acendol-r capsule sr allopathy (Aceclofenac (200mg) + Rabeprazole (20mg)) - Uses in Hindi, Side Effects, Substitutes & Price in India
acendol-r capsule sr allopathy (Aceclofenac (200mg) + Rabeprazole (20mg)) - Uses in Hindi, Side Effects, Substitutes & Price in India manufactured by Serum Institute Of India Ltd. Contains Aceclofenac (200mg) + Rabeprazole (20mg).

acendol-r capsule sr - Uses, Price, Side Effects & Substitutes

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🏭 Serum Institute Of India Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Jun 21, 2026
Medically Reviewed
By SaathiMed Expert Medical Panel

What is acendol-r capsule sr used for?

Altraday Capsule SR (Aceclofenac + Rabeprazole) is used to treat Rheumatoid arthritis. It contains Aceclofenac (200mg) + Rabeprazole (20mg), which Aceclofenac inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Rabepraz. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Aceclofenac + Rabeprazole
  • Manufacturer: Serum Institute Of India Ltd
  • Medicine Form: Allopathy
  • Pregnancy Category: A

🇮🇳 acendol-r capsule sr के बारे में संक्षिप्त जानकारी (Hindi Summary)

acendol-r capsule sr का उपयोग मुख्य रूप से pain analgesics और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Aceclofenac (200mg) + Rabeprazole (20mg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।

मुख्य फायदे (Key Benefits): Detailed medical information is being added to our database.... Read more below.

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

📋 Drug Information

Generic Name(s)Aceclofenac + Rabeprazole
Brand NameAltraday Capsule SR
ManufacturerSerum Institute Of India Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNSAIDs + Proton Pump Inhibitors
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from moisture
Shelf LifeAs per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionAceclofenac: Well absorbed orally; Rabeprazole: Rapidly absorbed after oral administration
DistributionAceclofenac: Widely distributed; Rabeprazole: High plasma protein binding
Protein BindingAceclofenac: >99%; Rabeprazole: ~96%
MetabolismAceclofenac: Hepatic via CYP2C9; Rabeprazole: Hepatic via CYP2C19 and CYP3A4
Half-LifeAceclofenac: ~4 hours; Rabeprazole: ~1-2 hours
ExcretionAceclofenac: Renal (primarily) and fecal; Rabeprazole: Renal (90%) and fecal
BioavailabilityAceclofenac: ~100%; Rabeprazole: ~52%
Onset of ActionAceclofenac: ~30 minutes; Rabeprazole: ~1 hour
Peak Plasma TimeAceclofenac: 1-3 hours; Rabeprazole: 2-4 hours
Duration of ActionAceclofenac: ~12 hours; Rabeprazole: ~24 hours

Pharmacodynamics

Mechanism of ActionAceclofenac inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Rabeprazole inhibits H+/K+ ATPase in gastric parietal cells, reducing gastric acid secretion
Target ReceptorAceclofenac: COX-1, COX-2; Rabeprazole: H+/K+ ATPase
Pharmacodynamic EffectsAceclofenac: Anti-inflammatory, analgesic, antipyretic; Rabeprazole: Gastric acid suppression

💡 How and when to take acendol-r capsule sr?

Follow your doctor's prescription exactly.

  • ✅ Take exactly as prescribed by your doctor.
  • ✅ Do not exceed the recommended dose
  • ✅ Complete the full course of medication
  • ✅ Store at room temperature (20-25°C), protect from moisture

⚙️ How acendol-r capsule sr Works

Aceclofenac inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Rabeprazole inhibits H+/K+ ATPase in gastric parietal cells, reducing gastric acid secretion

1 Aceclofenac inhibits COX enzymes, decreasing prostaglandin synthesis
⬇️
2 Reduced prostaglandins lead to decreased inflammation and pain
⬇️
3 Rabeprazole irreversibly binds to H+/K+ ATPase
⬇️
4 Inhibition of proton pump reduces gastric acid secretion
⬇️
5 Combined effect provides analgesia with GI protection

💊 acendol-r capsule sr Uses in Hindi (Ke Fayde), Benefits & Indications

Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis, Pain and inflammation with GI protection

⚠️ What are the side effects of acendol-r capsule sr?

✅ Common Side Effects

  • Nausea
  • Dyspepsia
  • Headache
  • Diarrhea
  • Abdominal pain

🚨 Serious Side Effects

  • GI bleeding
  • Renal impairment
  • Cardiovascular events
  • Stevens-Johnson syndrome

⚠️ Rare Side Effects

  • Hepatotoxicity
  • Agranulocytosis
  • Anaphylaxis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

🚨 Major Interactions

  • Warfarin
  • Methotrexate
  • Lithium
  • CYP2C19 inhibitors (e.g., fluconazole)

⚡ Moderate Interactions

  • Aspirin
  • Clopidogrel
  • Diuretics
  • ACE inhibitors

ℹ️ Minor Interactions

  • Antacids
  • Sucralfate

🍽️ Food Interactions

Food may delay absorption of aceclofenac; rabeprazole absorption unaffected

🍷 Alcohol Interaction

Increased risk of GI bleeding with aceclofenac

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to NSAIDs or PPIs, Active peptic ulcer, Severe renal impairment, History of GI bleeding, Third trimester pregnancy

📊 Monitoring Parameters

LFT, RFT, CBC, Blood pressure, GI symptoms

🤱 Lactation Safety

Aceclofenac: Excreted in milk, use caution; Rabeprazole: Excreted in milk, use caution

💊 Overdose Management

Symptomatic and supportive; gastric lavage if recent; monitor renal function

⏰ Missed Dose

Take as soon as remembered; skip if near next dose; do not double

🛑 Myths vs. Facts about acendol-r capsule sr

  • Myth: Generic substitutes of acendol-r capsule sr are less effective.
    Fact: Approved generic medicines contain the exact same active ingredients (Aceclofenac (200mg) + Rabeprazole (20mg)) and are just as safe and effective as the branded version.
  • Myth: Taking a double dose will cure my symptoms faster.
    Fact: Taking more than the prescribed dose of acendol-r capsule sr can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage.
  • Myth: This medicine is 100% safe for everyone.
    Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.

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