Sulbact 250 mg/125 mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or wheezing
- Swelling of the face, lips, tongue, or throat
- Severe skin rash with blistering or peeling
- Severe or persistent diarrhea, especially with blood or mucus
- Seizures or confusion
- Decreased urine output or swelling in the legs
- Yellowing of the skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is Sulria 250mg/125mg Tablet used for?
This medicine is a combination antibiotic injection containing ampicillin and sulbactam. It is used to treat moderate to severe bacterial infections, including skin, abdominal, gynecological, and respiratory tract infections. It works by killing bacteria and preventing their resistance to ampicillin.
- Generic Name: Ampicillin (250mg) + Sulbactam (125mg)
- Manufacturer: Riasmo Lifesciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Sulria 250mg/125mg Tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एक संयोजन एंटीबायोटिक इंजेक्शन है जिसमें एम्पीसिलीन और सल्बैक्टम होते हैं। इसका उपयोग मध्यम से गंभीर जीवाणु संक्रमणों के इलाज के लिए किया जाता है, जैसे त्वचा और मुलायम ऊतक संक्रमण, पेट के अंदर के संक्रमण, स्त्री रोग संबंधी संक्रमण, और श्वसन पथ के संक्रमण। यह दवा जीवाणुओं को मारती है और उनके प्रतिरोध को रोकती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, लालिमा या सूजन, दस्त, मतली, उल्टी और त्वचा पर दाने शामिल हैं। गंभीर दुष्प्रभावों में एनाफिलेक्सिस, गंभीर दस्त, और त्वचा की गंभीर प्रतिक्रियाएं शामिल हो सकती हैं। किसी भी असामान्य लक्षण को तुरंत अपने डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल एक योग्य स्वास्थ्य पेशेवर द्वारा दी जानी चाहिए। इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों के बारे में बताएं, विशेष रूप से गुर्दे की बीमारी, यकृत की बीमारी, या एंटीबायोटिक्स से एलर्जी। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं तो अपने डॉक्टर को बताएं। गंभीर एलर्जी प्रतिक्रिया के लक्षणों जैसे सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर त्वचा पर दाने होने पर तुरंत आपातकालीन चिकित्सा सहायता लें।
💊 Sulria 250mg/125mg Tablet Uses & Benefits
[{"condition":"Skin and soft tissue infections","description":"Used for treating bacterial infections of the skin and underlying tissues caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Effective against mixed aerobic and anaerobic bacterial infections within the abdominal cavity.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Used for pelvic inflammatory disease and other female reproductive tract infections.","evidence":"Well-established"},{"condition":"Respiratory tract infections","description":"Treats lower respiratory tract infections such as pneumonia and bronchitis when caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"May be used for osteomyelitis and septic arthritis caused by susceptible bacteria.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Prophylaxis in surgical procedures","description":"Sometimes used off-label to prevent surgical site infections in certain high-risk procedures.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Skin and soft tissue infections, Intra-abdominal infections, Gynecological infections, Respiratory tract infections, Bone and joint infections
📋 Drug Information
| Generic Name(s) | Ampicillin (250mg) + Sulbactam (125mg) |
| Brand Name | Sulria 250mg/125mg Tablet |
| Manufacturer | Riasmo Lifesciences |
| Packaging / Form | strip of 10 tablets (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Parenteral (intravenous or intramuscular injection) |
| Storage | Store the unreconstituted powder at room temperature (20°C to 25°C). After reconstitution, the solution should be used immediately or stored as directed by the manufacturer. Protect from light and moisture. |
| Shelf Life | The shelf life of the unreconstituted powder is typically 24 to 36 months from the date of manufacture. Refer to the product packaging for the exact expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines ampicillin, a penicillin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, and sulbactam, a beta-lactamase inhibitor that irreversibly inhibits certain beta-lactamase enzymes. This prevents the destruction of ampicillin by beta-lactamase-producing bacteria, thereby extending its antibacterial spectrum.
Mechanism Steps
💡 How to Take Sulria 250mg/125mg Tablet
Strength: Each vial contains ampicillin sodium equivalent to 250 mg ampicillin and sulbactam sodium equivalent to 125 mg sulbactam.
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the type and severity of infection, the patient's renal function, and other clinical factors. A common adult dose is 1.5 g to 3 g (ampicillin/sulbactam) administered intravenously or intramuscularly every 6 hours. The maximum recommended daily dose is 12 g (8 g ampicillin + 4 g sulbactam). For patients with renal impairment, the dose and/or dosing interval must be adjusted according to creatinine clearance. This information is for educational purposes only and does not replace professional medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have decreased renal function, which can increase the risk of toxicity. Dose selection should be cautious, and renal function should be monitored. Dose adjustment may be necessary based on creatinine clearance. |
| Renal Impairment | In patients with renal impairment, the dose and dosing interval should be adjusted based on creatinine clearance. For creatinine clearance of 15-29 mL/min, the usual dose is given every 12 hours. For creatinine clearance of 5-14 mL/min, the usual dose is given every 24 hours. For patients on hemodialysis, an additional dose should be given after each dialysis session. Close monitoring is required. |
| Hepatic Impairment | No specific dosage adjustment is provided for patients with hepatic impairment. However, caution is advised, and liver function should be monitored during therapy. |
| Maximum Daily Dose | The maximum recommended daily dose is 12 g (8 g ampicillin + 4 g sulbactam) for adults with normal renal function. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Sulria 250mg/125mg Tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Allopurinol | Major | |
| Oral contraceptives | Moderate | |
| Probenecid | Moderate | |
| Aminoglycosides | Moderate | |
| Chloramphenicol | Minor | |
| Tetracyclines | Minor |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Allopurinol
⚡ Moderate Interactions
- Oral contraceptives
- Probenecid
- Aminoglycosides
🍷 Alcohol Interaction
Alcohol may worsen gastrointestinal side effects such as nausea and diarrhea. It is advisable to avoid alcohol during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to ampicillin, sulbactam, or any other penicillin or beta-lactam antibiotic.","History of severe allergic reaction (e.g., anaphylaxis) to any beta-lactam antibiotic.","Concurrent use with live bacterial vaccines (e.g., typhoid vaccine) may reduce efficacy."]
⚠️ Warnings & Precautions
["Serious and occasionally fatal hypersensitivity reactions (anaphylaxis) have been reported. Before initiating therapy, inquire about previous hypersensitivity to penicillins, cephalosporins, or other allergens.","Clostridioides difficile-associated diarrhea (CDAD) has been reported. Consider this diagnosis in patients who present with diarrhea subsequent to administration of antibacterial agents.","Use with caution in patients with renal impairment. Dose adjustment may be necessary.","Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, appropriate measures should be taken.","Prescribing this medicine in the absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit and increases the risk of drug-resistant bacteria."]
🤱 Lactation Safety
Ampicillin and sulbactam are excreted in human milk in low concentrations. Caution should be exercised when administered to a nursing woman. Monitor the infant for diarrhea or thrush.
💊 Overdose Management
Overdose with this medicine may cause neuromuscular excitability or seizures, especially in patients with renal impairment. Treatment is symptomatic and supportive. Ampicillin and sulbactam can be removed from the blood by hemodialysis. In case of overdose, discontinue the drug and initiate supportive care.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If a dose is missed, it should be administered as soon as possible. However, if it is almost time for the next dose, the missed dose should be skipped, and the regular dosing schedule resumed. Do not double the dose to catch up.
Additional Safety Advice
This medicine must only be given by a healthcare professional. Before receiving this medicine, inform your doctor about all your medical conditions, especially kidney disease, liver disease, or any allergies to antibiotics. Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not attempt to self-administer this injection. If you experience any signs of a severe allergic reaction such as difficulty breathing, swelling of the face or throat, or a severe skin rash, seek emergency medical help immediately. Diarrhea that is severe or persists may be a sign of a serious bowel infection and should be reported to your doctor. Your doctor may monitor your kidney and liver function, as well as your blood counts, during treatment.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have decreased renal function, which can increase the risk of side effects. Dose adjustment based on creatinine clearance is recommended. Monitor renal function closely.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. It is classified as Pregnancy Category B, but use only if clearly needed. Inform your doctor if you become pregnant during treatment.
🏥 Post-Surgery Considerations
This medicine may be used to treat or prevent surgical site infections. It is often administered before, during, or after surgery as deemed appropriate by your surgeon. Follow your surgeon's instructions regarding its use.
🦷 Dental Procedures
This medicine may be used for dental infections or as prophylaxis before dental procedures in certain high-risk patients. Consult your dentist or doctor for appropriate use.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may feel tired or weak. Avoid strenuous exercise until you have fully recovered. Light activity such as walking is generally safe, but consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a healthcare setting, so it may require time off work for administration. You may experience fatigue or diarrhea, which can affect your daily activities. Avoid driving or operating heavy machinery if you feel unwell.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early may allow the infection to return and contribute to antibiotic resistance. Your doctor will determine the appropriate duration of therapy based on your condition.
📅 Long-Term Use Effects
Prolonged use of this medicine may lead to overgrowth of non-susceptible organisms, including fungi, and may increase the risk of antibiotic resistance. Long-term use may also rarely cause blood dyscrasias, liver enzyme elevations, or kidney problems. Regular monitoring of blood counts, liver and kidney function is advised for patients on prolonged therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Once you improve, your doctor may switch you to oral antibiotics to complete the treatment.
Evidence: Well-establishedIf you are allergic to penicillins, alternative antibiotics such as cephalosporins or fluoroquinolones may be used.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the efficacy of live bacterial vaccines (e.g., typhoid vaccine). Avoid vaccination with live bacterial vaccines during treatment. Inactivated vaccines are generally safe to administer.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze the unreconstituted powder
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light and moisture
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting, so travel advice is limited. If you are prescribed this medicine as part of a treatment regimen, ensure you carry a copy of your prescription and medical records. If you need to travel while on therapy, coordinate with your healthcare provider to arrange for administration at your destination. Store the unreconstituted vials at room temperature, away from direct sunlight and moisture. Always carry medicines in their original packaging with the prescription label intact. Check with the airline and destination country regarding regulations for carrying injectable medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours after starting treatment, but it is important to complete the full course as prescribed.
A: No, this medicine must be administered by a healthcare professional in a clinical setting.
A: Contact your healthcare provider to reschedule. Do not attempt to self-administer.
🤔 Common Patient Concerns
🔄 Substitutes for Sulria 250mg/125mg Tablet
View AllAlternative brands with exact same active ingredient:
-
sulbact 250 mg/125 mg injectionBiochem Pharmaceutical Industries ₹24.10 94% CHEAPER
-
ampirok tablet dtAstrum Healthcare Pvt Ltd ₹185.00 53.8% CHEAPER
-
synmega 250mg/125mg tabletAlniche Life Sciences Pvt Ltd ₹420.00 5% COSTLIER
-
aticef 250 mg/125 mg tabletAlgen Healthcare Limited ₹460.00 15% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: It is essential to complete the full course of treatment as prescribed by your doctor to prevent the infection from returning and to avoid antibiotic resistance. - Myth: This medicine is safe to self-administer at home.
Fact: This medicine is an injectable antibiotic and must only be administered by a qualified healthcare professional in a clinical setting.
🔄 Alternative Options
Generic Alternatives
- Ampicillin and sulbactam injection (generic)
Brand Alternatives
- Sulbact 250 mg/125 mg injection