Spree D 50mg/15mg Tablet - Diclofenac (50mg) + Serratiopeptidase (15mg) medicine

Amanzoflam 50mg/15mg Tablet: Complete Medicine Guide

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🏭 Spire Pharma 📦 strip of 10 tablets 💊 Allopathy 📅 Updated: Sep 23, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Diclofenac is generally avoided during pregnancy, especially in the third trimester, due to risks of premature closure of the ductus arteriosus and other complications. Serratiopeptidase safety in pregnancy is not established. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate to well-established for diclofenac; limited for the combination with serratiopeptidase.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is Spree D 50mg/15mg Tablet used for?

This medicine is a combination of Diclofenac 50 mg and Serratiopeptidase 15 mg used to relieve pain, inflammation, and swelling in conditions like arthritis, injuries, and after surgery. It works by reducing prostaglandins and breaking down inflammatory proteins. Take it with food, avoid alcohol, and do not exceed the prescribed dose.

  • Generic Name: Diclofenac (50mg) + Serratiopeptidase (15mg)
  • Manufacturer: Spire Pharma
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 Spree D 50mg/15mg Tablet के बारे में (Hindi Summary)

उपयोग: यह दवा डाइक्लोफेनाक 50 मिलीग्राम और सेरेशियोपेप्टिडेज़ 15 मिलीग्राम का संयोजन है। इसका उपयोग दर्द, सूजन और जलन को कम करने के लिए किया जाता है, जो गठिया, चोट, सर्जरी के बाद की सूजन और दांतों की समस्याओं में आम है। यह दवा सूजन पैदा करने वाले प्रोटीन को तोड़ने और दर्द पैदा करने वाले रसायनों को कम करने में मदद करती है। इसे भोजन के साथ लें और शराब से बचें।

साइड इफेक्ट्स: आम दुष्प्रभावों में पेट दर्द, जलन, मतली, उल्टी, दस्त, कब्ज, सिरदर्द, चक्कर आना और त्वचा पर चकत्ते शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, गुर्दे की समस्या, लीवर की समस्या, गंभीर एलर्जी और हृदय संबंधी घटनाएं शामिल हैं। यदि आपको काला मल, खून की उल्टी, गंभीर पेट दर्द, पेशाब कम आना, आंखों या त्वचा का पीलापन, सीने में दर्द या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को भोजन या दूध के साथ लें ताकि पेट में जलन कम हो। निर्धारित खुराक से अधिक न लें। शराब से बचें क्योंकि इससे पेट में रक्तस्राव का खतरा बढ़ता है। बिना डॉक्टर की सलाह के अन्य दर्द निवारक दवाएं न लें। अच्छी मात्रा में पानी पिएं। यदि आपको अल्सर, गुर्दे, लीवर, हृदय रोग या अस्थमा की समस्या है तो डॉक्टर को बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं बिना सलाह के इसका उपयोग न करें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 Spree D 50mg/15mg Tablet Uses & Benefits

[{"condition":"Osteoarthritis","description":"Reduces joint pain, stiffness, and inflammation" class="semantic-link" title="Medicines for swelling">swelling, improving mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Provides symptomatic relief of pain and inflammation as an adjunct to disease-modifying therapy.","evidence":"Well-established"},{"condition":"Ankylosing spondylitis","description":"Helps relieve back pain and stiffness associated with spinal inflammation.","evidence":"Well-established"},{"condition":"Acute musculoskeletal injuries","description":"Reduces pain and swelling after sprains, strains, and sports injuries.","evidence":"Well-established"},{"condition":"Post-operative inflammation","description":"Used to reduce swelling and pain after surgical procedures, including dental and orthopedic surgery.","evidence":"Moderate"},{"condition":"Dental inflammation","description":"Prescribed for pain and swelling after tooth extraction or other dental procedures.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed off-label for short-term relief of acute migraine attacks, but not for prevention.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual pain and inflammation.","evidence":"Limited"}]

Primary treatment for: Inflammatory pain conditions

Also treats: Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, Acute musculoskeletal injuries, Post-operative swelling, Dental inflammation

📋 Drug Information

Generic Name(s)Diclofenac (50mg) + Serratiopeptidase (15mg)
Brand NameSpree D 50mg/15mg Tablet
ManufacturerSpire Pharma
Packaging / Formstrip of 10 tablets (Allopathy)
Therapeutic Class
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Avoid alcohol completely while taking this medicine.
3
Do not take other NSAIDs or pain relievers without consulting your doctor.
4
Stay well hydrated throughout the day.
5
Do not exceed the prescribed dose or duration.
6
Report any unusual bleeding, bruising, or black stools immediately.
7
If you have kidney or liver disease, inform your doctor before starting this medicine.
8
Use the lowest effective dose for the shortest possible time.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic joint pain
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
✅
Swelling after injury
This medicine helps reduce swelling and inflammation.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDiclofenac is rapidly absorbed from the gastrointestinal tract after oral administration. Serratiopeptidase is absorbed intact to some extent, but its bioavailability is not well established.
DistributionDiclofenac is highly bound to plasma proteins and distributes into synovial fluid, liver, and other tissues. Serratiopeptidase distribution is not well characterized.
Protein BindingDiclofenac is approximately 99% bound to plasma proteins, primarily albumin. Protein binding of serratiopeptidase is not established from the available information.
MetabolismDiclofenac is extensively metabolized in the liver by cytochrome P450 enzymes, mainly CYP2C9, to several hydroxylated metabolites. Serratiopeptidase is likely degraded to amino acids and peptides.
Half-LifeThe elimination half-life of diclofenac is approximately 1 to 2 hours. The half-life of serratiopeptidase is not established from the available information.
ExcretionDiclofenac metabolites are excreted mainly in urine (about 65%) and bile/feces (about 35%). Serratiopeptidase is excreted as degradation products.
BioavailabilityThe oral bioavailability of diclofenac is approximately 50% to 60% due to first-pass metabolism. The bioavailability of serratiopeptidase is not established from the available information.
Onset of ActionDiclofenac begins to relieve pain within 30 to 60 minutes after oral administration. Serratiopeptidase may take several days to show noticeable anti-edema effects.
Peak Plasma TimePeak plasma concentration of diclofenac is reached in about 1 to 2 hours after oral intake. Peak time for serratiopeptidase is not established from the available information.
Duration of ActionThe analgesic and anti-inflammatory effect of diclofenac lasts approximately 4 to 6 hours. The duration of serratiopeptidase action is not well established.

How It Works

Diclofenac inhibits cyclooxygenase enzymes (COX-1 and COX-2), reducing the production of prostaglandins that mediate pain, inflammation, and fever. Serratiopeptidase is a proteolytic enzyme that hydrolyzes bradykinin, fibrin, and other inflammatory mediators, potentially reducing swelling and improving tissue repair. Together, they provide anti-inflammatory, analgesic, and anti-edema effects.

Mechanism Steps

1
COX enzyme inhibition: Diclofenac binds to and reversibly inhibits COX-1 and COX-2 enzymes, blocking the conversion of arachidonic acid to prostaglandin H2.
2
Reduced prostaglandin synthesis: Lower levels of prostaglandins decrease pain receptor sensitization, inflammation, and fever.
3
Proteolytic enzyme activity: Serratiopeptidase hydrolyzes bradykinin, fibrin, and other proteins involved in swelling and inflammation.
4
Reduced edema: Breakdown of fibrin and inflammatory exudates helps reduce tissue swelling and promotes drainage.
5
Combined symptomatic relief: The anti-inflammatory and anti-edema actions together reduce pain and improve mobility.

💡 How to Take Spree D 50mg/15mg Tablet

Strength: Each tablet contains Diclofenac 50 mg and Serratiopeptidase 15 mg.

1Take the tablet with a full glass of water.
2Take it with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Take at the same time each day as prescribed.
5Do not take more than the prescribed dose.
6If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally one to two times daily with food, as prescribed by a doctor. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. The maximum daily dose is generally 150 mg of diclofenac, but this may vary. Use the lowest effective dose for the shortest duration.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients are at higher risk of gastrointestinal, kidney, and cardiovascular side effects. Use the lowest effective dose for the shortest duration and monitor closely.
Renal ImpairmentUse with caution in patients with kidney impairment. Dose reduction may be necessary. Avoid in severe kidney disease.
Hepatic ImpairmentUse with caution in patients with liver impairment. Dose reduction may be necessary. Avoid in severe liver disease.
Maximum Daily DoseThe maximum daily dose of diclofenac is generally 150 mg, but the exact limit depends on the prescribed regimen. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of gastrointestinal bleeding.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of Spree D 50mg/15mg Tablet

✅ Common Side Effects

Stomach pain or heartburn (Common (5-10%))
Take with food or milk. If persistent, consult your doctor.
Nausea (Common (5-10%))
Take with meals and stay hydrated. Consult doctor if severe.
Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if persistent.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Diarrhea or constipation (Common (5-10%))
Maintain hydration. Consult doctor if it persists beyond a few days.

🚨 Serious Side Effects

Gastrointestinal bleeding or ulcer (Rare (<0.1%))
Seek immediate medical attention if you notice black stool, vomiting blood, or severe abdominal pain.
Kidney impairment (Rare (<0.1%))
Report decreased urine output, swelling, or fatigue to your doctor immediately.
Liver injury (Rare (<0.1%))
Seek medical attention if you develop yellowing of eyes or skin, dark urine, or severe fatigue.
Severe allergic reaction (Rare (<0.1%))
Stop the medicine and seek emergency care if you experience facial swelling, difficulty breathing, or rash.
Cardiovascular events (Rare (<0.1%))
Seek immediate care for chest pain, shortness of breath, or sudden weakness.

⚠️ Rare Side Effects

Aseptic meningitis
Seek immediate medical attention for severe headache, stiff neck, or fever.
Pancreatitis
Seek immediate care for severe upper abdominal pain radiating to the back.
Severe skin reactions
Stop the medicine and seek emergency care for blistering rash or peeling skin.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Corticosteroids Major
Methotrexate Major
Lithium Major
ACE inhibitors Moderate
Diuretics Moderate
Beta-blockers Moderate
SSRIs Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs
  • Corticosteroids
  • Methotrexate
  • Lithium

⚡ Moderate Interactions

  • ACE inhibitors
  • Diuretics
  • Beta-blockers
  • SSRIs

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine because it increases the risk of stomach bleeding and ulcers.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Active peptic ulcer or gastrointestinal bleeding","Severe kidney disease","Severe liver disease","Uncontrolled heart failure","History of NSAID-induced asthma or allergic reaction","Third trimester of pregnancy","Known allergy to diclofenac or serratiopeptidase"]

⚠️ Warnings & Precautions

["Take with food to reduce stomach upset.","Avoid alcohol.","Do not use for more than 7 days without medical advice.","Use with caution in the elderly.","Monitor kidney and liver function with long-term use.","May increase risk of cardiovascular events.","Do not use in children without medical advice.","Inform your doctor about all other medicines you take."]

🤱 Lactation Safety

Diclofenac is excreted in breast milk in small amounts. Serratiopeptidase safety during breastfeeding is not established. Consult your doctor before use.

💊 Overdose Management

Overdose may cause nausea, vomiting, abdominal pain, drowsiness, and gastrointestinal bleeding. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine with food or milk to reduce stomach irritation. Do not exceed the prescribed dose or duration. Avoid alcohol because it increases the risk of stomach bleeding. Do not take other NSAIDs or pain relievers without consulting your doctor. Stay well hydrated. Inform your doctor if you have a history of ulcers, kidney disease, liver disease, heart failure, or asthma. Do not use this medicine for minor aches without medical advice. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before use. Keep out of reach of children. Store at room temperature away from moisture and direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal, kidney, and cardiovascular side effects. Use the lowest effective dose for the shortest duration and monitor closely.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before taking this medicine. Diclofenac may affect ovulation and is generally avoided during pregnancy.

🏥 Post-Surgery Considerations

This medicine may be prescribed after surgery to reduce pain and swelling. Follow your surgeon's instructions carefully and avoid alcohol.

🦷 Dental Procedures

This medicine may be prescribed after dental procedures to reduce pain and swelling. Inform your dentist about all medicines you take.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming or walking.
😴
Practice good posture.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep.
🌞
Avoid smoking and excessive alcohol.

🏋️ Exercise Considerations

Avoid strenuous exercise or activities that may increase pain or swelling. Gentle stretching and low-impact exercises are generally safe. Consult your doctor before starting any new exercise routine.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseeds.
Reduce processed and fried food intake.
Stay well hydrated.
Eat plenty of fruits and vegetables.
Limit salt and sugar.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food.

🛑 When to Stop This Medicine

Stop this medicine if you experience severe side effects such as gastrointestinal bleeding, allergic reactions, or kidney problems. Do not stop abruptly if you have been taking it for a long time without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney impairment, liver injury, and cardiovascular events. Regular monitoring of kidney and liver function, blood pressure, and gastrointestinal symptoms is recommended. Use the lowest effective dose for the shortest duration.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain and improve mobility.

Evidence: Well-established
Hot and cold compresses

May help reduce swelling and pain in acute injuries.

Evidence: Moderate
Weight management

Reduces stress on joints and improves osteoarthritis symptoms.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are established. However, if you are scheduled for vaccination, inform your doctor about this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and avoid extreme heat or moisture. If traveling across time zones, adjust dosing times gradually as advised by your doctor. Keep it in your carry-on luggage. Check customs regulations for controlled medicines before international travel.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic knee pain
Started this medicine as prescribed for osteoarthritis. Within 2 weeks noticed significant improvement in morning stiffness. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 60-year-old man with post-operative swelling after knee surgery
Was prescribed this medicine for 5 days after surgery. Swelling reduced noticeably by day 3, and pain was well controlled. He was advised to avoid alcohol and monitor for stomach upset.
💡 Lesson: Short-term use after surgery can effectively reduce swelling and pain when taken as directed.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Diclofenac starts relieving pain within 30 to 60 minutes. Serratiopeptidase may take several days to reduce swelling.

Q: Can I take it on an empty stomach?

A: No, it should be taken with food or milk to reduce stomach upset.

Q: Is it safe during pregnancy?

A: It is generally avoided during pregnancy, especially in the third trimester. Consult your doctor.

Q: Can I take it with other painkillers?

A: Do not take other NSAIDs without consulting your doctor, as it increases the risk of side effects.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for Spree D 50mg/15mg Tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken on an empty stomach.
    Fact: It should be taken with food to reduce stomach upset and risk of ulcers.
  • Myth: It is safe to take for months without monitoring.
    Fact: Long-term use requires regular monitoring of kidney and liver function.
  • Myth: It can be combined with other painkillers freely.
    Fact: Combining with other NSAIDs increases the risk of side effects.

🔄 Alternative Options

Generic Alternatives

  • Diclofenac 50 mg + Serratiopeptidase 15 mg tablet

Brand Alternatives

  • Amanzoflam 50mg/15mg tablet

📊 Comparison with Similar Medicines

[{"medicine":"Diclofenac 50 mg + Serratiopeptidase 15 mg","composition":"Diclofenac 50 mg + Serratiopeptidase 15 mg","uses":"Pain, inflammation, swelling","notes":"Combination product"},{"medicine":"Diclofenac 50 mg alone","composition":"Diclofenac 50 mg","uses":"Pain, inflammation","notes":"No anti-edema enzyme"},{"medicine":"Aceclofenac 100 mg + Serratiopeptidase 15 mg","composition":"Aceclofenac 100 mg + Serratiopeptidase 15 mg","uses":"Pain, inflammation, swelling","notes":"Different NSAID"}]

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