Anafranil 10mg Tablet (Clomipramine): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Irregular heartbeat or palpitations
- Severe dizziness or fainting
- Seizures
- Difficulty breathing or swelling of face, lips, or tongue
- Signs of serotonin syndrome: agitation, hallucinations, fever, fast heartbeat, muscle stiffness
- Yellowing of skin or eyes, dark urine
- Unusual bleeding or bruising
- Suicidal thoughts or behaviour
If experiencing severe symptoms, call emergency services immediately.
What is sycomip 10mg tablet used for?
This medicine is a tricyclic antidepressant containing clomipramine 10 mg. It is used to treat obsessive-compulsive disorder, depression, and panic disorder. It works by increasing serotonin and norepinephrine in the brain. Common side effects include dry mouth, drowsiness, and constipation. It requires a prescription and should not be stopped suddenly.
- Generic Name: Clomipramine (10mg)
- Manufacturer: Ryon Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 sycomip 10mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोमिप्रामाइन हाइड्रोक्लोराइड 10 मिलीग्राम की एक टैबलेट है, जिसका उपयोग मुख्य रूप से ऑब्सेसिव-कंपल्सिव डिसऑर्डर (ओसीडी), अवसाद (डिप्रेशन), और पैनिक डिसऑर्डर के इलाज के लिए किया जाता है। यह दवा मस्तिष्क में सेरोटोनिन और नॉरएपिनेफ्रिन के स्तर को बढ़ाकर काम करती है, जिससे मूड बेहतर होता है और बार-बार आने वाले विचारों और व्यवहारों को कम करने में मदद मिलती है। यह दवा न्यूरोपैथिक दर्द में भी प्रभावी हो सकती है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें।
साइड इफेक्ट्स: आम दुष्प्रभावों में मुँह सूखना, नींद आना, चक्कर आना, कब्ज, धुंधली दृष्टि, पसीना आना और वजन बढ़ना शामिल हैं। गंभीर दुष्प्रभावों में अनियमित दिल की धड़कन, दौरे, गंभीर एलर्जी, और सेरोटोनिन सिंड्रोम जैसे लक्षण हो सकते हैं। यदि आपको कोई भी असामान्य लक्षण महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें, क्योंकि इससे withdrawal के लक्षण हो सकते हैं। शराब का सेवन न करें क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। अपनी सभी दवाओं के बारे में डॉक्टर को बताएं। नियमित जांच कराते रहें।
💊 sycomip 10mg tablet Uses & Benefits
[{"condition":"Obsessive-compulsive disorder (OCD)","description":"This medicine is effective in reducing the frequency and intensity of obsessive thoughts and compulsive behaviours in adults and children above 10 years.","evidence":"Well-established"},{"condition":"Major depressive disorder","description":"Used to treat symptoms of depression such as persistent sadness, loss of interest, and sleep disturbances when other antidepressants are not effective.","evidence":"Well-established"},{"condition":"Panic disorder with or without agoraphobia","description":"Helps to reduce the frequency and severity of panic attacks and associated avoidance behaviour.","evidence":"Well-established"},{"condition":"Chronic neuropathic pain","description":"Sometimes prescribed to relieve nerve pain, such as diabetic neuropathy or postherpetic neuralgia.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Premature ejaculation","description":"This medicine may be used off-label to delay ejaculation due to its serotonergic effects.","evidence":"Limited"},{"condition":"Cataplexy associated with narcolepsy","description":"Occasionally used to reduce cataplectic attacks, but not a first-line treatment.","evidence":"Limited"}]
Primary treatment for: Obsessive-compulsive disorder (OCD)
Also treats: Major depressive disorder, Panic disorder, Neuropathic pain
📋 Drug Information
| Generic Name(s) | Clomipramine (10mg) |
| Brand Name | sycomip 10mg tablet |
| Manufacturer | Ryon Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Tricyclic antidepressants |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct sunlight. Keep out of reach of children. |
| Shelf Life | Not established from the available information. Refer to the packaging for the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the reuptake of serotonin and norepinephrine in the brain, which increases their availability in the synaptic cleft. It also has anticholinergic, antihistaminic, and alpha-adrenergic blocking properties. The exact mechanism for its therapeutic effects in OCD and depression is not fully understood but is thought to involve these neurotransmitter changes.
Mechanism Steps
💡 How to Take sycomip 10mg tablet
Strength: 10 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual starting dose for adults is 25 mg once daily, gradually increased to a target dose of 100-150 mg per day for OCD, or up to 75-150 mg per day for depression, given in divided doses or as a single bedtime dose. The maximum recommended daily dose is 250 mg. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to treatment. |
| Pediatric Dosage | For children aged 10 years and older with OCD, the starting dose is 25 mg once daily, gradually increased to a maximum of 200 mg per day or 3 mg/kg/day, whichever is lower. Pediatric dosing is not established from available information for other indications. Consult a pediatrician. |
| Elderly Dosage | Elderly patients should start at a lower dose, typically 10-25 mg once daily, and increase gradually. The maximum dose should be lower than in younger adults due to increased sensitivity to side effects. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. Consult your doctor. |
| Maximum Daily Dose | 250 mg per day for adults; 200 mg per day or 3 mg/kg/day for children (whichever is lower). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of sycomip 10mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| SSRIs | Major | |
| Tramadol | Major | |
| Warfarin | Major | |
| CYP2D6 inhibitors | Moderate | |
| CNS depressants | Moderate | |
| Anticholinergics | Moderate | |
| Sympathomimetics | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- MAO inhibitors (e.g., phenelzine, tranylcypromine)
- SSRIs (e.g., fluoxetine, sertraline)
- Tramadol
- Warfarin
⚡ Moderate Interactions
- CYP2D6 inhibitors (e.g., quinidine, fluoxetine, paroxetine)
- CNS depressants (e.g., alcohol, benzodiazepines, opioids)
- Anticholinergic drugs (e.g., benztropine, diphenhydramine)
- Sympathomimetic drugs (e.g., pseudoephedrine, amphetamines)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase drowsiness, dizziness, and impair your ability to drive or operate machinery. It may also worsen depression and increase the risk of serotonin syndrome.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to clomipramine or other tricyclic antidepressants","Concurrent use with MAO inhibitors or within 14 days of stopping MAO inhibitor therapy","Acute recovery phase after myocardial infarction","Severe liver disease","History of seizures","Glaucoma (narrow-angle)","Urinary retention","Use in children under 10 years for OCD"]
⚠️ Warnings & Precautions
["May increase the risk of suicidal thoughts and behaviours, especially in children, adolescents, and young adults. Monitor closely for mood changes.","Can cause sedation and impair ability to drive or operate machinery. Avoid until you know how it affects you.","May cause orthostatic hypotension; rise slowly from sitting or lying positions.","Can cause anticholinergic effects such as dry mouth, constipation, and urinary retention. Use with caution in patients with benign prostatic hyperplasia.","May lower seizure threshold; use with caution in patients with a history of seizures.","Avoid abrupt discontinuation to prevent withdrawal symptoms. Taper gradually under medical supervision.","May interact with many other medicines; always inform your doctor about all medications you are taking.","Use with caution in elderly patients due to increased risk of falls, confusion, and cardiac effects."]
🤱 Lactation Safety
This medicine is excreted in breast milk and may cause serious adverse effects in the nursing infant. Breastfeeding is not recommended while taking this medicine. Consult your doctor for alternative options.
💊 Overdose Management
Overdose of this medicine can be life-threatening. Symptoms include irregular heartbeat, severe drowsiness, confusion, seizures, and coma. If you suspect an overdose, call emergency services immediately. Treatment is supportive and may include activated charcoal, gastric lavage, and management of cardiac arrhythmias. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not stop taking it suddenly, as this can cause withdrawal symptoms such as nausea, headache, and dizziness. Avoid alcohol while taking this medicine because it can increase drowsiness and impair your ability to drive or operate machinery. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. This medicine may interact with many other medicines, so always tell your doctor about all the medicines you are taking, including over-the-counter products and herbal supplements. Keep all appointments for blood tests and heart monitoring as advised. Store this medicine at room temperature away from moisture and heat. Do not share this medicine with anyone else, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the side effects of this medicine, especially drowsiness, dizziness, confusion, and cardiac effects. Start at a lower dose and monitor closely. Regular monitoring of heart, liver, and kidney function is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It may not be safe during pregnancy. Your doctor will weigh the benefits and risks and may recommend alternative treatments.
🏥 Post-Surgery Considerations
Inform your surgeon and anaesthesiologist that you are taking this medicine before any surgery. It may interact with anaesthetic agents and affect blood pressure and heart rhythm. Your doctor may advise temporary discontinuation or dose adjustment.
🦷 Dental Procedures
This medicine can cause dry mouth, which may increase the risk of dental cavities and gum disease. Inform your dentist that you are taking this medicine. Maintain good oral hygiene and regular dental check-ups.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, so avoid activities that require alertness, such as driving or operating heavy machinery, until you know how it affects you. Light to moderate exercise is generally safe, but rise slowly to prevent dizziness.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery. It may also affect concentration. Discuss with your doctor if your job requires alertness. Adjustments to the timing of the dose may help.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or need to discontinue, your doctor will gradually reduce the dose to prevent withdrawal symptoms. Seek immediate medical attention if you have serious side effects.
📅 Long-Term Use Effects
Long-term use of this medicine may require periodic monitoring of blood counts, liver function, and heart rhythm. Some patients may experience weight gain, sexual dysfunction, or dental problems due to dry mouth. Regular follow-up with your doctor is essential to assess the ongoing benefit and adjust the dose as needed. Do not stop the medicine without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
CBT is a first-line treatment for OCD and can be used alone or with medication.
Evidence: Well-establishedSSRIs are often preferred first-line for OCD and depression due to fewer side effects.
Evidence: Well-establishedTechniques such as yoga and meditation can help reduce anxiety and stress.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Consult your doctor regarding vaccinations while taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the timing of your doses. Check local customs regulations regarding prescription medicines before travelling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take 2-4 weeks or longer to notice improvement in symptoms. Side effects may appear earlier.
A: No, you should continue taking it as prescribed. Stopping suddenly can cause withdrawal symptoms and relapse. Consult your doctor before making any changes.
A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, alcohol can increase drowsiness, dizziness, and impair your ability to drive. It may also worsen depression.
A: Yes, weight gain is a common side effect. Maintaining a healthy diet and regular exercise can help manage it.
🤔 Common Patient Concerns
🔄 Substitutes for sycomip 10mg tablet
View AllAlternative brands with exact same active ingredient:
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clomifril 10mg tabletTorrent Pharmaceuticals Ltd ₹14.11 39.8% CHEAPER
-
anafranil 10mg tabletNovartis India Ltd ₹15.56 33.6% CHEAPER
-
imi-ci 10mg tabletSunrise Remedies Pvt Ltd ₹17.81 24% CHEAPER
-
obnil 10mg tabletA N Pharmacia ₹19.05 18.7% CHEAPER
-
liprax 10mg tablet srEmocare ₹22.50 4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is addictive.
Fact: This medicine is not addictive in the sense of causing cravings, but it can cause dependence and withdrawal symptoms if stopped abruptly. It should be tapered gradually under medical supervision. - Myth: This medicine works immediately.
Fact: It may take 2-4 weeks or longer for the full therapeutic effects to appear. Side effects may occur earlier. - Myth: You can stop taking this medicine once you feel better.
Fact: You should continue taking it as prescribed, even if you feel better, to prevent relapse. Stopping suddenly can cause withdrawal symptoms. - Myth: This medicine is only for severe mental illness.
Fact: It is used for various conditions, including OCD, depression, and panic disorder, which can range from mild to severe.
🔄 Alternative Options
Generic Alternatives
- Clomipramine hydrochloride 10 mg tablet
Brand Alternatives
- Anafranil 10 mg tablet