E Ova Plus 100mg Tablet: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe pelvic or abdominal pain
- Rapid weight gain or abdominal swelling
- Blurred vision, double vision, or flashing lights
- Difficulty breathing or chest pain
- Yellowing of skin or eyes
- Severe allergic reaction with swelling of face, lips, or throat
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is smartova 100 combipack used for?
This medicine is a combination of clomiphene 100 mg and coenzyme Q10 75 mg used to induce ovulation in women with fertility issues. It works by stimulating the release of hormones that trigger egg release from the ovaries. It is taken orally for 5 days at the start of the menstrual cycle, under medical supervision.
- Generic Name: Clomiphene (100mg) + Coenzyme Q10 (75mg)
- Manufacturer: Pharmanova India Drugs Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 smartova 100 combipack के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोमिफीन 100 मिलीग्राम और कोएंजाइम क्यू10 75 मिलीग्राम का संयोजन है, जिसका उपयोग महिलाओं में ओव्यूलेशन को प्रेरित करने के लिए किया जाता है। यह उन महिलाओं के लिए है जो नियमित रूप से ओव्यूलेट नहीं करती हैं या जिन्हें पीसीओएस है। यह दवा अंडे की गुणवत्ता में सुधार करने में मदद कर सकती है। इसे मुँह से लिया जाता है और डॉक्टर की सलाह के अनुसार ही लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में गर्म लहरें, मतली, पेट फूलना, स्तन में कोमलता, सिरदर्द और मूड स्विंग शामिल हैं। कुछ महिलाओं को धुंधली दृष्टि या दोहरी दृष्टि का अनुभव हो सकता है, जिसके लिए तुरंत डॉक्टर से संपर्क करना चाहिए। ओवेरियन हाइपरस्टिमुलेशन सिंड्रोम एक गंभीर दुष्प्रभाव है जिसमें पेट दर्द और सूजन हो सकती है।
सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। खुद से खुराक न बढ़ाएं या कम न करें। नियमित अल्ट्रासाउंड और रक्त परीक्षण करवाएं। यदि आपको पेट दर्द, सूजन या दृष्टि में बदलाव महसूस हो तो तुरंत डॉक्टर को बताएं। गर्भवती होने पर इस दवा का सेवन न करें। शराब का सेवन न करें।
💊 smartova 100 combipack Uses & Benefits
[{"condition":"Ovulation induction in polycystic ovary syndrome (PCOS)","description":"This medicine is used to stimulate ovulation in women with PCOS who are not ovulating regularly.","evidence":"Well-established"},{"condition":"Unexplained infertility","description":"It may be used to induce ovulation in women with unexplained infertility to improve chances of conception.","evidence":"Well-established"},{"condition":"Luteal phase defect","description":"Sometimes prescribed to support the luteal phase in fertility treatment cycles.","evidence":"Limited"},{"condition":"Male hypogonadism","description":"Rarely used off-label in men to increase testosterone levels, but not a standard use for this combination product.","evidence":"Limited"}]
Off-label uses: [{"condition":"Male infertility","description":"Clomiphene has been studied off-label to improve sperm production in some men, but this combination product is not approved for male use.","evidence":"Limited"},{"condition":"Gynecomastia","description":"Clomiphene may be used off-label to treat breast enlargement in men, but this is not a standard use.","evidence":"Limited"}]
Primary treatment for: Ovulatory dysfunction
Also treats: Polycystic ovary syndrome (PCOS), Unexplained infertility
📋 Drug Information
| Generic Name(s) | Clomiphene (100mg) + Coenzyme Q10 (75mg) |
| Brand Name | smartova 100 combipack |
| Manufacturer | Pharmanova India Drugs Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Keep in a cool, dry place away from direct sunlight. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Clomiphene works by blocking estrogen receptors in the hypothalamus and pituitary gland. This reduces the negative feedback of estrogen, leading to increased secretion of gonadotropin-releasing hormone (GnRH), which in turn raises follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels. These hormones stimulate the ovaries to produce and release eggs. Coenzyme Q10 is a fat-soluble antioxidant that participates in mitochondrial energy production and helps protect cells from oxidative damage. In the context of fertility, it is thought to improve egg quality and ovarian response, although its exact contribution in this combination is not fully established.
Mechanism Steps
💡 How to Take smartova 100 combipack
Strength: Each tablet contains clomiphene 100 mg and coenzyme Q10 75 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once daily for 5 days, starting on day 2 to 5 of the menstrual cycle, or as directed by your fertility specialist. The dose may be adjusted based on your response and the specific indication. Do not take more than the prescribed dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | This medicine is not intended for use in elderly women beyond reproductive age. Safety and efficacy have not been established in this population. |
| Renal Impairment | No specific dose adjustment is established for renal impairment. Use with caution and consult your doctor. |
| Hepatic Impairment | This medicine is contraindicated in women with liver disease. No specific dose adjustment is established for hepatic impairment. |
| Maximum Daily Dose | The maximum recommended daily dose is 100 mg of clomiphene and 75 mg of coenzyme Q10, as provided in this tablet. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of smartova 100 combipack
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Gonadotropins | Major | |
| Thyroid hormones | Moderate | |
| Antidiabetic medicines | Moderate | |
| Grapefruit juice | Moderate | |
| Paracetamol | Minor |
🚨 Major Interactions
- Other fertility medicines (e.g., gonadotropins)
- Warfarin
⚡ Moderate Interactions
- Thyroid hormones
- Antidiabetic medicines
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it may increase the risk of liver problems and can worsen side effects such as dizziness and mood changes. It is also advisable to avoid alcohol when trying to conceive.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Pregnancy","Liver disease","Unexplained abnormal vaginal bleeding","Ovarian cysts (except those due to PCOS)","Known hypersensitivity to clomiphene or coenzyme Q10"]
⚠️ Warnings & Precautions
["This medicine should only be used under the supervision of a fertility specialist.","Multiple pregnancies (twins, triplets) are a known risk.","Ovarian hyperstimulation syndrome can occur and may be serious.","Visual disturbances require immediate discontinuation and medical attention.","Do not use this medicine if you are already pregnant.","Use barrier contraception during treatment unless otherwise advised.","Inform your doctor about all other medicines you are taking."]
🤱 Lactation Safety
It is not known whether clomiphene or coenzyme Q10 passes into breast milk. This medicine is not recommended during breastfeeding because it may affect milk production and the safety for the infant is not established. Consult your doctor before breastfeeding while on this medicine.
💊 Overdose Management
Overdose of this medicine may cause severe ovarian hyperstimulation, visual disturbances, and abdominal pain. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. Contact your doctor if you are unsure.
Additional Safety Advice
Take this medicine exactly as prescribed by your fertility specialist. Do not increase or decrease the dose on your own. Attend all scheduled ultrasound and blood tests to monitor your ovarian response. Inform your doctor immediately if you experience pelvic pain, abdominal bloating, or visual changes. Avoid alcohol while taking this medicine. Do not take this medicine if you are pregnant or suspect you may be pregnant. Use a barrier method of contraception during treatment unless your doctor advises otherwise. Keep this medicine out of reach of children and store it in a cool, dry place.
👴 Special Considerations for Elderly
💡 For Patients Above 65
This medicine is not intended for use in women beyond reproductive age. Safety and efficacy have not been established in elderly patients.
🤰 Pregnancy Planning (TTC)
This medicine is used to help you conceive. If you are planning pregnancy, your doctor will prescribe it on specific days of your cycle. If you become pregnant while taking this medicine, stop it immediately and inform your doctor. Do not take this medicine if you are already pregnant.
🏥 Post-Surgery Considerations
If you have recently undergone surgery, inform your doctor before taking this medicine. There are no specific restrictions, but your overall health and recovery should be considered.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. There are no specific interactions, but it is important for your healthcare providers to know your medication history.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe while taking this medicine. However, if you experience pelvic pain or abdominal bloating due to ovarian enlargement, avoid strenuous activities and consult your doctor. Listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause visual disturbances or dizziness in some women, which could affect your ability to drive or operate machinery. If you experience these effects, avoid driving or operating heavy machinery until you feel normal. Otherwise, you can continue your usual daily activities.
🛑 When to Stop This Medicine
Stop taking this medicine and contact your doctor immediately if you experience visual disturbances, severe pelvic pain, rapid weight gain, or difficulty breathing. Do not stop the medicine without consulting your doctor unless advised to do so.
📅 Long-Term Use Effects
Long-term use of this medicine beyond the recommended duration is not advised without specialist supervision. Prolonged use may increase the risk of ovarian cysts and visual disturbances. Regular monitoring of ovarian response and liver function is recommended. If you do not conceive after 3 to 6 cycles, your doctor may consider alternative treatments.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another oral ovulation induction agent that may be used as an alternative, especially in PCOS.
Evidence: Well-establishedInjectable hormones used for ovulation induction in women who do not respond to oral agents.
Evidence: Well-establishedWeight loss, diet, and exercise can improve ovulation in women with PCOS.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions reported with this medicine. However, it is advisable to be up to date with routine vaccinations, especially rubella, before attempting pregnancy. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. Store at room temperature and away from direct sunlight. If crossing time zones, continue taking the medicine at the same time each day as prescribed; consult your doctor if you need to adjust the timing. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Ovulation typically occurs 5 to 10 days after completing the 5-day course. Your doctor will monitor your response with ultrasound or blood tests.
A: No, this is a prescription-only medicine and must be taken under the supervision of a fertility specialist.
A: This medicine increases the chance of multiple pregnancies, including twins, compared to natural conception. Your doctor will discuss this risk with you.
A: It is not recommended during breastfeeding because safety for the infant is not established. Consult your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for smartova 100 combipack
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine guarantees pregnancy.
Fact: It improves ovulation but does not guarantee pregnancy. Many factors affect fertility. - Myth: It is safe to take without monitoring.
Fact: It requires regular monitoring by a fertility specialist to avoid complications. - Myth: It can be taken at any time in the cycle.
Fact: It must be taken on specific days of the menstrual cycle as prescribed.
🔄 Alternative Options
Generic Alternatives
- Clomiphene 100 mg + Coenzyme Q10 75 mg tablet (generic)
Brand Alternatives
- E Ova Plus 100mg Tablet