Take voglimac r hd 0.5mg/0.3mg tablet
Strength: Each tablet contains repaglinide 0.5 mg and voglibose 0.3 mg. This is an immediate-release oral tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally just before each main meal, but the exact dose and frequency depend on your blood sugar levels, kidney and liver function, and other medicines you take. Your doctor may start with a lower dose and adjust gradually. The maximum daily dose should not be exceeded. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Never change the dose or stop the medicine without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the glucose-lowering effects of this medicine and are at higher risk of hypoglycemia. Treatment should be started at a low dose and adjusted carefully based on blood glucose, kidney function, and overall health. Regular monitoring is essential. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with mild to moderate kidney impairment, this medicine may be used with caution and close monitoring of blood glucose. In severe kidney impairment, it is generally not recommended because the risk of hypoglycemia increases. Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | This medicine should be avoided in patients with severe liver disease. In mild to moderate liver impairment, it may be used with caution and close monitoring of liver function and blood glucose. Dose must be individualized by a qualified clinician based on hepatic function. |
| Maximum Daily Dose | The maximum daily dose depends on the prescribed strength and frequency and must be determined by your doctor. Do not exceed the dose prescribed by your clinician. In general, the total daily dose of repaglinide should not exceed the maximum recommended for the specific product, and voglibose should not exceed the recommended daily amount. Always follow your prescription. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of voglimac r hd 0.5mg/0.3mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Gemfibrozil | Major | |
| Clarithromycin | Major | |
| Itraconazole | Major | |
| Ketoconazole | Major | |
| Cyclosporine | Major | |
| Beta-blockers | Moderate | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| Thyroid hormones | Moderate |
🚨 Major Interactions
- Gemfibrozil
- Clarithromycin
- Itraconazole and ketoconazole
- Cyclosporine
⚡ Moderate Interactions
- Beta-blockers
- ACE inhibitors
- Diuretics
- Corticosteroids
- Thyroid hormones
🍷 Alcohol Interaction
Alcohol can increase the risk of hypoglycemia when taken with this medicine, especially if you drink on an empty stomach or in large amounts. It can also worsen gastrointestinal side effects such as bloating, nausea, and diarrhea. It is best to avoid alcohol while taking this medicine. If you choose to drink, do so only occasionally and with food, and monitor your blood sugar closely.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe liver disease or hepatic impairment","Severe kidney impairment","Inflammatory bowel disease, intestinal obstruction, or chronic conditions with impaired digestion or absorption","Known hypersensitivity to repaglinide, voglibose, or any component of the tablet","Pregnancy and breastfeeding without specialist advice","Children and adolescents, as safety and efficacy are not established"]
⚠️ Warnings & Precautions
["This medicine can cause hypoglycemia, especially if meals are skipped, alcohol is consumed, or kidney or liver function is reduced.","Take this medicine just before meals as prescribed. Do not take it if you are not going to eat.","Tell your doctor about all other medicines, especially gemfibrozil, clarithromycin, azole antifungals, and cyclosporine, because they can increase the risk of low blood sugar.","Use with caution in elderly patients, who may be more sensitive to hypoglycemia.","Monitor liver and kidney function periodically, especially if you have existing liver or kidney disease.","Do not drive or operate machinery if you experience symptoms of hypoglycemia.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Do not share this medicine with others, even if they have similar symptoms."]
🤱 Lactation Safety
It is not known whether repaglinide or voglibose pass into breast milk in significant amounts. Because of limited data, this medicine is not recommended during breastfeeding. Mothers who need diabetes treatment while breastfeeding should discuss safer alternatives with their doctor.
💊 Overdose Management
Overdose of this medicine can cause severe and prolonged hypoglycemia. If you suspect an overdose, seek emergency medical care immediately. Treatment may include oral glucose if the person is conscious and able to swallow, or intravenous glucose and close monitoring in a hospital if the person is unconscious or unable to take oral glucose. Do not try to manage a suspected overdose at home. Carry medical identification stating that you take this medicine.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if you are about to eat a meal. If you have already eaten or it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you miss a meal, skip the dose that was meant to be taken with that meal to avoid hypoglycemia.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually just before meals, because repaglinide works quickly and needs to match your food intake. Do not skip meals after taking this medicine, as this can cause low blood sugar. Learn the early signs of hypoglycemia, such as sweating, trembling, hunger, and confusion, and keep a fast-acting sugar source like glucose tablets, candy, or fruit juice with you at all times. Check your blood sugar regularly as advised, especially during illness, travel, or changes in diet or activity. Tell your doctor about all other medicines, supplements, and herbal products you take, because many drugs can interact with this medicine. Avoid alcohol, as it can increase the risk of low blood sugar and stomach upset. Inform your doctor if you have kidney or liver problems, because the dose may need adjustment or this medicine may not be suitable for you. Do not start, stop, or change the dose without medical advice. If you become pregnant, plan to become pregnant, or are breastfeeding, contact your doctor immediately to discuss safer options. Keep this medicine out of reach of children and store it as directed on the pack.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of hypoglycemia and may be more sensitive to the effects of this medicine. They may also have reduced kidney function, which can increase drug levels. Treatment should be started at a low dose, with careful monitoring of blood sugar, kidney function, and liver function. Elderly patients should be advised to eat regular meals, avoid alcohol, and keep a fast-acting sugar source nearby. Falls and confusion from low blood sugar are important concerns in this age group.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, talk to your doctor before conception. This medicine is not recommended during pregnancy because of limited safety data. Insulin is generally the preferred treatment for diabetes during pregnancy. Your doctor will review your medicines and may switch you to a safer option before you conceive. Good blood sugar control before and during pregnancy is important for the health of both mother and baby.
🏥 Post-Surgery Considerations
After surgery, blood sugar can be unstable because of stress, changes in diet, and medications. This medicine may need to be adjusted or temporarily stopped, especially if you are not eating regular meals. Follow your surgeon's and diabetes doctor's instructions carefully. Monitor your blood sugar closely during recovery and report any signs of hypoglycemia or very high blood sugar to your medical team.
🦷 Dental Procedures
Inform your dentist that you take this medicine for diabetes. Dental procedures can affect your ability to eat normally, which may increase the risk of hypoglycemia if you take the medicine without food. Your dentist and diabetes doctor may advise adjusting your dose or meal plan around the procedure. Maintain good oral hygiene, as diabetes can increase the risk of gum disease.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise can lower blood sugar, and combining it with this medicine may increase the risk of hypoglycemia. Check your blood sugar before, during, and after exercise if you are on this medicine. Carry a fast-acting sugar source with you. If your blood sugar is low before exercise, treat it first and wait until it is normal. Discuss your exercise plan with your doctor, especially if you are starting a new routine or increasing intensity.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can affect your ability to drive or operate machinery if you experience low blood sugar. Do not drive or use heavy machinery if you feel shaky, dizzy, confused, or sweaty. Check your blood sugar before driving and keep a sugar source in your vehicle. Inform your employer about your diabetes and the possibility of hypoglycemia if your job involves safety-sensitive tasks. With good control and regular monitoring, most people can continue their normal work and daily activities.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your doctor may stop or change it if you develop severe side effects, severe hypoglycemia, liver or kidney problems, or if your treatment goals change. If you become pregnant or plan to become pregnant, contact your doctor to review safer options. If you need to stop for any reason, your doctor will guide you on how to do it safely and may prescribe an alternative.
📅 Long-Term Use Effects
Long-term use of this medicine can help maintain blood sugar control and reduce the risk of diabetes complications when combined with diet, exercise, and regular monitoring. However, it does not cure diabetes, and blood sugar can rise if the medicine is stopped. Long-term risks include weight gain, recurrent hypoglycemia, and possible liver enzyme changes. Regular monitoring of blood sugar, HbA1c, liver function, and kidney function is important. Your doctor may adjust or change the treatment over time based on your response and any side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A structured diet plan with controlled carbohydrates can significantly improve blood sugar control and may reduce the need for medicines.
Evidence: Well-establishedExercise improves insulin sensitivity and helps lower blood sugar, complementing medicine therapy.
Evidence: Well-establishedLosing excess weight can improve blood sugar control and reduce diabetes complications.
Evidence: Well-establishedMetformin, DPP-4 inhibitors, SGLT2 inhibitors, and GLP-1 receptor agonists are alternatives depending on patient factors.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
People with diabetes should stay up to date with recommended vaccines, including influenza, pneumococcal, hepatitis B, and COVID-19 vaccines as advised by their doctor. There are no known direct interactions between this medicine and vaccines. However, illness and fever can affect blood sugar control, so monitor your glucose closely around the time of vaccination and during any infection.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless the label specifically says so
✅ DO
Keep in the original container, tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children and pets
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label clearly visible. Bring a copy of your prescription and a doctor's letter explaining that you need this medicine for diabetes. Pack enough for the entire trip plus extra in case of delays. Keep it in your hand luggage, not in checked baggage, so it stays with you and is protected from extreme temperatures. If you cross time zones, discuss with your doctor how to adjust your meal and dosing schedule, because this medicine is taken before meals. Store it away from direct sunlight and heat. Check the customs rules of your destination for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Repaglinide starts lowering blood sugar within 15 to 30 minutes after you take it, which is why it is taken just before meals. Voglibose works during meal digestion. You may notice improvements in your post-meal sugar readings within days, but full benefits on HbA1c may take a few months.
A: It depends on how severe your kidney disease is. In mild to moderate kidney impairment, it may be used with caution and close monitoring. In severe kidney impairment, it is generally not recommended because the risk of low blood sugar increases. Your doctor will decide based on your kidney function tests.
A: These are signs of low blood sugar. Check your blood sugar if you can. If it is low, eat or drink something sugary, such as glucose tablets, candy, or fruit juice, and rest. If symptoms are severe or you become confused or unconscious, seek emergency medical help immediately.
A: No. Normal sugar readings mean the medicine is working. Stopping it without your doctor's advice can cause your sugar to rise again and lead to complications. Always consult your doctor before making any changes.
A: Repaglinide can cause some weight gain because it increases insulin release. Following a balanced diet and regular exercise can help manage weight. Discuss any significant weight changes with your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for voglimac r hd 0.5mg/0.3mg tablet
View AllAlternative brands with exact same active ingredient:
-
zrepag rapid 0.5mg/0.3mg tabletDaylon Healthcare ₹93.75 41.7% CHEAPER
-
vogli-rapid m 0.3mg/0.5mg/500mg tablet srMedley Pharmaceuticals ₹103.13 35.9% CHEAPER
-
vogli rapid m 0.5 tabletMedley Pharmaceuticals ₹103.13 35.9% CHEAPER
-
combose 0.5 tabletADN Life Sciences ₹111.56 30.6% CHEAPER
-
voglinorm-r tabletMicro Labs Ltd ₹120.00 25.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps control blood sugar but does not cure diabetes. It must be used along with diet, exercise, and regular monitoring. - Myth: I can eat sweets freely if I take this medicine.
Fact: This medicine works best with a balanced diet. Large amounts of sweets can worsen side effects and raise blood sugar. - Myth: If I feel better, I can stop the medicine.
Fact: Diabetes often has no symptoms even when blood sugar is high. Stopping the medicine without medical advice can lead to serious complications. - Myth: This medicine is safe for everyone with diabetes.
Fact: It is not suitable for people with type 1 diabetes, severe kidney or liver disease, or certain gut conditions. Always consult a doctor.
🔄 Alternative Options
Generic Alternatives
- Repaglinide 0.5 mg + Voglibose 0.3 mg tablet
Brand Alternatives
- Eurepa-V 0.5/0.3 Tablet