Piriton CS Syrup: Comprehensive Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Swelling of the face, lips, tongue, or throat
- Severe drowsiness or inability to stay awake
- Hallucinations, confusion, or unusual behavior
- Seizures
- Rapid or irregular heartbeat
- Severe dizziness or fainting
- Yellowing of the skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is tekof syrup used for?
This medicine is a combination syrup containing chlorpheniramine maleate (an antihistamine) and dextromethorphan hydrobromide (a cough suppressant). It is used to treat cough and allergy symptoms such as runny nose, sneezing, and itchy eyes. It works by blocking histamine and suppressing the cough reflex. It is for short-term use and should be taken as directed by a doctor.
- Generic Name: Chlorpheniramine Maleate (4mg/5ml) + Dextromethorphan Hydrobromide (10mg/5ml)
- Manufacturer: Gujarat Terce Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 tekof syrup के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोरफेनिरामाइन मेलिएट और डेक्सट्रोमेथोर्फन हाइड्रोब्रोमाइड का संयोजन है। इसका उपयोग खांसी और एलर्जी के लक्षणों जैसे नाक बहना, छींक आना, आंखों में खुजली और गले में खुजली के इलाज के लिए किया जाता है। यह दवा खांसी को दबाने और एलर्जी को कम करने में मदद करती है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, जी मिचलाना और धुंधली दृष्टि शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभावों में एलर्जी की प्रतिक्रिया, सांस लेने में कठिनाई, दिल की धड़कन तेज होना, भ्रम या मतिभ्रम शामिल हो सकते हैं। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं और दवाओं के बारे में बताएं। यदि आपको अस्थमा, ग्लूकोमा, प्रोस्टेट की समस्या, हृदय रोग, उच्च रक्तचाप या यकृत/गुर्दे की बीमारी है तो सावधानी बरतें। इस दवा के साथ शराब न लें। यह दवा नींद और चक्कर ला सकती है, इसलिए वाहन चलाने या मशीनरी चलाने से बचें। बच्चों को डॉक्टर की सलाह के बिना न दें।
💊 tekof syrup Uses & Benefits
[{"condition":"Allergic rhinitis","description":"Relieves sneezing, runny nose, itchy and watery eyes, and itching of the nose or throat associated with seasonal or perennial allergies.","evidence":"Well-established"},{"condition":"Common cold with cough","description":"Provides temporary relief of cough and upper respiratory symptoms such as nasal congestion and sneezing.","evidence":"Well-established"},{"condition":"Non-productive cough","description":"Suppresses dry, irritating cough by acting on the cough center in the brain.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Pruritus (itching) due to other causes","description":"Sometimes used off-label for relief of itching associated with urticaria or other skin conditions due to antihistamine effect.","evidence":"Limited"}]
Primary treatment for: Cough and allergic rhinitis
Also treats: Common cold, Allergic conjunctivitis, Urticaria
📋 Drug Information
| Generic Name(s) | Chlorpheniramine Maleate (4mg/5ml) + Dextromethorphan Hydrobromide (10mg/5ml) |
| Brand Name | tekof syrup |
| Manufacturer | Gujarat Terce Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep the bottle tightly closed. Do not refrigerate. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. Do not use after the expiry date printed on the package. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Chlorpheniramine maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors on effector cells, thereby reducing allergic symptoms such as sneezing, runny nose, and itching. Dextromethorphan hydrobromide is a centrally acting cough suppressant that acts on the cough center in the medulla oblongata to raise the threshold for coughing. It is a dextro-isomer of levorphanol but lacks analgesic and addictive properties at therapeutic doses.
Mechanism Steps
💡 How to Take tekof syrup
Strength: Each 5 ml of syrup contains 4 mg of chlorpheniramine maleate and 10 mg of dextromethorphan hydrobromide.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5 ml to 10 ml (one to two teaspoons) every 4 to 6 hours as needed for cough and allergy symptoms, not to exceed 6 doses in 24 hours. However, the dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to therapy. Do not exceed the recommended dose. Follow your doctor's instructions carefully. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine is not recommended for children under 2 years of age due to the risk of serious respiratory depression. For children 2 years and older, the dose should be determined by a pediatrician based on the child's weight and condition. |
| Elderly Dosage | Elderly patients (65 years and older) are more sensitive to the effects of chlorpheniramine and dextromethorphan, particularly drowsiness, dizziness, and anticholinergic effects. Use with caution and consider a lower initial dose. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment, the half-life of chlorpheniramine and dextromethorphan may be prolonged. Dose adjustment may be necessary. Use with caution and under medical supervision. Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | In patients with hepatic impairment, the metabolism of chlorpheniramine and dextromethorphan may be reduced, leading to increased plasma concentrations and risk of side effects. Use with caution and consider dose reduction. Dose must be individualized by a qualified clinician based on hepatic function. |
| Maximum Daily Dose | The maximum daily dose for adults is 60 ml (12 teaspoons) in 24 hours, providing 48 mg of chlorpheniramine maleate and 120 mg of dextromethorphan hydrobromide. Do not exceed this dose. For children, the maximum daily dose should be determined by a pediatrician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of tekof syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| CNS depressants | Major | |
| SSRIs | Major | |
| CYP2D6 inhibitors | Moderate | |
| Anticholinergics | Moderate | |
| Alcohol | Major | |
| Antihypertensives | Minor | |
| Diuretics | Minor | |
| Grapefruit juice | Moderate |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- CNS depressants (e.g., alcohol, benzodiazepines, opioids)
- Selective serotonin reuptake inhibitors (SSRIs)
⚡ Moderate Interactions
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
- Alcohol
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase drowsiness, dizziness, and the risk of central nervous system depression. Combining alcohol with chlorpheniramine and dextromethorphan can impair judgment, coordination, and reaction time, making activities like driving or operating machinery dangerous.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to chlorpheniramine, dextromethorphan, or any component of the formulation","Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOI therapy","Narrow-angle glaucoma","Urinary retention or prostatic hypertrophy","Severe liver disease","Severe coronary artery disease","Asthma attack (acute)","Children under 2 years of age (due to risk of serious respiratory depression)"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol and other CNS depressants.","Use with caution in patients with asthma, glaucoma, prostatic hypertrophy, or cardiovascular disease.","Do not exceed the recommended dose.","Not recommended for chronic cough or cough with excessive mucus unless directed by a doctor.","May cause excitation in children and elderly.","Consult doctor if symptoms persist beyond 7 days or are accompanied by fever, rash, or persistent headache."]
🤱 Lactation Safety
Chlorpheniramine and dextromethorphan may pass into breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Consult your doctor before use.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, dizziness, confusion, hallucinations, seizures, respiratory depression, and cardiac arrhythmias. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Before taking this medicine, inform your doctor if you have a history of asthma, glaucoma, difficulty urinating due to an enlarged prostate, thyroid problems, heart disease, high blood pressure, or liver or kidney disease. Do not take this medicine if you are currently taking a monoamine oxidase inhibitor or have taken one in the last 14 days. Avoid alcohol and other central nervous system depressants while using this medicine, as they can increase drowsiness and dizziness. This medicine may impair your ability to drive or operate heavy machinery, so avoid these activities until you know how it affects you. Do not exceed the recommended dose. Keep out of reach of children. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before use. Do not use this medicine for a chronic cough or a cough that produces a lot of mucus unless directed by a doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of chlorpheniramine and dextromethorphan, particularly drowsiness, dizziness, confusion, and anticholinergic effects such as dry mouth, constipation, and urinary retention. Use with caution and consider a lower initial dose. Regular monitoring for side effects is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this combination in pregnancy has not been established. Your doctor will weigh the potential benefits against the potential risks.
🏥 Post-Surgery Considerations
After surgery, use this medicine with caution as it may increase the risk of respiratory depression, especially if you are receiving other sedative medications. Consult your surgeon or anesthesiologist before taking this medicine.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with anesthetics or sedatives used during dental work, increasing the risk of drowsiness and other side effects.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness, which can impair your ability to exercise safely. Avoid strenuous exercise or activities that require balance and coordination until you know how the medicine affects you. If you exercise, do so in a safe environment and stay hydrated.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to perform work tasks, especially those requiring alertness, such as driving or operating machinery. It is advisable to avoid such activities until you know how the medicine affects you. Inform your employer if your job involves safety-sensitive tasks.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects. Do not stop abruptly if you have been taking it for a long time without consulting your doctor, as withdrawal symptoms may occur.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended. Prolonged use of chlorpheniramine may lead to tolerance and increased risk of side effects such as drowsiness and anticholinergic effects. Dextromethorphan can cause dependence and withdrawal symptoms with prolonged high-dose use. Regular monitoring of liver and kidney function may be required if used for extended periods. Consult your doctor if symptoms persist beyond 7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps relieve nasal congestion and runny nose without medication.
Evidence: Well-establishedCan soothe cough and sore throat, especially in children over 1 year.
Evidence: Well-establishedCan help loosen mucus and relieve congestion.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a vaccine, inform your healthcare provider that you are taking this medicine. It is generally safe to receive vaccines while taking this medicine, but follow your doctor's advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label intact. Bring a copy of your prescription or a letter from your doctor, especially for international travel. Store it at room temperature and protect it from extreme heat or cold. If crossing time zones, continue your regular dosing schedule as closely as possible, but do not double doses. Check customs regulations for carrying medications across borders.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 to 60 minutes after taking a dose.
A: Adults can take 5-10 ml every 4-6 hours as needed, not exceeding 6 doses in 24 hours. Follow your doctor's instructions.
A: It is not recommended for children under 2 years. For older children, consult a pediatrician for proper dosing.
A: Do not take with other medicines containing similar ingredients without consulting your doctor, as it may lead to overdose.
A: Common side effects include drowsiness, dizziness, dry mouth, and nausea. Serious side effects are rare but require immediate medical attention.
🤔 Common Patient Concerns
🔄 Substitutes for tekof syrup
View AllAlternative brands with exact same active ingredient:
-
presil plus syrupKentreck Laboratories Pvt Ltd ₹38.00 26.3% CHEAPER
-
cc go syrupIntas Pharmaceuticals Ltd ₹42.00 18.5% CHEAPER
-
Toxolite DX SyrupLitaka Pharmaceuticals Ltd ₹43.31 16% CHEAPER
-
nt kuf syrupHauz Pharma Pvt Ltd ₹45.00 12.7% CHEAPER
-
coricuff d syrupFervent Life Sciences Pvt Ltd ₹49.22 4.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure a cold.
Fact: This medicine only relieves symptoms; it does not cure the underlying viral infection. - Myth: It is safe to take more than the recommended dose for faster relief.
Fact: Taking more than the recommended dose can lead to serious side effects and is not safer or more effective. - Myth: This medicine is safe for children under 2 years.
Fact: This medicine is not recommended for children under 2 years due to the risk of serious respiratory depression.
🔄 Alternative Options
Generic Alternatives
- Chlorpheniramine + Dextromethorphan syrup (various manufacturers)
Brand Alternatives
- Piriton CS Syrup