Exatran 500mg Injection: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Sudden shortness of breath or chest pain
- Swelling or pain in one leg
- Severe headache with confusion or seizures
- Signs of allergic reaction: rash, itching, swelling of face or throat
- Decreased urine output or blood in urine
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is Trana-Zan Injection used for?
This medicine is a tranexamic acid injection used to control excessive bleeding by preventing the breakdown of blood clots. It is given intravenously by a healthcare professional.
- Generic Name: Tranexamic Acid (500mg/5ml)
- Manufacturer: Suzan Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Trana-Zan Injection के बारे में (Hindi Summary)
उपयोग: यह दवा ट्रैनेक्सैमिक एसिड का इंजेक्शन है, जिसका उपयोग अत्यधिक रक्तस्राव को नियंत्रित करने के लिए किया जाता है। यह रक्त के थक्कों को टूटने से रोकती है और इस प्रकार रक्तस्राव को कम करती है। इसका उपयोग मासिक धर्म में अत्यधिक रक्तस्राव, सर्जरी के बाद रक्तस्राव, और अन्य रक्तस्राव विकारों में किया जाता है। यह दवा केवल डॉक्टर या नर्स द्वारा नस में दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, चक्कर आना और सिरदर्द शामिल हैं। कुछ गंभीर दुष्प्रभाव जैसे रक्त के थक्के बनना, दौरे पड़ना, और एलर्जी प्रतिक्रिया भी हो सकती है। यदि आपको सांस लेने में कठिनाई, सीने में दर्द, या पैर में सूजन हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल अस्पताल या क्लिनिक में योग्य स्वास्थ्यकर्मी द्वारा दी जानी चाहिए। यदि आपको रक्त के थक्के बनने की समस्या, गुर्दे की बीमारी, या दौरे पड़ने का इतिहास है, तो अपने डॉक्टर को बताएं। इस दवा को स्वयं न लें। इसके बाद चक्कर आने पर वाहन न चलाएं। किसी भी असामान्य लक्षण की तुरंत रिपोर्ट करें।
💊 Trana-Zan Injection Uses & Benefits
[{"condition":"Heavy menstrual bleeding (menorrhagia)","description":"This medicine is used to reduce excessive menstrual blood loss in women with regular cycles, often given during bleeding days.","evidence":"Well-established"},{"condition":"Bleeding after surgery or trauma","description":"It helps control bleeding during and after surgical procedures, including cardiac, orthopaedic, and dental surgeries.","evidence":"Well-established"},{"condition":"Haemophilia and other bleeding disorders","description":"Used to prevent or control bleeding in patients with inherited bleeding disorders, especially before dental or minor surgical procedures.","evidence":"Well-established"},{"condition":"Epistaxis (nosebleeds)","description":"May be used to control severe or recurrent nosebleeds when other measures fail.","evidence":"Limited"},{"condition":"Upper gastrointestinal bleeding","description":"Sometimes used as an adjunct to control bleeding in the stomach or oesophagus.","evidence":"Limited"}]
Off-label uses: [{"condition":"Melasma (skin pigmentation)","description":"Oral or topical tranexamic acid has been studied for reducing facial pigmentation, but the injectable form is not standard for this use.","evidence":"Limited"},{"condition":"Hereditary angioedema","description":"May be used to prevent attacks in some patients, though other treatments are preferred.","evidence":"Limited"}]
Primary treatment for: Excessive bleeding (haemorrhage)
Also treats: Menorrhagia, Haemophilia, Surgical bleeding, Trauma, Epistaxis
📋 Drug Information
| Generic Name(s) | Tranexamic Acid (500mg/5ml) |
| Brand Name | Trana-Zan Injection |
| Manufacturer | Suzan Pharma |
| Packaging / Form | ampoule of 5 ml Injection (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Parenteral (intravenous) |
| Storage | Store below 30°C, protected from light. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Tranexamic acid is included in WHO guidelines for the treatment of postpartum haemorrhage and trauma-related bleeding. It is recommended for use in these settings when appropriate. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by reversibly blocking the lysine-binding sites on plasminogen molecules. This prevents plasminogen from binding to fibrin and being converted into plasmin, the enzyme responsible for breaking down blood clots. By inhibiting plasmin formation and activity, this medicine stabilises existing clots and reduces bleeding. It does not promote new clot formation but helps preserve clots that have already formed.
Mechanism Steps
💡 How to Take Trana-Zan Injection
Strength: Injection: 500 mg/5 ml (100 mg/ml)
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the indication, patient's weight, renal function, and clinical condition. For heavy menstrual bleeding, a common regimen is 1 g (2 vials of 500 mg/5 ml) intravenously every 6 to 8 hours as needed. For surgical bleeding, doses may range from 500 mg to 1 g given before, during, or after surgery. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function and may require dose adjustment. Use with caution and monitor renal function. |
| Renal Impairment | Dose reduction is required in patients with renal impairment. For serum creatinine 1.2-2.5 mg/dL, 10 mg/kg twice daily; for 2.5-5.0 mg/dL, 10 mg/kg once daily; for >5.0 mg/dL, 5 mg/kg once daily. Consult a nephrologist. |
| Hepatic Impairment | No specific dose adjustment is recommended for hepatic impairment, but use with caution. |
| Maximum Daily Dose | The maximum daily dose should not exceed 4 g (8 vials of 500 mg/5 ml) unless directed by a specialist. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Trana-Zan Injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Heparin | Major | |
| Alteplase | Major | |
| Oral contraceptives | Moderate | |
| Factor IX complex | Moderate |
🚨 Major Interactions
- Anticoagulants (e.g., warfarin, heparin)
- Thrombolytic agents (e.g., alteplase)
⚡ Moderate Interactions
- Oral contraceptives
- Factor IX complex concentrates
🍷 Alcohol Interaction
Alcohol may increase the risk of gastrointestinal bleeding and should be avoided while receiving this medicine, especially in patients with bleeding disorders.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active thromboembolic disease (e.g., deep vein thrombosis, pulmonary embolism)","History of thrombosis or stroke","Severe renal impairment (dose adjustment required)","Hypersensitivity to tranexamic acid","Subarachnoid haemorrhage"]
⚠️ Warnings & Precautions
["Use with caution in patients with a history of blood clots.","Adjust dose in renal impairment.","May cause seizures, especially in high doses or renal failure.","Avoid rapid injection to prevent hypotension.","Monitor for signs of thrombosis during treatment.","Not for intramuscular administration unless specified."]
🤱 Lactation Safety
Tranexamic acid passes into breast milk in small amounts. It is generally considered safe during breastfeeding, but consult your doctor before use.
💊 Overdose Management
Overdose may increase the risk of thrombosis and seizures. Treatment is supportive and symptomatic. There is no specific antidote. In case of overdose, seek immediate medical attention. Haemodialysis may be considered in severe cases.
⏰ Missed Dose
This medicine is usually given by a healthcare professional in a hospital or clinic setting. If you miss a scheduled dose, contact your doctor or nurse as soon as possible. Do not attempt to self-administer a missed dose.
Additional Safety Advice
This medicine must be administered only by a qualified healthcare professional in a setting equipped to manage bleeding and allergic reactions. Inform your doctor if you have a history of blood clots, kidney disease, seizures, or if you are pregnant or breastfeeding. Do not take this medicine if you have an active thrombotic disease. Your doctor may adjust the dose based on your kidney function. Avoid driving or operating heavy machinery immediately after receiving this injection if you feel dizzy or unwell. Do not self-administer this medicine. Report any unusual symptoms such as swelling, pain in the legs, chest pain, or difficulty breathing immediately. Keep all follow-up appointments and blood tests as advised by your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced kidney function and are at higher risk of side effects. Dose adjustment may be needed.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. It should be used only if clearly needed.
🏥 Post-Surgery Considerations
This medicine is often used during and after surgery to reduce bleeding. Follow your surgeon's instructions carefully.
🦷 Dental Procedures
This medicine may be used before dental procedures in patients with bleeding disorders to prevent excessive bleeding. Inform your dentist if you are receiving this medicine.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or contact sports immediately after receiving this medicine, as it may increase bleeding risk or cause dizziness.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a healthcare setting. You may feel dizzy or tired after administration. Avoid driving or operating machinery until you feel alert.
🛑 When to Stop This Medicine
This medicine is stopped when bleeding is controlled or as directed by your doctor. Do not stop without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine is not common. Prolonged use may increase the risk of thrombosis. Regular monitoring of renal function and signs of clotting is advised if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another antifibrinolytic that can be used to control bleeding.
Evidence: Well-establishedMay be needed to control the source of bleeding.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interaction with vaccines. However, inform your doctor if you are scheduled for vaccination.
📦 Storage Guide
✅ DO
Store below 30°C
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in direct sunlight
✈️ Traveling with This Medicine
This medicine is usually administered in a healthcare setting, so travel advice is limited. If you are prescribed this medicine for home use, carry it in its original packaging with the prescription. Store it below 30°C and protect it from light. Carry a copy of your prescription for customs. Inform your doctor if you are traveling across time zones, as dosing schedules may need adjustment.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within minutes after intravenous administration.
A: No, this is an injectable form and must be given intravenously by a healthcare professional.
A: It should be used during pregnancy only if clearly needed. Consult your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for Trana-Zan Injection
View AllAlternative brands with exact same active ingredient:
-
Texanis 500mg InjectionNeiss Labs Pvt Ltd ₹39.00 56.2% CHEAPER
-
exatran 500mg injectionMHS Pharmaceuticals Pvt Ltd ₹80.00 10.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally.
Fact: This medicine is an injection and must be given intravenously by a healthcare professional. - Myth: This medicine is safe for everyone.
Fact: It is contraindicated in patients with active blood clots or a history of thrombosis.
🔄 Alternative Options
Generic Alternatives
- Tranexamic acid injection 500 mg/5 ml
Brand Alternatives
- Exatran 500mg injection