Tinzox 500mg/50mg/500mg Tablet - Chlorzoxazone (500mg) + Diclofenac (50mg) medicine

Mobizox Tablet: Comprehensive Guide to Uses, Side Effects, and Safety

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🏭 Erma Life Sciences 📦 strip of 10 tablets 💊 Allopathy 📅 Updated: Sep 25, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Diclofenac is generally avoided in the third trimester due to risk of premature closure of the ductus arteriosus. Chlorzoxazone safety in pregnancy is not well established. Consult your doctor. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for the combination in acute musculoskeletal pain; individual components have well-established evidence.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is Tinzox 500mg/50mg/500mg Tablet used for?

This medicine is a combination of chlorzoxazone (a muscle relaxant) and diclofenac (an NSAID) used for short-term relief of acute musculoskeletal pain and muscle spasm. It works by reducing muscle spasm and inflammation. Take it with food and avoid alcohol.

  • Generic Name: Chlorzoxazone (500mg) + Diclofenac (50mg)
  • Manufacturer: Erma Life Sciences
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 Tinzox 500mg/50mg/500mg Tablet के बारे में (Hindi Summary)

उपयोग: यह दवा क्लोरज़ोक्साज़ोन और डाइक्लोफेनाक का संयोजन है। इसका उपयोग मांसपेशियों में ऐंठन, खिंचाव, मोच और चोट के कारण होने वाले दर्द और सूजन को कम करने के लिए किया जाता है। यह मांसपेशियों को आराम देती है और सूजन कम करती है। यह दवा केवल अल्पकालिक उपयोग के लिए है और डॉक्टर के परामर्श के बिना नहीं लेनी चाहिए।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सिरदर्द, चक्कर आना, नींद आना और मुँह सूखना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, किडनी या लीवर की समस्या, और एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको काला मल, खून की उल्टी, त्वचा या आंखों का पीलापन, या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। शराब न पिएं क्योंकि इससे पेट में रक्तस्राव और लीवर की समस्या का खतरा बढ़ सकता है। यदि आपको नींद या चक्कर आते हैं तो वाहन न चलाएं। 7-10 दिनों से अधिक इसका उपयोग न करें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 Tinzox 500mg/50mg/500mg Tablet Uses & Benefits

[{"condition":"Acute musculoskeletal pain with muscle spasm","description":"Relieves pain and reduces muscle spasm in conditions such as strains, sprains, and sports injuries.","evidence":"Well-established"},{"condition":"Low back pain with muscle spasm","description":"Helps reduce acute low back pain and associated muscle tightness.","evidence":"Well-established"},{"condition":"Post-operative pain and spasm","description":"Used short-term after surgery to manage pain and muscle spasm.","evidence":"Moderate"},{"condition":"Tension headache with muscle spasm","description":"May provide relief when muscle tension contributes to headache.","evidence":"Limited"}]

Off-label uses: [{"condition":"Fibromyalgia","description":"Sometimes prescribed off-label for muscle pain, but evidence is limited.","evidence":"Limited"},{"condition":"Temporomandibular joint disorders","description":"May be used off-label for jaw muscle spasm, but not first-line.","evidence":"Limited"}]

Primary treatment for: Acute musculoskeletal pain with muscle spasm

Also treats: Low back pain, Muscle strain, Sprain, Post-operative pain

📋 Drug Information

Generic Name(s)Chlorzoxazone (500mg) + Diclofenac (50mg)
Brand NameTinzox 500mg/50mg/500mg Tablet
ManufacturerErma Life Sciences
Packaging / Formstrip of 10 tablets (Allopathy)
Therapeutic Class
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Avoid alcohol while taking this medicine to prevent stomach bleeding and liver problems.
3
Do not drive or operate heavy machinery if you feel drowsy or dizzy.
4
Use the lowest effective dose for the shortest duration, usually not more than 7-10 days.
5
Inform your doctor if you have a history of ulcers, kidney or liver disease, or heart problems.
6
Report any unusual bleeding, bruising, or yellowing of eyes immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic joint pain
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
✅
Muscle spasm
This medicine is indicated for muscle spasm.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionChlorzoxazone is rapidly absorbed from the gastrointestinal tract after oral administration. Diclofenac is also well absorbed, but its bioavailability may be reduced if taken with food. Specific absorption data for the combination product are not established from the available information.
DistributionChlorzoxazone is distributed widely in the body, including the central nervous system. Diclofenac is highly bound to plasma proteins and distributes into synovial fluid. Specific distribution data for the combination are not established from the available information.
Protein BindingDiclofenac is approximately 99% bound to plasma proteins, primarily albumin. Chlorzoxazone protein binding is not well established. Specific data for the combination are not established from the available information.
MetabolismChlorzoxazone is extensively metabolized in the liver, primarily by cytochrome P450 2E1 (CYP2E1) to 6-hydroxychlorzoxazone. Diclofenac is metabolized in the liver by CYP2C9 to 4'-hydroxydiclofenac and by other enzymes. Specific metabolism data for the combination are not established from the available information.
Half-LifeThe elimination half-life of chlorzoxazone is approximately 1-2 hours. The elimination half-life of diclofenac is approximately 1-2 hours. Specific half-life data for the combination are not established from the available information.
ExcretionChlorzoxazone metabolites are excreted mainly in urine as glucuronide conjugates. Diclofenac metabolites are excreted in urine and bile. Specific excretion data for the combination are not established from the available information.
BioavailabilityThe bioavailability of chlorzoxazone is not well established. Diclofenac has a bioavailability of about 50-60% due to first-pass metabolism. Specific bioavailability data for the combination are not established from the available information.
Onset of ActionOnset of muscle relaxation is typically within 1 hour. Onset of analgesic effect for diclofenac is usually within 30-60 minutes. Specific onset data for the combination are not established from the available information.
Peak Plasma TimeChlorzoxazone peak plasma levels occur within 1-2 hours. Diclofenac peak plasma levels occur within 1-2 hours. Specific peak time data for the combination are not established from the available information.
Duration of ActionThe duration of action is typically 4-6 hours for chlorzoxazone and 4-6 hours for diclofenac. Specific duration data for the combination are not established from the available information.

How It Works

This medicine combines two active ingredients with complementary actions. Chlorzoxazone acts centrally on the spinal cord and brainstem to inhibit polysynaptic reflexes, reducing skeletal muscle spasm without affecting normal muscle function. Diclofenac is a nonsteroidal anti-inflammatory drug that reversibly inhibits cyclooxygenase enzymes, decreasing prostaglandin synthesis and thereby reducing inflammation, pain, and fever.

Mechanism Steps

1
Central muscle relaxation: Chlorzoxazone acts on the central nervous system to inhibit polysynaptic reflex arcs, reducing excessive muscle contraction.
2
COX enzyme inhibition: Diclofenac binds to and reversibly inhibits cyclooxygenase-1 and cyclooxygenase-2 enzymes.
3
Reduced prostaglandin synthesis: Inhibition of COX enzymes decreases the production of prostaglandins, which are mediators of pain and inflammation.
4
Analgesic and anti-inflammatory effect: The reduction in prostaglandins leads to less pain, swelling, and inflammation at the affected site.
5
Combined symptomatic relief: The muscle relaxant and anti-inflammatory actions together alleviate pain and spasm, improving function.

💡 How to Take Tinzox 500mg/50mg/500mg Tablet

Strength: Tablet containing chlorzoxazone 500 mg and diclofenac 50 mg.

1Take this medicine exactly as prescribed by your doctor.
2Swallow the tablet whole with a glass of water.
3Take it with food or milk to reduce stomach upset.
4Do not crush, chew, or break the tablet unless instructed.
5Follow a consistent schedule to maintain blood levels.
6Do not take more than the prescribed dose.

Dosage Information

Adult DosageThe usual adult dose is one tablet two to three times daily, or as prescribed by your doctor. The dose may vary depending on the severity of the condition and your response to treatment. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and gastrointestinal bleeding. Use with caution and at the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with kidney impairment. Dose reduction may be necessary. Avoid in severe kidney disease (eGFR <30 mL/min). Consult your doctor for dose adjustment.
Hepatic ImpairmentUse with caution in patients with liver impairment. Dose reduction may be necessary. Avoid in severe liver disease. Consult your doctor for dose adjustment.
Maximum Daily DoseThe maximum recommended daily dose is 3 tablets (chlorzoxazone 1500 mg and diclofenac 150 mg) per day. Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of stomach bleeding and liver problems.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of Tinzox 500mg/50mg/500mg Tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk. If persistent, consult your doctor.
Drowsiness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying position. Consult if severe.
Stomach pain (Common (5-10%))
Take with food. If severe or persistent, contact your doctor.
Headache (Common (5-10%))
Rest and stay hydrated. Consult if it persists.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black stools, vomiting blood, or severe abdominal pain.
Liver injury (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe fatigue to your doctor immediately.
Kidney impairment (Rare (<0.1%))
Seek medical help if you notice decreased urine output or swelling in legs.
Severe allergic reaction (Rare (<0.1%))
Call emergency services if you experience swelling of face, lips, or throat, or difficulty breathing.

⚠️ Rare Side Effects

Blood disorders (e.g., agranulocytosis, thrombocytopenia)
Report unusual bruising, bleeding, or fever to your doctor.
Severe skin reactions (e.g., Stevens-Johnson syndrome)
Seek immediate medical attention if you develop a rash with blisters or peeling skin.
Aseptic meningitis
Report severe headache, stiff neck, or sensitivity to light immediately.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Corticosteroids Major
Methotrexate Major
Lithium Major
Antihypertensives Moderate
SSRIs Moderate
Fluconazole Moderate
Disulfiram Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., aspirin, ibuprofen)
  • Corticosteroids
  • Methotrexate
  • Lithium

⚡ Moderate Interactions

  • Antihypertensives (e.g., ACE inhibitors, ARBs, diuretics)
  • SSRIs
  • CYP2C9 inhibitors (e.g., fluconazole)
  • CYP2E1 inhibitors (e.g., disulfiram)

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol can increase the risk of gastrointestinal bleeding, ulcers, and liver damage. It may also enhance drowsiness and dizziness caused by chlorzoxazone.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Active peptic ulcer or gastrointestinal bleeding","Severe kidney disease (eGFR

⚠️ Warnings & Precautions

["Take with food to reduce stomach upset.","Avoid alcohol and other NSAIDs.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Use with caution in elderly patients due to increased risk of side effects.","Do not use for more than 7-10 days without medical advice.","Inform your doctor if you have a history of ulcers, kidney or liver disease, high blood pressure, or heart problems.","Stop use and consult a doctor if you experience signs of allergic reaction, bleeding, or liver problems."]

🤱 Lactation Safety

Not established from the available information. Diclofenac may pass into breast milk in small amounts. Chlorzoxazone excretion in breast milk is unknown. Consult your doctor before use.

💊 Overdose Management

Overdose may cause nausea, vomiting, stomach pain, drowsiness, dizziness, and in severe cases, gastrointestinal bleeding, liver damage, or kidney failure. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Activated charcoal may be considered if within 1-2 hours of ingestion. Monitor vital signs, liver and kidney function, and electrolytes.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach upset. Avoid alcohol because it can increase the risk of stomach bleeding and liver problems. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Inform your doctor if you have a history of ulcers, kidney or liver disease, high blood pressure, or heart problems. Do not use this medicine for more than 7-10 days unless directed. Keep out of reach of children. Store at room temperature away from moisture and heat.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function closely. Avoid in frail elderly with multiple comorbidities.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended during pregnancy, especially in the third trimester, due to risk of premature closure of the ductus arteriosus and other complications. If you are planning pregnancy, consult your doctor for alternative pain relief options.

🏥 Post-Surgery Considerations

This medicine may be used for short-term post-operative pain and muscle spasm. However, it may increase bleeding risk and should be used with caution after surgery. Inform your surgeon if you are taking this medicine.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk. Your dentist may advise you to stop it temporarily before surgery.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming.
😴
Practice good posture.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep.

🏋️ Exercise Considerations

Avoid strenuous exercise or activities that could cause injury while taking this medicine, as it may cause drowsiness and dizziness. Gentle stretching and low-impact exercises may be beneficial after consulting your doctor.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated

💼 Impact on Daily Work & Life

This medicine may cause drowsiness and dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause stomach upset, so take it with food. Inform your employer if your job involves operating heavy machinery.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your pain does not improve within 7-10 days, or if you experience side effects such as stomach pain, black stools, yellowing of eyes, or severe dizziness. Do not stop abruptly if you have been taking it for a long time without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended due to the risk of gastrointestinal bleeding, ulcers, kidney impairment, liver injury, and cardiovascular events. If long-term use is necessary, regular monitoring of liver and kidney function, complete blood count, and blood pressure is advised. Consult your doctor for alternative treatments if pain persists beyond 7-10 days.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain.

Evidence: Well-established
Hot or cold packs

May help reduce muscle spasm and pain.

Evidence: Moderate
Acupuncture

May provide pain relief for some individuals.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Not established from the available information. This medicine does not interact with vaccines. However, if you are scheduled for vaccination, inform your doctor about all medicines you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for controlled substances. Do not leave in hot cars or checked luggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic knee pain
Started this medicine as prescribed for osteoarthritis. Within 2 weeks noticed significant improvement in morning stiffness. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 60-year-old man with acute low back pain
Was prescribed this medicine for severe muscle spasm. He took it with food and avoided alcohol. His pain improved within 3 days, and he stopped after 5 days as advised.
💡 Lesson: Short-term use as directed is effective and reduces risk of side effects.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain and muscle spasm within 1-2 hours after taking it.

Q: Can I take it on an empty stomach?

A: It is best taken with food or milk to reduce stomach upset.

Q: What should I do if I miss a dose?

A: Take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for Tinzox 500mg/50mg/500mg Tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken long-term for chronic pain.
    Fact: This medicine is intended for short-term use only, usually up to 7-10 days, because of the risk of gastrointestinal, liver, and kidney side effects.
  • Myth: It is safe to take with other painkillers.
    Fact: Taking this medicine with other NSAIDs increases the risk of bleeding and ulcers. Always consult your doctor before combining.
  • Myth: This medicine is a sleeping pill.
    Fact: Drowsiness is a side effect, but it is not a sleeping pill. It is a muscle relaxant and anti-inflammatory combination.

🔄 Alternative Options

Generic Alternatives

  • Chlorzoxazone + Diclofenac combination generics

Brand Alternatives

  • Mobizox
  • Chlorzoxazone + Diclofenac brands

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Chlorzoxazone 500 mg + Diclofenac 50 mg","uses":"Acute musculoskeletal pain with spasm","notes":"Combination of muscle relaxant and NSAID."},{"medicine":"Chlorzoxazone + Paracetamol","composition":"Chlorzoxazone 500 mg + Paracetamol 500 mg","uses":"Muscle spasm and pain","notes":"Paracetamol is safer for stomach but less anti-inflammatory."},{"medicine":"Diclofenac alone","composition":"Diclofenac 50 mg","uses":"Inflammation and pain","notes":"No muscle relaxant effect."}]

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