Metadoxine 300 mg Injection: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, or throat
- Difficulty breathing or wheezing
- Severe rash or hives
- Sudden drop in blood pressure or fainting
- Yellowing of the skin or eyes
- Severe abdominal pain or persistent vomiting
- Fast or irregular heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is viboliv 300 mg injection used for?
This medicine is a Metadoxine 300 mg injection used to speed up alcohol clearance and support liver function in acute alcohol intoxication and alcoholic liver disease. It is given only by a healthcare professional in a hospital or clinic setting.
- Generic Name: Metadoxine (300mg)
- Manufacturer: Dr Reddy's Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 viboliv 300 mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा मेटाडॉक्सिन 300 मिलीग्राम इंजेक्शन है, जिसका उपयोग शराब के तीव्र नशे और अल्कोहलिक लिवर रोग में सहायक उपचार के लिए किया जाता है। यह शरीर में शराब और उसके जहरीले पदार्थ एसिटाल्डिहाइड को तेजी से तोड़ने में मदद करती है और लिवर की कोशिकाओं को ऑक्सीडेटिव नुकसान से बचाती है। यह दवा केवल अस्पताल या क्लिनिक में योग्य डॉक्टर या नर्स द्वारा ही दी जाती है। मरीज को इसका सेवन खुद से नहीं करना चाहिए। इलाज के दौरान शराब का सेवन पूरी तरह बंद करना जरूरी है।
साइड इफेक्ट्स: इस दवा से आमतौर पर हल्के दुष्प्रभाव होते हैं, जैसे जी मिचलाना, उल्टी, सिरदर्द, चक्कर आना और इंजेक्शन लगाने की जगह पर दर्द या जलन। कभी-कभी नींद आना, मुंह सूखना या धातु जैसा स्वाद महसूस हो सकता है। गंभीर एलर्जी प्रतिक्रिया बहुत कम होती है, लेकिन अगर चेहरे या गले में सूजन, सांस लेने में तकलीफ, त्वचा पर चकत्ते या ब्लड प्रेशर अचानक गिर जाए तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल योग्य डॉक्टर या नर्स द्वारा अस्पताल या क्लिनिक में ही दी जानी चाहिए। अपने डॉक्टर को अपनी सभी दवाओं, सप्लीमेंट्स और पुरानी बीमारियों के बारे में बताएं। इलाज के दौरान शराब बिल्कुल न पिएं। अगर आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं या स्तनपान करा रही हैं, तो डॉक्टर को जरूर बताएं। इंजेक्शन के बाद अगर सूजन, सांस लेने में दिक्कत या गंभीर त्वचा प्रतिक्रिया हो तो तुरंत आपातकालीन मदद लें।
💊 viboliv 300 mg injection Uses & Benefits
[{"condition":"Acute alcohol intoxication","description":"This medicine is used to accelerate the metabolism of alcohol and acetaldehyde, helping to reduce blood alcohol levels and improve clinical signs of intoxication such as drowsiness, confusion, and unsteady gait.","evidence":"Established in clinical practice"},{"condition":"Alcoholic liver disease (supportive therapy)","description":"This medicine is used as an adjunct to support liver cell function, reduce oxidative stress, and improve biochemical markers in patients with alcohol-related liver injury.","evidence":"Moderate evidence"},{"condition":"Alcohol withdrawal support","description":"This medicine may be used as part of a supervised treatment plan to support patients during alcohol withdrawal, alongside standard supportive care.","evidence":"Limited evidence"}]
Off-label uses: [{"condition":"Non-alcoholic fatty liver disease","description":"Sometimes prescribed off-label to support liver function in patients with fatty liver not related to alcohol, but strong clinical evidence is lacking.","evidence":"Limited"},{"condition":"Drug-induced liver injury","description":"Occasionally used off-label as supportive therapy in selected cases of drug-induced liver injury, under specialist supervision.","evidence":"Limited"}]
Primary treatment for: Acute alcohol intoxication
Also treats: Alcoholic liver disease, Alcohol withdrawal syndrome
📋 Drug Information
| Generic Name(s) | Metadoxine (300mg) |
| Brand Name | viboliv 300 mg injection |
| Manufacturer | Dr Reddy's Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Hepatoprotectives |
| Route of Administration | Parenteral |
| Storage | Store in a cool, dry place protected from light. Do not freeze. Keep out of reach of children. Follow the storage instructions on the product label. |
| Shelf Life | Not established from the available information. Refer to the product packaging for the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Metadoxine works by increasing the activity of alcohol dehydrogenase and aldehyde dehydrogenase, the enzymes that break down alcohol and its toxic metabolite acetaldehyde. It also helps restore hepatic glutathione levels, reduces lipid peroxidation, and stabilizes liver cell membranes. These actions together accelerate alcohol clearance and protect liver cells from oxidative damage.
Mechanism Steps
💡 How to Take viboliv 300 mg injection
Strength: Metadoxine 300 mg injection (immediate release)
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is determined by the treating clinician based on the indication, severity of intoxication, liver function, and clinical response. It is typically given as a slow intravenous or intramuscular injection in a hospital or clinic setting. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-administer. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. The dose should be individualized by a clinician, and vital signs and liver function should be monitored closely. |
| Renal Impairment | Not established from the available information. Use with caution in patients with kidney impairment and follow clinician guidance. |
| Hepatic Impairment | Not established from the available information. Use with caution in patients with severe liver impairment and monitor liver function closely. |
| Maximum Daily Dose | Not established from the available information. The maximum daily dose must be determined by the treating clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of viboliv 300 mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Disulfiram | Major | |
| Sedatives and hypnotics | Major | |
| Anticonvulsants | Moderate | |
| Levodopa | Moderate | |
| Oral pyridoxine supplements | Minor |
🚨 Major Interactions
- Disulfiram
- Sedatives and hypnotics
⚡ Moderate Interactions
- Anticonvulsants
- Levodopa
🍷 Alcohol Interaction
Alcohol must be strictly avoided while receiving this medicine. Drinking alcohol during treatment can worsen liver injury, reduce the effectiveness of the injection, and increase the risk of serious complications. Patients should discuss safe long-term alcohol cessation strategies with their doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to Metadoxine or any component of the formulation","Severe uncontrolled liver failure where the risk outweighs the benefit","Concurrent use of disulfiram without specialist supervision","Pregnancy unless clearly needed and approved by the treating obstetrician"]
⚠️ Warnings & Precautions
["This medicine must be administered only by a qualified healthcare professional.","Do not drive or operate machinery until any dizziness or drowsiness has resolved.","Avoid alcohol completely during and after treatment.","Inform your doctor about all medicines, supplements, and herbal products you take.","Use with caution in patients with severe liver or kidney disease.","Report any signs of allergic reaction immediately.","Follow-up monitoring of liver function may be required."]
🤱 Lactation Safety
Not established from the available information. Breastfeeding women should consult their doctor before receiving this medicine.
💊 Overdose Management
There is no specific antidote for Metadoxine overdose. Treatment should be supportive and symptomatic, with close monitoring of vital signs, liver function, and neurological status. In case of suspected overdose, contact emergency medical services immediately and provide supportive care in a hospital setting.
⏰ Missed Dose
This medicine is given by a healthcare professional, so missed doses are uncommon. If a scheduled dose is missed, inform the treating team and follow their instruction. Do not attempt to self-administer an extra dose.
Additional Safety Advice
This medicine must be given only by a trained healthcare professional in a setting where emergency equipment and medicines are available. Inform your doctor about all prescription and non-prescription medicines you take, especially sedatives, antidepressants, anticonvulsants, and medicines for liver disease. Do not drink alcohol while receiving this medicine, because alcohol can worsen liver stress and reduce the benefit of treatment. Tell your doctor if you are pregnant, planning pregnancy, or breastfeeding. Do not attempt to self-administer this injection at home. If you notice swelling, breathing difficulty, or a severe skin reaction after the injection, seek emergency care immediately. Keep all follow-up appointments so your liver function and overall response can be monitored.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine. Monitor vital signs, liver function, and neurological status closely during treatment.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss this medicine with your doctor before receiving it. Safety in pregnancy is not established from available information.
🏥 Post-Surgery Considerations
Not established from the available information. Inform your surgeon and anesthesiologist if you have received this medicine recently.
🦷 Dental Procedures
Not established from the available information. Inform your dentist about all medicines you are taking.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid driving or operating heavy machinery until any dizziness or drowsiness has resolved. Light activity is generally safe once you feel well, but follow your doctor's advice based on your overall condition.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic setting, so it may require time away from work for treatment and monitoring. Do not drive or operate machinery until any dizziness or drowsiness has resolved. Discuss return-to-work timing with your doctor.
🛑 When to Stop This Medicine
This medicine is stopped by the treating clinician based on clinical improvement and response to treatment. Do not stop or adjust treatment on your own. If you experience a serious side effect, inform your doctor immediately.
📅 Long-Term Use Effects
Long-term effects of this medicine are not well established from available information. It is generally used for short-term supportive treatment in acute settings. Patients with alcoholic liver disease need regular monitoring of liver function, abstinence from alcohol, and long-term follow-up with a specialist.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Essential for long-term recovery in alcohol use disorders.
Evidence: Well-establishedThiamine, folic acid, and other vitamins support recovery in alcoholic liver disease.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Discuss routine vaccinations with your doctor, especially hepatitis A and B vaccination for liver protection.
📦 Storage Guide
✅ DO
Store in a cool, dry place protected from light
❌ DON'T
Do not freeze the injection
✅ DO
Keep in the original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
This medicine is given only in a hospital or clinic setting, so travel-related self-administration is not applicable. If you are receiving treatment and plan to travel, carry a copy of your prescription and medical records. Keep the injection in its original packaging and follow the storage instructions. Inform your treating doctor before travel so that follow-up and monitoring can be arranged at your destination.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The onset of action is not precisely established from available information. In clinical practice, improvement in alertness and reduction in intoxication signs may be seen within hours after administration under medical supervision.
A: No. This medicine is an injection that must be given only by a qualified healthcare professional in a hospital or clinic setting.
A: No. Alcohol must be strictly avoided during and after treatment because it can worsen liver injury and reduce the benefit of the medicine.
A: Safety in pregnancy is not established from available information. Use only if clearly needed and after consultation with your obstetrician.
🤔 Common Patient Concerns
🔄 Substitutes for viboliv 300 mg injection
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used as a home remedy for hangovers.
Fact: This medicine is a prescription injection that must be given only by a healthcare professional in a medical setting. - Myth: This medicine allows a person to drink alcohol safely.
Fact: Alcohol must be strictly avoided during treatment because it can worsen liver injury and reduce the benefit of the medicine. - Myth: This medicine is a cure for alcohol addiction.
Fact: This medicine supports alcohol clearance and liver function, but it is not a cure for alcohol addiction. Counselling and rehabilitation are important parts of care.
🔄 Alternative Options
Generic Alternatives
- Metadoxine 300 mg injection
Brand Alternatives
- Viboliv 300 mg injection