What is stiloz 50 tablet used for?

This medicine is a prescription medication used to improve blood flow in the legs and reduce leg pain while walking (intermittent claudication) caused by peripheral arterial disease. It works by relaxing blood vessels and preventing blood clots. It is not for everyone; people with heart failure should not take it.

Generic Name: Cilostazol (50mg)
Manufacturer: Integrace Pvt Ltd
Form: Allopathy
Pregnancy Category: Consult doctor
Prescription Required: Yes

🇮🇳 stiloz 50 tablet के बारे में (Hindi Summary)

उपयोग: यह दवा सिलोस्टाज़ोल 50 मिलीग्राम की गोली है, जिसका उपयोग पैरों में रक्त के प्रवाह को बेहतर बनाने और पैरों में दर्द (क्लॉडिकेशन) को कम करने के लिए किया जाता है। यह पेरिफेरल आर्टरी डिजीज (पैरों की धमनियों में रुकावट) के कारण होने वाले दर्द और ऐंठन में राहत देती है। यह दवा रक्त वाहिकाओं को फैलाकर और खून के थक्के बनने से रोककर काम करती है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए। दिल की बीमारी, खून बहने की समस्या या गंभीर लिवर रोग वाले मरीजों को यह दवा नहीं लेनी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, दस्त, पेट खराब होना, धड़कन तेज होना और चक्कर आना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभावों में अत्यधिक रक्तस्राव, दिल की विफलता और अनियमित दिल की धड़कन शामिल हैं। अगर आपको असामान्य रक्तस्राव, सांस लेने में तकलीफ, या पैरों में सूजन दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं के बारे में बताएं, खासकर दिल की बीमारी, रक्तस्राव विकार या लिवर की बीमारी। गर्भावस्था या स्तनपान के दौरान यह दवा न लें। इस दवा के साथ अंगूर का जूस न पिएं। इसे रोज एक ही समय पर, नाश्ते और दोपहर के खाने से 30 मिनट पहले लें। गोली को चबाएं या तोड़ें नहीं। अगर आपको खुराक लेना भूल जाए तो याद आते ही ले लें, लेकिन अगर अगली खुराक का समय हो गया है तो छोड़ी हुई खुराक न लें। डॉक्टर की सलाह के बिना दवा बंद न करें।

💊 stiloz 50 tablet Uses & Benefits

[{"condition":"Intermittent claudication due to peripheral arterial disease","description":"This medicine improves walking distance and reduces leg pain by increasing blood flow to the limbs.","evidence":"Well-established"},{"condition":"Secondary prevention of stroke","description":"In some regions, it is used to reduce the risk of recurrent stroke, particularly in patients with lacunar infarctions.","evidence":"Moderate"},{"condition":"Peripheral arterial disease","description":"It helps manage symptoms of poor circulation in the legs, such as cramping and fatigue.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Raynaud's phenomenon","description":"Sometimes prescribed to improve blood flow in fingers and toes.","evidence":"Limited"},{"condition":"Coronary artery disease","description":"Occasionally used as an adjunct in patients with stable angina, but not first-line.","evidence":"Limited"}]

Primary treatment for: Intermittent claudication due to peripheral arterial disease

Also treats: Peripheral arterial disease, Cerebrovascular disease (secondary stroke prevention)

📋 Drug Information

Generic Name(s)	Cilostazol (50mg)
Brand Name	stiloz 50 tablet
Manufacturer	Integrace Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	CARDIAC
Action Class	Phosphodiesterase III Inhibiotrs (PVD)
Route of Administration	Oral
Storage	Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and direct sunlight. Keep out of reach of children.
Shelf Life	24 months from the date of manufacture.
WHO Guideline	Not established from the available information.
ICMR Guideline	Not established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1

Take this medicine 30 minutes before breakfast and lunch to minimize food interactions and maximize absorption.

2

Avoid grapefruit and grapefruit juice completely while on this medicine, as it can dangerously increase drug levels.

3

Monitor your heart rate and report any palpitations, chest pain, or shortness of breath immediately.

4

Inform your doctor if you are taking any blood thinners, as this medicine can increase bleeding risk.

5

Do not stop this medicine abruptly without consulting your doctor, as symptoms may worsen.

6

Keep all follow-up appointments to monitor your heart, liver, and kidney function.

7

If you experience unusual bruising or bleeding, contact your doctor right away.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅

Leg pain while walking

This medicine is commonly prescribed for this.

Likely Use

❌

Fever

This medicine is not a fever reducer.

Not Primary

❌

Chest pain

This medicine is not for chest pain; it may worsen heart conditions.

Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is rapidly absorbed after oral administration. The absolute bioavailability is not well established but is estimated to be around 50-60% based on urinary recovery data. Food, especially a high-fat meal, can increase the peak plasma concentration and total exposure, but it is recommended to take it on an empty stomach to minimize variability.

DistributionThis medicine is widely distributed throughout the body. It is approximately 95-98% bound to plasma proteins, primarily albumin. The volume of distribution is not well characterized but is thought to be moderate.

Protein BindingApproximately 95-98% bound to plasma proteins, mainly albumin.

MetabolismThis medicine is extensively metabolized in the liver, primarily by the cytochrome P450 enzymes CYP3A4 and CYP2C19. Several metabolites have been identified, with some exhibiting pharmacological activity. The two major metabolites are more potent PDE3 inhibitors than the parent drug, contributing to the overall effect.

Half-LifeThe elimination half-life of this medicine is approximately 11-13 hours in healthy individuals. In patients with severe renal impairment, the half-life may be prolonged.

ExcretionThis medicine is primarily excreted in the urine as metabolites. About 74% of a radiolabeled dose is recovered in urine and about 20% in feces. Less than 1% is excreted unchanged in urine.

BioavailabilityThe absolute bioavailability of this medicine is not well established but is estimated to be around 50-60% based on urinary recovery data.

Onset of ActionThe onset of action for symptomatic improvement in intermittent claudication is typically within 2-4 weeks of starting therapy, but it may take up to 12 weeks for full benefit.

Peak Plasma TimePeak plasma concentrations are reached approximately 3-6 hours after oral administration on an empty stomach. With food, the peak may be delayed.

Duration of ActionThe duration of action is not precisely defined, but the effects on platelet inhibition and vasodilation persist for the dosing interval, typically 12 hours. Symptomatic improvement in walking distance is maintained with continued use.

How It Works

This medicine works by inhibiting phosphodiesterase type 3 (PDE3), an enzyme that breaks down cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in platelets and vascular smooth muscle cells. By blocking PDE3, it increases the levels of these cyclic nucleotides, leading to relaxation of vascular smooth muscle and inhibition of platelet aggregation. This results in vasodilation, improved blood flow, and reduced risk of clot formation. The overall effect is enhanced circulation, particularly in the peripheral arteries.

Mechanism Steps

1

Inhibition of PDE3 enzyme: This medicine selectively inhibits the phosphodiesterase type 3 enzyme in platelets and vascular smooth muscle cells.

2

Increased cAMP and cGMP: Inhibition of PDE3 leads to elevated levels of cyclic AMP and cyclic GMP within these cells.

3

Vasodilation: Elevated cyclic nucleotides cause relaxation of vascular smooth muscle, resulting in widening of blood vessels.

4

Inhibition of platelet aggregation: Increased cAMP in platelets reduces their ability to clump together, decreasing the risk of clot formation.

5

Improved blood flow: The combined effects lead to enhanced circulation, particularly in the peripheral arteries, reducing symptoms of claudication.

💡 How to Take stiloz 50 tablet

Strength: Cilostazol 50 mg immediate-release tablet

1Take this medicine orally with a full glass of water.

2Take it 30 minutes before breakfast and lunch, or as directed by your doctor.

3Swallow the tablet whole; do not crush, chew, or break it.

4If you have trouble swallowing the tablet, consult your pharmacist for advice.

5Take it at the same times each day to maintain consistent blood levels.

6Do not take it with grapefruit juice.

7If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult Dosage	The recommended adult dose of this medicine is 100 mg taken orally twice daily, approximately 30 minutes before breakfast and lunch. However, the dose may be adjusted based on individual response and tolerability. For patients taking certain interacting medications, a lower dose of 50 mg twice daily may be recommended. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric Dosage	Pediatric dosing is not established from available information. Consult a pediatrician.
Elderly Dosage	Elderly patients may be more sensitive to the effects of this medicine. Dose selection should be cautious, usually starting at the lower end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy.
Renal Impairment	No dose adjustment is required for patients with mild to moderate renal impairment. In patients with severe renal impairment (creatinine clearance <25 mL/min), the dose should be reduced or used with caution. Consult your doctor for specific dosing recommendations.
Hepatic Impairment	This medicine is contraindicated in patients with severe hepatic impairment. In patients with mild to moderate hepatic impairment, no dose adjustment is typically required, but caution is advised. Consult your doctor for specific dosing recommendations.
Maximum Daily Dose	The maximum recommended daily dose is 200 mg (100 mg twice daily). In patients taking certain interacting medications, the maximum daily dose may be 100 mg (50 mg twice daily).

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

Breakfast

Take 30 minutes before

Food can increase absorption and side effects.

Lunch

Take 30 minutes before

Maintains consistent blood levels.

Grapefruit

Avoid

Increases drug levels and risk of toxicity.

⏰ What to Do If You Miss a Dose

📌 Less than 6 hours have passed since the missed dose

→ Take the missed dose as soon as you remember.

💡 Continue with your regular schedule.

📌 More than 6 hours have passed since the missed dose

→ Skip the missed dose.

💡 Do not double dose to catch up.

⚠️ Side Effects of stiloz 50 tablet

✅ Common Side Effects

Headache (Common (5-10%))

Usually resolves on its own. If persistent or severe, consult your doctor.

Diarrhea (Common (5-10%))

Stay hydrated. If diarrhea persists for more than 2 days, contact your doctor.

Abnormal stools (Common (5-10%))

Usually temporary. Maintain fluid intake. Consult if bothersome.

Palpitations (Common (5-10%))

Report to your doctor if you feel your heart racing or pounding.

Dizziness (Uncommon (1-5%))

Avoid driving or operating machinery until you know how this medicine affects you.

🚨 Serious Side Effects

Severe bleeding (Rare (<0.1%))

Seek immediate medical attention if you notice blood in vomit, black tarry stools, or unexplained bruising.

Heart failure (Rare (<0.1%))

Report symptoms like shortness of breath, swelling in legs, or sudden weight gain to your doctor immediately.

Irregular heartbeat (arrhythmia) (Rare (<0.1%))

If you experience palpitations, fainting, or chest discomfort, seek emergency care.

Severe allergic reaction (Very rare (<0.01%))

Call emergency services if you develop rash, itching, swelling of face or throat, or difficulty breathing.

⚠️ Rare Side Effects

Thrombocytopenia

Report unusual bruising or bleeding to your doctor.

Hepatitis

Seek medical attention if you notice yellowing of eyes or skin, dark urine, or severe abdominal pain.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug	Severity	Effect
Ketoconazole	Major
Erythromycin	Major
Omeprazole	Moderate
Warfarin	Major
Aspirin	Moderate
Clopidogrel	Moderate
Grapefruit juice	Moderate
Diltiazem	Moderate
Rifampin	Moderate
St. John's wort	Moderate

🚨 Major Interactions

CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin)
CYP2C19 inhibitors (e.g., omeprazole)
Antiplatelet agents (e.g., aspirin, clopidogrel)
Anticoagulants (e.g., warfarin)

⚡ Moderate Interactions

Grapefruit juice
Omeprazole
Diltiazem

🍷 Alcohol Interaction

Alcohol may increase the risk of dizziness, drowsiness, and bleeding when taken with this medicine. It is advisable to avoid or limit alcohol consumption while on this medication.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Heart failure of any severity","History of hypersensitivity to Cilostazol or any component of the formulation","Active bleeding or bleeding disorders","Severe hepatic impairment","Pregnancy and lactation","Concomitant use with strong CYP3A4 inhibitors or CYP2C19 inhibitors"]

⚠️ Warnings & Precautions

["This medicine is contraindicated in patients with heart failure. It can cause fluid retention and worsen heart failure.","It can increase the risk of bleeding. Use with caution in patients on anticoagulants or antiplatelet agents.","It may cause tachycardia and palpitations. Use with caution in patients with cardiac arrhythmias.","It should be used with caution in patients with severe renal impairment.","Patients should be advised to avoid grapefruit juice while taking this medicine.","It may cause dizziness; patients should avoid driving or operating machinery until they know how it affects them.","The safety and efficacy in pediatric patients have not been established.","Elderly patients may be more sensitive to the effects of this medicine."]

🤱 Lactation Safety

It is not known whether this medicine is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

💊 Overdose Management

There is no specific antidote for overdose with this medicine. In case of overdose, symptomatic and supportive care should be provided. Monitor vital signs and observe for signs of toxicity such as severe headache, hypotension, tachycardia, and bleeding. Gastric lavage may be considered if the overdose is recent. Contact a poison control center for guidance.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.

Additional Safety Advice

General Safety

Before starting this medicine, inform your doctor about all your medical conditions, especially heart failure, bleeding disorders, or liver disease. Do not take this medicine if you are pregnant, planning to become pregnant, or breastfeeding, as its safety has not been established. Avoid grapefruit and grapefruit juice while taking this medicine, as it can increase drug levels in your body. Take this medicine at the same time each day, preferably 30 minutes before breakfast and lunch, or as prescribed. Do not crush or chew the tablet; swallow it whole with water. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Never double the dose. Keep all appointments with your doctor for regular monitoring of your heart, blood pressure, and bleeding parameters. Do not stop taking this medicine abruptly without consulting your doctor.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and palpitations. Dose selection should be cautious, and regular monitoring of heart and kidney function is advised.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended during pregnancy or when planning pregnancy. If you are planning to become pregnant, consult your doctor to discuss alternative treatments.

🏥 Post-Surgery Considerations

This medicine increases bleeding risk and should be stopped before any surgery, including dental procedures, as advised by your surgeon. Typically, it should be discontinued at least 48 hours before surgery.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine before any dental procedure, as it can increase bleeding. You may need to stop it temporarily as advised by your doctor.

💚 Lifestyle Tips for Better Results

🏃

Maintain a healthy weight to reduce stress on your legs.

🥗

Engage in regular low-impact exercise like walking or swimming as tolerated.

😴

Avoid smoking, as it worsens peripheral arterial disease.

💧

Manage conditions like diabetes and high blood pressure.

🧘

Elevate your legs when resting to improve circulation.

🌞

Wear comfortable, well-fitting shoes.

🏋️ Exercise Considerations

Start any exercise program gradually and stop if you experience severe leg pain, chest pain, or shortness of breath. Consult your doctor before starting a new exercise regimen.

🥗 Diet Recommendations

Eat a heart-healthy diet rich in fruits, vegetables, and whole grains.

Limit saturated fats and trans fats.

Reduce sodium intake to manage blood pressure.

Include omega-3 fatty acids from fish or flaxseed.

Stay well hydrated.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or palpitations, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause diarrhea, so plan accordingly if you have a job that requires you to be away from restrooms.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience serious side effects like severe bleeding, heart failure symptoms, or allergic reactions, seek immediate medical attention and your doctor will advise whether to stop.

📅 Long-Term Use Effects

Long-term use of this medicine is generally safe for patients without contraindications. However, it requires regular monitoring of heart function, blood pressure, and bleeding parameters. Some patients may develop tolerance to its effects, and its efficacy may diminish over time. It is important to have periodic evaluations to ensure it remains appropriate for your condition.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Supervised exercise therapy

A structured walking program can improve symptoms and walking distance.

Evidence: Well-established

Pentoxifylline

Another oral medicine for claudication, but may be less effective.

Evidence: Moderate

Revascularization procedures

Angioplasty or bypass surgery for severe cases.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, adjust your dosing schedule gradually in consultation with your doctor. Store at room temperature and avoid direct sunlight. Check customs regulations for prescription medicines in your destination country.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 62-year-old man with peripheral arterial disease and leg pain while walking.

He was prescribed this medicine 50 mg twice daily. After 4 weeks, he noticed he could walk to the park without stopping due to pain. He made sure to take it before meals and avoided grapefruit juice. He also started walking daily as advised by his doctor.

💡 Lesson: Consistent use and lifestyle changes can significantly improve symptoms of claudication.

👤 A 55-year-old woman with a history of heart failure was mistakenly prescribed this medicine.

She experienced worsening shortness of breath and swelling in her legs within a week. She consulted her cardiologist, who immediately stopped the medicine and explained that it is contraindicated in heart failure. Her symptoms improved after discontinuation.

💡 Lesson: Always inform your doctor about all your medical conditions, especially heart failure, before starting any new medicine.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start noticing improvement in leg pain within 2-4 weeks, but it may take up to 12 weeks for full benefit.

Q: Can I take this medicine with food?

A: It is best taken on an empty stomach, 30 minutes before meals. Food can increase absorption and side effects.

Q: What should I do if I miss a dose?

A: If you remember within 6 hours, take it. Otherwise, skip it and continue with your regular schedule. Do not double dose.

Q: Is it safe to take with alcohol?

A: Alcohol may increase dizziness and bleeding risk. It is best to avoid or limit alcohol.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

Can I take this medicine long-term?
Will it affect my kidney function?
Can I drive after taking this medicine?
Does it interact with my blood pressure medicine?
What if I miss a dose?
Can I drink alcohol while taking this?

🔄 Substitutes for stiloz 50 tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

Myth: This medicine can cure peripheral arterial disease.
Fact: This medicine helps manage symptoms but does not cure the underlying disease. Lifestyle changes and other treatments are also important.
Myth: This medicine is safe for everyone with leg pain.
Fact: It is not safe for people with heart failure or bleeding disorders. It should only be used under medical supervision.
Myth: You can take this medicine with grapefruit juice.
Fact: Grapefruit juice can increase the levels of this medicine and lead to serious side effects. It should be avoided.

🔄 Alternative Options

Generic Alternatives

Cilostazol 50 mg tablet

Brand Alternatives

Pletal

📊 Comparison with Similar Medicines

[{"medicine":"Cilostazol","class":"PDE3 inhibitor","primary_use":"Intermittent claudication","route":"Oral","common_side_effects":"Headache, diarrhea, palpitations"},{"medicine":"Pentoxifylline","class":"Xanthine derivative","primary_use":"Intermittent claudication","route":"Oral","common_side_effects":"Nausea, dizziness, headache"}]

Cilostazol 50mg Tablet: Complete Medicine Guide

When to Call Your Doctor IMMEDIATELY

What is stiloz 50 tablet used for?

🇮🇳 stiloz 50 tablet के बारे में (Hindi Summary)

💊 stiloz 50 tablet Uses & Benefits

📋 Drug Information

👨‍⚕️ Doctor's Practical Tips

🔍 Is This Medicine Right for Your Symptom?

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

How It Works

Mechanism Steps

💡 How to Take stiloz 50 tablet

Dosage Information

Dosage Timeline

🍽️ Food Timing Guide

⏰ What to Do If You Miss a Dose

⚠️ Side Effects of stiloz 50 tablet

✅ Common Side Effects

🚨 Serious Side Effects

⚠️ Rare Side Effects

🔬 Drug Interactions

🚨 Major Interactions

⚡ Moderate Interactions

🍷 Alcohol Interaction

🔎 Check Your Other Medicines

🛡️ Safety & Warnings

🚫 Contraindications

⚠️ Warnings & Precautions

🤱 Lactation Safety

💊 Overdose Management

⏰ Missed Dose

Additional Safety Advice

👴 Special Considerations for Elderly

💡 For Patients Above 65

🤰 Pregnancy Planning (TTC)

🏥 Post-Surgery Considerations

🦷 Dental Procedures

💚 Lifestyle Tips for Better Results

🏋️ Exercise Considerations

🥗 Diet Recommendations

💼 Impact on Daily Work & Life

🛑 When to Stop This Medicine

📅 Long-Term Use Effects

🌿 Non-Medicine Approaches

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

📦 Storage Guide

✅ DO

❌ DON'T

✅ DO

❌ DON'T

✅ DO

❌ DON'T

✈️ Traveling with This Medicine

💰 Cost Analysis & Savings

👥 Real Patient Stories

💬 Questions Patients Often Ask

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

🔄 Substitutes for stiloz 50 tablet

🛑 Myths vs. Facts

🔄 Alternative Options

Generic Alternatives

Brand Alternatives

📊 Comparison with Similar Medicines

😊 Was this information helpful?

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