ulsec dp 10mg/20mg capsule - Domperidone (10mg) + Omeprazole (20mg) medicine

Acizole D 10mg/20mg Capsule: Complete Medicine Guide

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🏭 Ultratech Pharmaceuticals 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for the combination in GERD with dyspepsia; limited for other uses.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in vomit or black, tarry stools
  • Severe abdominal pain or persistent vomiting
  • Chest pain, palpitations, or difficulty breathing
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes (jaundice)
  • Decreased urine output or severe dizziness
  • Severe diarrhea with fever or abdominal cramps

If experiencing severe symptoms, call emergency services immediately.

What is ulsec dp 10mg/20mg capsule used for?

This medicine is a combination of Domperidone and Omeprazole used to treat acid reflux and related stomach problems. It works by reducing stomach acid and improving stomach emptying.

  • Generic Name: Domperidone (10mg) + Omeprazole (20mg)
  • Manufacturer: Ultratech Pharmaceuticals
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 ulsec dp 10mg/20mg capsule के बारे में (Hindi Summary)

उपयोग: यह दवा डोम्पेरिडोन और ओमेप्राज़ोल का संयोजन है। इसका उपयोग एसिड रिफ्लक्स, गैस्ट्रोएसोफेजियल रिफ्लक्स डिजीज (GERD), अपच, और पेट से जुड़ी समस्याओं के इलाज के लिए किया जाता है। यह पेट में एसिड को कम करती है और पेट खाली होने की गति को बढ़ाती है, जिससे जलन, उल्टी, और पेट फूलने जैसे लक्षणों में राहत मिलती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, सिरदर्द, दस्त, पेट दर्द, और जी मिचलाना शामिल हैं। कुछ लोगों को चक्कर आना या थकान महसूस हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें अनियमित दिल की धड़कन, गंभीर एलर्जी, और लंबे समय तक उपयोग से मैग्नीशियम की कमी शामिल हो सकती है।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। अपने आप डोज़ न बढ़ाएं या कम न करें। कैप्सूल को पानी के साथ पूरा निगलें, चबाएं नहीं। इसे खाली पेट, भोजन से 30 मिनट पहले लें। शराब का सेवन न करें। अगर आपको चक्कर आते हैं तो वाहन न चलाएं। अपने डॉक्टर को अपनी सभी दवाओं और स्वास्थ्य स्थितियों के बारे में बताएं।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 ulsec dp 10mg/20mg capsule Uses & Benefits

[{"condition":"Gastroesophageal reflux disease (GERD) with dyspepsia","description":"Reduces acid reflux and improves stomach emptying, relieving heartburn, regurgitation, and bloating.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"Helps relieve symptoms like upper abdominal pain, early satiety, and postprandial fullness.","evidence":"Moderate"},{"condition":"Nausea and vomiting associated with acid-related disorders","description":"Domperidone reduces nausea and vomiting while omeprazole treats the underlying acid problem.","evidence":"Moderate"},{"condition":"Gastroparesis with acid reflux","description":"Improves gastric emptying and reduces acid exposure in patients with delayed stomach emptying.","evidence":"Limited"}]

Off-label uses: [{"condition":"Prevention of NSAID-induced ulcers in high-risk patients","description":"Omeprazole component may be used off-label for ulcer prevention, but the combination is not standard for this purpose.","evidence":"Limited"}]

Primary treatment for: Gastroesophageal reflux disease (GERD) with dyspepsia

Also treats: Functional dyspepsia, Gastroparesis, Nausea and vomiting associated with acid-related disorders

📋 Drug Information

Generic Name(s)Domperidone (10mg) + Omeprazole (20mg)
Brand Nameulsec dp 10mg/20mg capsule
ManufacturerUltratech Pharmaceuticals
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine on an empty stomach, at least 30 minutes before a meal, for best results.
2
Do not crush or chew the capsule; swallow it whole with water.
3
Avoid alcohol while taking this medicine to prevent worsening of stomach symptoms.
4
If you experience palpitations, dizziness, or fainting, stop the medicine and seek immediate medical attention.
5
Do not take this medicine for longer than prescribed without a medical review.
6
Inform your doctor if you are taking blood thinners, antidepressants, or antifungal medicines.
7
Keep a record of your symptoms to discuss with your doctor at follow-up.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Heartburn
This medicine is commonly prescribed for this.
Likely Use
Bloating
This medicine helps with bloating due to improved gastric emptying.
Likely Use
Nausea
Domperidone component helps relieve nausea.
Likely Use
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDomperidone is rapidly absorbed after oral administration, but its bioavailability is low (about 15%) due to extensive first-pass metabolism. Omeprazole is also rapidly absorbed, with peak plasma levels occurring within 0.5 to 3.5 hours. Food may delay the absorption of omeprazole but does not significantly affect the extent of absorption. The combination capsule is designed for immediate release.
DistributionDomperidone is widely distributed in the body but does not readily cross the blood-brain barrier. It is highly protein-bound (about 91-93%). Omeprazole is also highly protein-bound (about 95%) and distributes into gastric parietal cells. Both drugs have large volumes of distribution.
Protein BindingDomperidone: approximately 91-93% bound to plasma proteins. Omeprazole: approximately 95% bound to plasma proteins.
MetabolismDomperidone is extensively metabolized in the liver by CYP3A4 and CYP1A2 enzymes. Omeprazole is metabolized in the liver primarily by CYP2C19 and CYP3A4 enzymes. Genetic variations in CYP2C19 can affect omeprazole metabolism.
Half-LifeDomperidone: approximately 7-9 hours in healthy individuals. Omeprazole: approximately 0.5-1 hour, but the duration of acid suppression is much longer due to irreversible binding.
ExcretionDomperidone is excreted mainly in feces (about 66%) and urine (about 33%). Omeprazole is excreted mainly as metabolites in urine (about 80%) and feces (about 20%).
BioavailabilityDomperidone: about 15% due to first-pass metabolism. Omeprazole: about 30-40% after a single dose, increasing with repeated dosing.
Onset of ActionDomperidone: within 30-60 minutes for prokinetic effects. Omeprazole: acid suppression begins within 1 hour, but maximum effect may take several days.
Peak Plasma TimeDomperidone: 0.5-2 hours. Omeprazole: 0.5-3.5 hours.
Duration of ActionDomperidone: 6-8 hours. Omeprazole: acid suppression lasts up to 24 hours per dose.

How It Works

This medicine combines two active ingredients with complementary actions. Domperidone is a peripheral dopamine D2 receptor antagonist that blocks dopamine receptors in the chemoreceptor trigger zone and the gastrointestinal tract. This action increases lower esophageal sphincter tone, enhances gastric and duodenal peristalsis, and accelerates gastric emptying, which reduces nausea and vomiting. Omeprazole is a proton pump inhibitor that irreversibly inhibits the hydrogen-potassium ATPase enzyme in gastric parietal cells. This blocks the final step of acid secretion, leading to a profound and long-lasting reduction in both basal and stimulated gastric acid production. Together, they address both acid hypersecretion and impaired gastric motility.

Mechanism Steps

1
Domperidone blocks peripheral dopamine D2 receptors: Domperidone antagonizes dopamine D2 receptors in the gastrointestinal tract and chemoreceptor trigger zone, which enhances gastric motility and reduces nausea.
2
Increased gastric emptying and sphincter tone: This leads to faster stomach emptying and increased lower esophageal sphincter pressure, reducing reflux and bloating.
3
Omeprazole inhibits proton pumps: Omeprazole irreversibly binds to hydrogen-potassium ATPase in parietal cells, blocking the final step of acid secretion.
4
Reduced gastric acid secretion: This results in a marked decrease in basal and stimulated acid production, allowing healing of acid-related mucosal injury.
5
Combined symptomatic relief: The dual action addresses both acid reflux and delayed gastric emptying, providing comprehensive relief from dyspeptic symptoms.

💡 How to Take ulsec dp 10mg/20mg capsule

Strength: Capsule containing Domperidone 10 mg and Omeprazole 20 mg.

1Take the capsule whole with a glass of water.
2Swallow it whole; do not crush, chew, or open the capsule.
3Take it on an empty stomach, at least 30 minutes before a meal.
4If you take it twice daily, take the second dose before dinner.
5Follow your doctor's instructions exactly.
6Do not take more than the prescribed dose.

Dosage Information

Adult DosageThe usual adult dose is one capsule taken orally once or twice daily, preferably 30 minutes before meals. The exact dose and duration depend on the condition being treated and the patient's response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine. Use with caution and monitor for cardiac, renal, and hepatic function. Dose adjustment may be needed.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult your doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose reduction may be needed. Avoid in severe liver disease.
Maximum Daily DoseThe maximum recommended daily dose is 40 mg of omeprazole and 30 mg of domperidone, but this should not be exceeded without medical supervision.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take on an empty stomach
Food may delay absorption of omeprazole and domperidone.
Grapefruit
Avoid
May increase domperidone levels.
Alcohol
Avoid
May worsen stomach irritation and increase drowsiness.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of ulsec dp 10mg/20mg capsule

✅ Common Side Effects

Dry mouth (Common (1-10%))
Sip water frequently. Usually resolves on its own.
Headache (Common (1-10%))
Rest and stay hydrated. Consult doctor if severe or persistent.
Diarrhea (Common (1-10%))
Stay hydrated. Consult doctor if it persists beyond 2 days.
Abdominal pain (Common (1-10%))
Take with food if advised. Consult doctor if severe.
Nausea (Common (1-10%))
Take as directed. If nausea worsens, contact your doctor.

🚨 Serious Side Effects

Irregular heartbeat (QT prolongation) (Rare (<0.1%))
Seek immediate medical attention if you experience palpitations, dizziness, or fainting.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Call emergency services if you develop rash, swelling of face/lips/throat, or difficulty breathing.
Low magnesium levels (hypomagnesemia) (Rare (<0.1%) with long-term use)
Report muscle cramps, tremors, or irregular heartbeat to your doctor.
Clostridium difficile-associated diarrhea (Rare (<0.1%))
Seek medical attention if you have severe, persistent diarrhea with fever or abdominal pain.

⚠️ Rare Side Effects

Galactorrhea (breast milk secretion)
Consult your doctor if this occurs.
Gynecomastia (breast enlargement in men)
Report to your doctor.
Amenorrhea (absence of menstrual periods)
Consult your doctor.
Visual disturbances
Consult your doctor if persistent.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Warfarin Major
Clopidogrel Major
Methotrexate Major
Diazepam Moderate
Phenytoin Moderate
Atazanavir Moderate
Iron supplements Moderate
Antacids Minor
Sucralfate Minor

🚨 Major Interactions

  • Ketoconazole, itraconazole, clarithromycin, ritonavir
  • QT-prolonging drugs (e.g., amiodarone, sotalol, haloperidol)
  • Warfarin
  • Clopidogrel
  • Methotrexate

⚡ Moderate Interactions

  • Diazepam
  • Phenytoin
  • Atazanavir, nelfinavir
  • Iron supplements
  • Vitamin B12

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol can increase stomach acid, worsen reflux symptoms, and add to central nervous system effects like dizziness and drowsiness. It may also increase the risk of gastrointestinal bleeding.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to domperidone, omeprazole, or any component of the formulation","Prolactinoma (pituitary tumor)","Severe liver impairment","Known QT prolongation or history of torsades de pointes","Concomitant use with strong CYP3A4 inhibitors like ketoconazole, clarithromycin, ritonavir","Concomitant use with QT-prolonging drugs","Gastrointestinal obstruction, perforation, or bleeding"]

⚠️ Warnings & Precautions

["Use with caution in patients with heart disease or electrolyte imbalances.","Avoid in patients with known QT prolongation.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Long-term use may lead to vitamin B12 deficiency and bone fractures.","May increase risk of gastrointestinal infections like Salmonella and Campylobacter.","Use with caution in the elderly.","Do not use for more than 12 weeks without medical review.","Inform your doctor if you have kidney or liver disease."]

🤱 Lactation Safety

Domperidone passes into breast milk and may cause side effects in a nursing infant. Omeprazole also passes into breast milk but is considered compatible with breastfeeding. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose may cause drowsiness, disorientation, extrapyramidal symptoms, and QT prolongation. Seek immediate medical attention. Treatment is symptomatic and supportive. ECG monitoring is recommended. There is no specific antidote. Activated charcoal may be considered if overdose is recent.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not increase or decrease the dose on your own. Swallow the capsule whole with a glass of water; do not crush or chew it. It is best taken on an empty stomach, at least 30 minutes before a meal, but follow your doctor's specific instructions. Avoid alcohol while taking this medicine, as it can worsen stomach irritation and increase drowsiness. Do not drive or operate heavy machinery if you feel dizzy or sleepy. Inform your doctor if you have heart problems, liver disease, kidney disease, or low magnesium levels. Do not take this medicine for longer than recommended without medical supervision. Keep all follow-up appointments and report any new or worsening symptoms.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more prone to side effects like dizziness, electrolyte imbalances, and cardiac arrhythmias. Use with caution and monitor renal and hepatic function.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before taking this medicine. Both domperidone and omeprazole should be used during pregnancy only if clearly needed.

🏥 Post-Surgery Considerations

Use with caution after surgery, especially if you have had gastrointestinal surgery. Consult your surgeon before taking this medicine.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may affect bleeding risk or interact with medications used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Eat smaller, more frequent meals to reduce acid reflux.
🥗
Avoid spicy, fatty, and acidic foods that trigger symptoms.
😴
Do not lie down immediately after eating; wait at least 2-3 hours.
💧
Elevate the head of your bed to prevent nighttime reflux.
🧘
Maintain a healthy weight and avoid tight clothing.
🌞
Quit smoking and limit alcohol consumption.

🏋️ Exercise Considerations

Avoid vigorous exercise immediately after taking this medicine, especially if you experience dizziness or drowsiness. Light to moderate exercise is generally safe.

🥗 Diet Recommendations

Include high-fiber foods like fruits, vegetables, and whole grains.
Avoid caffeine, chocolate, and mint, which can worsen reflux.
Stay well hydrated by drinking water throughout the day.
Eat slowly and chew food thoroughly.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is usually safe to continue desk work.

🛑 When to Stop This Medicine

Do not stop this medicine abruptly without consulting your doctor. If you experience serious side effects like irregular heartbeat or severe allergic reactions, stop immediately and seek medical help. Your doctor will advise when to stop based on your condition.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to vitamin B12 deficiency, low magnesium levels, increased risk of bone fractures, and gastrointestinal infections. Regular monitoring of magnesium, vitamin B12, and bone health is advised. Do not use for more than 12 weeks without medical review.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet changes, weight loss, and avoiding trigger foods can help manage acid reflux.

Evidence: Well-established
Other proton pump inhibitors

Pantoprazole or rabeprazole may be used instead of omeprazole, depending on interactions.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known. However, long-term use of omeprazole may increase the risk of certain infections; ensure routine vaccinations are up to date.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from direct sunlight. If traveling across time zones, adjust dosing times gradually as advised by your doctor. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old man with chronic acid reflux and bloating
He was prescribed this medicine twice daily before meals. After two weeks, his heartburn and bloating significantly reduced. He learned to avoid spicy foods and alcohol, which helped even more.
💡 Lesson: Taking the medicine as prescribed and making lifestyle changes can greatly improve symptoms.
👤 A 60-year-old woman with functional dyspepsia
She experienced early satiety and nausea after meals. Her doctor prescribed this medicine once daily. She noticed improvement in her appetite and reduction in nausea within a week. She was advised to continue for a month and then review.
💡 Lesson: Consistent use and follow-up with the doctor are key to managing dyspepsia.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start feeling relief from nausea and bloating within 30-60 minutes, but full effects on acid reflux may take 1-4 days.

Q: Can I take it with other medicines?

A: It can interact with several medicines, so always inform your doctor about all medications you are taking.

Q: Is it safe during pregnancy?

A: Use only if clearly needed and prescribed by your doctor. Both ingredients should be used with caution during pregnancy.

Q: What if I miss a dose?

A: Take it as soon as you remember, but if it's almost time for the next dose, skip the missed dose and continue with your regular schedule.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for ulsec dp 10mg/20mg capsule

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken for any stomach pain.
    Fact: It is specifically for acid reflux and motility disorders, not all types of stomach pain.
  • Myth: It is safe to take indefinitely.
    Fact: Long-term use should be under medical supervision due to potential side effects.
  • Myth: You can stop it as soon as you feel better.
    Fact: Complete the prescribed course to prevent relapse.

🔄 Alternative Options

Generic Alternatives

  • Domperidone + Omeprazole capsules from other manufacturers

Brand Alternatives

  • Domperidone + Omeprazole capsules from other manufacturers

📊 Comparison with Similar Medicines

[{"medicine":"Domperidone + Omeprazole","composition":"Domperidone 10 mg + Omeprazole 20 mg","uses":"GERD with dyspepsia, functional dyspepsia","notes":"Combines prokinetic and PPI"},{"medicine":"Pantoprazole + Domperidone","composition":"Pantoprazole 40 mg + Domperidone 30 mg","uses":"GERD with dyspepsia","notes":"Pantoprazole has fewer drug interactions"}]

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