Kofrest Syrup: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or wheezing
- Swelling of face, lips, or throat
- Severe rash or blistering skin
- Blood in cough or vomit
- High fever with chills
- Chest pain
- Yellowing of eyes or skin
If experiencing severe symptoms, call emergency services immediately.
What is Sardex Syrup used for?
This medicine is a combination cough syrup containing Ammonium Chloride and Bromhexine. It helps loosen mucus and relieve productive cough. It is usually taken 5-10 mL three times a day with food. Do not exceed the recommended dose and consult a doctor if symptoms persist beyond 7 days.
- Generic Name: Ammonium Chloride (50mg) + Bromhexine (4mg)
- Manufacturer: Saar Biotech
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Sardex Syrup के बारे में (Hindi Summary)
उपयोग: यह दवा कफ निकालने वाली सिरप है जिसमें अमोनियम क्लोराइड और ब्रोमहेक्सिन होते हैं। यह गले और छाती में जमे हुए बलगम को पतला करके बाहर निकालने में मदद करती है। इसका उपयोग खांसी के साथ बलगम आने, ब्रोंकाइटिस और श्वसन संक्रमण में किया जाता है। यह सूखी खांसी के लिए नहीं है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, पेट में गड़बड़ी और दस्त शामिल हैं। कुछ लोगों को नींद या चक्कर आ सकते हैं। अगर आपको एलर्जी, सांस लेने में तकलीफ या त्वचा पर चकत्ते दिखें तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। ज्यादा मात्रा में न लें। दवा लेते समय खूब पानी पिएं। अगर नींद आती है तो गाड़ी न चलाएं। 7 दिन से ज्यादा इसका इस्तेमाल बिना डॉक्टर की सलाह के न करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 Sardex Syrup Uses & Benefits
[{"condition":"Productive cough","description":"Helps to loosen and thin mucus, making it easier to cough out.","evidence":"Well-established"},{"condition":"Bronchitis","description":"Used to relieve cough and mucus congestion in acute and chronic bronchitis.","evidence":"Well-established"},{"condition":"Tracheobronchitis","description":"Aids in clearing mucus from the airways in tracheobronchitis.","evidence":"Well-established"}]
Off-label uses: []
Primary treatment for: Productive cough
Also treats: Bronchitis, Tracheobronchitis
📋 Drug Information
| Generic Name(s) | Ammonium Chloride (50mg) + Bromhexine (4mg) |
| Brand Name | Sardex Syrup |
| Manufacturer | Saar Biotech |
| Packaging / Form | bottle of 100 ml Syrup (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep the bottle tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Ammonium Chloride acts as an expectorant by irritating the gastric mucosa, which reflexively stimulates respiratory tract secretions, thereby thinning mucus and making it easier to expel. Bromhexine is a mucolytic that increases serous bronchial secretion and reduces mucus viscosity by breaking down acidic mucopolysaccharide fibers. Together, they enhance mucus clearance from the airways.
Mechanism Steps
💡 How to Take Sardex Syrup
Strength: Each 5 mL of syrup contains Ammonium Chloride 50 mg and Bromhexine 4 mg.
Dosage Information
| Adult Dosage | The usual adult dose is 5-10 mL (1-2 teaspoons) three times a day, or as directed by your doctor. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Use with caution and consult a doctor for appropriate dosing. |
| Renal Impairment | Dose adjustment may be needed in patients with renal impairment. Consult your doctor. |
| Hepatic Impairment | Dose adjustment may be needed in patients with hepatic impairment. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose is 30 mL (6 teaspoons) in divided doses, unless otherwise prescribed by a doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Sardex Syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Codeine | Major | |
| Amoxicillin | Moderate | |
| Furosemide | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Cough suppressants (e.g., codeine, dextromethorphan)
⚡ Moderate Interactions
- Antibiotics (e.g., amoxicillin, tetracycline)
- Diuretics
🍷 Alcohol Interaction
Alcohol may increase drowsiness and dizziness. Avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to Ammonium Chloride or Bromhexine.","Severe liver disease.","Severe kidney disease.","Peptic ulcer disease.","Children under 12 years of age (unless prescribed by a doctor)."]
⚠️ Warnings & Precautions
["Do not exceed the recommended dose.","Avoid using for more than 7 days without medical advice.","Use with caution in patients with asthma or COPD.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Consult a doctor if cough persists or worsens, or if you develop a fever, rash, or difficulty breathing."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose may cause nausea, vomiting, diarrhea, and electrolyte imbalance. Seek immediate medical attention. Treatment is symptomatic and supportive.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Drink plenty of water while taking this medicine to help loosen mucus. Avoid driving or operating heavy machinery if you feel drowsy. Do not take this medicine for more than 7 days without consulting your doctor. If your cough persists or worsens, or if you develop a fever, rash, or difficulty breathing, seek medical attention. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Keep this medicine out of reach of children. Do not use it to treat a dry cough or a cough that does not produce mucus.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness and dizziness. Use with caution and consult a doctor for appropriate dosing.
🤰 Pregnancy Planning (TTC)
Consult your doctor before using this medicine if you are planning to become pregnant or are pregnant. The safety of this medicine during pregnancy is not well established.
🏥 Post-Surgery Considerations
Consult your doctor before using this medicine after surgery, especially if you are taking other medications or have underlying conditions.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may cause dry mouth or interact with anesthetics.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you have a cough or fever. Light activity like walking may be okay if you feel up to it. Consult your doctor before resuming intense exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is usually safe to work if you do not feel drowsy.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your cough persists for more than 7 days, worsens, or if you develop new symptoms like fever, rash, or difficulty breathing.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use may lead to electrolyte imbalance or liver enzyme changes. Regular monitoring may be required if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps loosen mucus and relieve congestion.
Evidence: Well-establishedCan help clear nasal passages and reduce postnasal drip.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor if you are due for any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, continue your regular dosing schedule as close as possible. Check customs regulations for carrying liquid medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 minutes to 1 hour after taking it.
A: It is best taken with food to reduce stomach upset.
A: It is not recommended for children under 12 years without medical advice.
🤔 Common Patient Concerns
🔄 Substitutes for Sardex Syrup
View AllAlternative brands with exact same active ingredient:
-
bravo expectorantPatson Laboratories Pvt Ltd ₹29.06 3.1% CHEAPER
-
Sonidril DMR SyrupBriskon Laboratories ₹29.25 2.5% CHEAPER
-
StayHappi Ammonium Chloride+Bromhexine+Dextromethorphan Hydrobromide+Menthol 50mg/4mg/5mg/2.5mg SyrupSarvagunaushdhi Pvt Ltd ₹37.50 25% COSTLIER
-
ambitus syrupSiomond Pharmaceuticals Pvt Ltd ₹40.22 34.1% COSTLIER
-
Trex-DMR SyrupMediwin Pharmaceuticals ₹46.88 56.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of cough.
Fact: This medicine is only for productive cough with thick mucus. It is not effective for dry cough. - Myth: It is safe to take this medicine for a long time.
Fact: This medicine should not be used for more than 7 days without medical advice.