Olmesartan Medoxomil + Chlorthalidone 40mg/12.5mg Tablet: Uses, Side Effects, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Swelling of face, lips, tongue, or throat
- Difficulty breathing or chest pain
- Decreased urine output or swelling in legs
- Severe abdominal pain with nausea and vomiting
- Irregular heartbeat or palpitations
- Severe diarrhea with weight loss
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is StayHappi Olmesartan Medoxomil+Chlorthalidone 40mg/12.5mg Tablet used for?
This medicine is a combination of Olmesartan Medoxomil and Chlorthalidone used to treat high blood pressure. It works by relaxing blood vessels and removing excess fluid from the body. It is taken once daily as prescribed by your doctor.
- Generic Name: Olmesartan Medoxomil (40mg) + Chlorthalidone (12.5mg)
- Manufacturer: Sarvagunaushdhi Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 StayHappi Olmesartan Medoxomil+Chlorthalidone 40mg/12.5mg Tablet के बारे में (Hindi Summary)
उपयोग: यह दवा उच्च रक्तचाप (हाइपरटेंशन) के इलाज के लिए इस्तेमाल की जाती है। इसमें ओल्मेसार्टन मेडोक्सोमिल और क्लोर्थालिडोन दो सक्रिय तत्व हैं। यह रक्त वाहिकाओं को आराम देकर और शरीर से अतिरिक्त नमक और पानी को बाहर निकालकर रक्तचाप को कम करती है। यह दवा उन वयस्कों के लिए है जिनका रक्तचाप एक दवा से नियंत्रित नहीं हो पाता। इसे डॉक्टर के निर्देशानुसार ही लें। गर्भवती महिलाओं को यह दवा नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, सिरदर्द, थकान और जी मिचलाना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। कुछ लोगों को पेशाब बार-बार आ सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको गंभीर चक्कर, बेहोशी, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या दिल की धड़कन अनियमित लगे, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। दवा की मात्रा खुद से न बदलें और न ही बंद करें। इस दवा से चक्कर आ सकते हैं, इसलिए उठते-बैठते समय धीरे-धीरे उठें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं। शराब न पिएं क्योंकि इससे चक्कर और कम रक्तचाप बढ़ सकता है। अगर आप गर्भवती हैं या गर्भधारण की योजना बना रही हैं, तो डॉक्टर को बताएं। नियमित रूप से रक्तचाप, किडनी फंक्शन और इलेक्ट्रोलाइट्स की जांच कराएं।
💊 StayHappi Olmesartan Medoxomil+Chlorthalidone 40mg/12.5mg Tablet Uses & Benefits
- [{"condition":"Hypertension","description":"This medicine is used to lower high blood pressure in adults when treatment with a single antihypertensive agent is insufficient.
- It helps reduce the risk of stroke, heart attack, and kidney problems.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Heart failure with reduced ejection fraction","description":"Sometimes used off-label as part of heart failure management, but not a standard first-line therapy.","evidence":"Limited"},{"condition":"Diuretic-induced hyponatremia prevention","description":"Not a primary use; chlorthalidone component may be used for other diuretic needs.","evidence":"Limited"}]
Primary treatment for: Hypertension
Also treats: Heart failure, Diabetic nephropathy, Stroke prevention
📋 Drug Information
| Generic Name(s) | Olmesartan Medoxomil (40mg) + Chlorthalidone (12.5mg) |
| Brand Name | StayHappi Olmesartan Medoxomil+Chlorthalidone 40mg/12.5mg Tablet |
| Manufacturer | Sarvagunaushdhi Pvt Ltd |
| Packaging / Form | strip of 10 tablets (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antihypertensive agents with complementary mechanisms. Olmesartan Medoxomil is a prodrug that is hydrolyzed to olmesartan, which selectively blocks the angiotensin II type 1 (AT1) receptor. By blocking AT1, it prevents angiotensin II from causing vasoconstriction and aldosterone release, leading to reduced blood pressure and decreased sodium retention. Chlorthalidone is a thiazide-like diuretic that inhibits the sodium-chloride symporter in the distal convoluted tubule of the kidney, increasing excretion of sodium, chloride, and water. This reduces plasma volume and cardiac output initially, and later reduces peripheral vascular resistance. The combination provides additive blood pressure lowering.
Mechanism Steps
💡 How to Take StayHappi Olmesartan Medoxomil+Chlorthalidone 40mg/12.5mg Tablet
Strength: Tablet: Olmesartan Medoxomil 40 mg + Chlorthalidone 12.5 mg
Dosage Information
| Adult Dosage | The usual adult dose is one tablet (Olmesartan Medoxomil 40 mg + Chlorthalidone 12.5 mg) taken orally once daily, with or without food. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to therapy. Do not exceed the recommended dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor closely for dizziness, falls, and electrolyte imbalances. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with mild to moderate renal impairment (eGFR 30-60 mL/min), no dose adjustment is usually required, but monitoring is advised. In severe renal impairment (eGFR <30 mL/min), use is not recommended unless under specialist supervision. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, no dose adjustment is usually required. In severe hepatic impairment, use is not recommended. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | One tablet (Olmesartan Medoxomil 40 mg + Chlorthalidone 12.5 mg) once daily. Do not exceed the recommended dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of StayHappi Olmesartan Medoxomil+Chlorthalidone 40mg/12.5mg Tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Potassium-sparing diuretics | Major | |
| Lithium | Major | |
| NSAIDs | Major | |
| Other antihypertensives | Major | |
| Corticosteroids | Moderate | |
| Digoxin | Moderate | |
| Oral hypoglycemics | Moderate | |
| Cholestyramine | Moderate | |
| Antacids | Minor | |
| Alcohol | Minor |
🚨 Major Interactions
- Potassium-sparing diuretics (e.g., spironolactone, triamterene)
- Lithium
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Other antihypertensives
⚡ Moderate Interactions
- Corticosteroids
- Digoxin
- Oral hypoglycemics
- Cholestyramine
🍷 Alcohol Interaction
Alcohol may enhance the blood pressure-lowering effect of this medicine, leading to dizziness, lightheadedness, and increased risk of fainting. It is advisable to avoid or limit alcohol consumption while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Pregnancy","Anuria (no urine production)","Hypersensitivity to olmesartan, chlorthalidone, or any component","Severe kidney impairment (eGFR
⚠️ Warnings & Precautions
["This medicine can cause fetal harm; discontinue as soon as pregnancy is detected.","May cause symptomatic hypotension, especially in volume-depleted patients.","Monitor renal function and electrolytes periodically.","May worsen glucose tolerance and increase uric acid levels.","Avoid in patients with a history of angioedema.","Use with caution in patients with severe heart failure or aortic/mitral stenosis.","Do not use potassium supplements without medical advice."]
🤱 Lactation Safety
Not recommended. Both olmesartan and chlorthalidone are excreted in breast milk and may cause harm to the nursing infant. Consult your doctor for alternative options if you are breastfeeding.
💊 Overdose Management
Overdose may cause severe hypotension, electrolyte imbalances, and dehydration. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and symptomatic, including intravenous fluids and electrolyte replacement. Hemodialysis may be considered for chlorthalidone removal, but olmesartan is not effectively removed by dialysis.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. This medicine can cause dizziness, especially when you stand up quickly; rise slowly from sitting or lying positions. Avoid driving or operating heavy machinery until you know how this medicine affects you. Drink adequate fluids to prevent dehydration, but follow your doctor's advice if you have heart or kidney problems. Avoid alcohol as it can intensify dizziness and low blood pressure. Inform your doctor if you have diabetes, gout, kidney or liver disease, or if you are pregnant or planning to become pregnant. Regular monitoring of blood pressure, kidney function, and electrolyte levels is important. Do not use potassium supplements or salt substitutes containing potassium without consulting your doctor. Keep all appointments for follow-up.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. They are at higher risk of dizziness, falls, and electrolyte imbalances. Start with a lower dose and monitor closely. Regular monitoring of kidney function and electrolytes is important.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy. If you are planning to become pregnant, consult your doctor to switch to a safer alternative before conception. Effective contraception should be used while taking this medicine.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be temporarily stopped before surgery to avoid blood pressure fluctuations during the procedure. Follow your doctor's instructions regarding when to resume.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth or dizziness during dental procedures. Your dentist may take precautions to manage blood pressure during the procedure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is generally safe while taking this medicine, but avoid sudden strenuous activities that may cause dizziness or fainting. Stay hydrated during exercise. If you experience chest pain, severe shortness of breath, or dizziness during exercise, stop and seek medical attention.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal activities once they adjust to the medication. Inform your employer if your job involves operating machinery or working at heights.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your blood pressure is well controlled for a long period, your doctor may consider adjusting or stopping the medication. Always follow your doctor's guidance.
📅 Long-Term Use Effects
Long-term use of this medicine may require regular monitoring of blood pressure, kidney function, and electrolyte levels. Chlorthalidone can cause electrolyte imbalances, increased blood sugar, and increased uric acid levels. Olmesartan may rarely cause sprue-like enteropathy. Regular follow-up with your doctor is essential to adjust the dose and manage any side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, and weight loss can help lower blood pressure and may reduce the need for medication.
Evidence: Well-establishedIf this medicine is not suitable, your doctor may prescribe alternative combinations such as ARB + calcium channel blocker.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, inform your healthcare provider about this medicine before receiving any vaccine. Keep your vaccinations up to date as advised by your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, consult your doctor about adjusting the timing of your dose. Store at room temperature and protect from moisture. Check customs regulations for carrying prescription medicines to your destination.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood pressure within 1-2 weeks, with maximal effect after 2-4 weeks.
A: Yes, you can take it with or without food. If it causes stomach upset, take it with a meal.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: No, this medicine is contraindicated during pregnancy as it can harm the fetus. Consult your doctor for alternative treatment.
A: No, do not stop taking this medicine without consulting your doctor. Stopping suddenly can cause blood pressure to rise again.
🤔 Common Patient Concerns
🔄 Substitutes for StayHappi Olmesartan Medoxomil+Chlorthalidone 40mg/12.5mg Tablet
View AllAlternative brands with exact same active ingredient:
-
davaindia olmesartan medoxomil+chlorthalidone 40mg/12.5mg tabletDavaindia Generic Pharmacy ₹58.00 27.2% CHEAPER
-
omnitrol ch 40mg/12.5mg tabletLeeford Healthcare Ltd ₹95.00 19.2% COSTLIER
-
olegard ch 40mg/12.5mg tabletOrganic Laboratories ₹96.25 20.8% COSTLIER
-
olmecap ch 40mg/12.5mg tabletVoopar Sciences Pvt Ltd ₹98.44 23.5% COSTLIER
-
olsem ch 40mg/12.5mg tabletAlde Medi Impex Ltd ₹112.50 41.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure high blood pressure permanently.
Fact: This medicine controls blood pressure but does not cure hypertension. Lifestyle changes and ongoing medication are usually needed. - Myth: You can stop taking this medicine once your blood pressure is normal.
Fact: Stopping suddenly can cause blood pressure to rise again. Always consult your doctor before stopping. - Myth: This medicine is safe during pregnancy.
Fact: This medicine is contraindicated during pregnancy as it can harm the fetus.
🔄 Alternative Options
Generic Alternatives
- Olmesartan Medoxomil + Chlorthalidone (generic)
Brand Alternatives
- Davaindia Olmesartan Medoxomil + Chlorthalidone 40mg/12.5mg Tablet