Durasalyn Liquid: Complete Medicine Guide for Patients
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe chest pain or pressure
- Irregular or very fast heartbeat
- Persistent vomiting or severe abdominal pain
- Seizures or loss of consciousness
- Sudden worsening of breathlessness after taking the medicine
- Swelling of face, lips, tongue, or throat
- Severe muscle weakness or cramps
- Confusion, extreme restlessness, or unusual behavior
If experiencing severe symptoms, call emergency services immediately.
What is ventiphylline pd 50mg/1mg syrup used for?
This medicine is an oral liquid combination of choline theophyllinate and salbutamol used to relieve wheezing and breathlessness in asthma and COPD. It works by relaxing the muscles around the airways. It must be taken exactly as prescribed because the theophylline component has a narrow safety margin.
- Generic Name: Choline Theophyllinate (50mg) + Salbutamol (1mg)
- Manufacturer: Yash Pharma Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ventiphylline pd 50mg/1mg syrup के बारे में (Hindi Summary)
उपयोग: यह दवा कोलीन थियोफिलिनेट और सालबुटामोल का मिश्रण है जो सांस की नली की मांसपेशियों को ढीला करके सांस लेने में आसानी देती है। इसका उपयोग दमा, क्रोनिक ब्रोंकाइटिस और सीओपीडी जैसी बीमारियों में घरघराहट, सीने में जकड़न और सांस फूलने की समस्या में किया जाता है। यह दवा केवल डॉक्टर की सलाह पर ही लेनी चाहिए क्योंकि इसमें थियोफिलिन की मात्रा का संतुलन बहुत महत्वपूर्ण होता है।
साइड इफेक्ट्स: इस दवा से कुछ लोगों में धड़कन तेज होना, हाथ कांपना, बेचैनी, सिरदर्द, जी मिचलाना, उल्टी, पेट में असहजता और बार-बार पेशाब आना जैसे सामान्य दुष्प्रभाव हो सकते हैं। गंभीर दुष्प्रभाव कम होते हैं लेकिन सीने में तेज दर्द, अनियमित धड़कन, लगातार उल्टी, दौरे या सांस लेने में अचानक कठिनाई हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, अपनी मर्जी से मात्रा न बढ़ाएं या घटाएं। इसे हमेशा खाने के बाद या डॉक्टर की सलाह के अनुसार लें। चाय, कॉफी, कोला और एनर्जी ड्रिंक जैसे कैफीन वाले पेय कम करें क्योंकि इनसे धड़कन और कांपना बढ़ सकता है। अन्य दवाओं के साथ लेने से पहले डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 ventiphylline pd 50mg/1mg syrup Uses & Benefits
[{"condition":"Bronchial asthma","description":"Used to relieve reversible airway obstruction and reduce wheezing, chest tightness, and breathlessness in patients with asthma when a combination bronchodilator is considered appropriate by the treating clinician.","evidence":"Established for theophylline and salbutamol individually; combination use is based on clinical practice."},{"condition":"Chronic obstructive pulmonary disease (COPD)","description":"Helps relax bronchial smooth muscle and improve airflow in selected patients with chronic bronchitis or emphysema who have a reversible component to their airway obstruction.","evidence":"Established for bronchodilator components; combination use is based on clinical practice."},{"condition":"Acute bronchospasm","description":"May be used as part of a clinician-directed regimen to relieve sudden narrowing of the airways, although inhaled short-acting beta-2 agonists remain the preferred first-line treatment for acute attacks.","evidence":"Supportive; inhaled therapy is preferred for acute relief."},{"condition":"Chronic reversible airway disease with mixed bronchospasm","description":"Prescribed when both rapid beta-2 mediated bronchodilation and longer-acting methylxanthine bronchodilation are desired under medical supervision.","evidence":"Clinical practice based; individual components are well established."}]
Off-label uses: [{"condition":"Apnea of prematurity","description":"Methylxanthines such as theophylline have been used in neonatal intensive care for apnea of prematurity, but this is a highly specialized use and not applicable to this oral liquid in general practice.","evidence":"Established for caffeine and theophylline in neonates under specialist care."},{"condition":"Bronchiolitis","description":"Bronchodilators have sometimes been tried in bronchiolitis, but evidence does not support routine use and guidelines generally advise against it.","evidence":"Limited and not recommended for routine use."}]
Primary treatment for: Bronchial asthma
Also treats: Chronic obstructive pulmonary disease, Chronic bronchitis, Emphysema with reversible airway obstruction
📋 Drug Information
| Generic Name(s) | Choline Theophyllinate (50mg) + Salbutamol (1mg) |
| Brand Name | ventiphylline pd 50mg/1mg syrup |
| Manufacturer | Yash Pharma Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C, away from direct sunlight and moisture. Keep the bottle tightly closed and do not freeze. Keep out of the reach of children. |
| Shelf Life | Refer to the expiry date printed on the pack. Do not use after the expiry date. Once opened, follow the manufacturer's instructions regarding use within a specified period if provided. |
| WHO Guideline | Not established from the available information for this specific combination product. International asthma and COPD guidelines generally recommend inhaled bronchodilators and inhaled corticosteroids as first-line therapy; oral theophylline combinations are considered in selected patients. |
| ICMR Guideline | Not established from the available information for this specific combination product. Indian guidelines for asthma and COPD emphasize inhaled therapy as the mainstay and reserve oral bronchodilator combinations for specific clinical situations. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two bronchodilators with different mechanisms. Choline theophyllinate is a salt of theophylline that inhibits phosphodiesterase enzymes, leading to increased cyclic AMP within bronchial smooth muscle cells, which promotes relaxation and widening of the airways. Theophylline also blocks adenosine receptors, which contributes to bronchodilation and may reduce airway inflammation and improve diaphragmatic contractility. Salbutamol is a selective beta-2 adrenergic receptor agonist that stimulates beta-2 receptors on bronchial smooth muscle, activating adenylate cyclase and raising cyclic AMP, which causes rapid relaxation of the airway muscles. The two components therefore act through complementary pathways to open the airways, making breathing easier in conditions with reversible bronchospasm.
Mechanism Steps
💡 How to Take ventiphylline pd 50mg/1mg syrup
Strength: Oral liquid containing choline theophyllinate 50 mg and salbutamol 1 mg per dose unit.
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, age, weight, severity of airway obstruction, and renal and hepatic function. It is usually taken two to three times a day, but the exact frequency and amount depend on the prescriber's assessment and the strength of the liquid. Because the theophylline component has a narrow therapeutic index, the dose may need to be adjusted based on clinical response and, where available, serum theophylline levels. Do not change the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific combination liquid. Consult a pediatrician for appropriate dosing and monitoring. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially theophylline toxicity and cardiac effects. Doses are often started lower and adjusted carefully based on renal and hepatic function, concurrent illnesses, and other medicines. Close monitoring is advised. |
| Renal Impairment | In patients with significant renal impairment, theophylline clearance may be reduced, and dose adjustment or monitoring may be required. Salbutamol is less affected by renal function. Consult your doctor for individualized dosing. |
| Hepatic Impairment | In patients with liver disease, theophylline metabolism is reduced, and blood levels can rise quickly. Dose reduction and close monitoring are usually necessary. Salbutamol is less dependent on liver function but should still be used with caution. |
| Maximum Daily Dose | The maximum daily dose must be determined by the treating clinician based on the patient's condition, age, weight, and theophylline blood levels. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ventiphylline pd 50mg/1mg syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ciprofloxacin | Major | |
| Propranolol | Major | |
| Erythromycin | Moderate | |
| Cimetidine | Moderate | |
| Furosemide | Moderate | |
| Digoxin | Moderate | |
| Phenytoin | Moderate | |
| Rifampicin | Moderate | |
| MAO inhibitors | Major | |
| Ketamine | Major |
🚨 Major Interactions
- Ciprofloxacin and other strong CYP1A2 inhibitors
- Propranolol and other non-selective beta-blockers
- Monoamine oxidase inhibitors and tricyclic antidepressants
- Ketamine
⚡ Moderate Interactions
- Erythromycin and clarithromycin
- Cimetidine
- Loop diuretics such as furosemide
- Corticosteroids
- Digoxin
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase the sedative and central nervous system effects of theophylline, worsen dehydration, and increase the risk of rapid heartbeat and low blood pressure. It may also affect liver metabolism of theophylline unpredictably. If you drink alcohol regularly, discuss this with your doctor before starting this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to choline theophyllinate, salbutamol, or any component of this medicine","Severe cardiac arrhythmias or unstable coronary artery disease","Active peptic ulcer disease","Uncontrolled hyperthyroidism","History of paradoxical bronchospasm with beta-2 agonists","Acute porphyria","Children under the age specified by the manufacturer unless directed by a pediatrician"]
⚠️ Warnings & Precautions
["Use with caution in patients with heart disease, hypertension, or arrhythmias.","Use with caution in patients with liver disease, as theophylline levels can rise.","Use with caution in patients with kidney disease, as theophylline may accumulate.","Use with caution in patients with seizure disorders, as theophylline can lower the seizure threshold.","Use with caution in patients with diabetes, as beta-2 agonists can raise blood sugar.","Use with caution in patients with hyperthyroidism, as both components can increase heart rate.","Avoid abrupt discontinuation without medical advice.","Do not exceed the prescribed dose, as theophylline has a narrow therapeutic index.","Inform your doctor if you smoke, as smoking can reduce theophylline levels and may require dose adjustment.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding."]
🤱 Lactation Safety
Salbutamol and theophylline are excreted in small amounts in breast milk. Theophylline can cause irritability or poor feeding in a nursing infant if maternal levels are high. Breastfeeding should be discussed with your doctor, and infant monitoring may be advised if this medicine is considered essential.
💊 Overdose Management
Overdose of this medicine can cause serious and potentially life-threatening effects, mainly from theophylline toxicity. Symptoms include severe nausea, vomiting, abdominal pain, restlessness, tremor, palpitations, rapid heartbeat, seizures, and coma. Salbutamol overdose can cause severe tachycardia, tremor, hypokalemia, and hyperglycemia. If overdose is suspected, seek emergency medical care immediately. Treatment is supportive and may include activated charcoal, monitoring of heart rhythm, correction of electrolyte abnormalities, and management of seizures. Do not attempt to treat overdose at home.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if it is still close to the scheduled time. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one, because this can increase the risk of theophylline toxicity and cardiac side effects. If you are unsure what to do, contact your doctor or pharmacist.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not increase, decrease, or stop the dose on your own, because the balance between benefit and toxicity is narrow for the theophylline component. Shake the bottle well before each use if it is a suspension, and use a proper measuring cup or oral syringe to get an accurate dose. Take this medicine at the same times each day to keep blood levels steady. Avoid drinks or foods that contain large amounts of caffeine, such as strong coffee, tea, cola, and energy drinks, because they can worsen palpitations, tremor, and sleeplessness. Tell your doctor about all other medicines you take, especially antibiotics, heart medicines, and antidepressants, as many can interact with this product. Do not drive or operate heavy machinery if you feel dizzy, shaky, or have a fast heartbeat. Keep this medicine out of the reach of children. Store it as directed on the label and check the expiry date before use. If you are pregnant, planning pregnancy, or breastfeeding, inform your doctor before using this medicine. Report any new or worsening symptoms, especially worsening breathlessness, chest pain, or irregular heartbeat, without delay.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to theophylline toxicity and cardiac side effects. Doses are often started lower and adjusted carefully. Regular monitoring of heart rate, blood pressure, kidney and liver function, and theophylline levels is advised. Falls risk may increase if dizziness or tremor occurs.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss this medicine with your doctor before conception. Theophylline and salbutamol should be used during pregnancy only when clearly needed and under medical supervision. Your doctor may adjust the dose or consider alternative treatments based on your condition.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. Theophylline and salbutamol can affect heart rate and interact with anesthetic agents. Your doctor may advise temporary dose adjustments or monitoring during the perioperative period.
🦷 Dental Procedures
Tell your dentist that you are taking this medicine before any dental procedure. It can cause dry mouth or palpitations, and interactions with local anesthetics containing adrenaline may occur. Your dentist may take precautions or consult your doctor if needed.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate physical activity is generally encouraged, but avoid strenuous exercise if you feel breathless, dizzy, or have a fast heartbeat. Warm up gradually and stop if you experience chest pain, severe breathlessness, or palpitations. If you have exercise-induced asthma, discuss with your doctor whether you need additional treatment before exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause dizziness, tremor, or palpitations in some people, which may affect your ability to drive or operate heavy machinery. Avoid driving or operating machinery until you know how this medicine affects you. Inform your employer if your work involves safety-sensitive tasks. Most people can continue their usual daily activities with appropriate precautions and dose adjustment.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. If you experience serious side effects such as severe palpitations, chest pain, seizures, or worsening breathlessness, seek immediate medical attention and follow your doctor's advice about stopping or changing the medicine. Your doctor will decide whether to stop, reduce, or switch the treatment based on your condition and response.
📅 Long-Term Use Effects
Long-term use of this medicine requires regular medical review because theophylline can accumulate in the body and cause toxicity, especially in the elderly and those with liver or heart disease. Monitoring may include heart rate, blood pressure, potassium levels, and theophylline blood levels where available. Prolonged use without monitoring can increase the risk of arrhythmias, seizures, and gastrointestinal effects. Your doctor may adjust the dose or change the treatment plan based on your response and any side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Inhaled short-acting beta-2 agonists are the preferred first-line treatment for acute bronchospasm and may be used instead of or alongside oral therapy.
Evidence: Well-establishedUsed as controller therapy in asthma to reduce airway inflammation and prevent attacks.
Evidence: Well-establishedA structured exercise and education program that can improve breathing capacity and quality of life in COPD.
Evidence: Well-establishedCan help improve breathing technique and reduce breathlessness in some patients.
Evidence: Supportive💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Patients with chronic lung diseases such as asthma and COPD should discuss influenza and pneumococcal vaccination with their doctor. There is no specific interaction between this medicine and vaccines, but vaccination status should be reviewed as part of comprehensive respiratory care.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate or freeze unless specified
✅ DO
Keep in the original container with the cap tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of the reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription and a doctor's note if you are traveling internationally, especially for longer trips. Keep the bottle in your hand luggage so it is not exposed to extreme temperatures in checked baggage. Store it at room temperature and protect it from direct sunlight and moisture. If you are crossing time zones, discuss with your doctor how to adjust the timing of doses to maintain steady levels. Do not pack it in a way that exposes it to heat or freezing.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Salbutamol starts working within minutes, while theophylline effects develop over 30 to 60 minutes. The full benefit may take a few days of regular use.
A: Yes, taking it with or after food is often recommended to reduce stomach upset. Be consistent with how you take it.
A: If it is almost time for the next dose, skip the missed dose. Do not double dose. Contact your doctor if you are unsure.
A: No, do not stop without consulting your doctor. Stopping suddenly can worsen your breathing problem.
A: Pediatric dosing is not established from available information for this specific combination. Consult a pediatrician.
🤔 Common Patient Concerns
🔄 Substitutes for ventiphylline pd 50mg/1mg syrup
View AllAlternative brands with exact same active ingredient:
-
efelin pd 50 mg/1 mg syrupIndoco Remedies Ltd ₹14.25 57.6% CHEAPER
-
salphyllin pd dropLincoln Pharmaceuticals Ltd ₹26.87 20.1% CHEAPER
-
onimar pd 50 mg/1 mg syrupEmcee Pharmaceuticals Pvt Ltd ₹33.55 0.2% CHEAPER
-
durasalyn liquidRaptakos Brett & Co Ltd ₹43.13 28.3% COSTLIER
-
ventex-pd syrupCure Quick Pharmaceuticals ₹86.67 157.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken whenever you feel breathless without a prescription.
Fact: This is a prescription medicine and should only be used under medical supervision because of the narrow safety margin of theophylline. - Myth: More medicine means faster relief.
Fact: Increasing the dose can cause serious heart and nervous system side effects; never exceed the prescribed dose. - Myth: This medicine can replace inhalers.
Fact: Inhaled medicines remain the preferred treatment for asthma and COPD; this oral combination is used only when prescribed. - Myth: It is safe to drink coffee while taking this medicine.
Fact: Caffeine can worsen palpitations, tremor, and sleeplessness; limit caffeine intake.
🔄 Alternative Options
Generic Alternatives
- Choline theophyllinate and salbutamol oral liquid
- Theophylline and salbutamol oral liquid