Mylagia P 500mcg/150mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat, or difficulty breathing.
- Thoughts of self-harm or suicide.
- Unexplained muscle pain, tenderness, or dark urine.
- Severe skin rash with blisters or peeling.
- Slow, shallow breathing, especially if taking opioids or sedatives.
- Yellowing of the skin or eyes, or severe abdominal pain.
- Sudden weight gain or swelling in the legs and feet.
- Unusual bleeding or bruising.
- Severe dizziness or fainting.
- Chest pain or irregular heartbeat.
If experiencing severe symptoms, call emergency services immediately.
What is Syzur-Plus Capsule used for?
This medicine is a combination of Methylcobalamin 500 mcg and Pregabalin 150 mg used to treat neuropathic pain. It works by reducing abnormal nerve signals and supporting nerve repair. It is taken orally, usually once or twice daily, and should only be used under medical supervision.
- Generic Name: Methylcobalamin (500mcg) + Pregabalin (150mg)
- Manufacturer: Prunus Pharmaceuticals & Chemicals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Syzur-Plus Capsule के बारे में (Hindi Summary)
उपयोग: यह दवा मेथिलकोबालामिन 500 माइक्रोग्राम और प्रेगाबालिन 150 मिलीग्राम का संयोजन है। इसका उपयोग मुख्य रूप से न्यूरोपैथिक दर्द (तंत्रिका दर्द) के इलाज के लिए किया जाता है, जो मधुमेह, दाद (शिंगल्स) या अन्य तंत्रिका क्षति के कारण हो सकता है। यह दवा तंत्रिकाओं को आराम देने और उनकी मरम्मत में मदद करने का काम करती है। यह दर्द, जलन, झुनझुनी और सुन्नपन को कम करने में सहायक है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, नींद आना, थकान, धुंधली दृष्टि, मुँह सूखना और पैरों में सूजन शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। कभी-कभी वजन बढ़ना, मनोदशा में बदलाव, भ्रम और याददाश्त में कमी भी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि चेहरे, होंठ या गले में सूजन, सांस लेने में कठिनाई, या मांसपेशियों में दर्द हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अपने आप बंद न करें। यह दवा नींद और चक्कर ला सकती है, इसलिए वाहन चलाने या मशीनरी चलाने से बचें। शराब का सेवन बिल्कुल न करें। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या कोई अन्य दवा ले रही हैं, तो डॉक्टर को बताएं। इसे बच्चों की पहुंच से दूर रखें। कमरे के तापमान पर सूखी जगह पर रखें।
💊 Syzur-Plus Capsule Uses & Benefits
- [{"condition":"Diabetic peripheral neuropathy","description":"This medicine helps relieve burning, tingling, and shooting pain caused by nerve damage in diabetes.
- Methylcobalamin supports nerve repair while pregabalin reduces neuropathic pain signals.","evidence":"Well-established"},{"condition":"Postherpetic neuralgia","description":"This medicine is used to manage persistent nerve pain that follows a shingles infection.
- Pregabalin is a first-line treatment for this condition, and methylcobalamin may aid nerve recovery.","evidence":"Well-established"},{"condition":"Neuropathic pain of other origins","description":"This medicine may be prescribed for neuropathic pain due to spinal cord injury, multiple sclerosis, or chemotherapy-induced peripheral neuropathy.
- The combination aims to address both pain and underlying nerve health.","evidence":"Moderate"},{"condition":"Fibromyalgia","description":"Pregabalin is approved for fibromyalgia in some regions, and the addition of methylcobalamin may help with associated neuropathic symptoms.
- However, combination evidence is limited.","evidence":"Limited"},{"condition":"Generalized anxiety disorder","description":"Pregabalin has anxiolytic properties and is used in some countries for generalized anxiety disorder.
- Methylcobalamin is added for its neurotropic effects, but this combination is not standard for anxiety alone.","evidence":"Limited"}]
Off-label uses: [{"condition":"Chronic low back pain with neuropathic component","description":"Sometimes prescribed off-label when nerve involvement is suspected. Evidence for the combination is not well established.","evidence":"Limited"},{"condition":"Migraine prophylaxis","description":"Pregabalin has been studied off-label for migraine prevention, but evidence is weak. Methylcobalamin may be added for its potential neuroprotective effects.","evidence":"Insufficient"},{"condition":"Restless legs syndrome","description":"Pregabalin may be used off-label for restless legs syndrome, but the role of methylcobalamin in this condition is not established.","evidence":"Limited"}]
Primary treatment for: Neuropathic pain
Also treats: Diabetic peripheral neuropathy, Postherpetic neuralgia, Fibromyalgia, Generalized anxiety disorder, Epilepsy (adjunctive therapy)
📋 Drug Information
| Generic Name(s) | Methylcobalamin (500mcg) + Pregabalin (150mg) |
| Brand Name | Syzur-Plus Capsule |
| Manufacturer | Prunus Pharmaceuticals & Chemicals Pvt Ltd |
| Packaging / Form | strip of 10 capsules (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C (59°F to 86°F). Keep it in the original container, tightly closed, away from moisture, heat, and direct sunlight. Do not refrigerate unless specified. Keep out of the reach of children and pets. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture. Do not use after the expiry date printed on the pack. Check the packaging for the specific expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding reduces the influx of calcium into presynaptic nerve terminals, which in turn decreases the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P. By dampening this excessive neuronal excitability, pregabalin effectively reduces neuropathic pain and has anticonvulsant and anxiolytic effects. Methylcobalamin is a coenzyme form of vitamin B12 that participates in the methylation of homocysteine to methionine and in the synthesis of myelin. It supports the integrity and function of peripheral nerves and may promote nerve regeneration. Together, these actions address both the symptomatic pain of neuropathy and the underlying nutritional deficiency that can contribute to nerve damage.
Mechanism Steps
💡 How to Take Syzur-Plus Capsule
Strength: Each tablet contains Methylcobalamin 500 mcg and Pregabalin 150 mg. The tablet is intended for oral administration. The release type is immediate release.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once or twice daily, or as directed by your physician. The dose of pregabalin may be started at 75 mg twice daily or 150 mg once daily, and may be increased gradually based on response and tolerability. The maximum recommended dose of pregabalin is 600 mg per day, but the dose in this fixed combination is 150 mg per tablet. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness, drowsiness, and peripheral edema. Dose reduction may be necessary based on renal function. Start with a low dose and titrate slowly. Regular monitoring of renal function is recommended. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. Pregabalin clearance is directly proportional to creatinine clearance. For patients with creatinine clearance between 30 and 60 mL/min, the dose may need to be reduced. For creatinine clearance between 15 and 30 mL/min, further reduction is needed. For patients on hemodialysis, an additional dose may be required after dialysis. Consult your doctor for specific dosing recommendations. |
| Hepatic Impairment | No dose adjustment is required for mild to moderate hepatic impairment. However, caution is advised in patients with severe hepatic impairment due to limited data. Monitor liver function periodically. |
| Maximum Daily Dose | The maximum recommended daily dose of pregabalin is 600 mg. In this fixed-dose combination, each tablet contains 150 mg of pregabalin. The maximum number of tablets per day should not exceed the equivalent of 600 mg of pregabalin, which is 4 tablets. However, the actual maximum dose for an individual patient must be determined by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Syzur-Plus Capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Opioids | Major | |
| Benzodiazepines | Major | |
| Alcohol | Major | |
| MAO inhibitors | Major | |
| Antihistamines | Moderate | |
| Antihypertensives | Moderate | |
| Thiazolidinediones | Moderate | |
| NSAIDs | Moderate | |
| Antacids | Minor | |
| Metformin | Minor |
🚨 Major Interactions
- Opioids (e.g., morphine, oxycodone)
- Benzodiazepines (e.g., diazepam, lorazepam)
- Alcohol
- MAO inhibitors
⚡ Moderate Interactions
- Antihistamines (e.g., diphenhydramine)
- Antihypertensives
- Thiazolidinediones (e.g., pioglitazone)
- NSAIDs
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Both alcohol and pregabalin are central nervous system depressants, and their combined use can lead to excessive sedation, dizziness, impaired coordination, and an increased risk of respiratory depression. This can impair your ability to drive or operate machinery and may be life-threatening. If you have a history of alcohol abuse, inform your doctor before starting this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to pregabalin, methylcobalamin, or any component of the formulation.","Severe renal impairment (creatinine clearance less than 30 mL/min) without dose adjustment.","Pregnancy unless the potential benefit clearly outweighs the risk.","Breastfeeding without medical advice.","Concurrent use with MAO inhibitors.","Patients with rare hereditary problems of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption (due to lactose content in some formulations)."]
⚠️ Warnings & Precautions
["This medicine may cause dizziness, drowsiness, and blurred vision. Avoid driving or operating heavy machinery until you know how it affects you.","Do not consume alcohol while taking this medicine, as it can increase sedation and respiratory depression.","This medicine may increase the risk of suicidal thoughts and behavior. Monitor mood changes closely.","Peripheral edema and weight gain may occur. Use with caution in patients with heart failure.","Renal impairment requires dose adjustment. Inform your doctor if you have kidney disease.","This medicine may impair your ability to perform tasks requiring mental alertness. Use caution.","Do not stop this medicine abruptly, as it may cause withdrawal symptoms such as insomnia, headache, nausea, and anxiety.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Keep this medicine out of the reach of children.","Store at room temperature away from moisture and heat."]
🤱 Lactation Safety
Pregabalin is excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Methylcobalamin is also excreted in breast milk and is considered safe. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose of this medicine may cause excessive sedation, dizziness, confusion, and respiratory depression. In case of suspected overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote for pregabalin. Hemodialysis may be considered in severe cases, especially in patients with renal impairment. Methylcobalamin is generally non-toxic even at high doses. Contact a poison control center or emergency room for guidance.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. This medicine can cause dizziness and drowsiness, so avoid driving or operating heavy machinery until you know how it affects you. Do not consume alcohol while taking this medicine, as it can increase drowsiness and impair your ability to think clearly. Inform your doctor if you have kidney problems, liver disease, heart failure, or a history of substance abuse. This medicine may interact with other medications, including opioids, benzodiazepines, and antihistamines, so always tell your doctor about all the medicines you are taking. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of the reach of children. Store it at room temperature, away from moisture and direct sunlight. Do not use this medicine after the expiry date printed on the pack. If you miss a dose, take it as soon as you remember, but skip it if it is almost time for your next dose. Never double the dose to make up for a missed one. Contact your doctor immediately if you experience any serious side effects or allergic reactions.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more susceptible to the side effects of this medicine, particularly dizziness, drowsiness, and peripheral edema. Renal function declines with age, so dose adjustment may be necessary. Start with a low dose and titrate slowly. Regular monitoring of renal function, mood, and fall risk is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Pregabalin may harm the fetus. Effective contraception should be used during treatment. If you become pregnant while taking this medicine, inform your doctor immediately. Methylcobalamin is generally safe, but the combination should be used only if clearly needed.
🏥 Post-Surgery Considerations
After surgery, this medicine may be continued if prescribed for neuropathic pain. However, it can interact with anesthetics and opioids used during surgery, increasing the risk of respiratory depression. Inform your anesthesiologist and surgeon about all medications you are taking. Dose adjustments may be needed based on your postoperative condition and renal function.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, especially if you are undergoing procedures that require sedation or anesthesia. Pregabalin can interact with sedatives used in dentistry, increasing drowsiness and respiratory depression. Your dentist may need to adjust the type or dose of anesthesia.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While exercise is beneficial, avoid high-impact activities that may exacerbate nerve pain or cause injury. If you experience dizziness or drowsiness, avoid activities that require balance and coordination. Consult your doctor or physical therapist before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause dizziness and drowsiness, which may affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is advisable to avoid such activities until you know how the medicine affects you. Inform your employer if your job involves safety-sensitive tasks. The sedative effects may also impact your productivity and concentration, so plan your work schedule accordingly.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects or if your doctor decides to discontinue, the dose should be tapered gradually over at least a week to prevent withdrawal symptoms. If you wish to stop for any reason, discuss with your doctor first.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to tolerance, dependence, and withdrawal symptoms if stopped abruptly. Pregabalin can cause weight gain, peripheral edema, and cognitive impairment with prolonged use. Regular monitoring of renal function, vitamin B12 levels, and mood is recommended. The dose should be tapered gradually under medical supervision when discontinuing. Methylcobalamin is generally safe for long-term use, but excessive accumulation is rare and usually harmless.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedHelps manage chronic pain and associated anxiety.
Evidence: ModerateMay provide relief for some types of neuropathic pain.
Evidence: LimitedCan be used as an adjunct for pain relief.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for any vaccination, inform your healthcare provider about all medications you are taking. Live vaccines should be avoided if you are immunocompromised, but this medicine does not cause immunosuppression.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or exposure to extreme temperatures. If crossing time zones, adjust your dosing schedule gradually to maintain consistent blood levels, but consult your doctor first. Store it at room temperature and avoid leaving it in a hot car. Check customs regulations for controlled substances, as pregabalin may be regulated in some countries. Always carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pregabalin starts reducing neuropathic pain within 1 to 2 hours after a dose, but full therapeutic effect may take several days to weeks. Methylcobalamin's effects on nerve health are gradual and may take weeks to months.
A: No, alcohol should be completely avoided while taking this medicine. It can increase sedation, dizziness, and the risk of respiratory depression.
A: Common side effects include dizziness, drowsiness, blurred vision, dry mouth, and peripheral edema. These are usually mild and improve over time.
A: This medicine can cause dizziness and drowsiness. Avoid driving or operating heavy machinery until you know how it affects you.
A: No, you should not stop this medicine abruptly as it can cause withdrawal symptoms such as insomnia, headache, nausea, and anxiety. Always consult your doctor before stopping.
A: Weight gain is a common side effect of pregabalin. Monitor your weight and follow a balanced diet. Consult your doctor if weight gain is significant.
A: Pregabalin is Pregnancy Category C. It should be used during pregnancy only if the potential benefit justifies the potential risk. Consult your doctor if you are pregnant or planning to become pregnant.
🤔 Common Patient Concerns
🔄 Substitutes for Syzur-Plus Capsule
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller like paracetamol.
Fact: This medicine is not a general painkiller. It is specifically for neuropathic pain and works on nerve signals, not on ordinary pain pathways. - Myth: You can stop taking this medicine once you feel better.
Fact: You should not stop this medicine abruptly as it can cause withdrawal symptoms. Always consult your doctor before stopping. - Myth: This medicine is addictive.
Fact: Pregabalin has a potential for abuse and dependence, but when taken as prescribed for medical reasons, the risk is low. However, it should be used with caution in patients with a history of substance abuse. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol should be avoided completely as it can increase sedation and the risk of respiratory depression.
🔄 Alternative Options
Generic Alternatives
- Methylcobalamin 500 mcg + Pregabalin 150 mg tablet (generic versions available from various manufacturers)
Brand Alternatives
- Not applicable. This is a generic medicine profile.