Eskinase 1.5miu Injection (Streptokinase 1,500,000 IU): Complete Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe headache, confusion, or sudden weakness (possible intracranial bleeding)
- Blood in vomit, stool, or urine
- Difficulty breathing or swelling of face, lips, or throat (anaphylaxis)
- Chest pain or palpitations (arrhythmias)
- Decreased urine output or swelling in legs (renal impairment)
- Uncontrolled bleeding from any site
If experiencing severe symptoms, call emergency services immediately.
What is stpase 1500000iu injection used for?
This medicine is a thrombolytic agent used in hospitals to dissolve blood clots in heart attack, pulmonary embolism, and deep vein thrombosis. It is given intravenously under strict medical supervision.
- Generic Name: Streptokinase (1500000IU)
- Manufacturer: Cadila Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 stpase 1500000iu injection के बारे में (Hindi Summary)
उपयोग: यह दवा स्ट्रेप्टोकाइनेज 1,500,000 IU इंजेक्शन है, जिसका उपयोग अस्पताल में खून के थक्कों को घोलने के लिए किया जाता है। यह दिल के दौरे, फेफड़ों में खून के थक्के (पल्मोनरी एम्बोलिज्म), और गहरी शिरा घनास्त्रता (डीवीटी) के इलाज में दी जाती है। यह केवल डॉक्टर की देखरेख में नस के माध्यम से दी जाती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन स्थल से खून बहना, बुखार, ठंड लगना, मतली और दाने शामिल हैं। गंभीर दुष्प्रभावों में गंभीर आंतरिक रक्तस्राव, एलर्जी, और हृदय ताल में गड़बड़ी हो सकती है। किसी भी असामान्य लक्षण पर तुरंत डॉक्टर को सूचित करें।
सुरक्षा सलाह: यह दवा केवल अस्पताल में योग्य स्वास्थ्यकर्मी द्वारा दी जानी चाहिए। उपचार के दौरान अपने डॉक्टर को किसी भी असामान्य रक्तस्राव, सूजन, या सांस लेने में कठिनाई के बारे में तुरंत बताएं। बिना डॉक्टर की सलाह के कोई अन्य रक्त पतला करने वाली दवा न लें।
💊 stpase 1500000iu injection Uses & Benefits
[{"condition":"Acute myocardial infarction (heart attack)","description":"Used to dissolve coronary artery clots and restore blood flow to the heart muscle, reducing damage and improving survival when administered promptly.","evidence":"Well-established"},{"condition":"Massive pulmonary embolism","description":"Helps dissolve clots in the pulmonary arteries, improving blood flow and oxygenation in life-threatening cases.","evidence":"Well-established"},{"condition":"Deep vein thrombosis","description":"Used in selected patients to dissolve large clots in deep veins, reducing the risk of pulmonary embolism and post-thrombotic syndrome.","evidence":"Established"},{"condition":"Occluded arteriovenous cannulae","description":"Instilled locally to clear blocked dialysis access sites, restoring patency.","evidence":"Established"}]
Off-label uses: [{"condition":"Acute ischemic stroke","description":"Sometimes used in selected patients within a narrow time window, but requires specialist evaluation due to bleeding risk.","evidence":"Limited"},{"condition":"Peripheral arterial occlusion","description":"May be used in limb-threatening ischemia when other treatments are not feasible.","evidence":"Limited"}]
Primary treatment for: Acute myocardial infarction
Also treats: Pulmonary embolism, Deep vein thrombosis, Occluded arteriovenous cannulae
📋 Drug Information
| Generic Name(s) | Streptokinase (1500000IU) |
| Brand Name | stpase 1500000iu injection |
| Manufacturer | Cadila Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | First Generation Thrombolytics |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store lyophilized powder at 2-8°C (refrigerate). Protect from light. After reconstitution, use immediately or store as directed by the manufacturer. |
| Shelf Life | Refer to the product label for the exact shelf life. Typically 24-36 months from the date of manufacture when stored properly. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Streptokinase binds to plasminogen, forming a streptokinase-plasminogen complex that catalytically converts other plasminogen molecules into plasmin. Plasmin is a proteolytic enzyme that degrades fibrin clots, leading to clot dissolution. This process is not fibrin-specific, so it can also degrade fibrinogen and other clotting factors, increasing bleeding risk.
Mechanism Steps
💡 How to Take stpase 1500000iu injection
Strength: Lyophilized powder for injection: 1,500,000 IU per vial.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the indication, patient's weight, and clinical condition. For acute myocardial infarction, a common regimen is 1,500,000 IU infused intravenously over 60 minutes. For pulmonary embolism, a loading dose of 250,000 IU over 30 minutes followed by 100,000 IU per hour for 24-72 hours may be used. For deep vein thrombosis, similar regimens are employed. For occluded cannulae, 250,000 IU in 2 mL may be instilled locally. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have increased risk of bleeding and should be monitored closely. Dose adjustment may be necessary based on renal and hepatic function. Consult a clinician. |
| Renal Impairment | No specific dose adjustment is established from available information. Use with caution in patients with renal impairment due to increased bleeding risk. |
| Hepatic Impairment | No specific dose adjustment is established from available information. Use with caution in patients with hepatic impairment due to increased bleeding risk. |
| Maximum Daily Dose | Not established from the available information. Dosing is individualized by a clinician. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of stpase 1500000iu injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Heparin | Major | |
| Aspirin | Major | |
| Clopidogrel | Major | |
| NSAIDs | Moderate | |
| Alteplase | Moderate | |
| Dextran | Moderate | |
| Antihypertensives | Minor |
🚨 Major Interactions
- Anticoagulants (e.g., warfarin, heparin)
- Antiplatelet agents (e.g., aspirin, clopidogrel)
- NSAIDs
⚡ Moderate Interactions
- Thrombolytic agents (e.g., alteplase)
- Dextran
🍷 Alcohol Interaction
Alcohol may increase the risk of bleeding and should be avoided during treatment with this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active internal bleeding","Recent stroke (within 2 months)","Recent intracranial or intraspinal surgery or trauma","Known bleeding diathesis","Severe uncontrolled hypertension","Known allergy to streptokinase","Recent streptococcal infection or prior streptokinase use within 6 months to 1 year"]
⚠️ Warnings & Precautions
["Administer only in a hospital setting with intensive care facilities.","Avoid intramuscular injections and unnecessary venipuncture.","Use with caution in patients with recent surgery, trauma, or peptic ulcer.","Antibodies may develop, reducing efficacy on repeat use.","Monitor for signs of bleeding and allergic reactions.","Do not use if the solution is discolored or contains particles."]
🤱 Lactation Safety
Not established from the available information. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause severe bleeding. Treatment is supportive and symptomatic. In case of significant bleeding, stop the infusion and consider administration of antifibrinolytic agents (e.g., tranexamic acid) or blood products as clinically indicated. There is no specific antidote.
⏰ Missed Dose
This medicine is given as a single dose or a short infusion in a hospital setting. Missed doses are not applicable. If a dose is missed, consult your healthcare provider immediately.
Additional Safety Advice
This medicine must be given only by a qualified healthcare professional in a hospital setting with resuscitation equipment available. Inform your doctor immediately if you experience any unusual bleeding, bruising, difficulty breathing, or swelling of the face or throat. Do not take any other blood-thinning medicines without consulting your doctor. Avoid activities that may cause injury. Your doctor will monitor your blood clotting parameters and vital signs during treatment.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients have a higher risk of bleeding and may require closer monitoring. Dose adjustment may be necessary based on renal and hepatic function.
🤰 Pregnancy Planning (TTC)
This medicine should be used during pregnancy only if clearly needed and the benefits outweigh the risks. Consult your doctor if you are planning pregnancy or are pregnant.
🏥 Post-Surgery Considerations
This medicine is contraindicated in recent surgery due to high bleeding risk. Consult your surgeon and physician before use.
🦷 Dental Procedures
Inform your dentist if you have received this medicine recently, as it may increase bleeding risk during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may cause injury immediately after treatment. Gradually resume activity as advised by your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
After treatment, you may need time off work to recover. Driving and operating machinery should be avoided until cleared by your doctor.
🛑 When to Stop This Medicine
This medicine is given as a single course in the hospital. Do not stop or adjust any treatment without consulting your doctor.
📅 Long-Term Use Effects
Long-term effects are not directly associated with a single dose of this medicine. However, patients may need ongoing anticoagulation and monitoring for underlying conditions. Repeat use may be less effective due to antibody formation.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May be used if streptokinase is contraindicated or ineffective.
Evidence: Well-establishedA procedure to remove clots mechanically, used in selected cases.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Consult your doctor regarding vaccination timing.
📦 Storage Guide
✅ DO
Store lyophilized powder at 2-8°C (refrigerate)
❌ DON'T
Do not freeze
✅ DO
Protect from light
❌ DON'T
Do not use if discolored or contains particles
✅ DO
Use immediately after reconstitution
❌ DON'T
Do not store reconstituted solution for long periods
✈️ Traveling with This Medicine
This medicine is administered only in a hospital setting and is not for self-administration. If you are traveling after treatment, carry a copy of your prescription and medical records. Inform your doctor before travel. Storage during travel is not applicable as it is given in a controlled environment.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The thrombolytic effect begins immediately after infusion, but clinical improvement may take minutes to hours.
A: Avoid activities that may cause injury, and do not take other blood-thinning medicines without consulting your doctor.
A: No, you should not drive or operate machinery immediately after treatment. Follow your doctor's advice.
🤔 Common Patient Concerns
🔄 Substitutes for stpase 1500000iu injection
View AllAlternative brands with exact same active ingredient:
-
klotbuster 1500000iu injectionAlembic Pharmaceuticals Ltd ₹776.50 61.3% CHEAPER
-
myokinase 1500000iu injectionBiocon ₹1,906.88 4.9% CHEAPER
-
stukinase 1500000iu injectionSamarth Life Sciences Pvt Ltd ₹1,970.00 1.8% CHEAPER
-
lupiflo 1500000iu injectionLupin Ltd ₹1,971.05 1.7% CHEAPER
-
icikinase 1.5miu injectionAbbott ₹2,005.48 SAME PRICE
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Streptokinase can be taken orally.
Fact: This medicine is given only by intravenous infusion in a hospital setting. - Myth: Streptokinase is safe for everyone with chest pain.
Fact: It is contraindicated in patients with active bleeding, recent stroke, or severe hypertension. - Myth: Streptokinase can be used repeatedly without issues.
Fact: Repeat use may be ineffective due to antibody formation and increases risk of allergic reactions.
🔄 Alternative Options
Generic Alternatives
- Streptokinase 1,500,000 IU injection (various manufacturers)
Brand Alternatives
- Eskinase 1.5miu injection