Pari CR 12.5 Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- New or worsening depression or suicidal thoughts.
- Agitation, hallucinations, rapid heart rate, fever, muscle stiffness, or seizures (serotonin syndrome).
- Severe allergic reactions such as rash, itching, swelling of face, lips, tongue, or throat, or difficulty breathing.
- Unusual bleeding or bruising.
- Headache, confusion, weakness, or unsteadiness (hyponatremia).
- Eye pain, vision changes, or swelling around the eyes (angle-closure glaucoma).
- Chest pain, shortness of breath, or irregular heartbeat.
If experiencing severe symptoms, call emergency services immediately.
What is roxetin cr 12.5 tablet used for?
This medicine contains Paroxetine 12.5 mg, an SSRI antidepressant used to treat depression, anxiety disorders, OCD, and PTSD. It works by increasing serotonin levels in the brain. Take it exactly as prescribed, and do not stop abruptly.
- Generic Name: Paroxetine (12.5mg)
- Manufacturer: S.P Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 roxetin cr 12.5 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पैरोक्सेटीन 12.5 मिलीग्राम युक्त एक एसएसआरआई एंटीडिप्रेसेंट है। इसका उपयोग अवसाद, चिंता विकार, जुनूनी-बाध्यकारी विकार (ओसीडी), पैनिक डिसऑर्डर, सामाजिक चिंता विकार, और पोस्ट-ट्रॉमेटिक स्ट्रेस डिसऑर्डर (पीटीएसडी) के इलाज के लिए किया जाता है। यह मस्तिष्क में सेरोटोनिन के स्तर को बढ़ाकर मूड को बेहतर बनाने, चिंता को कम करने और दोहराव वाले विचारों को कम करने में मदद करती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उनींदापन, चक्कर आना, अनिद्रा, पसीना आना, मुँह सूखना, कब्ज और यौन dysfunction शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन सेरोटोनिन सिंड्रोम, गंभीर एलर्जी प्रतिक्रियाएं, रक्तस्राव का खतरा, और सोडियम का निम्न स्तर शामिल हो सकते हैं। यदि आपको बेचैनी, भ्रम, तेज़ दिल की धड़कन, बुखार, मांसपेशियों में अकड़न या दौरे पड़ें तो तुरंत चिकित्सा सहायता लें।
सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। डॉक्टर की सलाह के बिना खुराक न बदलें और न ही अचानक बंद करें। इस दवा के साथ शराब का सेवन न करें। जब तक आपको पता न चले कि यह दवा आपको कैसे प्रभावित करती है, तब तक वाहन चलाने या मशीनरी चलाने से बचें। अपने डॉक्टर को सभी अन्य दवाओं, सप्लीमेंट्स और हर्बल उत्पादों के बारे में बताएं। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं, तो अपने डॉक्टर से जोखिम और लाभ पर चर्चा करें।
💊 roxetin cr 12.5 tablet Uses & Benefits
[{"condition":"Major Depressive Disorder","description":"This medicine is used to treat major depressive disorder by improving mood and reducing symptoms of depression.","evidence":"Well-established"},{"condition":"Obsessive-Compulsive Disorder","description":"This medicine helps reduce the frequency and intensity of obsessive thoughts and compulsive behaviors.","evidence":"Well-established"},{"condition":"Panic Disorder","description":"This medicine is effective in reducing the frequency and severity of panic attacks.","evidence":"Well-established"},{"condition":"Social Anxiety Disorder","description":"This medicine helps alleviate anxiety and fear in social situations.","evidence":"Well-established"},{"condition":"Generalized Anxiety Disorder","description":"This medicine is used to treat excessive, uncontrollable worry and anxiety.","evidence":"Well-established"},{"condition":"Post-Traumatic Stress Disorder","description":"This medicine can help reduce symptoms of PTSD, such as flashbacks and anxiety.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Premature Ejaculation","description":"Sometimes prescribed off-label to delay ejaculation.","evidence":"Limited"},{"condition":"Hot Flashes","description":"May be used off-label to reduce hot flashes in menopausal women.","evidence":"Limited"},{"condition":"Irritable Bowel Syndrome","description":"Sometimes used off-label for IBS with anxiety.","evidence":"Limited"}]
Primary treatment for: Major Depressive Disorder
Also treats: Obsessive-Compulsive Disorder, Panic Disorder, Social Anxiety Disorder, Generalized Anxiety Disorder, Post-Traumatic Stress Disorder
📋 Drug Information
| Generic Name(s) | Paroxetine (12.5mg) |
| Brand Name | roxetin cr 12.5 tablet |
| Manufacturer | S.P Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Selective Seretonin Reuptake inhibitors (SSRIs) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and heat. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by selectively inhibiting the reuptake of serotonin (5-hydroxytryptamine, 5-HT) at the presynaptic neuronal membrane. This inhibition increases the concentration of serotonin in the synaptic cleft, enhancing serotonergic neurotransmission. The exact mechanism by which this leads to antidepressant and anxiolytic effects is not fully understood but is thought to involve downstream changes in receptor sensitivity and neuroplasticity.
Mechanism Steps
💡 How to Take roxetin cr 12.5 tablet
Strength: Tablet, 12.5 mg
Dosage Information
| Adult Dosage | The usual starting dose of this medicine for adults is 12.5 mg to 25 mg once daily, depending on the condition being treated. For depression, the typical dose is 20 mg to 50 mg daily. For obsessive-compulsive disorder, the dose may range from 20 mg to 60 mg daily. For panic disorder, the usual dose is 10 mg to 60 mg daily. For social anxiety disorder, the dose is 20 mg to 60 mg daily. For generalized anxiety disorder, the dose is 20 mg to 50 mg daily. For post-traumatic stress disorder, the dose is 20 mg to 50 mg daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the maximum recommended dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Start with a lower dose, such as 10 mg daily, and increase gradually as needed. Monitor for hyponatremia and falls. |
| Renal Impairment | For patients with severe renal impairment (creatinine clearance <30 mL/min), a lower starting dose is recommended. Dose should be individualized by a qualified clinician. |
| Hepatic Impairment | For patients with hepatic impairment, a lower starting dose is recommended. Dose should be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 60 mg for adults, but doses above 40 mg have not been shown to be more effective and may increase side effects. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of roxetin cr 12.5 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Thioridazine | Major | |
| Pimozide | Major | |
| Warfarin | Major | |
| NSAIDs | Major | |
| Triptans | Major | |
| Tramadol | Major | |
| Linezolid | Major | |
| Methylene Blue | Major | |
| CYP2D6 Inhibitors | Moderate |
🚨 Major Interactions
- Monoamine Oxidase Inhibitors (MAOIs)
- Thioridazine
- Pimozide
- Warfarin
- NSAIDs (e.g., ibuprofen, aspirin)
- Triptans (e.g., sumatriptan)
- Tramadol
- Linezolid
- Methylene Blue
⚡ Moderate Interactions
- CYP2D6 Inhibitors (e.g., fluoxetine, quinidine)
- CYP2D6 Substrates (e.g., metoprolol, flecainide)
- Alcohol
- Anticoagulants (e.g., heparin)
- Antiplatelet drugs (e.g., clopidogrel)
- Diuretics
- Other SSRIs/SNRIs
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase drowsiness, dizziness, and difficulty concentrating, and may worsen depression.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to paroxetine or any component of the formulation.","Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping an MAOI.","Concurrent use with thioridazine or pimozide.","Uncontrolled narrow-angle glaucoma."]
⚠️ Warnings & Precautions
["Antidepressants may increase the risk of suicidal thoughts and behaviors in children, adolescents, and young adults. Monitor closely for clinical worsening.","Serotonin syndrome may occur, especially with concomitant serotonergic drugs. Discontinue if symptoms occur.","May increase bleeding risk, especially when used with NSAIDs, aspirin, or anticoagulants.","May cause hyponatremia, particularly in elderly patients. Monitor sodium levels.","May impair physical and mental abilities required for driving or operating machinery. Use caution until you know how it affects you.","Do not stop this medicine abruptly; taper gradually to avoid discontinuation symptoms.","Use with caution in patients with a history of mania or bipolar disorder.","May cause angle-closure glaucoma in patients with untreated narrow anterior chamber angles.","Use with caution in patients with hepatic or renal impairment; dose adjustment may be needed."]
🤱 Lactation Safety
This medicine is excreted in human breast milk in small amounts. There have been reports of infants experiencing adverse effects. The benefits of breastfeeding should be weighed against the potential risks to the infant. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, drowsiness, tachycardia, tremor, and in severe cases, serotonin syndrome, seizures, and coma. There is no specific antidote. Treatment should be supportive and symptomatic. Gastric lavage may be considered if ingestion is recent. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your clinician. Avoid alcohol while taking this medicine, as it can increase drowsiness and impair judgment. Use caution when driving or operating heavy machinery until you know how this medicine affects you. Inform your doctor about all other medications, supplements, and herbal products you are taking, especially MAOIs, anticoagulants, and NSAIDs. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits with your doctor. Do not share this medicine with others, even if they have similar symptoms. Store this medicine at room temperature away from moisture and heat. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially hyponatremia and falls. Start with a lower dose and monitor closely. Regular monitoring of sodium levels and renal function is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking or continuing this medicine. Paroxetine may increase the risk of congenital malformations. Your doctor will discuss alternative treatment options if needed.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with certain anesthetic agents and increase the risk of bleeding. Your doctor may advise you to temporarily stop the medicine before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may increase the risk of bleeding during dental procedures. Your dentist may take precautions to manage bleeding.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness or dizziness, especially when you first start taking it. Avoid strenuous exercise or activities that require alertness until you know how it affects you. Stay hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness, dizziness, or difficulty concentrating, which can affect your ability to drive or operate machinery. It is important to assess your alertness before performing such tasks. Discuss any work-related challenges with your doctor.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Your doctor will determine when and how to gradually taper the dose to avoid withdrawal symptoms and relapse. If you experience severe side effects, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term use of this medicine may be associated with weight gain, sexual dysfunction, and an increased risk of bone fractures. Regular monitoring of mood, side effects, and overall health is recommended. Do not stop the medicine without consulting your doctor, as abrupt discontinuation can cause withdrawal symptoms. Periodic review of the need for continued treatment is advised.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A type of talk therapy that can be effective for depression and anxiety disorders.
Evidence: Well-establishedPhysical activity can help improve mood and reduce anxiety.
Evidence: Well-establishedCan help manage stress and improve emotional well-being.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, consult your doctor about adjusting the timing of your dose. Store at room temperature and avoid exposure to heat or moisture. Check local customs regulations for carrying prescription medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine may take 1-4 weeks to start working, with full benefits often seen after 6-8 weeks. It is important to take it consistently as prescribed.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, you should not stop this medicine abruptly as it can cause withdrawal symptoms. Your doctor will gradually reduce the dose under medical supervision.
A: This medicine may increase the risk of congenital malformations if taken during pregnancy. Consult your doctor to weigh the benefits and risks.
A: It is advisable to avoid alcohol while taking this medicine as it can increase drowsiness and impair judgment.
🤔 Common Patient Concerns
🔄 Substitutes for roxetin cr 12.5 tablet
View AllAlternative brands with exact same active ingredient:
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atext 12.5mg tablet prAtral Cyrus Lifesciences ₹10.50 90.2% CHEAPER
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paroxitin 12.5 cr tabletZeelab Pharmacy Pvt Ltd ₹30.00 71.9% CHEAPER
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paro 12.5mg tablet crD D Pharmaceuticals ₹75.00 29.8% CHEAPER
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paroxit 12.5mg tablet crTweet India Pharmaceuticals Pvt Ltd ₹75.00 29.8% CHEAPER
-
parona 12.5mg tablet crWellona Pharmaceutical Private Limited ₹75.00 29.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is addictive.
Fact: This medicine is not considered addictive, but it can cause dependence and withdrawal symptoms if stopped abruptly. It should be tapered gradually under medical supervision. - Myth: This medicine works immediately.
Fact: This medicine may take several weeks to show its full effects. It is important to take it consistently as prescribed. - Myth: You can stop taking this medicine once you feel better.
Fact: You should not stop taking this medicine without consulting your doctor. Stopping abruptly can cause withdrawal symptoms and relapse of your condition. - Myth: This medicine is safe to take with any other medication.
Fact: This medicine can interact with many other medications, including MAOIs, NSAIDs, and blood thinners. Always inform your doctor about all medications you are taking.
🔄 Alternative Options
Generic Alternatives
- Paroxetine 12.5 mg tablet
Brand Alternatives
- Pari CR 12.5 Tablet