Egpride 50 Tablet (Levosulpiride 50mg): Complete Uses, Side Effects, and Safety Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- High fever with severe muscle stiffness, confusion, or sweating
- Palpitations, fainting, or chest discomfort
- Uncontrollable shaking, muscle rigidity, or difficulty walking
- Swelling of the face, lips, or throat, or difficulty breathing
- Yellowing of the eyes or skin, or dark urine
- Severe abdominal pain or persistent vomiting
- Unusual repetitive movements of the face, tongue, or limbs
If experiencing severe symptoms, call emergency services immediately.
What is sulgiride 50mg tablet used for?
This medicine contains Levosulpiride 50mg, a dopamine D2 receptor antagonist used to treat nausea, vomiting, and functional dyspepsia. It works by blocking dopamine signals in the brain and gut, which reduces nausea and improves stomach emptying. It is usually taken before meals, and it can cause drowsiness, so avoid driving until you know how it affects you.
- Generic Name: Levosulpiride (50mg)
- Manufacturer: East West Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 sulgiride 50mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा लेवोसल्पिराइड 50 मिलीग्राम की गोली है, जिसका उपयोग मुख्य रूप से उल्टी, जी मिचलाना और पेट से जुड़ी समस्याओं जैसे कार्यात्मक अपच में किया जाता है। यह दवा दिमाग और पेट में डोपामिन नामक रसायन को रोककर उल्टी की भावना को कम करती है और पेट खाली होने की प्रक्रिया को तेज करती है। इसे आमतौर पर खाने से पहले लेने की सलाह दी जाती है। इस दवा से नींद आ सकती है, इसलिए गाड़ी चलाने या मशीन चलाने से बचें। इसे डॉक्टर की सलाह के बिना लंबे समय तक न लें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना और सिरदर्द शामिल हैं। कुछ लोगों में स्तनों में दर्द, दूध का स्राव या मासिक धर्म में बदलाव हो सकता है। कभी-कभी हाथ-पैर कांपना, मांसपेशियों में अकड़न या बेचैनी हो सकती है। बहुत कम मामलों में तेज बुखार, मांसपेशियों में गंभीर अकड़न और भ्रम जैसी गंभीर स्थिति हो सकती है, जिसके लिए तुरंत डॉक्टर से मिलना चाहिए। अगर कोई भी दुष्प्रभाव लंबे समय तक बना रहे या गंभीर लगे, तो डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें और अपनी मर्जी से मात्रा न बढ़ाएँ या घटाएँ। गोली को पानी के साथ पूरा निगलें और खाने से पहले लें, क्योंकि इससे दवा जल्दी असर करती है। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक गाड़ी चलाने या मशीन चलाने से बचें। इस दवा के साथ शराब न पिएँ, क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएँ, खासकर अवसाद, दिल की धड़कन, पार्किंसन या मानसिक बीमारी की दवाओं के बारे में। किडनी या लिवर की बीमारी हो तो डॉक्टर को जरूर बताएँ। दवा को बच्चों से दूर और ठंडी सूखी जगह पर रखें।
💊 sulgiride 50mg tablet Uses & Benefits
[{"condition":"Nausea and vomiting","description":"This medicine is used to control nausea and vomiting by blocking dopamine D2 receptors in the chemoreceptor trigger zone of the brain.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"It helps relieve post-meal fullness, upper abdominal bloating, early satiety, and discomfort in patients with functional dyspepsia.","evidence":"Well-established"},{"condition":"Diabetic gastroparesis","description":"This medicine improves delayed gastric emptying in some patients with diabetic gastroparesis, although evidence is moderate.","evidence":"Moderate"},{"condition":"Gastroesophageal reflux disease (GERD) as add-on","description":"Sometimes used as an add-on to acid-suppressing therapy to improve gastric emptying and reduce regurgitation symptoms.","evidence":"Limited"},{"condition":"Non-ulcer dyspepsia with delayed gastric emptying","description":"Prescribed when dyspeptic symptoms are thought to be related to slow stomach emptying.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Premature ejaculation","description":"Levosulpiride has been studied off-label for premature ejaculation because of its effect on dopamine pathways, but it is not a standard treatment.","evidence":"Limited"},{"condition":"Tourette syndrome and tic disorders","description":"Occasionally used off-label for tic disorders based on dopamine-blocking activity, but not a first-line option.","evidence":"Limited"},{"condition":"Depression augmentation","description":"Sometimes added to antidepressant therapy in specialist settings, but evidence is not strong enough for routine use.","evidence":"Limited"}]
Primary treatment for: Nausea and vomiting
Also treats: Functional dyspepsia, Diabetic gastroparesis, Gastroesophageal reflux disease, Non-ulcer dyspepsia
📋 Drug Information
| Generic Name(s) | Levosulpiride (50mg) |
| Brand Name | sulgiride 50mg tablet |
| Manufacturer | East West Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Atypical Antipsychotics |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C, in a dry place away from direct sunlight and moisture. Keep the tablets in their original container and out of the reach of children. |
| Shelf Life | Not established from the available information. Refer to the expiry date printed on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Levosulpiride is a substituted benzamide that acts mainly as a selective dopamine D2 receptor antagonist. By blocking D2 receptors in the chemoreceptor trigger zone of the area postrema, it reduces the nausea signal sent to the vomiting centre. At the same time, it blocks D2 receptors in the gastrointestinal tract, which removes dopamine-mediated inhibition of acetylcholine release and thereby improves gastric and intestinal motility. This dual action explains why the medicine is useful both for nausea and for symptoms of delayed gastric emptying. Levosulpiride also has weak activity at serotonin receptors, which may contribute to its prokinetic effect. It is the levo-enantiomer of sulpiride and is generally used at lower doses than sulpiride.
Mechanism Steps
💡 How to Take sulgiride 50mg tablet
Strength: Levosulpiride 50mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 50mg taken two to three times a day before meals, but the exact dose and frequency depend on the condition being treated, the severity of symptoms, and the patient's kidney and liver function. Some patients may need a lower dose if they have kidney or liver problems or if they are elderly. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not change the dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and movement-related symptoms. A lower starting dose may be advised, and kidney function should be checked before and during treatment. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Levosulpiride is mainly excreted by the kidneys, so the dose may need to be reduced in patients with moderate to severe kidney impairment. In severe renal impairment, this medicine is generally avoided unless clearly necessary. Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | Levosulpiride undergoes some liver metabolism, so caution is advised in patients with liver disease. The dose may need to be reduced in severe hepatic impairment. Dose must be individualized by a qualified clinician based on hepatic function. |
| Maximum Daily Dose | The maximum daily dose is not established from the available information for this specific product. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of sulgiride 50mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Metoclopramide | Major | |
| Levodopa | Major | |
| Amiodarone | Major | |
| Haloperidol | Major | |
| Diazepam | Moderate | |
| Amlodipine | Moderate | |
| Lithium | Moderate | |
| Aluminium hydroxide antacid | Minor | |
| Furosemide | Minor | |
| Morphine | Minor |
🚨 Major Interactions
- Other dopamine antagonists such as metoclopramide, haloperidol, or risperidone
- Levodopa and other dopamine agonists
- Medicines that prolong the QT interval such as amiodarone, sotalol, or haloperidol
- Alcohol
⚡ Moderate Interactions
- Sedatives and hypnotics such as benzodiazepines
- Antihypertensive medicines
- Anticholinergic medicines
- Lithium
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it increases drowsiness, dizziness, and the risk of falls. Alcohol can also worsen the sedative effect on the brain and may increase the chance of movement-related side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to Levosulpiride or other benzamide medicines","Pheochromocytoma","Epilepsy or a history of seizures","Severe kidney disease unless specifically advised by a specialist","Severe liver disease unless specifically advised by a specialist","Breast cancer or prolactin-dependent tumours","Concurrent use with levodopa or other dopamine agonists","Pregnancy and breastfeeding unless clearly advised by a doctor"]
⚠️ Warnings & Precautions
["This medicine can cause drowsiness and dizziness, so avoid driving or operating machinery until you know how it affects you.","Do not drink alcohol while taking this medicine.","Use with caution in elderly patients, who are more prone to movement-related side effects and falls.","Use with caution in patients with heart disease or a history of abnormal heart rhythms.","Use with caution in patients with kidney or liver disease, as dose adjustment may be needed.","Do not use for longer than your doctor advises without a review.","Tell your doctor if you have Parkinson's disease, as this medicine can worsen symptoms.","Tell your doctor if you are pregnant, planning pregnancy, or breastfeeding."]
🤱 Lactation Safety
Levosulpiride passes into breast milk and can raise prolactin levels, which may affect milk production. It is generally not recommended during breastfeeding unless your doctor advises otherwise after weighing the benefits and risks.
💊 Overdose Management
Overdose of this medicine may cause severe drowsiness, dizziness, low blood pressure, abnormal heart rhythms, or movement-related symptoms. If you suspect an overdose, seek emergency medical care immediately. Treatment is supportive, with monitoring of heart rhythm, blood pressure, and breathing. There is no specific antidote, and activated charcoal may be considered by a doctor if the overdose is recent.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, provided there is still a long time before your next dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor and do not increase or decrease the dose on your own. Swallow the tablet whole with a glass of water, preferably before meals, because taking it on an empty stomach helps it work better for nausea and stomach emptying problems. Avoid driving, riding a motorcycle, or operating heavy machinery until you know how this medicine affects your alertness, since drowsiness and dizziness are common. Do not drink alcohol while taking this medicine because alcohol can increase drowsiness and worsen dizziness. Tell your doctor about all other medicines you take, especially medicines for depression, heart rhythm problems, Parkinson's disease, or other antipsychotic medicines, because some combinations can be unsafe. If you have kidney or liver disease, your doctor may need to adjust the dose or monitor you more closely. Do not take this medicine for longer than your doctor advises without a review, and do not share it with anyone else. Keep the tablets in their original packaging, away from moisture and direct sunlight, and out of the reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to experience drowsiness, dizziness, and movement-related side effects from this medicine. They are also more prone to falls. A lower starting dose may be advised, and kidney function should be checked before and during treatment. Regular review is important to avoid long-term complications.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss this medicine with your doctor before conception. Levosulpiride is not recommended during pregnancy unless the benefit clearly outweighs the risk. Your doctor may consider alternative treatments that are safer during pregnancy.
🏥 Post-Surgery Considerations
This medicine may be used after surgery to treat nausea and vomiting, but it should only be given under medical supervision. It can cause drowsiness, which may add to the effects of anaesthesia and pain medicines. Inform your surgical team if you are taking this medicine before any operation.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It can cause dry mouth, which may increase the risk of dental problems, and drowsiness may interact with sedatives used during dental work. Your dentist may advise adjustments to your dental treatment plan.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, so avoid strenuous exercise or activities that require balance until you know how it affects you. If you feel dizzy or weak, stop exercising and rest. Light walking after meals may help digestion, but consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive, operate machinery, or perform tasks that require alertness. It is best to avoid driving until you know how the medicine affects you. If your work involves operating heavy equipment or working at heights, discuss with your doctor whether adjustments are needed. Most people can continue their usual desk work, but take care when standing up quickly.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your doctor will decide when to stop based on your symptoms and response to treatment. If you experience serious side effects such as high fever with muscle stiffness, abnormal heart rhythms, or uncontrolled movements, seek medical attention immediately, and your doctor may advise stopping the medicine. For long-term use, regular review is needed to decide whether to continue.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of movement-related side effects such as tremor, stiffness, and restlessness, and can cause persistent elevation of prolactin levels, leading to breast tenderness, milk discharge, or menstrual irregularities. Rarely, tardive dyskinesia may occur with prolonged use. Regular review by your doctor is important, and the medicine should be used at the lowest effective dose for the shortest necessary duration. Monitoring may include assessment of movement symptoms, prolactin levels if symptoms appear, and kidney function.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Small, frequent, low-fat meals can help reduce symptoms of functional dyspepsia and gastroparesis.
Evidence: Well-establishedRelaxation techniques and psychological support can help reduce digestive symptoms aggravated by stress.
Evidence: ModerateMedicines such as domperidone or metoclopramide may be considered as alternatives, depending on the condition.
Evidence: ModerateSome studies suggest acupuncture may help with functional dyspepsia symptoms, but evidence is limited.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive routine vaccinations while taking this medicine unless your doctor advises otherwise.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of the reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with the prescription label clearly visible. Keep a copy of your prescription with you in case customs or security asks for it. Store the tablets in a cool, dry place away from direct sunlight, and avoid leaving them in a hot car or checked luggage. If you are crossing time zones, continue taking the medicine at the same intervals as prescribed, but adjust the timing gradually if your doctor advises. Carry enough supply for the entire trip plus a few extra days in case of delays. If you need to declare medicines at customs, keep them in your hand luggage for easy access.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 to 60 minutes after taking a dose, but the full benefit for symptoms like bloating and fullness may take a few days of regular use.
A: It is best taken before meals, as this helps it work faster for nausea and stomach emptying problems. Follow your doctor's instructions about timing.
A: Common side effects include drowsiness, dizziness, dry mouth, and headache. Some people may notice breast tenderness or menstrual changes due to raised prolactin levels.
A: No, alcohol should be avoided because it increases drowsiness, dizziness, and the risk of falls.
A: Long-term use should be reviewed by your doctor because of the risk of movement-related side effects and raised prolactin levels. Do not continue it for months without a medical review.
A: Do not stop this medicine suddenly without talking to your doctor. Your doctor will advise you on how to stop it safely, especially if you have been taking it for a long time.
🤔 Common Patient Concerns
🔄 Substitutes for sulgiride 50mg tablet
View AllAlternative brands with exact same active ingredient:
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levoride 50mg tabletPsycormedies ₹74.06 24.8% CHEAPER
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lefit 50mg tabletTas Med India Pvt Ltd ₹74.06 24.8% CHEAPER
-
levogold 50mg tabletLupin Ltd ₹74.06 24.8% CHEAPER
-
lsd 50mg tabletJpee Healthcare ₹77.81 21% CHEAPER
-
levosul 50mg tabletD D Pharmaceuticals ₹81.56 17.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller.
Fact: This medicine is not a painkiller. It is used for nausea, vomiting, and stomach emptying problems. - Myth: This medicine can be taken for any stomach problem.
Fact: This medicine is specifically for nausea, vomiting, and functional dyspepsia. It is not suitable for all stomach problems. - Myth: This medicine is safe to take for months without review.
Fact: Long-term use should be reviewed by a doctor because of the risk of movement-related side effects and raised prolactin levels. - Myth: This medicine can be taken with alcohol without any problem.
Fact: Alcohol increases drowsiness and dizziness and should be avoided while taking this medicine.
🔄 Alternative Options
Generic Alternatives
- Levosulpiride 50mg tablet
Brand Alternatives
- Egpride 50 Tablet