Lesuride Tablet (Levosulpiride 25 mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- High fever with muscle rigidity and confusion
- Involuntary repetitive movements of the face or tongue
- Severe dizziness or fainting
- Palpitations or irregular heartbeat
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is retune-ls tablet used for?
This medicine is a prokinetic and anti-emetic tablet containing Levosulpiride 25 mg. It is used to treat functional dyspepsia, diabetic gastroparesis, and nausea. It works by blocking dopamine D2 receptors, which speeds up stomach emptying and reduces vomiting. It is available only by prescription.
- Generic Name: Levosulpiride (25mg)
- Manufacturer: Zuventus Healthcare Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 retune-ls tablet के बारे में (Hindi Summary)
उपयोग: यह दवा लेवोसल्पिराइड 25 मिलीग्राम की गोली है, जिसका उपयोग पेट की समस्याओं जैसे अपच, पेट फूलना, जी मिचलाना और उल्टी के इलाज के लिए किया जाता है। यह दवा पेट की गति को तेज करती है और उल्टी को रोकती है। यह डायबिटीज से जुड़ी गैस्ट्रोपेरेसिस में भी फायदेमंद होती है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, सिरदर्द, मुँह सूखना, जी मिचलाना और कब्ज शामिल हैं। कभी-कभी यह मांसपेशियों में अकड़न, कंपन या असामान्य हरकतें पैदा कर सकती है। दुर्लभ मामलों में यह गंभीर स्थिति न्यूरोलेप्टिक मैलिग्नेंट सिंड्रोम का कारण बन सकती है। अगर कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। बिना सलाह के खुराक न बढ़ाएं या घटाएं। इस दवा को लेने के दौरान वाहन चलाने या मशीनरी चलाने से बचें क्योंकि इससे नींद और चक्कर आ सकते हैं। शराब का सेवन न करें। अगर आप गर्भवती हैं, स्तनपान करा रही हैं, या कोई अन्य दवा ले रही हैं, तो डॉक्टर को बताएं। दवा को बच्चों की पहुंच से दूर रखें।
💊 retune-ls tablet Uses & Benefits
[{"condition":"Functional dyspepsia","description":"Relieves symptoms such as bloating, early satiety, upper abdominal pain, and nausea by accelerating gastric emptying.","evidence":"Well-established"},{"condition":"Diabetic gastroparesis","description":"Helps improve delayed stomach emptying in people with diabetes, reducing nausea, vomiting, and bloating.","evidence":"Moderate"},{"condition":"Nausea and vomiting","description":"Used as an anti-emetic to control nausea and vomiting from various causes, including chemotherapy and postoperative nausea.","evidence":"Moderate"},{"condition":"Gastroesophageal reflux disease (GERD)","description":"May be used as an add-on therapy to reduce reflux symptoms by promoting gastric emptying.","evidence":"Limited"}]
Off-label uses: [{"condition":"Premature ejaculation","description":"Sometimes prescribed off-label due to its prolactin-raising and dopamine-blocking effects.","evidence":"Limited"},{"condition":"Depression augmentation","description":"Occasionally used as an adjunct in treatment-resistant depression.","evidence":"Limited"}]
Primary treatment for: Functional dyspepsia
Also treats: Diabetic gastroparesis, Nausea and vomiting, Gastroesophageal reflux disease
📋 Drug Information
| Generic Name(s) | Levosulpiride (25mg) |
| Brand Name | retune-ls tablet |
| Manufacturer | Zuventus Healthcare Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Atypical Antipsychotics |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by selectively blocking dopamine D2 receptors in the chemoreceptor trigger zone of the brain and in the gastrointestinal tract. By blocking these receptors, it reduces the emetic signals and enhances gastric motility, leading to faster stomach emptying and improved symptoms of dyspepsia. At higher doses, it also has antipsychotic effects, but at the 25 mg dose used for gastrointestinal conditions, its prokinetic and anti-emetic actions predominate.
Mechanism Steps
💡 How to Take retune-ls tablet
Strength: Tablet, 25 mg
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 25 mg taken once or twice daily, preferably before meals. However, the dose may vary depending on the condition being treated and the patient's response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially extrapyramidal symptoms and drowsiness. A lower starting dose may be considered, and dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with severe renal impairment, dose reduction may be necessary. Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | In patients with severe hepatic impairment, dose reduction may be necessary. Dose must be individualized by a qualified clinician based on hepatic function. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine is 50 mg, but this may vary based on the indication and patient factors. Always follow your doctor's prescription. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of retune-ls tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Levodopa | Major | |
| Other antipsychotics | Major | |
| QT-prolonging drugs | Major | |
| CNS depressants | Moderate | |
| Antihypertensives | Moderate | |
| Metoclopramide | Moderate | |
| Antacids | Minor | |
| Opioid analgesics | Minor |
🚨 Major Interactions
- Levodopa
- Other antipsychotics
- QT-prolonging drugs
⚡ Moderate Interactions
- CNS depressants
- Antihypertensives
- Metoclopramide
🍷 Alcohol Interaction
Avoid consuming alcohol while taking this medicine, as it can increase drowsiness, dizziness, and the risk of other central nervous system side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to levosulpiride or any component of the formulation","Pheochromocytoma","Breast cancer","Epilepsy","Severe renal impairment","Severe hepatic impairment","Concomitant use with levodopa"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol consumption while taking this medicine.","Use with caution in elderly patients due to increased risk of extrapyramidal symptoms.","May increase prolactin levels; monitor for signs of hyperprolactinemia.","Can cause QT prolongation; use with caution in patients with cardiac disease.","Do not stop abruptly; taper gradually under medical supervision.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding."]
🤱 Lactation Safety
This medicine may pass into breast milk. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose of this medicine may cause severe drowsiness, dizziness, extrapyramidal symptoms, and hypotension. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not increase or decrease the dose without medical advice. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause drowsiness or dizziness. Do not consume alcohol while taking this medicine, as it can worsen drowsiness and other side effects. Inform your doctor if you have a history of heart disease, kidney or liver problems, epilepsy, or Parkinson's disease. This medicine may interact with other medicines, so always tell your doctor about all the medicines you are taking, including over-the-counter products and herbal supplements. Do not stop taking this medicine abruptly without consulting your doctor, as withdrawal symptoms may occur. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits with your doctor before taking this medicine. Keep this medicine out of reach of children and store it in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to extrapyramidal symptoms, drowsiness, and dizziness. A lower starting dose may be considered, and close monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established, and it should be used only if clearly needed.
🏥 Post-Surgery Considerations
This medicine may be used postoperatively for nausea and vomiting, but it should be used with caution due to the risk of extrapyramidal symptoms and QT prolongation. Inform your surgeon and anesthesiologist if you are taking this medicine.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may interact with anesthetics or other medications used during dental procedures. It may also cause dry mouth, which can affect dental health.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness or dizziness. Avoid strenuous exercise or activities requiring alertness until you know how this medicine affects you. Light to moderate exercise is generally safe.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness and dizziness, which can affect your ability to drive or operate machinery. It is advisable to avoid such activities until you know how this medicine affects you. Inform your employer if your work involves operating heavy machinery.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms worsen, contact your doctor immediately. Your doctor will decide whether to adjust the dose or stop the medicine.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of extrapyramidal symptoms, tardive dyskinesia, and hyperprolactinemia. Regular monitoring of symptoms and prolactin levels is advised. Periodic assessment of renal and hepatic function is also recommended. The need for continued therapy should be reassessed periodically by your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Eating small, frequent meals and avoiding trigger foods can help manage dyspepsia.
Evidence: Well-establishedYoga, meditation, and relaxation techniques can reduce stress-related stomach symptoms.
Evidence: ModerateDomperidone or metoclopramide may be alternatives, but they have their own side effects.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor before any vaccination if you are on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and away from direct sunlight. If crossing time zones, adjust your dosing schedule gradually under medical guidance. Check local customs regulations regarding prescription medicines before you travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 1 to 2 hours after taking a dose. However, full therapeutic benefits for conditions like functional dyspepsia may take a few days to weeks.
A: It is best to take this medicine before meals to enhance its absorption and prokinetic effect. However, if it causes stomach upset, you may take it with food after consulting your doctor.
A: Long-term use should be under medical supervision. Regular monitoring for side effects such as extrapyramidal symptoms and prolactin levels may be needed.
A: No, do not stop this medicine abruptly without consulting your doctor, as withdrawal symptoms may occur. Your doctor may taper the dose gradually.
🤔 Common Patient Concerns
🔄 Substitutes for retune-ls tablet
View AllAlternative brands with exact same active ingredient:
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stayhappi levosulpiride 25mg tabletSarvagunaushdhi Pvt Ltd ₹12.19 69.2% CHEAPER
-
drbest l 25mg tablet srDR Best pharmaceuticals Pvt Ltd ₹18.75 52.6% CHEAPER
-
tocid 25mg injectionLemford Biotech Pvt Ltd ₹42.19 6.6% COSTLIER
-
Levonxt 25mg TabletHumbing Ethicals ₹42.19 6.6% COSTLIER
-
TILPRIDE 25MG TABLETTablets India Limited ₹45.08 14% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill.
Fact: This medicine is not a sleeping pill. It is a prokinetic and anti-emetic used for stomach problems. Drowsiness is a side effect, not the main purpose. - Myth: This medicine can be taken for any stomach pain.
Fact: This medicine is specifically for functional dyspepsia, gastroparesis, and nausea. It is not a general painkiller and should not be used for all types of stomach pain. - Myth: This medicine is safe to take without a prescription.
Fact: This medicine is a prescription drug and should only be taken under medical supervision.
🔄 Alternative Options
Generic Alternatives
- Levosulpiride 25 mg tablet
Brand Alternatives
- Lesuride
- Levopraid
- Sulpiride