Sclerifuma 120 Capsule DR: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- New or worsening neurological symptoms such as weakness, confusion, or vision changes
- Severe allergic reactions like rash, hives, or swelling of face or throat
- Yellowing of skin or eyes, dark urine, or severe fatigue
- Persistent fever, chills, or sore throat
- Unusual bleeding or bruising
- Severe abdominal pain or persistent vomiting
If experiencing severe symptoms, call emergency services immediately.
What is sclerifuma 120 capsule dr used for?
This medicine is a delayed-release capsule containing dimethyl fumarate 120 mg, used to treat relapsing forms of multiple sclerosis. It works by reducing inflammation and oxidative stress, helping to lower relapse rates and slow disability progression.
- Generic Name: Dimethyl fumarate (120mg)
- Manufacturer: Sun Pharmaceutical Industries Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 sclerifuma 120 capsule dr के बारे में (Hindi Summary)
उपयोग: यह दवा डाइमिथाइल फ्यूमरेट 120 मिलीग्राम युक्त एक डिलेड-रिलीज़ कैप्सूल है, जिसका उपयोग मुख्य रूप से रिलैप्सिंग मल्टीपल स्क्लेरोसिस के इलाज के लिए किया जाता है। यह सूजन और ऑक्सीडेटिव तनाव को कम करके रिलैप्स की संख्या घटाने और विकलांगता की प्रगति को धीमा करने में मदद करती है। यह दवा केवल डॉक्टर के पर्चे पर ही ली जानी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में फ्लशिंग, पेट दर्द, दस्त, मतली और उल्टी शामिल हैं। गंभीर दुष्प्रभावों में प्रोग्रेसिव मल्टीफोकल ल्यूकोएन्सेफैलोपैथी (पीएमएल), गंभीर एलर्जी, लीवर की क्षति और सफेद रक्त कोशिकाओं की कमी हो सकती है। कोई भी नए लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। कैप्सूल को पूरा निगलें, चबाएं या खोलें नहीं। इसे भोजन के साथ लेने से फ्लशिंग और पेट की परेशानी कम हो सकती है। डॉक्टर की सलाह के बिना दवा बंद न करें। लीवर एंजाइम और रक्त गणना की नियमित जांच कराएं। गर्भवती होने या स्तनपान कराने पर डॉक्टर को बताएं।
💊 sclerifuma 120 capsule dr Uses & Benefits
[{"condition":"Relapsing-remitting multiple sclerosis","description":"Reduces relapse rate and slows disability progression in adults with relapsing forms of MS.","evidence":"Well-established"},{"condition":"Psoriasis","description":"May be used off-label for moderate-to-severe plaque psoriasis in some patients.","evidence":"Limited"}]
Off-label uses: [{"condition":"Psoriasis","description":"Sometimes prescribed off-label for moderate-to-severe plaque psoriasis.","evidence":"Limited"}]
Primary treatment for: Relapsing-remitting multiple sclerosis
Also treats: Psoriasis
📋 Drug Information
| Generic Name(s) | Dimethyl fumarate (120mg) |
| Brand Name | sclerifuma 120 capsule dr |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Immunomodulator- Multiple sclerosis (oral) |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in the original container. Protect from light and moisture. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Dimethyl fumarate is a prodrug that is metabolized to monomethyl fumarate, which activates the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. This activation leads to increased expression of antioxidant response element genes, reducing oxidative stress. It also modulates immune cell function by shifting cytokine production from a pro-inflammatory Th1/Th17 profile toward a Th2 anti-inflammatory profile. Additionally, it may reduce lymphocyte counts and affect cell survival pathways.
Mechanism Steps
💡 How to Take sclerifuma 120 capsule dr
Strength: Delayed-release capsule, 120 mg
Dosage Information
| Adult Dosage | The usual starting dose is 120 mg twice daily for 7 days, then 240 mg twice daily thereafter. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients, but use with caution due to potential for reduced renal or hepatic function. |
| Renal Impairment | No dose adjustment is needed for mild renal impairment. Use with caution in severe renal impairment. |
| Hepatic Impairment | No dose adjustment is needed for mild hepatic impairment. Use with caution in severe hepatic impairment. |
| Maximum Daily Dose | 480 mg per day (as 240 mg twice daily). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of sclerifuma 120 capsule dr
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Live vaccines | Major | |
| Immunosuppressants | Major | |
| Aspirin | Moderate |
🚨 Major Interactions
- Live vaccines
- Immunosuppressants
⚡ Moderate Interactions
- Aspirin
- Nephrotoxic drugs
🍷 Alcohol Interaction
Alcohol may worsen flushing and stomach upset. It is advisable to limit or avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to dimethyl fumarate or any component","Concurrent use of live vaccines"]
⚠️ Warnings & Precautions
["Progressive multifocal leukoencephalopathy (PML) has been reported.","Liver injury may occur.","Low white blood cell counts may occur.","Flushing is common but usually decreases over time.","Avoid live vaccines during treatment."]
🤱 Lactation Safety
It is not known if dimethyl fumarate passes into breast milk. Consult your doctor before breastfeeding.
💊 Overdose Management
There is no specific antidote. In case of overdose, seek immediate medical attention and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Swallow the capsule whole; do not crush, chew, or open it. Taking it with food may reduce flushing and stomach upset. Do not stop this medicine without consulting your doctor, as stopping suddenly may worsen your condition. Avoid live vaccines while on this medicine. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Regular blood tests to monitor liver enzymes and complete blood count are important. Report any signs of infection, unusual bruising, or bleeding promptly.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to side effects. Use with caution and monitor renal and hepatic function.
🤰 Pregnancy Planning (TTC)
Consult your doctor if you are planning pregnancy. This medicine should be used during pregnancy only if clearly needed. Effective contraception is recommended for women of childbearing potential.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may affect wound healing and infection risk.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may increase risk of bleeding or infection. Good oral hygiene is important.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid overexertion if you feel fatigued. Consult your doctor before starting a new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some patients. Avoid driving or operating heavy machinery until you know how it affects you. Most patients can continue their normal activities.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects, your doctor may advise stopping or changing the treatment.
📅 Long-Term Use Effects
Long-term use may require regular monitoring of liver enzymes and blood counts. Some patients may experience persistent flushing or gastrointestinal symptoms. The risk of PML increases with prolonged use and certain other factors. Regular follow-up with your neurologist is essential.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help manage symptoms and improve mobility.
Evidence: Well-establishedMay have a role in managing multiple sclerosis, but evidence is limited.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Avoid live vaccines while taking this medicine. Inactivated vaccines are generally safe, but consult your doctor for timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from light and moisture. If traveling across time zones, adjust dosing times gradually as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take several weeks to months to see the full benefit.
A: Yes, taking it with food can reduce flushing and stomach upset.
A: Take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for sclerifuma 120 capsule dr
View AllAlternative brands with exact same active ingredient:
-
MS 120 Capsule DRMSN Laboratories ₹360.94 10% COSTLIER
-
dyfira 120mg capsuleIntas Pharmaceuticals Ltd ₹773.00 135.7% COSTLIER
-
sclerogem 120mg capsuleCipla Ltd ₹1,625.00 395.4% COSTLIER
-
tecfidera 120mg capsuleEisai Pharmaceuticals India Pvt Ltd ₹21,093.00 6330.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine cures multiple sclerosis.
Fact: It helps manage the disease but does not cure it. - Myth: You can stop this medicine anytime.
Fact: Stopping suddenly may worsen your condition. Always consult your doctor.
🔄 Alternative Options
Generic Alternatives
- Dimethyl fumarate delayed-release capsules
Brand Alternatives
- Sclerifuma 120 capsule dr