Apsonim T 100mg/2mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit, or black tarry stools.
- Severe abdominal pain or persistent stomach upset.
- Yellowing of skin or eyes (jaundice).
- Dark urine or decreased urine output.
- Severe dizziness, fainting, or unusually slow heartbeat.
- Swelling of face, lips, tongue, or throat, or difficulty breathing.
- Unusual bleeding or bruising.
- Severe headache with visual changes.
If experiencing severe symptoms, call emergency services immediately.
What is vc mr plus 100mg/2mg capsule used for?
This medicine is a combination of nimesulide (an NSAID) and tizanidine (a muscle relaxant) used for short-term relief of acute musculoskeletal pain and muscle spasm. It is typically taken one tablet twice daily with food for up to 5-7 days. It is not recommended for long-term use due to risks of liver and stomach problems.
- Generic Name: Nimesulide (100mg) + Tizanidine (2mg)
- Manufacturer: Carion Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 vc mr plus 100mg/2mg capsule के बारे में (Hindi Summary)
उपयोग: यह दवा नाइमेसुलाइड और टिज़ानिडीन का संयोजन है, जिसका उपयोग मांसपेशियों में ऐंठन और दर्द के अल्पकालिक उपचार के लिए किया जाता है। यह आमतौर पर कमर दर्द, गर्दन दर्द, और चोट के कारण होने वाली मांसपेशियों की समस्याओं में राहत देती है। यह दवा केवल 5 से 7 दिनों तक ही लेनी चाहिए, क्योंकि लंबे समय तक उपयोग से लीवर और पेट की समस्याएं हो सकती हैं। इसे डॉक्टर की सलाह के अनुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, जी मिचलाना, और थकान शामिल हैं। कभी-कभी पेट में जलन या दर्द भी हो सकता है। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, लीवर की क्षति, और एलर्जी प्रतिक्रियाएं शामिल हैं। यदि आपको पीलिया, गहरे रंग का पेशाब, या लगातार पेट दर्द हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, आमतौर पर भोजन के साथ। शराब का सेवन बिल्कुल न करें क्योंकि इससे नींद और लीवर की समस्या बढ़ सकती है। दवा लेने के बाद वाहन चलाने या मशीन चलाने से बचें। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको लीवर, किडनी, या पेट की बीमारी है, तो डॉक्टर को बताएं। बिना डॉक्टर की सलाह के अन्य दर्द निवारक दवाएं न लें।
💊 vc mr plus 100mg/2mg capsule Uses & Benefits
[{"condition":"Acute musculoskeletal pain with muscle spasm","description":"Short-term relief of pain and spasm in conditions such as acute low back pain, neck pain, and myofascial pain syndrome.","evidence":"Well-established for short-term use"},{"condition":"Post-traumatic muscle spasm","description":"Used to reduce pain and spasm following sprains, strains, and other soft tissue injuries.","evidence":"Commonly used, evidence supports short-term benefit"},{"condition":"Post-operative pain with spasm","description":"May be used for short-term management of pain and muscle spasm after certain surgical procedures.","evidence":"Limited to short-term use under medical supervision"}]
Off-label uses: [{"condition":"Tension-type headache with muscle tightness","description":"Sometimes prescribed off-label for tension headaches accompanied by neck and shoulder muscle spasm.","evidence":"Limited"},{"condition":"Temporomandibular joint disorder","description":"May be used off-label for short-term relief of jaw muscle spasm and pain.","evidence":"Limited"}]
Primary treatment for: Acute musculoskeletal pain with muscle spasm
Also treats: Low back pain, Neck pain, Myofascial pain syndrome, Post-traumatic muscle spasm
📋 Drug Information
| Generic Name(s) | Nimesulide (100mg) + Tizanidine (2mg) |
| Brand Name | vc mr plus 100mg/2mg capsule |
| Manufacturer | Carion Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place. Protect from light and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. The World Health Organization does not have specific guidelines for this fixed-dose combination. |
| ICMR Guideline | Not established from the available information. The Indian Council of Medical Research does not have specific guidelines for this fixed-dose combination. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins, which are mediators of pain, inflammation, and fever. Tizanidine is a centrally acting alpha-2 adrenergic agonist that reduces the release of excitatory neurotransmitters from spinal interneurons, thereby decreasing muscle tone and spasticity. Together, they provide both anti-inflammatory and muscle relaxant effects.
Mechanism Steps
💡 How to Take vc mr plus 100mg/2mg capsule
Strength: Each tablet contains nimesulide 100 mg and tizanidine 2 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally one to two times daily, as prescribed by your doctor. The exact dose and duration depend on the severity of your condition, your response to treatment, and your kidney and liver function. Do not exceed the recommended dose or duration. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the effects of this medicine, especially drowsiness, dizziness, and hypotension. Use with caution and at the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction may be necessary. Not recommended in severe renal impairment (eGFR <30 mL/min). Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | Contraindicated in severe hepatic impairment. Use with caution in mild to moderate hepatic impairment; dose reduction and close monitoring of liver function are advised. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 2 tablets (200 mg nimesulide and 4 mg tizanidine) per day, but the exact maximum should be determined by a qualified clinician. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of vc mr plus 100mg/2mg capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Fluvoxamine | Major | |
| Ciprofloxacin | Major | |
| Warfarin | Major | |
| Lisinopril | Moderate | |
| Furosemide | Moderate | |
| Lithium | Major | |
| Aspirin | Major | |
| Ibuprofen | Major | |
| Cimetidine | Moderate | |
| Oral contraceptives | Moderate |
🚨 Major Interactions
- CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin)
- Antihypertensive drugs
- Other NSAIDs (including aspirin)
- Warfarin
- Lithium
⚡ Moderate Interactions
- Diuretics (e.g., furosemide)
- ACE inhibitors and ARBs
- Oral contraceptives
- Cimetidine
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Alcohol increases the sedative effects of tizanidine and the risk of gastrointestinal bleeding and liver damage from nimesulide. It can also cause severe drowsiness, dizziness, and impaired motor skills.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nimesulide, tizanidine, or any component of the formulation.","Active peptic ulcer disease or history of recurrent ulcers.","Severe liver impairment or active liver disease.","Severe kidney impairment (eGFR
⚠️ Warnings & Precautions
["This medicine should only be used for short-term treatment (maximum 5-7 days) due to the risk of hepatotoxicity and gastrointestinal bleeding.","Avoid in patients with cardiovascular disease, hypertension, or cerebrovascular disease.","Use with caution in elderly patients due to increased risk of side effects.","Do not use with other NSAIDs or anticoagulants.","May cause drowsiness and dizziness; avoid driving or operating machinery.","Monitor blood pressure regularly as tizanidine can cause hypotension.","Discontinue immediately if signs of liver injury occur.","Do not use in patients with severe renal impairment.","Alcohol consumption should be avoided.","Inform your doctor if you have diabetes, as NSAIDs may affect blood sugar control."]
🤱 Lactation Safety
Not established from the available information. Nimesulide and tizanidine may pass into breast milk. Breastfeeding is not recommended while taking this medicine unless specifically advised by a doctor.
💊 Overdose Management
Overdose of this medicine may cause severe drowsiness, dizziness, hypotension, bradycardia, nausea, vomiting, and potentially liver or kidney damage. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs, liver and kidney function, and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually with food to reduce stomach upset. Do not exceed the recommended dose or duration of treatment. Avoid alcohol completely while taking this medicine because it can increase drowsiness and the risk of liver damage. Do not drive or operate heavy machinery until you know how this medicine affects you, as it can cause sedation and dizziness. Inform your doctor if you have a history of stomach ulcers, liver disease, kidney disease, heart disease, or low blood pressure. Do not take other NSAIDs or pain relievers without consulting your doctor. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of reach of children and store it in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) are at higher risk of side effects such as drowsiness, dizziness, hypotension, gastrointestinal bleeding, and kidney impairment. Use the lowest effective dose for the shortest duration. Monitor blood pressure, kidney function, and liver function regularly. Avoid concomitant use with other NSAIDs or antihypertensives without medical supervision.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended for women planning pregnancy or those who are pregnant. Nimesulide may interfere with ovulation and is associated with risks to the fetus, especially in the third trimester. Tizanidine may also affect fetal development. Consult your doctor for alternative pain management options if you are planning pregnancy.
🏥 Post-Surgery Considerations
This medicine may be used for short-term management of post-operative pain and muscle spasm, but only under strict medical supervision. It is not recommended after certain surgeries, especially those involving the gastrointestinal tract, due to the risk of bleeding. Inform your surgeon and anesthesiologist about all medicines you are taking before surgery.
🦷 Dental Procedures
If you are scheduled for dental procedures, inform your dentist that you are taking this medicine. Nimesulide can increase bleeding risk, and tizanidine can cause drowsiness. Your dentist may advise you to stop the medicine temporarily before the procedure. Do not stop without consulting your prescribing doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, avoid strenuous exercise or heavy lifting as it may worsen muscle spasm or cause injury. Gentle stretching and low-impact activities are recommended. Due to the risk of drowsiness and dizziness, avoid activities that require balance and coordination. Consult your physiotherapist for a safe exercise plan.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and fatigue, which may affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is advisable to avoid such activities until you know how the medicine affects you. Take frequent breaks if you have a desk job and maintain good posture. Inform your employer if your work involves safety-sensitive tasks.
🛑 When to Stop This Medicine
Stop taking this medicine if you experience any serious side effects such as severe abdominal pain, black stools, yellowing of eyes or skin, dark urine, severe dizziness, or allergic reactions. Also stop if your symptoms improve and your doctor advises discontinuation. Do not stop abruptly if you have been taking it for a longer duration without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of serious side effects. Prolonged use of nimesulide can lead to liver damage, kidney impairment, and gastrointestinal bleeding. Tizanidine can cause tolerance, dependence, and persistent drowsiness. Regular monitoring of liver and kidney function is advised if used for more than a few days. Always consult your doctor before extending treatment beyond 7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and muscle spasm.
Evidence: Well-establishedHelps relax muscles and reduce pain.
Evidence: Commonly usedMay provide relief for some patients with musculoskeletal pain.
Evidence: LimitedMay help with spinal alignment and pain relief.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, adjust dosing times gradually under medical advice. Do not pack it in checked luggage; keep it in your carry-on. Check customs regulations for restricted medicines in your destination country. Avoid alcohol during travel and stay hydrated.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain and muscle spasm within 30 to 60 minutes after taking it.
A: It should only be used for short-term treatment, typically not exceeding 5 to 7 days, unless your doctor advises otherwise.
A: No, alcohol should be completely avoided as it increases the risk of sedation, liver damage, and stomach bleeding.
A: It can affect kidney function, especially with prolonged use or in people with pre-existing kidney disease. Your doctor may monitor your kidney function.
A: This medicine can cause drowsiness and dizziness. Avoid driving or operating machinery until you know how it affects you.
🤔 Common Patient Concerns
🔄 Substitutes for vc mr plus 100mg/2mg capsule
View AllAlternative brands with exact same active ingredient:
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nisul mr tabletIntas Pharmaceuticals Ltd ₹5.63 93.9% CHEAPER
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Tromazine 100 mg/2 mg TabletPsychotropics India Ltd ₹6.31 93.1% CHEAPER
-
neulab tz tabletLaborate Pharmaceuticals India Ltd ₹20.00 78.2% CHEAPER
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Naba T TabletMonokem Labs ₹22.50 75.5% CHEAPER
-
nimeson tn 100 mg/2 mg tabletUnison Pharmaceuticals Pvt Ltd ₹24.19 73.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken long-term for chronic pain.
Fact: This medicine is only for short-term use (up to 5-7 days) due to risks of liver damage and gastrointestinal bleeding. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol increases the risk of sedation, liver damage, and stomach bleeding. It should be avoided. - Myth: This medicine is safe for everyone.
Fact: It is not safe for people with liver disease, kidney disease, stomach ulcers, or pregnant women.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Tizanidine combination (generic)
Brand Alternatives
- Aps Biotech Pvt Ltd's Apsonim T 100mg/2mg Tablet