Alcin TZ 500mg/600mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Sudden pain, swelling, or inability to move a joint (possible tendon rupture)
- Numbness, tingling, or burning in hands or feet
- Seizures or severe confusion
- Swelling of face, lips, or throat, or difficulty breathing
- Yellowing of skin or eyes, dark urine, or severe abdominal pain
- Blood in stool or vomit
- Decreased urine output or swelling in legs
If experiencing severe symptoms, call emergency services immediately.
What is ulgram 500mg/600mg tablet used for?
This medicine is a combination antibiotic and antiprotozoal tablet containing Ciprofloxacin 500 mg and Tinidazole 600 mg. It is used to treat mixed bacterial and protozoal infections, particularly of the gastrointestinal tract. It works by inhibiting bacterial DNA replication and damaging protozoal DNA. It must be taken exactly as prescribed, and alcohol must be avoided.
- Generic Name: Ciprofloxacin (500mg) + Tinidazole (600mg)
- Manufacturer: Ultramark Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ulgram 500mg/600mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सिप्रोफ्लोक्सासिन और टिनिडाजोल का संयोजन है, जिसका उपयोग विभिन्न जीवाणु और प्रोटोज़ोआ संक्रमणों के इलाज के लिए किया जाता है। यह मुख्य रूप से पेट और आंतों के संक्रमण, दस्त, अमीबिक पेचिश, और गियार्डिया के इलाज में प्रभावी है। यह दवा संक्रमण पैदा करने वाले सूक्ष्मजीवों को मारकर काम करती है। इसे डॉक्टर के निर्देशानुसार ही लें और कोर्स पूरा करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, मुँह में धातु जैसा स्वाद, सिरदर्द, चक्कर आना और दस्त शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें टेंडन टूटना, दौरे, गंभीर एलर्जी, और यकृत की क्षति शामिल हो सकती है। शराब के साथ इस दवा का सेवन करने पर गंभीर प्रतिक्रिया हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक न छोड़ें और कोर्स पूरा करें। दवा को पूरे गिलास पानी के साथ निगलें। उपचार के दौरान और अंतिम खुराक के 72 घंटे बाद तक शराब का सेवन बिल्कुल न करें। एंटासिड, दूध, या आयरन सप्लीमेंट के साथ इस दवा को न लें; कम से कम 2 घंटे पहले या 6 घंटे बाद लें। यदि आपको टेंडन में दर्द, सूजन, या कमजोरी महसूस हो, तो तुरंत डॉक्टर से मिलें। धूप में जाने से बचें और सनस्क्रीन का उपयोग करें।
💊 ulgram 500mg/600mg tablet Uses & Benefits
[{"condition":"Infectious diarrhoea","description":"Used to treat diarrhoea caused by susceptible bacteria and protozoa, especially when both aerobic and anaerobic pathogens are suspected.","evidence":"Well-established"},{"condition":"Amoebic dysentery","description":"Effective against Entamoeba histolytica, the parasite causing amoebic dysentery, due to the tinidazole component.","evidence":"Well-established"},{"condition":"Giardiasis","description":"Tinidazole component is highly effective against Giardia lamblia, a common cause of waterborne diarrhoea.","evidence":"Well-established"},{"condition":"Bacterial vaginosis","description":"May be used to treat bacterial vaginosis, though not always first-line; combination covers anaerobic bacteria.","evidence":"Moderate"},{"condition":"Pelvic inflammatory disease","description":"Sometimes used as part of a regimen for pelvic inflammatory disease when anaerobic coverage is needed.","evidence":"Moderate"},{"condition":"Intra-abdominal infections","description":"Used in some cases of intra-abdominal infections where mixed aerobic and anaerobic flora are involved.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Prophylaxis in colorectal surgery","description":"Occasionally used off-label for surgical prophylaxis in colorectal procedures, but not standard.","evidence":"Limited"},{"condition":"Traveler's diarrhoea prophylaxis","description":"Not recommended for routine prophylaxis due to resistance and side effects.","evidence":"Limited"}]
Primary treatment for: Mixed bacterial and protozoal infections of the gastrointestinal tract
Also treats: Amoebic dysentery, Giardiasis, Bacterial vaginosis, Pelvic inflammatory disease, Intra-abdominal infections
📋 Drug Information
| Generic Name(s) | Ciprofloxacin (500mg) + Tinidazole (600mg) |
| Brand Name | ulgram 500mg/600mg tablet |
| Manufacturer | Ultramark Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antimicrobial agents with distinct mechanisms. Ciprofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes required for DNA replication, recombination, and repair, leading to bacterial cell death. Tinidazole is a nitroimidazole that enters anaerobic organisms and protozoa, where its nitro group is reduced to reactive intermediates that damage DNA, inhibiting nucleic acid synthesis and causing cell death. Together, they provide broad coverage against many aerobic Gram-negative bacteria and anaerobic bacteria/protozoa.
Mechanism Steps
💡 How to Take ulgram 500mg/600mg tablet
Strength: Tablet containing Ciprofloxacin 500 mg and Tinidazole 600 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally twice daily, or as prescribed by your doctor. The exact dose and duration depend on the type and severity of the infection, your kidney and liver function, and other medications you are taking. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-medicate or adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more susceptible to side effects such as tendon rupture, CNS effects, and renal impairment. Dose adjustment may be necessary based on renal function. Use with caution and monitor closely. |
| Renal Impairment | In patients with renal impairment (creatinine clearance <30 mL/min), the dose of ciprofloxacin may need to be reduced. Tinidazole dose may also require adjustment. Consult a clinician for individualized dosing. |
| Hepatic Impairment | In patients with severe hepatic impairment, dose adjustment may be necessary. Monitor liver function closely. Consult a clinician for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is typically 1000 mg of ciprofloxacin and 1200 mg of tinidazole, but this must be determined by a qualified clinician based on the specific indication and patient factors. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ulgram 500mg/600mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Tizanidine | Major | |
| Theophylline | Major | |
| Antacids | Major | |
| Alcohol | Major | |
| Caffeine | Moderate | |
| Cyclosporine | Moderate | |
| Phenytoin | Moderate | |
| Methotrexate | Moderate | |
| Oral hypoglycemics | Moderate |
🚨 Major Interactions
- Warfarin
- Tizanidine
- Theophylline
- Antacids, sucralfate, iron, zinc, dairy
- Alcohol
⚡ Moderate Interactions
- Caffeine
- Cyclosporine
- Phenytoin
- Methotrexate
- Oral hypoglycemics
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 72 hours after the last dose. Tinidazole can cause a disulfiram-like reaction characterized by severe nausea, vomiting, flushing, headache, and palpitations. Additionally, alcohol may worsen liver toxicity and reduce the effectiveness of treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to ciprofloxacin, tinidazole, or other quinolones/nitroimidazoles","History of tendon disorders associated with fluoroquinolone use","Myasthenia gravis (may worsen muscle weakness)","Pregnancy (especially first trimester) unless clearly needed","Breastfeeding unless benefit outweighs risk","Children and adolescents (except specific approved indications)","Severe renal impairment (dose adjustment required)","Alcohol use during and for 72 hours after therapy"]
⚠️ Warnings & Precautions
["Fluoroquinolones, including ciprofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions, including tendinitis, tendon rupture, peripheral neuropathy, and CNS effects. Reserve for patients with no alternative treatment options for certain infections.","Avoid alcohol completely during and for 72 hours after treatment due to disulfiram-like reaction.","May cause dizziness and confusion; avoid driving or operating machinery until you know how it affects you.","May cause photosensitivity; avoid excessive sun exposure and use sunscreen.","Use with caution in patients with epilepsy or CNS disorders; may increase seizure risk.","May exacerbate muscle weakness in patients with myasthenia gravis.","Prolonged use may result in overgrowth of non-susceptible organisms, including fungi.","Do not use in patients with a history of tendon disorders related to fluoroquinolone use.","Adjust dose in renal impairment; monitor renal function.","May cause hypoglycemia or hyperglycemia; monitor blood glucose in diabetic patients."]
🤱 Lactation Safety
Ciprofloxacin and tinidazole are excreted in breast milk. Because of potential serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
Overdose may cause nausea, vomiting, abdominal pain, dizziness, and possibly seizures. There is no specific antidote. Treatment is symptomatic and supportive. Maintain adequate hydration to prevent crystalluria. Monitor renal function and ECG. In case of overdose, seek immediate medical attention or contact a poison control center.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop early, even if you feel better. Swallow the tablet whole with a full glass of water. Avoid alcohol completely during treatment and for at least 72 hours after the last dose, as it can cause a severe reaction. Do not take antacids, dairy products, or iron supplements within 2 hours before or 6 hours after this medicine, as they reduce absorption. Inform your doctor if you have kidney or liver problems, epilepsy, or tendon disorders. Avoid excessive sunlight and use sunscreen, as this medicine can make your skin more sensitive to UV rays. If you experience pain, swelling, or rupture of a tendon, stop the medicine and seek medical help immediately. Do not share this medicine with others.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, CNS effects, and renal impairment. Dose adjustment may be needed based on kidney function. Monitor closely for side effects.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. It is not recommended during pregnancy unless clearly needed. Use effective contraception during treatment.
🏥 Post-Surgery Considerations
This medicine may be used to treat or prevent infections after surgery. Inform your surgeon if you are taking it. It may interact with anesthetics and other medications.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may interact with certain antibiotics or anesthetics used during dental procedures. Maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, as it may increase the risk of tendon injury. If you experience joint pain or swelling, stop exercising and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, confusion, or fatigue, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. Take sick leave if needed to rest and recover.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor, even if you feel better. Stopping early can lead to incomplete treatment and resistance. If you experience serious side effects such as tendon pain, severe allergic reaction, or seizures, stop the medicine and seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to bacterial resistance, superinfection, and rare serious side effects such as tendon rupture, peripheral neuropathy, and liver injury. It is not intended for prolonged use unless specifically directed by a clinician. Regular monitoring of renal and hepatic function may be required.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Essential for managing dehydration from diarrhoea.
Evidence: Well-establishedMay help restore gut flora after antibiotic treatment.
Evidence: ModerateFor confirmed protozoal infections, targeted therapy may be used.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are due for a vaccine, inform your doctor. Live vaccines should not be given during acute infection.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from light and moisture. If traveling across time zones, adjust dosing times gradually under medical advice. Avoid alcohol during travel. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but you must complete the full prescribed course.
A: Yes, take it with food to reduce stomach upset. Avoid dairy products within 2 hours before or 6 hours after.
A: Take it as soon as you remember, but skip if it's almost time for the next dose. Do not double dose.
A: It should be used in pregnancy only if clearly needed. Consult your doctor.
A: No, alcohol must be strictly avoided during and for 72 hours after treatment.
🤔 Common Patient Concerns
🔄 Substitutes for ulgram 500mg/600mg tablet
View AllAlternative brands with exact same active ingredient:
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cipalgo-ct 500mg/600mg tabcapTerrace Pharmaceuticals ₹16.00 69% CHEAPER
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cylox tz 500mg/600mg tabletWinmac Laboratories Ltd ₹17.50 66.1% CHEAPER
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citoz tz 500 mg/600 mg tabletElder Pharmaceuticals Ltd ₹22.50 56.4% CHEAPER
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lucipro t tabletLupin Ltd ₹24.61 52.3% CHEAPER
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encitin 500 mg/600 mg tabletAgron Remedies Pvt Ltd ₹25.89 49.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of diarrhoea.
Fact: This medicine is only effective against susceptible bacteria and protozoa. It is not effective for viral diarrhoea or other causes. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full prescribed course to prevent resistance and ensure complete eradication of the infection. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol can cause a severe disulfiram-like reaction with tinidazole and should be strictly avoided. - Myth: This medicine is safe for children.
Fact: This medicine is not recommended for children unless specifically approved by a pediatrician.
🔄 Alternative Options
Generic Alternatives
- Ciprofloxacin 500 mg + Tinidazole 600 mg tablet (various manufacturers)
Brand Alternatives
- Alcin TZ 500mg/600mg Tablet