Pipzo 2.25 gm Injection: A Comprehensive Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe, persistent diarrhea or bloody stools
- Seizures or confusion
- Decreased urine output or swelling in legs
- Unusual bleeding or bruising
- Severe skin rash with blistering or peeling
- High fever with chills not improving
If experiencing severe symptoms, call emergency services immediately.
What is Syntazo 2gm/250mg Injection used for?
This medicine is a combination antibiotic containing piperacillin and tazobactam, used to treat serious bacterial infections. It is given by injection in a hospital setting.
- Generic Name: Piperacillin (2gm) + Tazobactum (250mg)
- Manufacturer: Zyphar's Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Syntazo 2gm/250mg Injection के बारे में (Hindi Summary)
उपयोग: यह दवा पिपेरासिलिन और टैज़ोबैक्टम का संयोजन है, जिसका उपयोग गंभीर जीवाणु संक्रमणों के इलाज के लिए किया जाता है। यह अस्पताल में इंजेक्शन के रूप में दी जाती है। यह निमोनिया, मूत्र मार्ग संक्रमण, पेट के संक्रमण, त्वचा संक्रमण और स्त्री रोग संबंधी संक्रमणों के इलाज में प्रभावी है। यह दवा केवल डॉक्टर की सलाह पर ही दी जानी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, सिरदर्द, अनिद्रा, दाने और इंजेक्शन स्थल पर दर्द या सूजन शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, गंभीर दस्त, दौरे और गुर्दे की समस्याएं शामिल हो सकती हैं। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा दी जानी चाहिए। इसे स्वयं न लें। अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों और दवाओं के बारे में बताएं। गुर्दे की बीमारी, एलर्जी या रक्तस्राव विकार होने पर सावधानी बरतें। उपचार के दौरान अल्कोहल से बचें। दवा का पूरा कोर्स पूरा करें।
💊 Syntazo 2gm/250mg Injection Uses & Benefits
[{"condition":"Hospital-acquired pneumonia","description":"Used to treat pneumonia acquired during hospital stay, especially caused by Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Effective against severe kidney and bladder infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Complicated intra-abdominal infections","description":"Used for infections like appendicitis, peritonitis, and abdominal abscesses.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats severe cellulitis, abscesses, and diabetic foot infections.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Used for pelvic inflammatory disease and postpartum infections.","evidence":"Well-established"},{"condition":"Febrile neutropenia","description":"Empiric therapy for fever in patients with low white blood cell counts.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Meningitis","description":"Sometimes used off-label for bacterial meningitis when other options are unsuitable.","evidence":"Limited"},{"condition":"Prosthetic joint infections","description":"May be used in combination therapy for infected joint replacements.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Hospital-acquired pneumonia, Complicated urinary tract infections, Complicated intra-abdominal infections, Skin and soft tissue infections, Gynecological infections, Febrile neutropenia
📋 Drug Information
| Generic Name(s) | Piperacillin (2gm) + Tazobactum (250mg) |
| Brand Name | Syntazo 2gm/250mg Injection |
| Manufacturer | Zyphar's Pharmaceuticals Pvt Ltd |
| Packaging / Form | vial of 1 Injection (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Parenteral (intravenous or intramuscular) |
| Storage | Store the unreconstituted powder at room temperature (20-25°C). After reconstitution, the solution should be used immediately or stored as per the manufacturer's instructions, typically refrigerated (2-8°C) and used within 24 hours. Protect from light and moisture. |
| Shelf Life | The shelf life of the unreconstituted product is typically 24 months from the date of manufacture. Check the expiry date on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines piperacillin, a semisynthetic penicillin antibiotic, and tazobactam, a beta-lactamase inhibitor. Piperacillin kills bacteria by binding to specific penicillin-binding proteins (PBPs) inside the bacterial cell wall, inhibiting the final cross-linking step of peptidoglycan synthesis. This weakens the cell wall and leads to bacterial cell lysis and death. Tazobactam is a beta-lactamase inhibitor that protects piperacillin from degradation by many beta-lactamase enzymes produced by resistant bacteria. Tazobactam binds irreversibly to these enzymes, extending piperacillin's spectrum of activity against beta-lactamase-producing organisms.
Mechanism Steps
💡 How to Take Syntazo 2gm/250mg Injection
Strength: This medicine is available as a sterile powder for injection in vials containing 2.25 g (2 g piperacillin + 0.25 g tazobactam), 3.375 g (3 g piperacillin + 0.375 g tazobactam), and 4.5 g (4 g piperacillin + 0.5 g tazobactam). The specific strength is 2.25 g per vial.
Dosage Information
| Adult Dosage | The usual adult dose is 3.375 g (3 g piperacillin + 0.375 g tazobactam) or 4.5 g (4 g piperacillin + 0.5 g tazobactam) administered intravenously every 6 to 8 hours, depending on the severity and type of infection. For hospital-acquired pneumonia, the recommended dose is 4.5 g every 6 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function; dose should be adjusted based on creatinine clearance. Monitor renal function closely. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For creatinine clearance (CrCl) 20-40 mL/min, the usual dose is 3.375 g every 6 hours. For CrCl <20 mL/min, the dose is 2.25 g every 6 hours. For patients on hemodialysis, the dose is 2.25 g every 8 hours plus an additional 0.75 g after each dialysis session. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No specific dose adjustment is recommended for hepatic impairment alone. However, monitor liver function. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 18 g (16 g piperacillin + 2 g tazobactam) per day, but this should not be exceeded. Dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Syntazo 2gm/250mg Injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Vecuronium | Major | |
| Gentamicin | Moderate | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate | |
| Heparin | Minor | |
| Furosemide | Minor |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Vecuronium
⚡ Moderate Interactions
- Aminoglycosides (e.g., gentamicin)
- Probenecid
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol may worsen side effects such as nausea, dizziness, and drowsiness. It is advisable to avoid alcohol during treatment with this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to penicillins, cephalosporins, or beta-lactamase inhibitors","History of anaphylaxis to any beta-lactam antibiotic","Severe renal impairment requiring dose adjustment without monitoring"]
⚠️ Warnings & Precautions
["Serious allergic reactions, including anaphylaxis, can occur. Discontinue immediately if suspected.","Clostridioides difficile-associated diarrhea may occur; report severe diarrhea.","Seizures may occur, especially in patients with renal impairment. Dose adjustment may be needed.","Use with caution in patients with bleeding disorders or on anticoagulants.","May cause false-positive results in certain urine glucose tests.","Prolonged use may lead to superinfection with resistant organisms.","Monitor renal and hepatic function during therapy."]
🤱 Lactation Safety
Piperacillin and tazobactam are excreted in human milk in low amounts. Caution should be exercised when administered to a nursing woman. Consult your doctor to weigh the benefits and risks.
💊 Overdose Management
Overdose may cause nausea, vomiting, diarrhea, and seizures. Treatment is supportive and symptomatic. Piperacillin and tazobactam can be removed by hemodialysis. In case of overdose, seek immediate medical attention.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If a dose is missed, contact your healthcare provider for instructions. Do not attempt to self-administer.
Additional Safety Advice
This medicine must be administered only by a healthcare professional in a clinical setting. Do not attempt to self-administer. Inform your doctor about all your medical conditions, especially kidney disease, bleeding disorders, or allergies to antibiotics. Tell your doctor about all medications you are taking, including over-the-counter drugs and herbal supplements. Complete the full course as prescribed, even if you feel better, to prevent resistance. Report any signs of allergic reaction, severe diarrhea, or unusual bleeding immediately. Your doctor may monitor your kidney function, blood counts, and liver enzymes during treatment. Use with caution in elderly patients and those with kidney impairment; dose adjustments may be needed. Avoid alcohol during treatment as it may worsen side effects. This medicine may interact with other drugs, so always consult your healthcare provider before taking any new medication.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, so dose adjustment is often necessary. They may also be more susceptible to side effects like confusion, seizures, and bleeding. Close monitoring is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor before starting this medicine. It is classified as Pregnancy Category B, meaning it should be used only if clearly needed. Effective contraception is advised during treatment if you are of childbearing age.
🏥 Post-Surgery Considerations
This medicine is often used to prevent or treat surgical site infections. It may be administered before, during, or after surgery. Follow your surgeon's instructions regarding its use and monitor for signs of infection.
🦷 Dental Procedures
If you are scheduled for dental work, inform your dentist that you are receiving this medicine. It may interact with certain antibiotics used in dentistry. Your dentist may need to coordinate with your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While on this medicine, you may feel weak or dizzy. Avoid strenuous exercise until you feel fully recovered. Light activity like walking is fine if you feel up to it. Consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so you may need to take time off work during treatment. You may experience fatigue, dizziness, or diarrhea, which can affect your ability to work. Avoid driving or operating machinery until you feel normal. Discuss with your employer about sick leave.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early may lead to incomplete treatment and antibiotic resistance. Your doctor will determine the appropriate duration based on your infection and response to treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, superinfections (such as fungal infections), and rarely, blood disorders or kidney problems. Prolonged therapy should be avoided unless necessary. Regular monitoring of kidney and liver function is advised during extended treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the bacteria and sensitivity, other antibiotics like cephalosporins, carbapenems, or fluoroquinolones may be used.
Evidence: Well-establishedRest, hydration, and fever control can complement antibiotic therapy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, if you are due for vaccinations, inform your doctor, as antibiotics may affect the response to certain live vaccines. Generally, inactivated vaccines can be given safely.
📦 Storage Guide
✅ DO
Store the unreconstituted powder at room temperature (20-25°C).
❌ DON'T
Do not freeze the powder.
✅ DO
After reconstitution, use immediately or refrigerate (2-8°C) and use within 24 hours.
❌ DON'T
Do not use if the solution is cloudy or contains particles.
✅ DO
Keep in original packaging to protect from light and moisture.
❌ DON'T
Do not store in bathroom cabinet.
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting, so travel advice is limited. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medication as directed. For international travel, check customs regulations regarding injectable antibiotics. Always carry your doctor's contact information.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within hours after administration. You may notice improvement in symptoms within 24 to 48 hours, but complete recovery depends on the infection and your overall health.
A: No, this medicine must be administered by a healthcare professional in a hospital or clinic setting. It is not for self-administration.
A: Since it is given by a healthcare professional, missed doses are unlikely. If you miss a dose, inform your doctor or nurse immediately.
A: No specific food restrictions are required, as the medicine is given intravenously. However, maintaining good hydration and nutrition supports recovery.
A: This medicine may cause dizziness or drowsiness. Avoid driving or operating machinery until you know how it affects you.
🤔 Common Patient Concerns
🔄 Substitutes for Syntazo 2gm/250mg Injection
View AllAlternative brands with exact same active ingredient:
-
Tazy 2gm/250mg InjectionFeron Healthcare Pvt Ltd ₹190.31 31.8% CHEAPER
-
pipzo 2.25 gm injectionAlkem Laboratories Ltd ₹204.61 26.7% CHEAPER
-
pepar 2.5gm injectionGlenmark Pharmaceuticals Ltd ₹427.97 53.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally.
Fact: This medicine is only available as an injection and must be given by a healthcare professional. - Myth: This medicine is safe for everyone.
Fact: It is contraindicated in patients with severe penicillin allergy and requires dose adjustment in kidney disease. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course as prescribed to prevent resistance and relapse.
🔄 Alternative Options
Generic Alternatives
- Piperacillin and Tazobactam for Injection
Brand Alternatives
- Pipzo 2.25 gm Injection
- Tazact 2.25 gm Injection
- Zosyn 2.25 gm Injection
- Piptaz 2.25 gm Injection