Amitax 250mg Injection (Amikacin): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Decreased urine output or no urine output
- Swelling in the legs, ankles, or feet
- Ringing in the ears or hearing loss
- Dizziness or loss of balance
- Muscle weakness or difficulty breathing
- Severe allergic reaction (rash, hives, swelling of face or throat, difficulty breathing)
- Severe or persistent diarrhea
- Confusion or seizures
If experiencing severe symptoms, call emergency services immediately.
What is bacticin 250mg injection used for?
This medicine is an injectable aminoglycoside antibiotic containing Amikacin 250mg. It is used to treat serious bacterial infections by killing bacteria through inhibition of protein synthesis. It is administered by a healthcare professional and requires monitoring of kidney function and hearing.
- Generic Name: Amikacin (250mg)
- Manufacturer: SPM Drugs Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 bacticin 250mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक शक्तिशाली एंटीबायोटिक है जिसमें अमिकासिन 250mg सक्रिय घटक के रूप में होता है। यह गंभीर जीवाणु संक्रमणों के इलाज के लिए इंजेक्शन के रूप में दी जाती है। यह आमतौर पर अस्पताल में डॉक्टर या नर्स द्वारा दी जाती है। यह उन संक्रमणों के लिए उपयोग की जाती है जो अन्य एंटीबायोटिक्स से ठीक नहीं होते, जैसे कि निमोनिया, मूत्र मार्ग संक्रमण, और पेट के संक्रमण। यह दवा बैक्टीरिया को मारने का काम करती है। इसका उपयोग केवल डॉक्टर की सलाह पर ही किया जाना चाहिए।
साइड इफेक्ट्स: इस दवा के कुछ सामान्य दुष्प्रभाव हो सकते हैं जैसे इंजेक्शन की जगह पर दर्द या लालिमा, मतली, उल्टी, सिरदर्द और बुखार। गंभीर दुष्प्रभावों में गुर्दे की क्षति, सुनने की क्षमता में कमी, कान में घंटी बजना, चक्कर आना, और मांसपेशियों में कमजोरी शामिल हैं। यदि आपको कोई भी गंभीर लक्षण महसूस हो, तो तुरंत अपने डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल डॉक्टर की देखरेख में ही दी जानी चाहिए। इसे घर पर स्वयं न लें। इलाज के दौरान अपने गुर्दे की कार्यप्रणाली और सुनने की क्षमता की नियमित जांच करवाएं। पर्याप्त पानी पीते रहें। शराब का सेवन न करें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर को बताएं। कान में घंटी बजना, सुनाई न देना, चक्कर आना, या पेशाब कम आना जैसे लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
💊 bacticin 250mg injection Uses & Benefits
- [{"condition":"Serious gram-negative bacterial infections","description":"This medicine is used to treat severe infections caused by susceptible gram-negative bacteria, including Pseudomonas aeruginosa, Escherichia coli, and Klebsiella species.
- It is often used when other antibiotics are ineffective or contraindicated.","evidence":"Well-established"},{"condition":"Hospital-acquired pneumonia","description":"This medicine may be used to treat pneumonia acquired during a hospital stay, especially when caused by multidrug-resistant gram-negative bacteria.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"It is effective against complicated urinary tract infections caused by susceptible bacteria, particularly when the infection has spread to the kidneys or bloodstream.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"This medicine can be part of a combination therapy for serious intra-abdominal infections such as peritonitis and abscesses.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"It may be used to treat osteomyelitis and septic arthritis caused by gram-negative bacteria.","evidence":"Well-established"},{"condition":"Neonatal sepsis","description":"This medicine is sometimes used in newborns with suspected or confirmed sepsis caused by gram-negative organisms, though dosing is highly specialized.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Mycobacterium avium complex (MAC) infection","description":"This medicine may be used off-label as part of a combination regimen for treating MAC infections in immunocompromised patients, such as those with advanced HIV.","evidence":"Limited"},{"condition":"Cystic fibrosis exacerbations","description":"Inhaled or intravenous amikacin may be used off-label to manage acute pulmonary exacerbations in cystic fibrosis patients with Pseudomonas aeruginosa infections.","evidence":"Limited"}]
Primary treatment for: Serious bacterial infections
Also treats: Hospital-acquired pneumonia, Complicated urinary tract infections, Intra-abdominal infections, Bone and joint infections, Neonatal sepsis
📋 Drug Information
| Generic Name(s) | Amikacin (250mg) |
| Brand Name | bacticin 250mg injection |
| Manufacturer | SPM Drugs Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OPHTHAL |
| Action Class | Aminoglycosides |
| Route of Administration | Parenteral (intramuscular or intravenous) |
| Storage | Store this medicine at room temperature, between 15°C and 30°C (59°F and 86°F). Protect it from light and excessive heat. Do not freeze. Keep it out of the reach of children. Once the vial is opened, use it immediately or as directed by the healthcare professional. Discard any unused portion. |
| Shelf Life | The shelf life of this medicine is typically 24 to 36 months from the date of manufacture, depending on the specific product. Always check the expiration date on the vial before use. Do not use if the solution is discolored or contains particulate matter. |
| WHO Guideline | The World Health Organization (WHO) includes amikacin in its Model List of Essential Medicines for the treatment of serious bacterial infections. It is recommended for use in healthcare settings where monitoring of kidney function and hearing is available. WHO guidelines emphasize the importance of using amikacin judiciously to prevent antimicrobial resistance. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) has published guidelines on antimicrobial use that include amikacin as a reserve antibiotic for serious infections caused by multidrug-resistant gram-negative bacteria. The guidelines recommend therapeutic drug monitoring and renal function monitoring during therapy. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding irreversibly to the 30S ribosomal subunit of susceptible bacteria. This binding interferes with the initiation of protein synthesis and causes misreading of the genetic code, leading to the production of abnormal, nonfunctional proteins. These faulty proteins disrupt bacterial cell membrane integrity, ultimately causing bacterial cell death. This medicine is bactericidal, meaning it kills bacteria directly, and its action is concentration-dependent, meaning higher concentrations kill bacteria more effectively.
Mechanism Steps
💡 How to Take bacticin 250mg injection
Strength: This medicine is available as a 250mg injection.
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, severity of infection, patient's age, weight, and renal function. For adults with normal kidney function, a typical dose is 15 mg/kg per day, divided into two or three equal doses, administered every 8 to 12 hours. For serious infections, a once-daily dosing regimen of 15 to 20 mg/kg may be used. The maximum daily dose is usually 1.5 grams. Dose adjustments are required for patients with impaired kidney function. Therapeutic drug monitoring may be performed to ensure optimal dosing. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. Dosing in children is weight-based and must be determined by a qualified clinician, taking into account the child's age, weight, and kidney function. Typically, a dose of 15 to 20 mg/kg per day divided every 8 to 12 hours is used, but this must be individualized. |
| Elderly Dosage | Elderly patients are more likely to have reduced kidney function, which can increase the risk of toxicity from this medicine. Therefore, kidney function should be assessed before and during treatment, and the dose should be adjusted accordingly. The dose must be individualized by a qualified clinician based on renal function and clinical response. |
| Renal Impairment | In patients with impaired kidney function, the dose of this medicine must be reduced and the dosing interval extended. The dose is typically adjusted based on creatinine clearance. For patients with a creatinine clearance of 10-50 mL/min, the dose may be reduced by 25-50% and given every 12 to 18 hours. For patients with a creatinine clearance less than 10 mL/min, the dose may be reduced by 50-75% and given every 24 to 48 hours. Therapeutic drug monitoring is highly recommended. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | This medicine is primarily excreted by the kidneys, so hepatic impairment does not significantly affect its pharmacokinetics. No specific dose adjustment is required for patients with liver disease. However, the dose must be individualized by a qualified clinician based on the patient's overall clinical status. |
| Maximum Daily Dose | The maximum daily dose of this medicine is typically 1.5 grams per day, but this may vary based on the indication and patient factors. The dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of bacticin 250mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Furosemide | Major | |
| Gentamicin | Major | |
| Succinylcholine | Major | |
| Amphotericin B | Major | |
| Cyclosporine | Major | |
| Indomethacin | Moderate | |
| Vancomycin | Moderate | |
| Warfarin | Minor | |
| Oral contraceptives | Minor | |
| Digoxin | Minor |
🚨 Major Interactions
- Other aminoglycosides (e.g., gentamicin, tobramycin)
- Loop diuretics (e.g., furosemide, ethacrynic acid)
- Neuromuscular blocking agents (e.g., succinylcholine, vecuronium)
- Amphotericin B
- Cyclosporine
- Cephalosporins (e.g., cephaloridine)
⚡ Moderate Interactions
- Indomethacin
- Beta-lactam antibiotics (e.g., penicillins, cephalosporins)
- Vancomycin
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine. Alcohol can increase the risk of kidney damage and may worsen side effects such as nausea and dizziness. It is best to abstain from alcohol during treatment and for a few days after the last dose.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to amikacin or other aminoglycosides","Pre-existing severe kidney disease","Pre-existing hearing loss or vestibular dysfunction","Myasthenia gravis","Concurrent use with other nephrotoxic or ototoxic drugs, unless benefits outweigh risks"]
⚠️ Warnings & Precautions
["This medicine can cause serious kidney damage. Monitor kidney function closely.","This medicine can cause irreversible hearing loss. Monitor hearing function, especially with prolonged use.","This medicine can cause neuromuscular blockade and respiratory depression, particularly when given rapidly intravenously or to patients with neuromuscular disorders.","This medicine should be used with caution in elderly patients due to reduced kidney function.","This medicine can cause fetal harm when administered to pregnant women. Use only if clearly needed.","This medicine may exacerbate muscle weakness in patients with myasthenia gravis.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","This medicine should not be mixed with other drugs in the same syringe or infusion bag unless compatibility is established."]
🤱 Lactation Safety
This medicine is excreted in human breast milk in small amounts. Because of the potential for serious adverse reactions in nursing infants, including ototoxicity and nephrotoxicity, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother. Consult your doctor before breastfeeding while receiving this medicine.
💊 Overdose Management
In case of overdose, immediate medical attention is required. There is no specific antidote for amikacin overdose. Treatment is supportive and symptomatic. Hemodialysis or peritoneal dialysis may help remove amikacin from the blood, especially in patients with impaired kidney function. Close monitoring of kidney function, hearing, and neuromuscular function is essential. If you suspect an overdose, contact your doctor or a poison control center immediately.
⏰ Missed Dose
This medicine is administered by a healthcare professional, so missed doses are unlikely to occur outside of a hospital setting. If you miss a scheduled dose, contact your healthcare provider as soon as possible. Do not attempt to self-administer a double dose to make up for a missed one. Your doctor will determine the appropriate course of action.
Additional Safety Advice
This medicine is a potent antibiotic that must be administered by a healthcare professional. It is given by injection, so you will not be able to take it at home. While you are receiving this medicine, your doctor will likely monitor your kidney function and hearing through regular tests to catch any early signs of side effects. It is very important to stay well hydrated during treatment to help your kidneys process the medicine. Do not skip doses or stop treatment early, even if you start feeling better, as this can lead to the infection returning and becoming harder to treat. Inform your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements, as this medicine can interact with many other substances. Avoid alcohol while receiving this medicine, as it can increase the risk of kidney problems. If you are pregnant, planning to become pregnant, or breastfeeding, tell your doctor before receiving this medicine, as it may harm the baby. If you experience any ringing in the ears, hearing loss, dizziness, or decreased urination, report it to your doctor immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of kidney damage and hearing loss from this medicine due to age-related decline in kidney function. Kidney function should be assessed before and during treatment, and the dose should be adjusted accordingly. Close monitoring is essential.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before receiving this medicine. This medicine can harm the fetus. Effective contraception should be used during treatment. If you become pregnant while on this medicine, inform your doctor immediately.
🏥 Post-Surgery Considerations
This medicine may be used to treat or prevent infections after surgery. It is important to monitor for signs of infection and report any fever, redness, or drainage from the surgical site. Follow your surgeon's instructions for wound care and follow-up.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, as it may interact with other medicines used during dental procedures. There is no specific contraindication to dental work, but your dentist may need to take precautions if you have a bleeding disorder or are on other medications.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may feel weak or tired. Avoid strenuous exercise until you have recovered from the infection. If you experience muscle weakness or difficulty breathing, seek medical attention immediately. Light activity such as walking may be beneficial once you feel better, but consult your doctor first.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic setting, so you may need to take time off work or arrange for transportation. You may feel tired or weak during treatment, so it is best to rest. Driving may be unsafe if you experience dizziness or muscle weakness. Consult your doctor before resuming normal activities.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. The full course of treatment must be completed to ensure the infection is fully cleared and to prevent resistance. If you experience severe side effects, your doctor may decide to stop the medicine or switch to an alternative. Always follow your doctor's instructions.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to cumulative kidney damage and hearing loss. The risk increases with higher doses and longer duration of therapy. Regular monitoring of kidney function and hearing is essential. If you experience any signs of toxicity, your doctor may adjust the dose or switch to a different antibiotic. Long-term use can also lead to bacterial resistance, making future infections harder to treat.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the bacteria causing the infection, other antibiotics such as beta-lactams, fluoroquinolones, or carbapenems may be used.
Evidence: Well-establishedIn some cases, this medicine may be used in combination with other antibiotics to broaden coverage or achieve synergy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, it is important to be up to date with routine vaccinations. If you are due for any live vaccines, consult your doctor, as antibiotics generally do not interfere with vaccine efficacy, but the underlying infection may be a reason to postpone vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in direct sunlight
✅ DO
Check expiration date before use
❌ DON'T
Do not use if expired or if solution is discolored
✈️ Traveling with This Medicine
This medicine is given by a healthcare professional, so it is not typically self-administered during travel. If you are traveling and need to continue treatment, ensure you have a copy of your prescription and a letter from your doctor explaining the medical necessity. Carry the medicine in its original packaging. Check with the airline and destination country about regulations for carrying injectable medicines. Store the medicine at room temperature and protect it from light. Plan your doses around your travel schedule and consult your doctor for any adjustments.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working quickly, but you may not feel better immediately. Improvement in symptoms such as fever and pain usually occurs within 2 to 3 days. It is important to complete the full course of treatment as prescribed.
A: No, this medicine must be administered by a healthcare professional in a hospital or clinic setting. It requires monitoring for side effects and proper injection technique.
A: The most important side effects are kidney damage and hearing loss. Report any decrease in urine output, swelling, ringing in the ears, or hearing difficulty to your doctor immediately.
A: This medicine can harm the unborn baby, including causing hearing loss and kidney damage. It should only be used during pregnancy if clearly needed and under strict medical supervision.
A: It is best to avoid alcohol during treatment as it can increase the risk of kidney damage and worsen side effects.
🤔 Common Patient Concerns
🔄 Substitutes for bacticin 250mg injection
View AllAlternative brands with exact same active ingredient:
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amipic 250mg injectionPCI Pharmaceuticals ₹6.87 79.8% CHEAPER
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amisac 250mg injectionShreya Life Sciences Pvt Ltd ₹7.62 77.6% CHEAPER
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amikop 250mg injectionKopran Ltd ₹8.00 76.5% CHEAPER
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cachmik 250mg injectionCachet Pharmaceuticals Pvt Ltd ₹8.18 75.9% CHEAPER
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akasyn 250mg injectionGlenmark Pharmaceuticals Ltd ₹9.37 72.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Amikacin can be taken orally.
Fact: Amikacin is not effective orally and must be given by injection. - Myth: Amikacin is safe for everyone.
Fact: Amikacin can cause serious kidney and hearing damage, and is not safe for everyone. It should only be used under medical supervision. - Myth: You can stop amikacin as soon as you feel better.
Fact: You must complete the full course of treatment as prescribed, even if you feel better, to prevent the infection from returning and to reduce the risk of antibiotic resistance. - Myth: Amikacin is a painkiller.
Fact: Amikacin is an antibiotic used to treat bacterial infections. It does not relieve pain.
🔄 Alternative Options
Generic Alternatives
- Amikacin 250mg injection
Brand Alternatives
- Amitax 250mg injection