Progeny 500 Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of face, lips, tongue, or throat
- Difficulty breathing or chest pain
- Severe headache with vision changes
- Calf pain or swelling in one leg
- Yellowing of skin or eyes
- Severe abdominal pain
- Unusual vaginal bleeding
If experiencing severe symptoms, call emergency services immediately.
What is stable 500mg injection used for?
This medicine is a progesterone injection used to support the uterine lining in fertility treatments and to treat progesterone deficiency. It is given by a healthcare professional as an intramuscular injection.
- Generic Name: Progesterone (500mg)
- Manufacturer: Domagk Smith Labs Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 stable 500mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा प्रोजेस्टेरोन हार्मोन का इंजेक्शन है, जिसका उपयोग मुख्य रूप से प्रजनन उपचार (जैसे IVF) में गर्भाशय की परत को तैयार करने और भ्रूण को बनाए रखने के लिए किया जाता है। यह प्रोजेस्टेरोन की कमी से होने वाली समस्याओं जैसे मासिक धर्म में गड़बड़ी और गर्भपात के खतरे में भी दी जाती है। यह इंजेक्शन डॉक्टर या नर्स द्वारा मांसपेशी में लगाया जाता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन वाली जगह पर दर्द, सूजन या लालिमा, सिरदर्द, स्तनों में कोमलता, मूड में बदलाव, नींद आना और चक्कर आना शामिल हैं। कुछ लोगों को मतली, पेट में सूजन या पानी का जमाव भी हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको सांस लेने में तकलीफ, सीने में दर्द, पैर में सूजन या दर्द, या त्वचा का पीला पड़ना दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही लगाई जानी चाहिए। खुद से इंजेक्शन न लगाएं। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं, खासकर खून पतला करने वाली दवाएं और मधुमेह की दवाएं। इस दवा के साथ शराब न पिएं क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। अगर आपको नींद या चक्कर आएं तो वाहन न चलाएं। नियमित जांच के लिए डॉक्टर के पास जाते रहें।
💊 stable 500mg injection Uses & Benefits
[{"condition":"Luteal phase support in assisted reproductive technology (ART) cycles","description":"This medicine is given to support the endometrial lining after egg retrieval or embryo transfer, helping to maintain progesterone levels needed for implantation and early pregnancy.","evidence":"Well-established"},{"condition":"Progesterone deficiency states","description":"It is used to treat conditions caused by low endogenous progesterone, such as secondary amenorrhea and certain menstrual irregularities, when clinically indicated.","evidence":"Well-established"},{"condition":"Threatened or recurrent miscarriage associated with luteal phase defect","description":"In selected patients, progesterone supplementation may be prescribed to support early pregnancy when a luteal phase defect is identified.","evidence":"Moderate"},{"condition":"Endometrial preparation for frozen embryo transfer","description":"This medicine helps transform the endometrium into a receptive state before transfer of a frozen embryo in programmed cycles.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Catamenial epilepsy","description":"Progesterone has been studied as an add-on treatment for seizures that cluster around the menstrual cycle in some women.","evidence":"Limited"},{"condition":"Premenstrual syndrome (PMS) with prominent luteal symptoms","description":"In some cases, progesterone supplementation is tried for severe PMS symptoms, though evidence is mixed.","evidence":"Limited"}]
Primary treatment for: Progesterone deficiency states and luteal phase support in assisted reproductive technology
Also treats: Secondary amenorrhea, Threatened miscarriage, Endometrial preparation for frozen embryo transfer
📋 Drug Information
| Generic Name(s) | Progesterone (500mg) |
| Brand Name | stable 500mg injection |
| Manufacturer | Domagk Smith Labs Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Natural Progesterone |
| Route of Administration | Parenteral (intramuscular injection) |
| Storage | Store in a cool, dry place away from direct sunlight. Do not freeze. Keep in the original container until use. |
| Shelf Life | Refer to the packaging for the exact shelf life. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine delivers progesterone, which binds to and activates intracellular progesterone receptors in target tissues such as the endometrium, myometrium, and mammary glands. Upon binding, the receptor complex moves into the nucleus and modulates gene transcription, leading to secretory transformation of the endometrium, relaxation of uterine smooth muscle, and suppression of gonadotropin release through feedback on the hypothalamus and pituitary. These actions prepare the uterus for implantation and help maintain early pregnancy.
Mechanism Steps
💡 How to Take stable 500mg injection
Strength: 500 mg injection (immediate release)
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the indication, the patient's response, and the treatment protocol. For luteal phase support in assisted reproductive technology, a common regimen may involve daily intramuscular injections, but the exact dose and duration must be determined by your fertility specialist. Do not self-administer. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | There is limited information on the use of this medicine in elderly patients. Dose must be individualized by a qualified clinician based on clinical status and other medications. |
| Renal Impairment | No specific dose adjustment is established from the available information. Use with caution in patients with renal impairment and follow your doctor's guidance. |
| Hepatic Impairment | Progesterone is metabolized in the liver. Patients with hepatic impairment may require dose adjustment or careful monitoring. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose is not established from the available information. Dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of stable 500mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Rifampicin | Major | |
| Ketoconazole | Major | |
| Bromocriptine | Moderate | |
| Insulin | Moderate | |
| Carbamazepine | Major | |
| Phenytoin | Major | |
| Ritonavir | Major | |
| Paracetamol | Minor | |
| Ibuprofen | Minor |
🚨 Major Interactions
- Warfarin
- Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin)
- Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
⚡ Moderate Interactions
- Bromocriptine
- Diabetes medicines (insulin, oral hypoglycemics)
🍷 Alcohol Interaction
Avoid alcohol while using this medicine because it can increase drowsiness, dizziness, and impair your ability to drive or operate machinery.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to progesterone or any component of the formulation","Undiagnosed vaginal bleeding","Known or suspected breast cancer","Active or history of thromboembolic disorders (e.g., deep vein thrombosis, pulmonary embolism)","Severe liver disease","Known or suspected progesterone-dependent tumors"]
⚠️ Warnings & Precautions
["This medicine must be administered only by a healthcare professional.","Use with caution in patients with a history of blood clots, liver disease, or heart disease.","May cause drowsiness or dizziness; avoid driving or operating machinery until you know how it affects you.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Do not use if the solution is discolored or contains particles.","Keep out of reach of children."]
🤱 Lactation Safety
Progesterone is present in breast milk, but the amount from injectable use is generally considered low. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose with this medicine is unlikely because it is given by a healthcare professional. If accidental overdose occurs, seek immediate medical attention. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a scheduled dose, contact your doctor or clinic immediately for guidance. Do not try to self-administer an extra dose. Your doctor will advise whether to take the missed dose or skip it based on your treatment plan.
Additional Safety Advice
This medicine must be administered only by a qualified healthcare professional. Do not attempt to self-inject. Inform your doctor about all medicines you take, especially blood thinners, diabetes medicines, and other hormonal products. Avoid alcohol while using this medicine because it can worsen drowsiness and dizziness. Do not drive or operate heavy machinery if you feel sleepy or dizzy after the injection. Tell your doctor immediately if you notice calf pain, chest pain, shortness of breath, severe headache, or vision changes. Keep all follow-up appointments so your doctor can monitor your response and adjust treatment if needed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Limited data are available for elderly patients. Use with caution and individualize dose based on clinical status.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. It is often used as part of fertility treatment under medical supervision.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist if you are taking this medicine before any surgery. It may affect blood clotting and interact with other medicines.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, especially before any dental surgery, as it may affect bleeding risk.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you feel dizzy or drowsy after the injection. Consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. Plan your work schedule around your injection appointments.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will determine the appropriate duration of treatment based on your condition and response.
📅 Long-Term Use Effects
Long-term use of this medicine should be under medical supervision. Prolonged use may increase the risk of blood clots, liver problems, and fluid retention. Regular monitoring of liver function and clinical response is advised. Discuss with your doctor if you need treatment for more than a few weeks.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Oral micronized progesterone is an alternative for some indications, but it may have different absorption and side effect profiles.
Evidence: Well-establishedVaginal suppositories or gels are commonly used for luteal support and may be preferred in some cases.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established from the available information. Consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
If you need to travel while on this medicine, carry it in its original packaging with the prescription label. Keep a copy of your prescription with you. Since it is an injection, you may need to arrange for administration by a healthcare professional at your destination. Store it at room temperature and protect it from extreme heat or cold. Check airline and customs regulations for carrying injectable medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The onset of action depends on the clinical effect. Endometrial changes may begin within 24-48 hours, but full effect may take several days.
A: Some patients experience pain, redness, or swelling at the injection site. This is usually mild and temporary.
A: No, this medicine must be given by a qualified healthcare professional.
🤔 Common Patient Concerns
🔄 Substitutes for stable 500mg injection
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prolustar depo 500mg injectionCadila Pharmaceuticals Ltd ₹37.50 59.2% CHEAPER
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maloxy 500mg injectionMalar Healthcare ₹55.00 40.2% CHEAPER
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dyno 500mg injectionDynamic Laboratories Pvt Ltd ₹68.00 26.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Progesterone injections can be self-administered at home.
Fact: This medicine must be given by a qualified healthcare professional to ensure proper technique and safety. - Myth: Progesterone injections are only for women trying to conceive.
Fact: They are also used for other gynecological conditions such as secondary amenorrhea and luteal phase support. - Myth: Progesterone injections cause immediate weight gain.
Fact: Some patients may experience fluid retention, but significant weight gain is not a common effect.
🔄 Alternative Options
Generic Alternatives
- Progesterone injection
Brand Alternatives
- Progeny 500 injection