sd 75 mg/15 mg tablet - Diclofenac (75mg) + Serratiopeptidase (15mg) medicine

Biodic 75 mg/15 mg Tablet: Complete Medicine Guide

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🏭 Serum Institute Of India Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 24, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Diclofenac is not recommended during the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus. Serratiopeptidase safety in pregnancy is not established. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate to well-established for diclofenac; limited for serratiopeptidase.
Reviewed by
SaathiMed Expert Panel | Oct 24, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bleeding or bruising
  • Severe skin rash with blisters

If experiencing severe symptoms, call emergency services immediately.

What is sd 75 mg/15 mg tablet used for?

This medicine is a combination of diclofenac, an anti-inflammatory pain reliever, and serratiopeptidase, an enzyme that reduces swelling. It is used for conditions like arthritis, injuries, and post-surgical swelling. Take it with food to avoid stomach upset and avoid alcohol.

  • Generic Name: Diclofenac (75mg) + Serratiopeptidase (15mg)
  • Manufacturer: Serum Institute Of India Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 sd 75 mg/15 mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा डाइक्लोफेनाक और सेरेशियोपेप्टिडेज का संयोजन है। इसका उपयोग दर्द और सूजन को कम करने के लिए किया जाता है, जैसे गठिया, चोट, और सर्जरी के बाद की सूजन में। यह दवा सूजन पैदा करने वाले रसायनों को रोककर काम करती है। इसे भोजन के साथ लें ताकि पेट में जलन न हो। शराब का सेवन न करें। गर्भावस्था में इसका उपयोग डॉक्टर की सलाह के बिना न करें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में पेट दर्द, जलन, मतली, उल्टी, दस्त, सिरदर्द, चक्कर आना और त्वचा पर दाने शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, गुर्दे की समस्या, यकृत की क्षति, गंभीर एलर्जी और हृदय संबंधी घटनाएं शामिल हो सकती हैं। यदि आपको काला मल, खून की उल्टी, गंभीर पेट दर्द, सीने में दर्द, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या त्वचा या आंखों का पीला पड़ना दिखे तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को भोजन या दूध के साथ लें ताकि पेट में जलन न हो। खाली पेट न लें। इस दवा के साथ शराब का सेवन न करें क्योंकि इससे पेट में रक्तस्राव का खतरा बढ़ जाता है। अन्य दर्द निवारक दवाओं (जैसे इबुप्रोफेन, नेप्रोक्सन, या एस्पिरिन) को डॉक्टर की सलाह के बिना न लें। यदि आपको पेट के अल्सर, गुर्दे या यकृत की बीमारी, हृदय की समस्या, या अस्थमा है तो अपने डॉक्टर को बताएं। सबसे कम प्रभावी खुराक का उपयोग करें। बिना डॉक्टर की सलाह के 7 दिनों से अधिक इस दवा का उपयोग न करें। यदि आप गर्भवती हैं या गर्भवती होने की योजना बना रही हैं, तो इस दवा को लेने से पहले अपने डॉक्टर से परामर्श करें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 sd 75 mg/15 mg tablet Uses & Benefits

[{"condition":"Osteoarthritis","description":"Relieves pain and improves joint mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Reduces joint pain, inflammation" class="semantic-link" title="Medicines for swelling">swelling, and stiffness in rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Ankylosing spondylitis","description":"Helps alleviate back pain and stiffness associated with ankylosing spondylitis.","evidence":"Well-established"},{"condition":"Acute musculoskeletal injuries","description":"Reduces pain and swelling in sprains, strains, and sports injuries.","evidence":"Well-established"},{"condition":"Post-operative swelling","description":"Helps reduce inflammation and edema after surgical procedures.","evidence":"Moderate"},{"condition":"Dental pain","description":"Provides relief from dental pain and inflammation after dental procedures.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed off-label for preventing migraines, but evidence is limited.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual pain, but not a first-line treatment.","evidence":"Limited"}]

Primary treatment for: Inflammatory conditions with pain and swelling

Also treats: Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, Acute musculoskeletal injuries, Post-operative swelling, Dental pain

📋 Drug Information

Generic Name(s)Diclofenac (75mg) + Serratiopeptidase (15mg)
Brand Namesd 75 mg/15 mg tablet
ManufacturerSerum Institute Of India Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine with food or milk to minimize stomach irritation.
2
Use the lowest effective dose for the shortest duration possible.
3
Avoid alcohol completely while taking this medicine to prevent gastrointestinal bleeding.
4
Do not take other NSAIDs or pain relievers without consulting your doctor.
5
Monitor for signs of gastrointestinal bleeding such as black stools or vomiting blood.
6
If you have kidney or liver disease, your doctor may need to adjust the dose or monitor you closely.
7
Do not use this medicine for more than 7 days without medical advice.
8
Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic joint pain
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
✅
Swelling after injury
This medicine helps reduce inflammation and swelling.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDiclofenac is rapidly and completely absorbed from the gastrointestinal tract after oral administration. Serratiopeptidase is absorbed through the intestinal mucosa, but its bioavailability is limited due to its protein nature.
DistributionDiclofenac is highly bound to plasma proteins and distributes widely into body tissues, including synovial fluid. Serratiopeptidase distribution is not well characterized.
Protein BindingDiclofenac is approximately 99% bound to plasma proteins, primarily albumin. Serratiopeptidase binding is not established from the available information.
MetabolismDiclofenac is extensively metabolized in the liver by cytochrome P450 enzymes, primarily CYP2C9, to several metabolites. Serratiopeptidase is metabolized as a protein.
Half-LifeThe elimination half-life of diclofenac is approximately 1-2 hours. The half-life of serratiopeptidase is not established from the available information.
ExcretionDiclofenac metabolites are excreted mainly in urine (about 65%) and bile/feces (about 35%). Serratiopeptidase is excreted as peptides and amino acids.
BioavailabilityThe oral bioavailability of diclofenac is approximately 50-60% due to first-pass metabolism. The bioavailability of serratiopeptidase is not established from the available information.
Onset of ActionDiclofenac provides pain relief within 30-60 minutes after oral administration. Serratiopeptidase onset is slower, typically within a few hours.
Peak Plasma TimeDiclofenac reaches peak plasma concentration in about 1-2 hours. Serratiopeptidase peak time is not established from the available information.
Duration of ActionDiclofenac provides pain relief for 4-6 hours. Serratiopeptidase duration is not established from the available information.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Diclofenac is a nonsteroidal anti-inflammatory drug that reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), leading to decreased synthesis of prostaglandins, prostacyclin, and thromboxane. This results in analgesic, antipyretic, and anti-inflammatory effects. Serratiopeptidase is a proteolytic enzyme that hydrolyzes proteins into smaller peptides and amino acids. It helps reduce inflammation by breaking down fibrin and other proteins involved in swelling, and it may also improve tissue repair and reduce mucus viscosity.

Mechanism Steps

1
COX enzyme inhibition by diclofenac: Diclofenac binds to and reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), blocking the conversion of arachidonic acid to prostaglandin H2.
2
Reduced prostaglandin synthesis: Inhibition of COX enzymes leads to decreased production of prostaglandins, prostacyclin, and thromboxane, which are mediators of pain, inflammation, and fever.
3
Proteolytic action of serratiopeptidase: Serratiopeptidase hydrolyzes proteins such as fibrin and bradykinin, reducing swelling and inflammation.
4
Enhanced tissue repair: Serratiopeptidase may promote tissue repair by clearing debris and improving microcirculation.

💡 How to Take sd 75 mg/15 mg tablet

Strength: Tablet containing Diclofenac 75 mg and Serratiopeptidase 15 mg.

1Take the tablet orally with a full glass of water.
2Take it with food or milk to reduce stomach upset.
3Swallow the tablet whole. Do not crush or chew.
4Take it at the same time each day if prescribed regularly.
5Do not take more than the prescribed dose.
6If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally once or twice daily, preferably after meals. The exact dose and duration depend on the condition being treated, its severity, and your response to therapy. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. Use the lowest effective dose for the shortest duration possible.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients are at higher risk of side effects, especially gastrointestinal bleeding and kidney problems. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function.
Renal ImpairmentUse with caution in patients with kidney disease. Dose reduction may be necessary. Consult your doctor for individualized dosing.
Hepatic ImpairmentUse with caution in patients with liver disease. Dose reduction may be necessary. Consult your doctor for individualized dosing.
Maximum Daily DoseThe maximum daily dose of diclofenac should not exceed 150 mg. The maximum daily dose of serratiopeptidase is not established from the available information. Do not exceed the prescribed dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.
Alcohol
Avoid
Increases risk of gastrointestinal bleeding.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of sd 75 mg/15 mg tablet

✅ Common Side Effects

Stomach pain (Common (5-10%))
Take with food or milk. Consult doctor if persistent.
Heartburn (Common (5-10%))
Take with food. Avoid lying down immediately after taking.
Nausea (Common (5-10%))
Take with food. Consult doctor if severe.
Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if persistent.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black stool, vomiting blood, or severe abdominal pain.
Kidney problems (Rare (<0.1%))
Report decreased urine output, swelling, or fatigue to your doctor immediately.
Liver damage (Rare (<0.1%))
Seek medical help if you notice yellowing of skin or eyes, dark urine, or severe fatigue.
Severe allergic reaction (Rare (<0.1%))
Seek emergency help if you experience swelling of face, lips, or throat, or difficulty breathing.
Cardiovascular events (Rare (<0.1%))
Seek immediate medical attention if you experience chest pain, shortness of breath, or weakness.

⚠️ Rare Side Effects

Aseptic meningitis
Seek immediate medical attention if you experience severe headache, stiff neck, or fever.
Pancreatitis
Seek immediate medical attention if you experience severe abdominal pain radiating to the back.
Stevens-Johnson syndrome
Seek emergency help if you develop a rash with blisters or peeling skin.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Corticosteroids Major
Methotrexate Major
Lithium Major
ACE inhibitors Moderate
Diuretics Moderate
Beta-blockers Moderate
SSRIs Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs
  • Corticosteroids
  • Methotrexate
  • Lithium

⚡ Moderate Interactions

  • ACE inhibitors
  • Diuretics
  • Beta-blockers
  • SSRIs

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and can worsen stomach irritation caused by diclofenac.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Active peptic ulcer or gastrointestinal bleeding","Severe kidney disease","Severe liver disease","Heart failure","History of asthma, urticaria, or allergic reaction to NSAIDs","Third trimester of pregnancy","Coronary artery bypass graft surgery"]

⚠️ Warnings & Precautions

["Take with food to reduce stomach upset.","Avoid alcohol while taking this medicine.","Do not take other NSAIDs concurrently.","Use with caution in the elderly.","Monitor kidney and liver function during long-term use.","May increase risk of cardiovascular events.","Do not use for more than 7 days without medical advice.","Inform your doctor if you have a history of stomach ulcers or bleeding."]

🤱 Lactation Safety

Diclofenac is excreted in breast milk in small amounts. Serratiopeptidase safety during breastfeeding is not established. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose of this medicine may cause severe stomach pain, vomiting, bleeding, drowsiness, and kidney failure. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Activated charcoal may be used if taken recently. Monitor vital signs and provide supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.

Additional Safety Advice

General Safety

Take this medicine with food or milk to reduce stomach upset. Do not take it on an empty stomach. Avoid alcohol while taking this medicine as it increases the risk of stomach bleeding. Do not take other NSAIDs (such as ibuprofen, naproxen, or aspirin) without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart problems, or asthma. Use the lowest effective dose for the shortest duration possible. Do not use this medicine for more than 7 days without medical advice. If you are pregnant or planning to become pregnant, consult your doctor before taking this medicine. Do not breastfeed while taking this medicine without medical advice. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before taking this medicine. Diclofenac may affect ovulation and is not recommended during the third trimester. Serratiopeptidase safety in pregnancy is not established.

🏥 Post-Surgery Considerations

This medicine may be prescribed after surgery to reduce pain and swelling. Take it as directed by your surgeon. Inform your surgeon if you have a history of stomach ulcers or bleeding. Do not use for prolonged periods without medical advice.

🦷 Dental Procedures

This medicine may be prescribed for dental pain and swelling after procedures. Take it with food to avoid stomach upset. Inform your dentist if you have a history of stomach ulcers or bleeding. Do not use for more than 7 days without dental advice.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming.
😴
Practice good posture.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep.
🌞
Stay well hydrated.

🏋️ Exercise Considerations

Avoid strenuous exercise or activities that may increase pain and swelling. Consult your doctor or physiotherapist for appropriate exercises. Stop exercise if you experience increased pain, dizziness, or shortness of breath.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated
Eat plenty of fruits and vegetables
Limit salt and sugar intake

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. Take it with food to minimize stomach upset. Inform your employer if your work involves operating machinery.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if you experience severe side effects such as gastrointestinal bleeding, kidney problems, liver damage, or allergic reactions. Do not stop abruptly if you are on long-term therapy without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney problems, liver damage, and cardiovascular events. Regular monitoring of kidney and liver function, blood pressure, and complete blood count is recommended. Use the lowest effective dose for the shortest duration possible.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain.

Evidence: Well-established
Hot and cold therapy

May help reduce pain and swelling.

Evidence: Moderate
Acupuncture

May provide pain relief for some conditions.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are established. However, inform your doctor if you are scheduled for any vaccination while taking this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing times gradually as advised by your doctor. Keep enough supply for your trip. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic knee pain
Started this medicine as prescribed for osteoarthritis. Within 2 weeks noticed significant improvement in morning stiffness. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 60-year-old man with post-operative swelling after knee surgery
Was prescribed this medicine for swelling and pain after surgery. Took it regularly with meals and noticed reduced swelling within a few days. Also followed physiotherapy advice.
💡 Lesson: Combining medicine with rehabilitation and taking it with food leads to better recovery.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Diclofenac provides pain relief within 30-60 minutes, while serratiopeptidase may take a few hours to reduce swelling.

Q: Can I take this medicine on an empty stomach?

A: No, it should be taken with food or milk to reduce stomach upset.

Q: Is it safe to take this medicine during pregnancy?

A: Diclofenac is not recommended during the third trimester. Consult your doctor before use.

Q: Can I drink alcohol while taking this medicine?

A: No, alcohol increases the risk of gastrointestinal bleeding.

Q: How long can I take this medicine?

A: Do not use for more than 7 days without medical advice. Long-term use requires monitoring.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for sd 75 mg/15 mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken for any type of pain.
    Fact: This medicine is specifically for inflammatory pain and swelling. It is not effective for all types of pain and should only be used as prescribed.
  • Myth: It is safe to take this medicine long-term without monitoring.
    Fact: Long-term use requires regular monitoring of kidney and liver function and carries risks of gastrointestinal and cardiovascular side effects.
  • Myth: This medicine is safe to take during pregnancy.
    Fact: Diclofenac is not recommended during the third trimester of pregnancy. Consult your doctor before use.

🔄 Alternative Options

Generic Alternatives

  • Diclofenac 75 mg + Serratiopeptidase 15 mg tablet

Brand Alternatives

  • Biodic 75 mg/15 mg tablet

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Diclofenac 75 mg + Serratiopeptidase 15 mg","route":"Oral","onset":"30-60 minutes","duration":"4-6 hours"},{"medicine":"Diclofenac 50 mg + Serratiopeptidase 10 mg","composition":"Diclofenac 50 mg + Serratiopeptidase 10 mg","route":"Oral","onset":"30-60 minutes","duration":"4-6 hours"},{"medicine":"Aceclofenac 100 mg + Serratiopeptidase 15 mg","composition":"Aceclofenac 100 mg + Serratiopeptidase 15 mg","route":"Oral","onset":"30-60 minutes","duration":"4-6 hours"}]

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