Clonil 10mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Irregular or fast heartbeat
- Severe dizziness or fainting
- Seizures
- Difficulty breathing or swelling of face, lips, or throat
- Yellowing of skin or eyes
- Unusual bleeding or bruising
- Confusion or hallucinations
- Suicidal thoughts or self-harm urges
If experiencing severe symptoms, call emergency services immediately.
What is clomifril 10mg tablet used for?
Clonil 10mg tablet contains Clomipramine, a tricyclic antidepressant used mainly for obsessive-compulsive disorder (OCD) and depression. It works by increasing serotonin and norepinephrine in the brain. It is taken orally, usually at bedtime, and requires 2-4 weeks for full effect. Do not stop abruptly.
- Generic Name: Clomipramine
- Manufacturer: Torrent Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 clomifril 10mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोमिप्रामिन 10 मिलीग्राम टैबलेट के रूप में उपलब्ध है और मुख्य रूप से ऑब्सेसिव-कंपल्सिव डिसऑर्डर (ओसीडी) और अवसाद के इलाज के लिए इस्तेमाल की जाती है। यह मस्तिष्क में सेरोटोनिन और नॉरएपिनेफ्रिन के स्तर को बढ़ाकर मूड को बेहतर बनाती है और चिंता तथा जबरदस्ती के विचारों को कम करती है। यह दवा पैनिक डिसऑर्डर और कुछ पुराने दर्द की स्थितियों में भी प्रभावी हो सकती है। इसे डॉक्टर की सलाह के अनुसार ही लें और अचानक बंद न करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, नींद आना, चक्कर आना, कब्ज, धुंधली दृष्टि और वजन बढ़ना शामिल हैं। गंभीर दुष्प्रभावों में अनियमित दिल की धड़कन, बेहोशी, दौरे और एलर्जी की प्रतिक्रिया हो सकती है। यदि आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या त्वचा पर चकत्ते दिखें तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें। यह दवा नींद और चक्कर ला सकती है, इसलिए वाहन चलाने या मशीन चलाने से बचें। शराब का सेवन न करें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर से सलाह लें। अपनी सभी दवाओं के बारे में डॉक्टर को बताएं।
💊 clomifril 10mg tablet Uses & Benefits
- [{"condition":"Obsessive-compulsive disorder (OCD)","description":"This medicine is effective in reducing the frequency and intensity of obsessive thoughts and compulsive behaviours.
- It is often used when SSRIs are not fully effective.","evidence":"Well-established"},{"condition":"Major depressive disorder","description":"Used to treat depression, especially when other antidepressants have not worked.
- It helps improve mood, sleep, and appetite.","evidence":"Well-established"},{"condition":"Panic disorder","description":"May reduce the frequency and severity of panic attacks and associated anxiety.","evidence":"Moderate"},{"condition":"Chronic pain syndromes","description":"Sometimes prescribed for neuropathic pain, fibromyalgia, and other chronic pain conditions due to its effects on pain pathways.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Premature ejaculation","description":"Clomipramine can delay ejaculation and is sometimes used off-label for this condition.","evidence":"Limited"},{"condition":"Cataplexy in narcolepsy","description":"May help reduce cataplexy attacks, but not a first-line treatment.","evidence":"Limited"}]
Primary treatment for: Obsessive-compulsive disorder (OCD)
Also treats: Major depressive disorder, Panic disorder, Chronic pain syndromes
📋 Drug Information
| Generic Name(s) | Clomipramine |
| Brand Name | Anafranil |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Tricyclic antidepressants |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container, tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by blocking the reuptake of serotonin and norepinephrine in the brain, which increases their availability in the synaptic cleft. It also has anticholinergic, antihistaminic, and alpha-adrenergic blocking properties. The increased neurotransmitter levels help regulate mood, anxiety, and pain perception. Its therapeutic effects in OCD are thought to be primarily due to serotonin reuptake inhibition.
Mechanism Steps
💡 How to Take clomifril 10mg tablet
Strength: Clomipramine 10 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual starting dose for adults is 25 mg once daily, taken at bedtime to minimize daytime sedation. The dose may be gradually increased by your doctor based on your response and tolerability. For OCD, doses typically range from 100 mg to 250 mg daily, but your doctor will determine the right dose for you. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and cardiac effects. Start with a lower dose (e.g., 10-25 mg daily) and titrate slowly under close medical supervision. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be required. Regular monitoring of liver function is advised. |
| Maximum Daily Dose | The maximum recommended daily dose is 250 mg for adults, but doses above 150 mg should be used with caution and under specialist supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of clomifril 10mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| SSRIs | Major | |
| CYP2D6 inhibitors | Major | |
| Anticholinergics | Moderate | |
| CNS depressants | Moderate | |
| Antihypertensives | Moderate | |
| Thyroid medications | Moderate | |
| Cimetidine | Minor | |
| Oral contraceptives | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- MAO inhibitors (e.g., phenelzine, tranylcypromine)
- SSRIs (e.g., fluoxetine, sertraline)
- Other tricyclic antidepressants
- CYP2D6 inhibitors (e.g., quinidine, fluoxetine, paroxetine)
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., benztropine, diphenhydramine)
- CNS depressants (e.g., alcohol, benzodiazepines, opioids)
- Antihypertensives (e.g., beta-blockers, clonidine)
- Thyroid medications
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase drowsiness, dizziness, and impair your ability to think and react. It may also worsen depression and anxiety.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to clomipramine or other tricyclic antidepressants","Concurrent use with MAO inhibitors or within 14 days of stopping an MAOI","Recent myocardial infarction","Severe liver disease","Narrow-angle glaucoma","Urinary retention","Concurrent use with cisapride"]
⚠️ Warnings & Precautions
["May increase risk of suicidal thoughts and behaviors in children, adolescents, and young adults. Monitor closely.","May cause drowsiness and impair ability to drive or operate machinery.","May cause orthostatic hypotension; advise patients to rise slowly.","Use with caution in patients with epilepsy, as it may lower seizure threshold.","May worsen symptoms of psychosis or mania in susceptible individuals.","Do not stop abruptly; taper gradually to avoid withdrawal symptoms.","Use with caution in patients with hyperthyroidism or those on thyroid medication.","May affect blood sugar control in diabetics; monitor glucose levels."]
🤱 Lactation Safety
Clomipramine is excreted in breast milk. Breastfeeding is not recommended while taking this medicine unless the benefits outweigh the risks. Consult your doctor.
💊 Overdose Management
Overdose of this medicine can be life-threatening. Symptoms include irregular heartbeat, severe drowsiness, confusion, seizures, and coma. Seek emergency medical help immediately. Treatment is supportive and may include gastric lavage, activated charcoal, and management of cardiac arrhythmias. There is no specific antidote. Physostigmine may be used cautiously for severe anticholinergic effects but is not routinely recommended.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop suddenly without medical advice. This medicine may make you feel drowsy or dizzy, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Stand up slowly from a sitting or lying position to prevent dizziness. Avoid alcohol while taking this medicine as it can worsen drowsiness and affect your mood. Inform your doctor if you have heart problems, epilepsy, glaucoma, difficulty urinating, or liver or kidney disease. Tell your doctor about all other medicines you are taking, especially MAOIs, other antidepressants, and blood thinners. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of reach of children and store it as directed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and cardiac effects. Start with a lower dose and titrate slowly. Regular monitoring of heart and kidney function is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before starting or continuing this medicine. The risks and benefits should be carefully weighed. Do not stop suddenly without medical advice.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect blood pressure and heart rhythm. Your doctor may advise temporary dose adjustments.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It can cause dry mouth, which may increase the risk of dental problems. Maintain good oral hygiene and stay hydrated.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness. Avoid strenuous exercise or activities that require alertness until you know how it affects you. Stay hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery. It may also affect concentration. Discuss with your doctor before resuming such activities. It is important to take it at bedtime to minimize daytime sedation.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects or need to discontinue, your doctor will guide you through a gradual taper to avoid withdrawal symptoms.
📅 Long-Term Use Effects
Long-term use of this medicine may require periodic monitoring of heart function, liver function, and blood counts. It can cause weight gain and sexual dysfunction. Do not stop suddenly. Regular follow-up with your doctor is important to assess ongoing benefits and side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
CBT is effective for OCD and depression and can be used alongside or instead of medication.
Evidence: Well-establishedSSRIs are often first-line for OCD and depression with a better side effect profile.
Evidence: Well-establishedMindfulness and relaxation can help reduce anxiety symptoms.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, consult your doctor before receiving any live vaccines while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the timing of your doses. Check local customs regulations for controlled substances.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take 2 to 4 weeks for initial effects and up to 10 to 12 weeks for full benefits in OCD.
A: No, you should not stop abruptly. Consult your doctor for a gradual taper to avoid withdrawal symptoms.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Consult your doctor. The use of this medicine during pregnancy should be based on a careful risk-benefit assessment.
🤔 Common Patient Concerns
🔄 Substitutes for clomifril 10mg tablet
View AllAlternative brands with exact same active ingredient:
-
anafranil 10mg tabletNovartis India Ltd ₹15.56 10.3% COSTLIER
-
imi-ci 10mg tabletSunrise Remedies Pvt Ltd ₹17.81 26.2% COSTLIER
-
obnil 10mg tabletA N Pharmacia ₹19.05 35% COSTLIER
-
liprax 10mg tablet srEmocare ₹22.50 59.5% COSTLIER
-
clomicare 10mg tabletLifecare Neuro Products Ltd ₹23.44 66.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Clonil 10mg is a sleeping pill.
Fact: It is an antidepressant used for OCD and depression, not a sleeping pill. It may cause drowsiness as a side effect. - Myth: You can stop taking Clonil 10mg once you feel better.
Fact: You should never stop abruptly. Always consult your doctor for a gradual taper to avoid withdrawal symptoms. - Myth: Clonil 10mg is addictive.
Fact: It is not considered addictive, but it can cause dependence if stopped suddenly. It should be tapered under medical supervision.
🔄 Alternative Options
Generic Alternatives
- Clomipramine 10mg tablet
Brand Alternatives
- Clonil 10mg tablet