Rosofibric 35 mg/10 mg Capsule: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Unexplained muscle pain, tenderness, or weakness, especially with fever or dark urine.
- Yellowing of skin or eyes, dark urine, or severe abdominal pain.
- Signs of allergic reaction: rash, itching, swelling of face, lips, or throat, difficulty breathing.
- Severe, persistent abdominal pain that may radiate to the back (possible pancreatitis).
- Decreased urine output or swelling in legs (possible kidney problems).
- Unusual bleeding or bruising.
- New or worsening shortness of breath or dry cough.
If experiencing severe symptoms, call emergency services immediately.
What is Rosofibric 35 mg/10 mg Capsule used for?
This medicine is a combination of fenofibrate and rosuvastatin used to treat mixed dyslipidemia by lowering LDL cholesterol and triglycerides while raising HDL cholesterol. It is taken once daily with food under medical supervision.
- Generic Name: Fenofibrate (35mg) + Rosuvastatin (10mg)
- Manufacturer: Delvin Formulations Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Rosofibric 35 mg/10 mg Capsule के बारे में (Hindi Summary)
उपयोग: यह दवा फेनोफिब्रेट और रोसुवास्टेटिन का संयोजन है, जिसका उपयोग रक्त में कोलेस्ट्रॉल और ट्राइग्लिसराइड के स्तर को कम करने के लिए किया जाता है। यह मिश्रित डिस्लिपिडेमिया के इलाज में मदद करती है, जिसमें एलडीएल कोलेस्ट्रॉल और ट्राइग्लिसराइड दोनों बढ़े हुए होते हैं। यह दवा हृदय रोग और स्ट्रोक के खतरे को कम करने में सहायक है। इसे डॉक्टर की सलाह के अनुसार ही लें, आमतौर पर दिन में एक बार भोजन के साथ।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, मतली, पेट में परेशानी, दस्त, कब्ज, मांसपेशियों में दर्द और लीवर एंजाइम में मामूली वृद्धि शामिल हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन मांसपेशियों में तेज दर्द, कमजोरी, गहरे रंग का पेशाब, पीलिया, या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, आमतौर पर भोजन के साथ। कैप्सूल को चबाएं या तोड़ें नहीं, पूरा निगल लें। शराब का सेवन न करें या सीमित करें क्योंकि इससे लीवर और मांसपेशियों की समस्या बढ़ सकती है। अन्य दवाओं, सप्लीमेंट्स और हर्बल उत्पादों के बारे में अपने डॉक्टर को बताएं। नियमित रूप से लीवर, किडनी और लिपिड प्रोफाइल की जांच कराएं। गर्भावस्था या स्तनपान के दौरान इस दवा का सेवन न करें।
💊 Rosofibric 35 mg/10 mg Capsule Uses & Benefits
[{"condition":"Mixed dyslipidemia","description":"This medicine is used to lower elevated LDL cholesterol and triglycerides while raising HDL cholesterol in adults with mixed lipid disorders.","evidence":"Well-established"},{"condition":"Hypertriglyceridemia with elevated LDL","description":"It helps reduce high triglyceride levels and LDL cholesterol when both are above target despite diet and exercise.","evidence":"Well-established"},{"condition":"Primary hypercholesterolemia","description":"Used as an adjunct to diet to reduce total cholesterol and LDL cholesterol in patients who require additional lowering.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Non-alcoholic fatty liver disease (NAFLD)","description":"Sometimes prescribed off-label to improve lipid profile and liver enzymes in patients with NAFLD, but evidence is limited and not definitive.","evidence":"Limited"},{"condition":"Diabetic dyslipidemia","description":"May be used off-label in some patients with type 2 diabetes and mixed lipid abnormalities, though statin therapy alone is often preferred first-line.","evidence":"Limited"}]
Primary treatment for: Mixed dyslipidemia
Also treats: Hypertriglyceridemia, Hypercholesterolemia, Diabetic dyslipidemia, Metabolic syndrome
📋 Drug Information
| Generic Name(s) | Fenofibrate (35mg) + Rosuvastatin (10mg) |
| Brand Name | Rosofibric 35 mg/10 mg Capsule |
| Manufacturer | Delvin Formulations Pvt Ltd |
| Packaging / Form | strip of 10 capsules (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Do not refrigerate or freeze. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary lipid-lowering actions. Fenofibrate activates peroxisome proliferator-activated receptor alpha (PPAR-alpha), which increases the activity of lipoprotein lipase and enhances fatty acid oxidation, leading to reduced triglyceride levels and increased HDL cholesterol. Rosuvastatin selectively inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis in the liver, which upregulates LDL receptors and increases clearance of LDL cholesterol from the blood. Together, they provide broader lipid control than either agent alone.
Mechanism Steps
💡 How to Take Rosofibric 35 mg/10 mg Capsule
Strength: Capsule containing fenofibrate 35 mg and rosuvastatin 10 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one capsule (fenofibrate 35 mg + rosuvastatin 10 mg) taken orally once daily with food. However, the exact dose and frequency must be individualized by a qualified clinician based on your lipid levels, kidney and liver function, and other medications. Do not adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the effects of this medicine, especially muscle and kidney effects. Dose should be individualized by a clinician, and renal function should be monitored regularly. |
| Renal Impairment | In patients with mild to moderate renal impairment, dose adjustment may be necessary. This medicine is contraindicated in severe renal impairment (eGFR <30 mL/min/1.73 m²). Consult your doctor for appropriate dosing. |
| Hepatic Impairment | This medicine is contraindicated in patients with active liver disease or unexplained persistent transaminase elevations. In patients with mild hepatic impairment, use with caution and monitor liver function closely. Dose adjustment may be required. |
| Maximum Daily Dose | The maximum recommended daily dose is one capsule (fenofibrate 35 mg + rosuvastatin 10 mg). Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Rosofibric 35 mg/10 mg Capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Cyclosporine | Major | |
| Gemfibrozil | Major | |
| Protease inhibitors | Major | |
| Colchicine | Moderate | |
| Azole antifungals | Moderate | |
| Macrolide antibiotics | Moderate | |
| Antacids | Minor | |
| Oral contraceptives | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Cyclosporine
- Gemfibrozil
- Protease inhibitors (e.g., ritonavir, lopinavir)
⚡ Moderate Interactions
- Fibrates other than fenofibrate (e.g., bezafibrate)
- Colchicine
- Azole antifungals (e.g., itraconazole, ketoconazole)
- Macrolide antibiotics (e.g., clarithromycin, erythromycin)
🍷 Alcohol Interaction
Drinking alcohol while taking this medicine can increase the risk of liver damage and may worsen muscle-related side effects. It is advisable to limit or avoid alcohol consumption during treatment. If you drink alcohol regularly, discuss this with your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active liver disease or unexplained persistent elevations of serum transaminases.","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Muscle effects: Report unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or dark urine.","Liver effects: Report yellowing of skin or eyes, dark urine, or abdominal pain.","Kidney effects: Dose adjustment may be needed in renal impairment; monitor renal function.","Gallstones: Fenofibrate may increase cholesterol excretion into bile, raising risk of gallstones.","Alcohol: Avoid excessive alcohol consumption due to increased risk of liver and muscle toxicity.","Diabetes: May affect blood sugar control; monitor glucose levels.","Thyroid disease: Hypothyroidism may increase risk of myopathy; treat before starting therapy.","Pediatric use: Safety and effectiveness not established.","Elderly: Use with caution; monitor renal and muscle function."]
🤱 Lactation Safety
It is not known whether fenofibrate or rosuvastatin are excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, this medicine should not be used while breastfeeding. Alternative lipid-lowering strategies should be discussed with your doctor.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of suspected overdose, seek immediate medical attention. Treatment should be symptomatic and supportive. Monitor liver and kidney function, and observe for signs of muscle toxicity. Hemodialysis is not expected to significantly enhance elimination.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually once daily with food to improve absorption and reduce stomach upset. Do not crush, chew, or open the capsule; swallow it whole with a glass of water. Avoid drinking excessive alcohol while on this medicine because it can increase the risk of liver problems and muscle side effects. Inform your doctor about all other medicines, supplements, and herbal products you are taking, especially blood thinners, other cholesterol-lowering drugs, and certain antibiotics or antifungals. Regular blood tests to check liver function, kidney function, and lipid levels are important. Do not use this medicine if you are pregnant, planning to become pregnant, or breastfeeding. Keep all follow-up appointments and report any unusual symptoms promptly.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to muscle and kidney side effects. Dose should be individualized, and renal function should be monitored regularly. Falls and muscle weakness should be evaluated promptly.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy and in women planning to become pregnant. If you are planning pregnancy, consult your doctor to switch to a safer alternative before conception. Use effective contraception while taking this medicine.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may need to be temporarily stopped, especially if you are at risk of bleeding or kidney problems. Follow your doctor's instructions regarding when to resume.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. There is no specific contraindication, but your dentist should be aware of your medication list, especially if you are taking blood thinners.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Regular exercise is encouraged, but if you experience unusual muscle pain, weakness, or fatigue during exercise, stop and consult your doctor. This could be a sign of muscle toxicity. Stay well hydrated during workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness, muscle weakness, or fatigue, avoid these activities until you feel better. Most people can continue their normal work and daily activities while taking this medicine.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as severe muscle pain, liver problems, or allergic reactions, seek immediate medical attention and follow your doctor's advice regarding discontinuation. Your doctor may adjust the dose or switch to an alternative treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe when monitored appropriately. It effectively reduces cardiovascular risk by maintaining healthy lipid levels. Regular monitoring of liver enzymes, kidney function, and muscle symptoms is important. In some patients, long-term use may be associated with increased risk of gallstones, liver enzyme elevations, or muscle problems. Your doctor will periodically assess the benefits and risks and may adjust the dose or switch to alternative therapies if needed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, and weight management can improve lipid levels and complement medicine.
Evidence: Well-establishedStatins alone, fibrates alone, or other combinations may be appropriate based on your lipid profile.
Evidence: Well-establishedOmega-3 fatty acids, plant sterols, and red yeast rice may have modest lipid-lowering effects.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medicines you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C).
❌ DON'T
Do not refrigerate or freeze.
✅ DO
Keep in the original container, tightly closed.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Protect from light and moisture.
❌ DON'T
Do not store in bathroom cabinet.
✅ DO
Keep out of reach of children.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and protect from direct sunlight. If crossing time zones, continue taking your dose at the same local time as usual, but consult your doctor if you need specific timing adjustments. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 1 to 2 weeks, but maximum lipid-lowering effects are usually seen after 4 weeks of consistent use.
A: It is best taken with food to improve absorption of fenofibrate and reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Limit grapefruit juice and avoid excessive alcohol consumption while taking this medicine.
A: No, do not stop without consulting your doctor. Cholesterol levels can rise again if the medicine is stopped.
🤔 Common Patient Concerns
🔄 Substitutes for Rosofibric 35 mg/10 mg Capsule
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken without food.
Fact: Fenofibrate absorption is better when taken with food, and food reduces stomach upset. - Myth: Once cholesterol levels are normal, the medicine can be stopped.
Fact: Cholesterol levels may rise again if the medicine is stopped. Always consult your doctor before discontinuing. - Myth: This medicine is safe during pregnancy.
Fact: This medicine is contraindicated during pregnancy as it may harm the fetus. - Myth: Muscle pain is always a sign of serious muscle damage.
Fact: Mild muscle pain can occur, but severe pain with weakness or dark urine requires immediate medical attention.
🔄 Alternative Options
Generic Alternatives
- Fenofibrate + Rosuvastatin generic capsules (various manufacturers)
Brand Alternatives
- Rosofibric 35 mg/10 mg Capsule