Shreyzid Syrup: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Palpitations or irregular heartbeat
- Fainting or dizziness
- Severe abdominal pain
- Blood in vomit or stool
- Signs of allergic reaction (rash, swelling, difficulty breathing)
- Yellowing of eyes or skin
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is sur-d oral suspension used for?
This medicine is a combination of domperidone and sucralfate used to treat acid reflux, gastritis, and functional dyspepsia. It works by improving stomach emptying and protecting the stomach lining.
- Generic Name: Domperidone (5mg) + Sucralfate (500mg)
- Manufacturer: Chemo Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 sur-d oral suspension के बारे में (Hindi Summary)
उपयोग: यह दवा डोम्पेरिडोन और सुक्राल्फेट का संयोजन है, जिसका उपयोग एसिड रिफ्लक्स, गैस्ट्र्रिटिस और अपच के लक्षणों के इलाज के लिए किया जाता है। यह पेट खाली होने में मदद करती है और पेट की परत की रक्षा करती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, सिरदर्द, पेट में ऐंठन, दस्त और जी मिचलाना शामिल हैं। गंभीर दुष्प्रभावों में अनियमित दिल की धड़कन, एलर्जी प्रतिक्रिया और स्तन में दर्द या स्राव हो सकता है। यदि आपको धड़कन तेज होना, चक्कर आना या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक को न बढ़ाएं और न ही लंबे समय तक बिना सलाह के लें। उपयोग से पहले बोतल को अच्छी तरह हिलाएं। सटीक खुराक के लिए मापने वाला कप या सिरिंज का उपयोग करें। इस दवा के साथ शराब न लें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।
💊 sur-d oral suspension Uses & Benefits
[{"condition":"Gastroesophageal reflux disease (GERD)","description":"Helps reduce acid reflux symptoms by improving gastric emptying and protecting the esophageal mucosa.","evidence":"Moderate"},{"condition":"Functional dyspepsia","description":"Relieves symptoms such as postprandial fullness, early satiety, and upper abdominal discomfort.","evidence":"Moderate"},{"condition":"Gastritis","description":"Soothes inflamed stomach lining and reduces associated nausea and pain.","evidence":"Limited"},{"condition":"Nausea and vomiting associated with delayed gastric emptying","description":"Domperidone component helps accelerate stomach emptying and reduces nausea.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Diabetic gastroparesis","description":"Sometimes used to improve gastric emptying in diabetic patients, but evidence is limited and requires specialist supervision.","evidence":"Limited"}]
Primary treatment for: Gastroesophageal reflux disease (GERD)
Also treats: Functional dyspepsia, Gastritis, Nausea and vomiting
📋 Drug Information
| Generic Name(s) | Domperidone (5mg) + Sucralfate (500mg) |
| Brand Name | sur-d oral suspension |
| Manufacturer | Chemo Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Do not freeze. Keep the bottle tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Domperidone is a peripheral dopamine D2 receptor antagonist that blocks dopamine receptors in the chemoreceptor trigger zone and the gastrointestinal tract, thereby enhancing gastric motility and accelerating gastric emptying without significant central nervous system effects. Sucralfate is a complex of aluminum hydroxide and sulfated sucrose that polymerizes in the acidic environment of the stomach to form a viscous paste. This paste selectively binds to damaged mucosa, creating a physical barrier that protects against acid, pepsin, and bile salts. Together, they improve upper gastrointestinal symptoms by promoting motility and protecting the mucosal lining.
Mechanism Steps
💡 How to Take sur-d oral suspension
Strength: Each 5 mL of syrup contains Domperidone 5 mg and Sucralfate 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 mL (containing domperidone 5 mg and sucralfate 500 mg) taken orally three to four times daily, preferably 30 minutes before meals and at bedtime. However, the exact dose and frequency must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, and renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially cardiac effects and drowsiness. Dose adjustment may be necessary based on renal and hepatic function. Use with caution. |
| Renal Impairment | In patients with severe renal impairment (creatinine clearance <30 mL/min), domperidone dose should be reduced or avoided. Sucralfate may accumulate aluminum; use with caution. Consult a nephrologist. |
| Hepatic Impairment | In patients with hepatic impairment, domperidone should be used with caution due to reduced metabolism. Dose reduction may be required. Sucralfate is generally safe but monitor for side effects. |
| Maximum Daily Dose | The maximum recommended daily dose of domperidone is 30 mg (which corresponds to 60 mL of this syrup). Do not exceed this dose without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of sur-d oral suspension
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Clarithromycin | Major | |
| Amiodarone | Major | |
| Levodopa | Moderate | |
| Warfarin | Moderate | |
| Digoxin | Moderate | |
| Antacids | Moderate | |
| Tetracycline | Minor | |
| Ciprofloxacin | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Ketoconazole, itraconazole, clarithromycin, ritonavir
- QT-prolonging drugs (e.g., amiodarone, sotalol, haloperidol)
- Antacids containing aluminum or magnesium
⚡ Moderate Interactions
- Levodopa
- Warfarin
- Digoxin
🍷 Alcohol Interaction
Alcohol may worsen gastrointestinal irritation and increase the risk of side effects such as drowsiness and dizziness. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to domperidone or sucralfate","Prolactin-releasing pituitary tumor (prolactinoma)","Gastrointestinal obstruction, perforation, or active bleeding","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["Use with caution in patients with heart disease or electrolyte imbalances.","Avoid in patients with known QT prolongation.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not use for prolonged periods without medical supervision.","Sucralfate may cause constipation; increase dietary fiber and fluid intake.","Use with caution in elderly patients due to increased risk of side effects.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding."]
🤱 Lactation Safety
Domperidone passes into breast milk and may cause side effects in the infant. Sucralfate is minimally absorbed and unlikely to affect the breastfed infant. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause drowsiness, extrapyramidal symptoms, and QT prolongation. Seek immediate medical attention. Treatment is supportive and symptomatic. Activated charcoal may be considered if ingestion is recent. Monitor ECG and vital signs.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not increase the dose or take it for longer than recommended without medical advice. Shake the bottle well before each use if it is a suspension. Use a proper measuring device to ensure accurate dosing. Avoid alcohol while taking this medicine because it can worsen stomach irritation and increase drowsiness. Inform your doctor about all other medicines you take, especially antacids, antibiotics, and heart medications. If you have kidney or liver problems, your doctor may need to adjust the dose or monitor you more closely. Do not use this medicine if you are pregnant or breastfeeding without consulting your doctor. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to cardiac side effects and drug interactions. Use with caution and monitor renal function.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor. Domperidone may not be suitable; alternative treatments may be considered.
🏥 Post-Surgery Considerations
Use with caution after gastrointestinal surgery. Consult your surgeon before taking this medicine.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may affect bleeding risk or interact with anesthetics.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid vigorous exercise immediately after meals as it may worsen reflux. Light walking after meals can aid digestion.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It should not significantly impact desk work.
🛑 When to Stop This Medicine
Do not stop this medicine abruptly without consulting your doctor. If you experience serious side effects like irregular heartbeat or allergic reactions, stop immediately and seek medical help.
📅 Long-Term Use Effects
Long-term use of this medicine should be under medical supervision. Prolonged use of domperidone may increase the risk of cardiac arrhythmias and hyperprolactinemia. Sucralfate may cause constipation and, rarely, aluminum accumulation in patients with kidney disease. Regular monitoring of symptoms, renal function, and cardiac status is advised.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Dietary changes, weight loss, and head elevation can reduce reflux symptoms.
Evidence: Well-establishedMay be prescribed for more severe acid reflux.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. Continue routine vaccinations as per schedule.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from direct sunlight. If traveling across time zones, adjust dosing times gradually under medical guidance. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling relief within 30 to 60 minutes after taking a dose, but consistent use for a few days is often needed for full benefit.
A: It can interact with several medicines, especially those affecting heart rhythm or stomach acid. Always inform your doctor about all medicines you take.
A: Domperidone is not recommended during pregnancy unless clearly needed. Sucralfate is considered safe. Consult your doctor before use.
🤔 Common Patient Concerns
🔄 Substitutes for sur-d oral suspension
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken indefinitely for acidity.
Fact: It should be used only for the duration prescribed by your doctor. Long-term use requires monitoring. - Myth: It is safe to take with any other medication.
Fact: It can interact with several drugs, including heart medications and antibiotics. Always consult your doctor.
🔄 Alternative Options
Generic Alternatives
- Domperidone + Sucralfate oral suspension (generic)
Brand Alternatives
- Shreyzid Syrup