Ursodil-SR Tablet: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of skin or eyes (jaundice)
- Dark urine or pale stools
- Severe abdominal pain, especially in the upper right side
- Persistent nausea and vomiting
- Sudden swelling of face, lips, or throat
- Difficulty breathing or swallowing
- Unusual bleeding or bruising
- Extreme fatigue or weakness
If experiencing severe symptoms, call emergency services immediately.
What is ursodil -sr tablet used for?
This medicine contains Ursodeoxycholic Acid 500 mg, used to dissolve cholesterol gallstones and treat chronic liver diseases like primary biliary cholangitis. It works by reducing cholesterol in bile and protecting liver cells.
- Generic Name: Ursodeoxycholic Acid (500mg)
- Manufacturer: Zydus Cadila
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ursodil -sr tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मुख्य रूप से पित्ताशय की पथरी को घोलने और पुरानी लिवर बीमारियों जैसे प्राइमरी बिलियरी कोलैंगाइटिस के इलाज के लिए इस्तेमाल की जाती है। यह पित्त में कोलेस्ट्रॉल को कम करके और लिवर की कोशिकाओं की रक्षा करके काम करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, दस्त, पेट में असहजता और उल्टी शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन लिवर की समस्या बढ़ सकती है, जिससे त्वचा या आंखें पीली हो सकती हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे पानी के साथ निगलें, चबाएं नहीं। भोजन के साथ लेने से पेट की परेशानी कम हो सकती है। नियमित रूप से लिवर फंक्शन टेस्ट कराएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। शराब से बचें।
💊 ursodil -sr tablet Uses & Benefits
[{"condition":"Cholesterol gallstones","description":"Used to dissolve small, radiolucent cholesterol gallstones in patients who cannot undergo surgery or who have mild symptoms.","evidence":"Well-established"},{"condition":"Primary biliary cholangitis","description":"Improves liver biochemistry and delays progression of this chronic autoimmune liver disease.","evidence":"Well-established"},{"condition":"Primary sclerosing cholangitis","description":"May be used off-label to improve liver enzymes, though evidence for long-term benefit is limited.","evidence":"Limited"},{"condition":"Intrahepatic cholestasis of pregnancy","description":"Helps relieve itching and improve liver function in pregnant women with this condition.","evidence":"Moderate"},{"condition":"Cystic fibrosis-related liver disease","description":"May improve bile flow and liver function in some patients with cystic fibrosis.","evidence":"Limited"}]
Off-label uses: [{"condition":"Non-alcoholic steatohepatitis","description":"Sometimes prescribed to improve liver enzymes, but evidence for significant benefit is lacking.","evidence":"Limited"},{"condition":"Biliary dyskinesia","description":"Occasionally used to relieve symptoms of bile flow dysfunction, but evidence is insufficient.","evidence":"Insufficient"}]
Primary treatment for: Cholesterol gallstones
Also treats: Primary biliary cholangitis, Primary sclerosing cholangitis, Intrahepatic cholestasis of pregnancy, Cystic fibrosis-related liver disease
📋 Drug Information
| Generic Name(s) | Ursodeoxycholic Acid (500mg) |
| Brand Name | ursodil -sr tablet |
| Manufacturer | Zydus Cadila |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Hepatoprotectives |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in a cool, dry place away from direct sunlight. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by replacing hydrophobic bile acids in the bile acid pool with the more hydrophilic ursodeoxycholic acid. This reduces cholesterol absorption from the intestine, decreases cholesterol secretion into bile, and disperses cholesterol in bile, making it less likely to form stones. It also protects liver cells from the toxic effects of retained bile acids and stimulates bile flow, which helps flush out bile and reduce cholestasis.
Mechanism Steps
💡 How to Take ursodil -sr tablet
Strength: Ursodeoxycholic Acid 500 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine for dissolving gallstones is 8-10 mg per kg of body weight per day, divided into 2-3 doses. For primary biliary cholangitis, the typical dose is 13-15 mg per kg per day, divided into 2-4 doses. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not adjust the dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients, but they should be monitored closely for liver function and side effects. Consult your doctor for personalized dosing. |
| Renal Impairment | No dose adjustment is needed for patients with kidney impairment. However, consult your doctor for personalized advice. |
| Hepatic Impairment | In patients with severe liver impairment, this medicine should be used with caution. Dose adjustment may be necessary. Consult your doctor for personalized dosing. |
| Maximum Daily Dose | The maximum daily dose should not exceed 20 mg per kg of body weight unless directed by a specialist. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ursodil -sr tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Aluminum-based antacids | Major | |
| Cholestyramine | Major | |
| Cyclosporine | Major | |
| Ciprofloxacin | Moderate | |
| Nitrendipine | Moderate | |
| Dapsone | Moderate | |
| Oral contraceptives | Minor | |
| Rosuvastatin | Minor |
🚨 Major Interactions
- Aluminum-based antacids
- Cholestyramine, colestipol, colesevelam
- Cyclosporine
⚡ Moderate Interactions
- Ciprofloxacin
- Nitrendipine
- Dapsone
🍷 Alcohol Interaction
Alcohol may increase the risk of liver problems while taking this medicine. It is advisable to avoid alcohol or limit its consumption. Consult your doctor for personalized advice.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Acute inflammation of the gallbladder or bile ducts","Complete blockage of the bile ducts","Severe liver failure","Calcified or large gallstones that cannot be dissolved","Hypersensitivity to ursodeoxycholic acid or any component of the tablet"]
⚠️ Warnings & Precautions
["Take this medicine exactly as prescribed. Do not exceed the recommended dose.","Inform your doctor if you have any liver disease, as dose adjustment may be needed.","Regular monitoring of liver function is essential during treatment.","This medicine may not be effective for all types of gallstones; follow-up imaging is necessary.","Avoid alcohol while taking this medicine to reduce the risk of liver problems.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Do not use this medicine for weight loss or other unapproved purposes."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose with this medicine is unlikely to cause serious effects. However, if you suspect an overdose, contact your doctor or a poison control center immediately. Symptoms of overdose may include severe diarrhea, nausea, or vomiting. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. Swallow the tablet whole with a glass of water; do not crush or chew it. You may take it with or without food, but taking it with meals may help reduce stomach upset. Attend all scheduled blood tests to monitor your liver function and cholesterol levels. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Avoid alcohol while taking this medicine, as it can increase the risk of liver problems. Keep all follow-up appointments so your doctor can assess how well the medicine is working. Store the tablets in a cool, dry place away from direct sunlight and out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine. Regular monitoring of liver function is recommended. No specific dose adjustment is usually needed, but consult your doctor for personalized advice.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is considered safe in pregnancy when prescribed, but your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
If you have recently undergone surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It is generally safe to continue, but your doctor may adjust the dose based on your condition.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. No specific precautions are usually needed, but it is important for your dentist to know your complete medication history.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine does not usually affect your ability to exercise. However, if you have gallstones or liver disease, consult your doctor before starting any new exercise regimen. Avoid strenuous activities if you experience abdominal pain or fatigue.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to work or drive. However, if you experience side effects like dizziness or fatigue, avoid driving or operating heavy machinery until you know how the medicine affects you.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Your doctor will determine the appropriate duration of treatment based on your condition and response. If you experience serious side effects, contact your doctor immediately; they may advise you to stop.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe and well-tolerated. Regular monitoring of liver function and gallstone status is necessary. In some cases, prolonged use may lead to gallstone calcification, making them resistant to dissolution. It may also cause mild hair thinning. Always follow your doctor's advice regarding duration of treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Removal of the gallbladder is a definitive treatment for symptomatic gallstones.
Evidence: Well-establishedUses shock waves to break up gallstones, but not suitable for all patients.
Evidence: ModerateDiet and exercise can help prevent gallstones and support liver health.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medicines you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry your medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from direct sunlight and moisture. If crossing time zones, continue taking your doses at the same intervals as prescribed; you may need to adjust timing gradually. Check customs regulations for carrying prescription medicines. Always pack enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: For gallstone dissolution, it may take several months to years depending on the size of the stones. For liver conditions, improvement in liver enzymes may be seen within weeks.
A: Yes, you can take it with or without food, but taking it with meals is recommended to improve absorption and reduce stomach upset.
A: This medicine is considered safe for use in pregnancy when prescribed by a doctor, especially for intrahepatic cholestasis of pregnancy. Always consult your doctor before taking any medicine during pregnancy.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, do not stop taking this medicine without consulting your doctor. Stopping suddenly may cause your condition to worsen or gallstones to recur.
🤔 Common Patient Concerns
🔄 Substitutes for ursodil -sr tablet
View AllAlternative brands with exact same active ingredient:
-
urdox 500mg capsuleZydus Cadila ₹142.43 84.7% CHEAPER
-
ursoford 500 tabletLeeford Healthcare Ltd ₹450.00 51.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can dissolve all types of gallstones.
Fact: It is only effective for small, cholesterol-rich gallstones that are not calcified. - Myth: This medicine is a painkiller.
Fact: It is not a painkiller; it works by dissolving gallstones and improving liver function. - Myth: You can stop taking this medicine once you feel better.
Fact: You should only stop if your doctor advises, as stopping early may cause gallstones to recur or liver condition to worsen.
🔄 Alternative Options
Generic Alternatives
- Ursodeoxycholic Acid 500 mg tablet
Brand Alternatives
- Ursodil -SR Tablet