Synate 10mg Injection (Furosemide): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Rapid or irregular heartbeat
- Decreased urine output
- Ringing in the ears or hearing loss
- Severe abdominal pain or vomiting
- Swelling of face, lips, or throat
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is synate 10mg injection used for?
This medicine is a loop diuretic injection containing furosemide 10 mg. It is used to treat fluid overload in conditions like heart failure, kidney disease, and liver disease. It works by increasing urine output and must be given by a healthcare professional.
- Generic Name: Furosemide (10mg)
- Manufacturer: SPM Drugs Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 synate 10mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा फ्यूरोसेमाइड 10 मिलीग्राम इंजेक्शन है, जिसका उपयोग शरीर में अतिरिक्त तरल पदार्थ को बाहर निकालने के लिए किया जाता है। यह हृदय विफलता, गुर्दे की बीमारी और यकृत की बीमारी के कारण होने वाली सूजन और फेफड़ों में पानी भरने के इलाज में दिया जाता है। यह दवा केवल डॉक्टर या नर्स द्वारा इंजेक्शन के रूप में दी जाती है, घर पर खुद से नहीं लगाई जाती।
साइड इफेक्ट्स: आम दुष्प्रभावों में बार-बार पेशाब आना, चक्कर आना, सिरदर्द, मतली और पोटैशियम जैसे इलेक्ट्रोलाइट्स की कमी शामिल है। गंभीर दुष्प्रभावों में गंभीर निर्जलीकरण, निम्न रक्तचाप, गुर्दे की चोट, सुनने में कमी और एलर्जी प्रतिक्रिया हो सकती है। कान में घंटी बजना या सुनाई न देना तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल या क्लिनिक में डॉक्टर या नर्स द्वारा दी जानी चाहिए। इसे घर पर खुद से न लगाएं। इलाज के दौरान रक्तचाप, पोटैशियम और गुर्दे की कार्यप्रणाली की निगरानी जरूरी है। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं, खासकर डिगॉक्सिन, लिथियम और एंटीबायोटिक्स।
💊 synate 10mg injection Uses & Benefits
[{"condition":"Acute pulmonary edema","description":"Rapidly reduces fluid accumulation in the lungs by promoting diuresis, easing breathing.","evidence":"Well-established"},{"condition":"Congestive heart failure exacerbation","description":"Relieves fluid overload and reduces cardiac workload in acute decompensation.","evidence":"Well-established"},{"condition":"Edema due to renal impairment","description":"Helps manage fluid retention in patients with kidney disease when oral therapy is inadequate.","evidence":"Well-established"},{"condition":"Edema due to hepatic cirrhosis","description":"Used cautiously with albumin or other diuretics to manage ascites and peripheral edema.","evidence":"Well-established"},{"condition":"Hypertensive crisis with fluid overload","description":"May be used as an adjunct to control blood pressure when fluid overload is present.","evidence":"Supportive"}]
Off-label uses: [{"condition":"Hypercalcemia","description":"Loop diuretics can increase calcium excretion, but this is not a first-line treatment.","evidence":"Limited"},{"condition":"Acute kidney injury prophylaxis","description":"Sometimes used to maintain urine output, but evidence does not support routine use.","evidence":"Limited"}]
Primary treatment for: Fluid overload due to congestive heart failure, renal or hepatic edema, and acute pulmonary edema.
Also treats: Hypertension, Cirrhosis with ascites, Nephrotic syndrome, Acute kidney injury
📋 Drug Information
| Generic Name(s) | Furosemide (10mg) |
| Brand Name | synate 10mg injection |
| Manufacturer | SPM Drugs Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | High-ceiling Diuretics (Inhibitors of Na+-K+- 2Cl cotransport) |
| Route of Administration | Parenteral (intramuscular or intravenous injection) |
| Storage | Store at room temperature (15-30°C). Protect from light and freezing. Keep in original packaging. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Furosemide is included in the WHO Model List of Essential Medicines for the treatment of edema and hypertension. |
| ICMR Guideline | ICMR guidelines recommend furosemide for the management of fluid overload in heart failure and renal disease, with close monitoring of electrolytes and renal function. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Furosemide inhibits the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, reducing sodium reabsorption and causing a powerful diuretic effect. This leads to increased excretion of water, sodium, chloride, magnesium, and calcium. The resulting fluid loss reduces preload and relieves edema.
Mechanism Steps
💡 How to Take synate 10mg injection
Strength: Injection: 10 mg per 1 mL (10 mg/mL).
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the patient's condition, fluid status, renal function, and response to therapy. For acute pulmonary edema, an initial dose of 20-40 mg intramuscularly or intravenously may be given, followed by adjustment according to response. Doses may range from 20 mg to 80 mg or more, but must be determined by a doctor. Do not self-administer. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of furosemide, especially hypotension and electrolyte imbalances. Start with lower doses and monitor closely. |
| Renal Impairment | In patients with renal impairment, higher doses may be required to achieve a diuretic effect, but the risk of toxicity is increased. Dose must be individualized by a clinician based on renal function. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be necessary. Monitor electrolytes and liver function. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the clinical situation. Doses up to 600 mg per day have been used in severe renal impairment, but only under close medical supervision. Individual dosing must be determined by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of synate 10mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Digoxin | Major | |
| Lithium | Major | |
| Gentamicin | Major | |
| NSAIDs | Major | |
| Corticosteroids | Moderate | |
| Sucralfate | Moderate | |
| Phenytoin | Moderate | |
| Probenecid | Minor | |
| Indomethacin | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Digoxin
- Lithium
- Aminoglycosides (e.g., gentamicin)
- NSAIDs
- Antihypertensives
⚡ Moderate Interactions
- Corticosteroids
- Sucralfate
- Phenytoin
🍷 Alcohol Interaction
Alcohol may enhance the hypotensive and diuretic effects of this medicine, increasing the risk of dizziness, fainting, and dehydration. Avoid alcohol during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Anuria (absence of urine production)","Severe electrolyte depletion (e.g., hypokalemia, hyponatremia)","Hypersensitivity to furosemide or sulfonamides","Hepatic coma","Severe hypovolemia or dehydration"]
⚠️ Warnings & Precautions
["Administer cautiously in patients with renal impairment; dose adjustment may be required.","Monitor electrolytes closely, especially potassium and sodium.","Rapid intravenous injection may cause ototoxicity; administer slowly.","May cause hypotension; monitor blood pressure.","Use with caution in patients with diabetes mellitus; may affect glucose tolerance.","Avoid in patients with known sulfonamide allergy.","Not for self-administration; must be given by a healthcare professional."]
🤱 Lactation Safety
Furosemide is excreted in breast milk. It may reduce milk production. Use with caution in breastfeeding mothers; consult a doctor.
💊 Overdose Management
Overdose may cause severe dehydration, electrolyte imbalance, and hypotension. Treatment is supportive and symptomatic. Monitor vital signs, electrolytes, and renal function. There is no specific antidote. Contact a poison control center or emergency services immediately.
⏰ Missed Dose
This medicine is administered by a healthcare professional. If a dose is missed, it will be given as soon as possible according to the prescribed schedule. Do not attempt to self-administer.
Additional Safety Advice
This medicine must be administered only by a qualified healthcare professional in a setting where vital signs and fluid balance can be monitored. Patients should inform their doctor about all other medicines, especially digoxin, lithium, and aminoglycosides. Adequate hydration and electrolyte monitoring are essential. Do not attempt to self-administer this injection. Report any ringing in the ears, hearing difficulty, or unusual weakness immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more susceptible to dehydration, electrolyte imbalances, and hypotension. Lower doses and close monitoring are recommended.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before receiving this medicine. It should be used during pregnancy only if clearly needed.
🏥 Post-Surgery Considerations
This medicine may be used after surgery to manage fluid overload. It requires close monitoring of fluid balance and electrolytes.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, as it may affect blood pressure and fluid balance. No specific precautions are usually needed for dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise until your fluid and electrolyte status is stable. Dizziness and low blood pressure may increase the risk of falls. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness and increased urination, which can affect your ability to drive or operate machinery. It is usually given in a hospital setting, so work impact is minimal during administration. After discharge, adjust your schedule to accommodate frequent urination.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. It is given under medical supervision, and the decision to stop will be made by your healthcare provider based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to electrolyte imbalances, dehydration, and kidney function changes. Regular monitoring of blood tests is required. It may also cause hearing problems with prolonged high doses. Your doctor will adjust the dose based on your response and monitor for side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May be used once the acute phase is over.
Evidence: Well-establishedHelps manage fluid balance long-term.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, inform your doctor about your vaccination status before receiving this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting and is not for self-administration during travel. If you are prescribed this medicine, ensure you carry a copy of your prescription and medical records. Store at room temperature and protect from light. For international travel, check local regulations regarding injectable medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 5 minutes after intravenous injection and within 30 minutes after intramuscular injection.
A: No, this medicine must be given by a healthcare professional in a clinical setting.
A: Avoid alcohol and high-sodium foods. Inform your doctor about all other medicines you are taking.
🤔 Common Patient Concerns
🔄 Substitutes for synate 10mg injection
View AllAlternative brands with exact same active ingredient:
-
Furene 10mg InjectionTribhawan Injectables ₹3.15 34.6% COSTLIER
-
Tesix 10mg InjectionTamman Titoe Pharma Pvt Ltd ₹3.28 40.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be self-administered at home.
Fact: This medicine is an injection that must be given by a healthcare professional in a clinical setting. - Myth: This medicine is safe for everyone.
Fact: It is contraindicated in certain conditions like anuria and severe electrolyte imbalance. - Myth: This medicine can be used for weight loss.
Fact: This medicine is not a weight-loss drug and should only be used for medical conditions as prescribed.
🔄 Alternative Options
Generic Alternatives
- Furosemide injection
Brand Alternatives
- Lasix
- Frusemide