Hepamac Tablet: Complete Guide to Uses, Dosage, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of the skin or eyes (jaundice)
- Severe abdominal pain or swelling
- Vomiting blood or black, tarry stools
- Confusion, drowsiness, or changes in behavior
- Difficulty breathing or swelling of the face, lips, or throat
- Decreased urine output or swelling in the legs
- Persistent vomiting or inability to keep fluids down
If experiencing severe symptoms, call emergency services immediately.
What is silokyne l 250mg/140mg tablet used for?
This medicine is a combination of L-Ornithine L-Aspartate and Silymarin used to support liver function and lower ammonia levels in people with liver disease. It is taken orally with food, usually one tablet one to three times daily as prescribed by a doctor.
- Generic Name: L-Ornithine L-Aspartate (250mg) + Silymarin (140mg)
- Manufacturer: Kyna Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 silokyne l 250mg/140mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा लीवर की सेहत के लिए इस्तेमाल की जाती है। इसमें एल-ऑर्निथिन एल-एस्पार्टेट और सिलीमेरिन दो सक्रिय तत्व होते हैं। यह लीवर में अमोनिया के स्तर को कम करने में मदद करती है और लीवर की कोशिकाओं को नुकसान से बचाती है। डॉक्टर इस दवा को क्रोनिक लीवर रोग, फैटी लीवर, शराब से होने वाले लीवर नुकसान और हेपेटिक एन्सेफेलोपैथी जैसी समस्याओं में लिखते हैं। यह दवा लीवर की कार्यक्षमता सुधारने में सहायक होती है, लेकिन यह लीवर रोग का पूरा इलाज नहीं है। इसे डॉक्टर की सलाह के अनुसार ही लेना चाहिए।
साइड इफेक्ट्स: इस दवा को लेने पर आमतौर पर हल्के दुष्प्रभाव हो सकते हैं, जैसे जी मिचलाना, पेट में गड़बड़ी, दस्त या सिरदर्द। ये लक्षण आमतौर पर कुछ समय में ठीक हो जाते हैं। कभी-कभी त्वचा पर रैश, खुजली या सूजन हो सकती है। गंभीर दुष्प्रभाव बहुत कम होते हैं, लेकिन अगर आपको आंखों या त्वचा का पीला पड़ना, गंभीर पेट दर्द, या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे पानी के साथ पूरा निगलें, चबाएं नहीं। इसे भोजन के साथ या भोजन के बाद लें ताकि पेट में जलन न हो। इस दवा को लेते समय शराब बिल्कुल न पिएं, क्योंकि इससे लीवर को और नुकसान हो सकता है। अपने डॉक्टर को अपनी सभी दवाओं और सप्लीमेंट्स के बारे में बताएं। नियमित रूप से लीवर फंक्शन टेस्ट कराते रहें। गर्भावस्था या स्तनपान के दौरान इस दवा का उपयोग करने से पहले डॉक्टर से सलाह लें।
💊 silokyne l 250mg/140mg tablet Uses & Benefits
[{"condition":"Chronic liver disease","description":"Used as supportive therapy to improve liver function and reduce symptoms in people with long-standing liver conditions.","evidence":"Moderate"},{"condition":"Hepatic encephalopathy","description":"L-Ornithine L-Aspartate helps lower blood ammonia levels, which can improve mental alertness and reduce confusion in hepatic encephalopathy.","evidence":"Moderate to well-established for the L-Ornithine L-Aspartate component"},{"condition":"Alcohol-related liver damage","description":"Silymarin may help protect liver cells from further damage, while L-Ornithine L-Aspartate supports ammonia clearance.","evidence":"Limited to moderate"},{"condition":"Non-alcoholic fatty liver disease (NAFLD)","description":"Sometimes prescribed as an add-on to lifestyle changes to support liver health in fatty liver disease.","evidence":"Limited"},{"condition":"Drug-induced liver injury","description":"May be used as supportive care when liver damage is caused by certain medicines or toxins.","evidence":"Limited"}]
Off-label uses: [{"condition":"General liver detoxification","description":"Some people use this medicine without a specific liver diagnosis for general liver support, but this is not a standard approved use.","evidence":"Limited"},{"condition":"Hangover prevention","description":"There is no reliable evidence that this medicine prevents hangovers, and it should not be used for this purpose.","evidence":"Not established"}]
Primary treatment for: Chronic liver disease
Also treats: Hepatic encephalopathy, Alcohol-related liver damage, Non-alcoholic fatty liver disease, Drug-induced liver injury
📋 Drug Information
| Generic Name(s) | L-Ornithine L-Aspartate (250mg) + Silymarin (140mg) |
| Brand Name | silokyne l 250mg/140mg tablet |
| Manufacturer | Kyna Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a cool, dry place. Protect from direct sunlight and moisture. Keep the tablets in the original container or blister pack. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. Guidelines may vary by region and condition. Consult your doctor for the most appropriate treatment for your condition. |
| ICMR Guideline | Not established from the available information. Please refer to your doctor for guidance based on Indian medical practice. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works through two complementary ingredients. L-Ornithine L-Aspartate provides ornithine and aspartate, which are involved in the urea cycle and help convert ammonia into urea for safe removal from the body. This reduces blood ammonia levels, which is important because high ammonia can affect brain function. Silymarin, a plant-derived flavonolignan complex, helps stabilize liver cell membranes, reduces oxidative stress, and supports the regeneration of healthy liver cells. Together, these actions help protect the liver and improve its ability to handle toxins and waste products.
Mechanism Steps
💡 How to Take silokyne l 250mg/140mg tablet
Strength: Each tablet contains L-Ornithine L-Aspartate 250 mg and Silymarin 140 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken one to three times daily, depending on the condition being treated and your doctor's assessment. The exact dose and duration must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not change the dose without consulting your doctor. Take the tablet with or after food to reduce stomach upset. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. The dose is usually the same as for adults, but your doctor may adjust it based on kidney and liver function. Regular monitoring is advised. |
| Renal Impairment | In patients with mild to moderate kidney disease, no dose adjustment is usually needed. In severe kidney disease, the dose may need to be reduced or the medicine avoided. Consult your doctor for personalized advice. |
| Hepatic Impairment | This medicine is used to support liver function. In severe liver disease, the dose may be adjusted by your doctor. Regular liver function monitoring is recommended. |
| Maximum Daily Dose | The maximum daily dose is usually three tablets per day, but this must be confirmed by your doctor. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of silokyne l 250mg/140mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | |
| Paracetamol (high dose) | Moderate | |
| Methotrexate | Moderate | |
| Isoniazid | Moderate | |
| Diabetes medicines | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Alcohol
⚡ Moderate Interactions
- Hepatotoxic drugs (e.g., paracetamol in high doses, methotrexate, isoniazid)
- Diabetes medicines
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine. Alcohol can worsen liver damage, reduce the effectiveness of treatment, and increase the risk of side effects. If you drink alcohol regularly, talk to your doctor about safe ways to stop.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to L-Ornithine L-Aspartate, Silymarin, or any other ingredient in this medicine","Severe kidney disease with reduced urine output","Rare genetic conditions such as arginineemia or hyperammonemia due to enzyme defects","Use in children unless specifically prescribed by a pediatrician"]
⚠️ Warnings & Precautions
["Do not take this medicine without a doctor's prescription.","Avoid alcohol completely during treatment.","Inform your doctor if you have kidney disease, liver disease, or diabetes.","Do not exceed the recommended dose.","Keep all follow-up appointments and lab tests.","If you are pregnant or breastfeeding, consult your doctor before use.","Do not use this medicine to treat any condition other than the one prescribed.","Store out of reach of children."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Consult your doctor before using this medicine while breastfeeding. Your doctor will weigh the benefits and risks.
💊 Overdose Management
If you accidentally take more than the prescribed dose, contact your doctor or visit the nearest hospital immediately. Take the medicine pack with you. Treatment is supportive and based on symptoms. There is no specific antidote. Do not try to vomit unless told by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. If it is almost time, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Swallow the tablet whole with a glass of water, preferably with or after a meal to reduce stomach upset. Do not crush, chew, or break the tablet unless your doctor advises otherwise. Avoid alcohol completely while taking this medicine, as alcohol can worsen liver damage and reduce the benefit of treatment. Inform your doctor about all other medicines, supplements, and herbal products you are taking, because some may interact with this medicine. Keep all follow-up appointments and get regular liver function tests as advised. If you are pregnant, planning pregnancy, or breastfeeding, talk to your doctor before using this medicine. Store the tablets in a cool, dry place away from direct sunlight and out of reach of children. Do not use this medicine after the expiry date printed on the pack.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced kidney and liver function, which can affect how this medicine is processed. Your doctor may adjust the dose or monitor you more closely. Regular check-ups are important.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss this medicine with your doctor before conception. Your doctor will review whether it is safe to continue or if an alternative is needed. Do not start or stop any medicine without medical advice.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. They will decide whether to continue or temporarily stop it. Follow your doctor's instructions carefully after surgery.
🦷 Dental Procedures
Tell your dentist that you are taking this medicine before any dental procedure. There are no specific precautions, but it is important for your dentist to know your full medicine list.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Regular physical activity is good for liver health, but avoid strenuous exercise if you feel very tired or unwell. Start slowly and increase gradually. If you have advanced liver disease, consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to work or drive. However, if you feel dizzy, tired, or unwell, avoid driving or operating heavy machinery until you feel better. Inform your employer if you need any adjustments due to your liver condition.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Your doctor will decide when it is safe to stop based on your condition, symptoms, and lab test results. If you experience severe side effects, contact your doctor immediately for advice.
📅 Long-Term Use Effects
Long-term use of this medicine is generally well tolerated when monitored by a doctor. Regular liver function tests and clinical reviews are recommended to assess ongoing benefit and detect any changes. In some people, long-term use may be needed to manage chronic liver conditions. Do not stop the medicine without consulting your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Weight loss, healthy diet, and regular exercise can improve liver health, especially in fatty liver disease.
Evidence: Well-establishedStopping alcohol is essential for anyone with alcohol-related liver disease.
Evidence: Well-establishedYour doctor may prescribe other medicines such as lactulose or rifaximin for hepatic encephalopathy.
Evidence: Well-established for specific conditions💉 Vaccination Considerations
💉 If You're Getting Vaccinated
People with chronic liver disease should discuss vaccination against hepatitis A and hepatitis B with their doctor. These vaccines can help prevent additional liver infections. There are no known interactions between this medicine and vaccines.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container or blister pack
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry your medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking your doses at the same intervals as prescribed; consult your doctor if you need help adjusting the schedule. Check local customs rules for carrying prescription medicines. Carry enough supply for your entire trip plus a few extra days.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The ammonia-lowering effect can begin within hours, but noticeable improvement in symptoms may take days to weeks. Liver function tests may improve over several weeks of regular use.
A: No, alcohol should be completely avoided while taking this medicine because it can worsen liver damage and reduce the medicine's benefit.
A: This medicine is generally safe for long-term use when prescribed and monitored by a doctor. Regular liver function tests are advised.
A: Consult your doctor before taking this medicine during pregnancy. There is limited data on its safety in pregnancy.
A: If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for silokyne l 250mg/140mg tablet
View AllAlternative brands with exact same active ingredient:
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hepaseal tabletZegchem ₹121.88 52.9% COSTLIER
-
hepabert tabletHilbert Healthcare ₹168.75 111.8% COSTLIER
-
triohep 250mg/140mg tabletAmazone Pharmaceuticals Pvt Ltd ₹206.25 158.8% COSTLIER
-
livpalm s softgel capsuleRekin Pharma Pvt. Ltd. ₹215.63 170.6% COSTLIER
-
hepamac tabletUnimac Pharmaceuticals Pvt Ltd ₹271.80 241.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure all liver diseases.
Fact: This medicine supports liver function but does not cure all liver diseases. It is used as part of a treatment plan prescribed by your doctor. - Myth: You can drink alcohol while taking this medicine.
Fact: Alcohol should be completely avoided because it can worsen liver damage and reduce the benefit of this medicine. - Myth: This medicine is a general tonic for everyone.
Fact: This medicine is a prescription medicine for specific liver conditions. It should not be taken without a doctor's advice.
🔄 Alternative Options
Generic Alternatives
- L-Ornithine L-Aspartate 250 mg + Silymarin 140 mg tablet (generic)
Brand Alternatives
- Heptral
- Legalon
- Silymarin
- Liv.52
- Udiliv