Proflur Eye Drop: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden loss of vision or severe decrease in vision
- Severe eye pain that does not improve with the prescribed medicine
- Increasing redness, swelling, or discharge from the eye
- Signs of an allergic reaction such as rash, hives, or swelling of the face, lips, or throat
- Chest pain, difficulty breathing, or wheezing
- Severe headache with nausea or visual changes
- Unusual bleeding or bruising, especially if you take blood thinners
If experiencing severe symptoms, call emergency services immediately.
What is Tofler Eye Drop used for?
This medicine is an eye drop that combines flurbiprofen, an anti-inflammatory medicine, with phenyl mercuric nitrate, a preservative. It is used to reduce eye pain and swelling after eye surgery and to help keep the pupil dilated during surgery. It is available only by prescription and must be used exactly as directed by an eye care professional.
- Generic Name: Flurbiprofen (0.03% w/v) + Phenyl Mercuric Nitrate (0.001% w/v)
- Manufacturer: Total Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Tofler Eye Drop के बारे में (Hindi Summary)
उपयोग: यह दवा एक आई ड्रॉप है जिसमें फ्लर्बिप्रोफेन और फेनिल मर्क्यूरिक नाइट्रेट होते हैं। यह आंख की सर्जरी के बाद होने वाली सूजन, दर्द और लालिमा को कम करने के लिए इस्तेमाल की जाती है। यह सर्जरी के दौरान पुतली को फैला हुआ रखने में भी मदद करती है। यह दवा केवल डॉक्टर के पर्चे पर मिलती है और आंखों में डालने के लिए ही है। इसे मुँह से नहीं लेना चाहिए और न ही इंजेक्शन के रूप में इस्तेमाल करना चाहिए।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में आंख में डालते समय हल्की जलन या चुभन, आंख का लाल होना, धुंधला दिखना और आंख में कुछ होने का एहसास शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ मिनटों में ठीक हो जाते हैं। कभी-कभी आंख में तेज दर्द, लगातार लालिमा, सूजन या एलर्जी जैसी गंभीर समस्या हो सकती है। अगर ऐसा हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को आंख में डालने से पहले और बाद में अपने हाथ अच्छी तरह धोएं। ड्रॉपर की नोक को आंख, पलक या किसी भी सतह से न छुएं। एक बूंद आंख में डालें, आंख को धीरे से बंद करें और नाक के पास वाले कोने पर हल्का दबाव डालें। अगर आप कॉन्टैक्ट लेंस पहनते हैं तो दवा डालने से पहले उन्हें निकाल दें और कम से कम पंद्रह मिनट बाद ही वापस लगाएं। दवा की बोतल को ठंडी और सूखी जगह पर रखें और बच्चों की पहुंच से दूर रखें। गर्भवती या स्तनपान कराने वाली महिलाएं बिना डॉक्टर की सलाह के इसका इस्तेमाल न करें।
💊 Tofler Eye Drop Uses & Benefits
[{"condition":"Postoperative ocular inflammation after cataract surgery","description":"This medicine is used to reduce pain, redness, and swelling in the eye after cataract surgery and other eye operations.","evidence":"Well-established"},{"condition":"Postoperative ocular pain","description":"It helps relieve discomfort and aching in the eye following surgical procedures.","evidence":"Well-established"},{"condition":"Inhibition of intraoperative miosis","description":"It is used to help prevent the pupil from constricting during eye surgery, which gives the surgeon a better view.","evidence":"Well-established"},{"condition":"Anterior segment inflammation","description":"It may be used to reduce inflammation in the front part of the eye in certain non-infectious conditions.","evidence":"Moderate"},{"condition":"Cystoid macular edema prevention after cataract surgery","description":"Some eye care professionals use this medicine as part of a regimen to lower the risk of fluid accumulation in the macula after surgery.","evidence":"Limited"}]
Off-label uses: [{"condition":"Allergic conjunctivitis","description":"Sometimes used to reduce itching and redness in allergic eye conditions, though other treatments are usually preferred.","evidence":"Limited"},{"condition":"Corneal abrasion pain","description":"Occasionally used to ease pain from a scratched cornea, but only under close medical supervision.","evidence":"Limited"}]
Primary treatment for: Postoperative ocular inflammation and pain
Also treats: Post-cataract surgery inflammation, Intraoperative miosis prevention, Anterior segment inflammation
📋 Drug Information
| Generic Name(s) | Flurbiprofen (0.03% w/v) + Phenyl Mercuric Nitrate (0.001% w/v) |
| Brand Name | Tofler Eye Drop |
| Manufacturer | Total Healthcare |
| Packaging / Form | packet of 5 ml Eye Drop (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Ophthalmic |
| Storage | Store this medicine at room temperature, between 15°C and 30°C, away from direct sunlight and excessive heat. Keep the bottle tightly closed when not in use. Do not freeze the product. Write the date of opening on the bottle and discard it after the recommended in-use period, usually four weeks after opening, unless your pharmacist or doctor advises otherwise. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture when stored properly and unopened. Once opened, the bottle should generally be used within four weeks and then discarded, unless the label states a different in-use period. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works because flurbiprofen blocks the cyclooxygenase enzymes, known as COX-1 and COX-2, in the eye. These enzymes normally convert a fatty acid called arachidonic acid into prostaglandins, which are chemical messengers that cause pain, redness, swelling, and pupil constriction. By blocking these enzymes, flurbiprofen lowers prostaglandin levels in the eye, which reduces inflammation and pain and helps keep the pupil dilated during surgery. Phenyl mercuric nitrate does not treat eye disease; it acts as a preservative that stops bacteria and fungi from growing in the bottle, keeping the solution safe to use over multiple days.
Mechanism Steps
💡 How to Take Tofler Eye Drop
Strength: This medicine is an ophthalmic solution containing flurbiprofen 0.03% w/v and phenyl mercuric nitrate 0.001% w/v.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one drop placed into the affected eye or eyes, typically four times a day, starting 24 hours before eye surgery and continuing for the first two weeks after surgery, or as directed by your eye care professional. Some doctors may recommend a different schedule depending on the type of surgery and the level of inflammation. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and the specific eye condition being treated. Never increase or decrease the dose or frequency without consulting your eye doctor. |
| Pediatric Dosage | Pediatric dosing for this medicine is not established from available information. Consult a pediatrician or pediatric eye specialist for guidance. |
| Elderly Dosage | Elderly patients may use this medicine at the same dose as younger adults, but they should be monitored more closely for eye irritation, delayed healing, and any signs of systemic effects. Dose must be individualized by a qualified clinician based on the patient's overall health and other medicines. |
| Renal Impairment | No specific dose adjustment is usually required for this eye drop in patients with kidney problems because systemic absorption is very low. However, if you have severe kidney disease, inform your doctor before using this medicine, especially if you use it for a long time. |
| Hepatic Impairment | No specific dose adjustment is usually required for this eye drop in patients with liver problems because systemic absorption is very low. However, if you have severe liver disease, inform your doctor before using this medicine, especially if you use it for a long time. |
| Maximum Daily Dose | The maximum daily dose is generally one drop in the affected eye or eyes four times a day, as prescribed by your eye care professional. Do not exceed the prescribed frequency without medical advice. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Tofler Eye Drop
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Clopidogrel | Major | |
| Other ocular NSAIDs | Major | |
| Corticosteroid eye drops | Moderate | |
| Antibiotic eye drops | Moderate | |
| Lithium | Moderate | |
| Methotrexate | Moderate | |
| Antihypertensives | Minor | |
| Diuretics | Minor | |
| Mercury-containing eye products | Minor |
🚨 Major Interactions
- Other topical ocular NSAIDs
- Oral anticoagulants such as warfarin
- Oral antiplatelet drugs such as clopidogrel
⚡ Moderate Interactions
- Corticosteroid eye drops
- Antibiotic eye drops
- Lithium
- Methotrexate
🍷 Alcohol Interaction
Alcohol is not known to interact directly with this eye drop. However, alcohol can cause dehydration and may worsen eye dryness or irritation, so it is best to drink alcohol only in moderation while using this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy or hypersensitivity to flurbiprofen or other NSAIDs","Known allergy to phenyl mercuric nitrate or other mercury-containing preservatives","Active viral, fungal, or untreated bacterial eye infection","Use in place of antibiotics for an infected eye","Use during or immediately after certain types of eye surgery where NSAIDs are not advised by the surgeon"]
⚠️ Warnings & Precautions
["This medicine is for eye use only and must never be swallowed or injected.","Do not touch the dropper tip to any surface, including the eye, to avoid contamination.","Remove contact lenses before use and wait at least fifteen minutes before reinserting them, unless told otherwise by your eye doctor.","Use with caution if you have a history of bleeding disorders or take blood-thinning medicines.","Use with caution if you have had allergic reactions to aspirin or other NSAIDs.","Do not use this medicine for longer than prescribed without medical supervision.","If you are pregnant or breastfeeding, consult your doctor before using this medicine.","Keep this medicine out of the reach of children.","Stop using the medicine and seek medical advice if you develop severe eye pain, vision loss, or signs of an allergic reaction."]
🤱 Lactation Safety
It is not known whether flurbiprofen or phenyl mercuric nitrate passes into breast milk in significant amounts after eye drop use. Because systemic absorption is low, the risk to a breastfed infant is expected to be small, but breastfeeding mothers should consult their doctor before using this medicine.
💊 Overdose Management
Overdose from this eye drop is unlikely because it is applied topically to the eye. If the medicine is accidentally swallowed, especially by a child, contact a poison control center or emergency medical service immediately. Signs of systemic NSAID overdose may include stomach pain, nausea, vomiting, drowsiness, and in severe cases, breathing difficulty or kidney problems. Treatment is supportive and should be guided by a healthcare professional.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember, unless it is almost time for your next dose. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not use a double dose to make up for a missed one.
Additional Safety Advice
Always wash your hands thoroughly with soap and water before and after putting this medicine into your eye. Tilt your head back, pull down the lower eyelid to form a small pocket, and place one drop into the pocket without letting the dropper tip touch your eye, eyelid, or any surface. Close your eye gently for about one to two minutes and press lightly on the inner corner of the eye near the nose to help the medicine stay in the eye and reduce drainage into the throat. If you wear contact lenses, remove them before using this medicine and wait at least fifteen minutes before putting them back, unless your eye care professional has told you otherwise. Do not use this medicine if the solution looks cloudy, has particles floating in it, or if the seal on the bottle is broken. Do not share your eye drops with anyone else, because this can spread infection. Keep the bottle tightly closed when not in use and store it out of reach of children. Do not use this medicine for longer than prescribed without checking with your doctor, because long-term use of NSAID eye drops may increase the risk of certain eye problems. If you are pregnant, planning to become pregnant, or breastfeeding, speak with your doctor before using this medicine. Tell your doctor about all other eye drops or medicines you are using, because some may interact with this product.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of NSAIDs and may heal more slowly after eye surgery. They should use this medicine exactly as prescribed and report any unusual symptoms, such as increased eye irritation, prolonged redness, or delayed healing, to their eye doctor promptly.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss this medicine with your doctor before use. NSAIDs such as flurbiprofen may affect ovulation and early pregnancy, so your doctor may recommend an alternative treatment if needed.
🏥 Post-Surgery Considerations
This medicine is often prescribed after eye surgery to reduce inflammation and pain. Use it exactly as your surgeon directs, and attend all follow-up visits. Do not rub your eye or get water in it until your surgeon says it is safe. Report any increase in pain, redness, or decrease in vision immediately.
🦷 Dental Procedures
Tell your dentist if you are using this medicine, especially if you are also taking blood thinners or have a bleeding disorder. Eye drops are unlikely to affect dental procedures, but your dentist should know about all medicines you use.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
After eye surgery, avoid strenuous exercise, heavy lifting, and activities that increase pressure in the eye until your eye doctor says it is safe. Gentle walking is usually fine, but always follow your surgeon's specific advice. If you feel pain or pressure in the eye during exercise, stop and contact your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause temporary blurred vision right after instillation, so wait until your vision is clear before driving or operating machinery. Most people can return to desk work soon after eye surgery, but jobs that involve heavy lifting, dust, or eye strain may need to be avoided for a short period. Follow your eye doctor's advice about when to return to your normal work routine.
🛑 When to Stop This Medicine
Stop using this medicine when your eye doctor tells you to stop, usually after the prescribed course is complete. Do not stop suddenly on your own if you are still having symptoms, and do not continue using it for longer than prescribed. If you develop severe eye pain, vision loss, or signs of an allergic reaction, stop the medicine and seek medical help immediately.
📅 Long-Term Use Effects
Long-term use of this medicine beyond the prescribed period is not recommended without supervision by an eye care professional. Prolonged use of NSAID eye drops may increase the risk of corneal problems, delayed healing, and eye surface irritation. If you need to use this medicine for more than a few weeks, your doctor should monitor your eye regularly. Do not continue using this medicine on your own for a long time.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Applying a clean, cool compress over the closed eyelid may help reduce mild swelling and discomfort after eye surgery.
Evidence: LimitedLubricating eye drops can help soothe dryness and irritation, but they should not replace prescribed anti-inflammatory treatment.
Evidence: ModerateYour eye doctor may choose a different NSAID eye drop such as ketorolac, bromfenac, or nepafenac based on your condition.
Evidence: Well-establishedIn some cases, steroid eye drops may be used instead of or in addition to NSAID eye drops, but they carry different risks and must be supervised.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this eye drop and vaccines. You can receive routine vaccinations while using this medicine, but inform your doctor about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not freeze the bottle
✅ DO
Keep the bottle tightly closed when not in use
❌ DON'T
Do not leave the cap off for long periods
✅ DO
Keep away from direct sunlight and heat
❌ DON'T
Do not store in a hot car or near a stove
✅ DO
Write the date of opening on the bottle
❌ DON'T
Do not use after four weeks of opening, unless advised otherwise
✅ DO
Keep out of reach of children
❌ DON'T
Do not share your eye drops with others
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in your hand luggage in its original packaging along with a copy of your prescription. Keep it at room temperature and avoid leaving it in a hot car or in direct sunlight. If you are crossing time zones, continue using the drops at the intervals recommended by your eye doctor, but you may need to adjust the timing gradually. Check the customs rules of your destination country for prescription eye drops, and carry enough supply for your entire trip. If you need to use the drops during a flight, you can do so in the lavatory or at your seat with clean hands.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts reducing eye pain and inflammation within 30 to 60 minutes after a dose, but the full benefit may take a few days of regular use.
A: The usual frequency is one drop in the affected eye four times a day, but your eye doctor will give you a specific schedule based on your condition and surgery.
A: You should remove your contact lenses before using this medicine and wait at least fifteen minutes before putting them back, unless your eye doctor tells you otherwise.
A: If you remember within a short time, take the missed dose. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: The safety of this medicine during pregnancy is not fully established. NSAIDs like flurbiprofen may affect the fetus, especially in the third trimester, so use it only if your doctor advises it.
A: Yes, but you should wait at least five to ten minutes between different eye drops. Tell your eye doctor about all other eye medicines you use.
A: The usual duration is about two weeks after surgery, but your eye doctor will decide how long you should use it based on your healing and condition.
A: Common side effects include mild stinging, redness, blurred vision, and a foreign body sensation. Serious side effects are rare but include severe eye pain, vision loss, and allergic reactions.
🤔 Common Patient Concerns
🔄 Substitutes for Tofler Eye Drop
View AllAlternative brands with exact same active ingredient:
-
saplure eye dropSapient Laboratories Pvt Ltd ₹37.50 14.3% COSTLIER
-
proflur eye dropNri Vision Care India Limited ₹56.25 71.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This eye drop can be used for any kind of eye redness.
Fact: This medicine is a prescription anti-inflammatory eye drop meant for specific conditions such as after eye surgery. It should not be used for ordinary eye redness without medical advice. - Myth: More drops will make the eye heal faster.
Fact: Using more drops than prescribed does not speed up healing and may increase the risk of side effects. Always follow your eye doctor's instructions. - Myth: It is safe to use this medicine for months without checking with a doctor.
Fact: Long-term use of NSAID eye drops should be supervised by an eye care professional because of possible effects on the eye surface and healing. - Myth: This medicine can replace antibiotics for an eye infection.
Fact: This medicine does not treat infections. If you have an eye infection, you need appropriate antibiotic or antifungal treatment prescribed by a doctor.
🔄 Alternative Options
Generic Alternatives
- Flurbiprofen ophthalmic solution 0.03%
Brand Alternatives
- Proflur Eye Drop