sinocet tablet - Paracetamol (500mg) + Phenylpropanolamine (25mg) medicine

Aceper Tablet: Complete Medicine Guide

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🏭 Pharmatech Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 21, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Limited due to safety concerns.
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe headache with blurred vision
  • Chest pain or palpitations
  • Yellowing of skin or eyes
  • Dark urine or severe abdominal pain
  • Swelling of face, lips, or throat
  • Seizures or loss of consciousness

If experiencing severe symptoms, call emergency services immediately.

What is sinocet tablet used for?

This medicine is a combination of Paracetamol and Phenylpropanolamine used for short-term relief of nasal congestion, headache, and fever associated with cold or allergies. It works by reducing pain and fever and constricting nasal blood vessels. It should not be used in people with high blood pressure or heart disease.

  • Generic Name: Paracetamol (500mg) + Phenylpropanolamine (25mg)
  • Manufacturer: Pharmatech Healthcare
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 sinocet tablet के बारे में (Hindi Summary)

उपयोग: यह दवा पैरासिटामोल और फेनिलप्रोपेनॉलामाइन का संयोजन है, जिसका उपयोग सर्दी, एलर्जी या साइनसाइटिस के कारण होने वाली नाक की भीड़, सिरदर्द और बुखार से राहत के लिए किया जाता है। यह दवा नाक के रक्त वाहिकाओं को सिकोड़कर भीड़ को कम करती है और दर्द व बुखार को कम करती है। यह केवल अल्पकालिक उपयोग के लिए है और इसे 5-7 दिनों से अधिक नहीं लेना चाहिए। उच्च रक्तचाप, हृदय रोग, थायरॉइड, मधुमेह या ग्लूकोमा वाले रोगियों को इसका सेवन नहीं करना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में परेशानी, मुँह सूखना, सिरदर्द, चक्कर आना और बेचैनी शामिल हैं। फेनिलप्रोपेनॉलामाइन के कारण हृदय गति बढ़ सकती है और रक्तचाप बढ़ सकता है। दुर्लभ मामलों में गंभीर उच्च रक्तचाप, अनियमित हृदय गति, दौरे और यकृत की क्षति हो सकती है। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। अनुशंसित खुराक से अधिक न लें। शराब का सेवन न करें क्योंकि इससे यकृत की क्षति का खतरा बढ़ सकता है। यदि आपको उच्च रक्तचाप, हृदय रोग है या आप MAO अवरोधक ले रहे हैं तो इस दवा का सेवन न करें। चक्कर आने पर वाहन न चलाएं। 5 दिनों से अधिक उपयोग करने से पहले डॉक्टर से सलाह लें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 sinocet tablet Uses & Benefits

[{"condition":"Common cold","description":"Provides temporary relief of nasal congestion, headache, and fever associated with the common cold.","evidence":"Well-established for short-term symptomatic relief."},{"condition":"Allergic rhinitis","description":"Helps reduce nasal stuffiness and sinus pressure caused by allergies.","evidence":"Well-established for short-term use."},{"condition":"Sinusitis","description":"Relieves sinus congestion and associated pain or fever.","evidence":"Well-established for symptomatic relief."},{"condition":"Influenza","description":"Reduces fever, body aches, and nasal congestion during flu.","evidence":"Well-established for symptomatic relief."}]

Off-label uses: [{"condition":"Weight loss","description":"Phenylpropanolamine was historically used as an appetite suppressant, but this is no longer recommended due to safety concerns.","evidence":"Limited and not recommended."}]

Primary treatment for: Common cold

Also treats: Allergic rhinitis, Sinusitis, Influenza

📋 Drug Information

Generic Name(s)Paracetamol (500mg) + Phenylpropanolamine (25mg)
Brand Namesinocet tablet
ManufacturerPharmatech Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture.
Shelf Life24 months from date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Do not exceed the recommended dose or duration of use.
3
Avoid alcohol while taking this medicine.
4
Monitor your blood pressure if you have hypertension.
5
Consult your doctor if symptoms persist beyond 5 days.
6
Do not use with other paracetamol-containing products.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Nasal congestion
This medicine is commonly used for this symptom.
Likely Use
Fever
Paracetamol in this medicine helps reduce fever.
Likely Use
Headache
Paracetamol provides pain relief.
Likely Use
Chest pain
This medicine is not for chest pain; seek immediate medical help.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionParacetamol is rapidly and almost completely absorbed from the gastrointestinal tract. Phenylpropanolamine is also absorbed from the gastrointestinal tract, but its bioavailability is variable. Food may delay absorption of paracetamol.
DistributionParacetamol distributes widely into body tissues, with a volume of distribution of about 0.9 L/kg. Phenylpropanolamine distributes into various tissues, including the central nervous system.
Protein BindingParacetamol is minimally bound to plasma proteins (about 10-25%). Phenylpropanolamine binding is not well established.
MetabolismParacetamol is metabolized primarily in the liver via glucuronidation and sulfation, with a small fraction metabolized by CYP2E1 to a toxic intermediate (NAPQI) that is detoxified by glutathione. Phenylpropanolamine undergoes limited metabolism, primarily by monoamine oxidase and catechol-O-methyltransferase.
Half-LifeParacetamol half-life is about 2-3 hours in adults. Phenylpropanolamine half-life is approximately 3-4 hours.
ExcretionParacetamol is excreted in urine as glucuronide and sulfate conjugates. Phenylpropanolamine is excreted unchanged in urine.
BioavailabilityParacetamol bioavailability is about 80-100%. Phenylpropanolamine bioavailability is approximately 40-60%.
Onset of ActionParacetamol onset of action is within 30-60 minutes. Phenylpropanolamine onset is within 15-30 minutes.
Peak Plasma TimeParacetamol peak plasma concentration occurs at 0.5-2 hours. Phenylpropanolamine peak occurs at 1-2 hours.
Duration of ActionParacetamol duration is 4-6 hours. Phenylpropanolamine duration is 4-6 hours.

How It Works

Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis, which raises the pain threshold and lowers fever. Phenylpropanolamine is a sympathomimetic amine that directly and indirectly stimulates alpha-adrenergic receptors, causing vasoconstriction in the nasal mucosa, thereby reducing swelling and congestion. It also has some beta-adrenergic activity, which can increase heart rate and blood pressure.

Mechanism Steps

1
Paracetamol central action: Paracetamol inhibits prostaglandin synthesis in the brain, reducing pain and fever.
2
Phenylpropanolamine alpha-adrenergic stimulation: Phenylpropanolamine binds to alpha-adrenergic receptors on nasal blood vessels, causing vasoconstriction.
3
Reduced nasal congestion: Vasoconstriction decreases blood flow and swelling in the nasal passages, easing breathing.
4
Additional beta-adrenergic effects: Phenylpropanolamine may also stimulate beta receptors, leading to increased heart rate and blood pressure.

💡 How to Take sinocet tablet

Strength: Tablet: Paracetamol 500 mg + Phenylpropanolamine 25 mg

1Take this medicine orally with a full glass of water.
2Take with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Take at regular intervals as prescribed.
5Do not exceed the recommended dose.

Dosage Information

Adult DosageThe usual adult dose is one tablet every 4 to 6 hours as needed for symptoms, not to exceed 6 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not use for more than 5-7 days without medical advice.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of phenylpropanolamine. Use with caution and lower doses may be appropriate. Consult a doctor.
Renal ImpairmentUse with caution in renal impairment. Dose adjustment may be required. Consult a doctor.
Hepatic ImpairmentUse with caution in hepatic impairment. Dose adjustment may be required. Consult a doctor.
Maximum Daily DoseMaximum 6 tablets in 24 hours (3000 mg paracetamol and 150 mg phenylpropanolamine).

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals or snacks
Reduces stomach upset.
Alcohol
Avoid
Increases risk of liver damage and stomach bleeding.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of sinocet tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk to reduce nausea. If persistent, consult doctor.
Dry mouth (Common (5-10%))
Sip water frequently or chew sugarless gum. Usually resolves.
Headache (Common (5-10%))
Rest and stay hydrated. If severe, consult doctor.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Insomnia (Uncommon (1-5%))
Avoid taking close to bedtime. Consult doctor if persistent.

🚨 Serious Side Effects

Hypertensive crisis (Rare (<0.1%))
Seek immediate medical attention if you experience severe headache, blurred vision, or chest pain.
Severe liver damage (Rare (<0.1%))
Seek immediate medical attention if you notice yellowing of skin or eyes, dark urine, or severe abdominal pain.
Arrhythmias (Rare (<0.1%))
Seek immediate medical attention if you feel palpitations, irregular heartbeat, or fainting.
Seizures (Very rare (<0.01%))
Seek immediate medical attention if you experience convulsions or loss of consciousness.

⚠️ Rare Side Effects

Hallucinations
Seek immediate medical attention.
Severe allergic reactions (anaphylaxis)
Seek immediate medical attention if you experience swelling of face, lips, throat, or difficulty breathing.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAOIs Major
Warfarin Major
Beta-blockers Moderate
Tricyclic antidepressants Moderate
Digoxin Moderate
Antacids Minor
Caffeine Minor

🚨 Major Interactions

  • Monoamine oxidase inhibitors (MAOIs)
  • Other sympathomimetics
  • Warfarin

⚡ Moderate Interactions

  • Beta-blockers
  • Tricyclic antidepressants
  • Digoxin

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol can increase the risk of liver damage from paracetamol and may worsen stomach irritation. It can also increase the stimulant effects of phenylpropanolamine, leading to increased heart rate and blood pressure.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to paracetamol or phenylpropanolamine","Severe hypertension or cardiovascular disease","Hyperthyroidism","Diabetes mellitus","Closed-angle glaucoma","Prostatic hypertrophy","Use with MAO inhibitors","Severe liver or kidney impairment"]

⚠️ Warnings & Precautions

["Do not exceed recommended dose or duration.","Avoid in patients with high blood pressure or heart disease.","Use with caution in elderly and those with kidney or liver disease.","May cause dizziness; avoid driving until you know how it affects you.","Do not use with other paracetamol-containing products.","Consult doctor if symptoms persist beyond 5 days."]

🤱 Lactation Safety

Not established from the available information. Consult your doctor before use.

💊 Overdose Management

Overdose can cause severe liver damage from paracetamol and hypertensive crisis from phenylpropanolamine. Seek immediate medical attention. Treatment includes activated charcoal, acetylcysteine for paracetamol toxicity, and supportive care for cardiovascular effects.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of use. Avoid alcohol while taking this medicine as it can increase the risk of liver damage and stomach bleeding. Do not use this medicine if you have uncontrolled high blood pressure, heart disease, or are taking MAO inhibitors. Inform your doctor about all other medications you are taking, especially blood pressure medicines, antidepressants, and blood thinners. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Keep out of reach of children. Store at room temperature away from moisture and heat. If symptoms persist or worsen after 5 days, consult your doctor.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the cardiovascular effects of phenylpropanolamine. Use with caution and monitor blood pressure.

🤰 Pregnancy Planning (TTC)

Consult your doctor before taking this medicine if you are pregnant, planning pregnancy, or breastfeeding. Safety is not established.

🏥 Post-Surgery Considerations

Consult your doctor before using this medicine after surgery, especially if you have cardiovascular conditions.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may interact with anesthetics or affect blood pressure.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help thin nasal secretions.
🥗
Get plenty of rest to support recovery.
😴
Use a humidifier to ease nasal congestion.
💧
Avoid allergens and irritants like smoke.
🧘
Practice good hand hygiene to prevent infections.

🏋️ Exercise Considerations

Avoid strenuous exercise if you feel dizzy or fatigued. Light activity is fine if you feel up to it.

🥗 Diet Recommendations

Drink warm fluids like soups and teas.
Include vitamin C-rich fruits and vegetables.
Avoid alcohol and caffeine.
Eat light, easily digestible meals.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause insomnia if taken late in the day.

🛑 When to Stop This Medicine

Stop taking this medicine if symptoms resolve or after 5-7 days of use. Consult your doctor before stopping if you have been on it for a longer period or if you have underlying health conditions.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended due to the risk of hypertension, cardiac effects, and liver damage from paracetamol. It should only be used for short-term symptomatic relief. Regular monitoring of blood pressure and liver function may be needed if used for extended periods.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Saline nasal spray

Helps relieve nasal congestion without systemic effects.

Evidence: Well-established
Steam inhalation

Can temporarily ease nasal stuffiness.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and avoid extreme heat or moisture. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying medications.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with common cold and nasal congestion
He took this medicine as prescribed and experienced relief from congestion and headache within an hour. He was advised not to exceed the dose and to avoid alcohol. He recovered fully in 3 days.
💡 Lesson: Short-term use as prescribed provides effective symptom relief.
👤 A 50-year-old woman with hypertension
She took this medicine for cold symptoms without consulting her doctor and experienced a severe headache and elevated blood pressure. She was advised to avoid phenylpropanolamine-containing products.
💡 Lesson: People with high blood pressure should avoid this medicine due to risk of hypertensive crisis.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30-60 minutes after taking it.

Q: Can I take it on an empty stomach?

A: It is best taken with food to reduce stomach upset.

Q: Is it safe for children?

A: Pediatric dosing is not established. Consult a pediatrician.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my blood pressure?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for sinocet tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is safe for everyone.
    Fact: It is not safe for people with high blood pressure, heart disease, or those taking MAO inhibitors.
  • Myth: It can be taken for long periods.
    Fact: It should only be used for short-term relief, usually not more than 5-7 days.

🔄 Alternative Options

Generic Alternatives

  • Paracetamol + Phenylpropanolamine combination products

📊 Comparison with Similar Medicines

[{"medicine":"Paracetamol + Phenylpropanolamine","composition":"Paracetamol 500 mg + Phenylpropanolamine 25 mg","onset":"30-60 minutes","duration":"4-6 hours","notes":"Phenylpropanolamine has been associated with stroke risk."},{"medicine":"Paracetamol + Phenylephrine","composition":"Paracetamol 500 mg + Phenylephrine 5 mg","onset":"30-60 minutes","duration":"4-6 hours","notes":"Phenylephrine is considered safer than phenylpropanolamine."}]

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