Acutrol 800 Tablet (Sevelamer 800mg): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Severe abdominal pain that does not go away
- Persistent vomiting or inability to keep fluids down
- Blood in stool or black, tarry stools
- Fever with abdominal pain or diarrhoea
- Sudden swelling of the face, lips, or throat
- Difficulty breathing or wheezing
- Signs of dehydration such as very little urine, dry mouth, or dizziness
- Yellowing of the skin or eyes
- Severe constipation with no bowel movement for several days
If experiencing severe symptoms, call emergency services immediately.
What is renvela 800mg sachet used for?
This medicine is a phosphate binder used to lower high phosphate levels in people with chronic kidney disease. It works by binding phosphate from food in the gut so it cannot be absorbed. It must be taken with meals and the dose is adjusted based on blood tests.
- Generic Name: Sevelamer (800mg)
- Manufacturer: Sanofi India Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 renvela 800mg sachet के बारे में (Hindi Summary)
उपयोग: यह दवा मुख्य रूप से किडनी की बीमारी वाले मरीजों में खून में फॉस्फेट का स्तर बढ़ने (हाइपरफॉस्फेटेमिया) के इलाज के लिए इस्तेमाल की जाती है। जब किडनी ठीक से काम नहीं करती, तो खाने से निकला फॉस्फेट शरीर से बाहर नहीं निकल पाता और खून में जमा होने लगता है। यह दवा खाने के साथ लेने पर आंतों में फॉस्फेट को बांध लेती है, जिससे वह शरीर में सोख नहीं पाता और मल के रास्ते बाहर निकल जाता है। इससे खून में फॉस्फेट का स्तर कम होता है और दिल, नसों तथा हड्डियों को नुकसान से बचाया जा सकता है। यह दवा डायलिसिस कराने वाले मरीजों और गंभीर किडनी रोग वाले लोगों के लिए खास तौर पर फायदेमंद है। इसे हमेशा खाने के साथ ही लेना चाहिए, वरना यह काम नहीं करेगी।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में जी मिचलाना, उल्टी, पेट दर्द, कब्ज, दस्त, अपच और पेट में गैस बनना शामिल है। ये आमतौर पर हल्के होते हैं और खाने के साथ दवा लेने पर कम हो जाते हैं। कुछ लोगों को सिरदर्द, थकान या मांसपेशियों में दर्द हो सकता है। लंबे समय तक इस्तेमाल से शरीर में विटामिन ए, डी, ई, के और जिंक की कमी हो सकती है, इसलिए डॉक्टर समय-समय पर खून की जांच करते रहते हैं। गंभीर दुष्प्रभाव बहुत कम होते हैं, लेकिन आंतों में सूजन, रुकावट या छेद जैसी समस्याएं हो सकती हैं। अगर पेट में तेज दर्द, लगातार उल्टी, खून वाला दस्त या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार और खाने के साथ लें। इसे पूरा निगलें, चबाएं या तोड़ें नहीं। खाना छोड़ें नहीं, क्योंकि यह दवा सिर्फ खाने के फॉस्फेट को बांधती है। दूसरी दवाएं लेने से पहले या बाद में कम से कम 1 से 3 घंटे का अंतर रखें, क्योंकि यह दवा कुछ दवाओं के सोखने को कम कर सकती है। अपनी सभी ब्लड टेस्ट और डॉक्टर की जांच समय पर कराएं। अगर आपको कब्ज, पेट की गंभीर समस्या या आंतों की बीमारी है, तो डॉक्टर को बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं बिना डॉक्टर की सलाह के यह दवा न लें। इसे ठंडी, सूखी जगह पर, धूप से दूर और बच्चों की पहुंच से बाहर रखें। कोई भी नई दवा, विटामिन या हर्बल सप्लीमेंट शुरू करने से पहले अपने डॉक्टर से पूछें।
💊 renvela 800mg sachet Uses & Benefits
[{"condition":"Hyperphosphatemia in chronic kidney disease","description":"This medicine is used to lower high phosphate levels in adults with chronic kidney disease who are on dialysis or have advanced kidney impairment, when dietary phosphate restriction alone is not enough.","evidence":"Well-established"},{"condition":"Hyperphosphatemia in dialysis patients","description":"It is commonly prescribed for people receiving hemodialysis or peritoneal dialysis to control phosphate levels and reduce the risk of vascular calcification and bone disease.","evidence":"Well-established"},{"condition":"Chronic kidney disease without dialysis","description":"Sometimes used in advanced chronic kidney disease before dialysis starts, if phosphate levels remain high despite diet, to help protect the heart and bones.","evidence":"Established"}]
Off-label uses: [{"condition":"Hyperphosphatemia in chronic kidney disease with normal or mildly reduced kidney function","description":"Rarely, it may be considered in selected patients with early kidney disease and high phosphate, but this is not a standard use and should only be decided by a kidney specialist.","evidence":"Limited"},{"condition":"Reducing phosphate absorption in patients with tumour lysis syndrome","description":"There are occasional reports of use in tumour lysis syndrome to manage high phosphate, but this is not a routine or approved indication.","evidence":"Limited"}]
Primary treatment for: Hyperphosphatemia in chronic kidney disease
Also treats: Chronic kidney disease, End-stage renal disease on dialysis, Renal osteodystrophy, Vascular calcification
📋 Drug Information
| Generic Name(s) | Sevelamer (800mg) |
| Brand Name | renvela 800mg sachet |
| Manufacturer | Sanofi India Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OTHERS |
| Action Class | Phosphorous binder |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in the original container, tightly closed, away from direct sunlight, moisture, and heat. Do not refrigerate unless specifically instructed. |
| Shelf Life | Typically 24 to 36 months from the date of manufacture, depending on the manufacturer and pack. Always check the expiry date on the pack and do not use after it has passed. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works as a non-absorbed phosphate binder. After you swallow the tablet, the active ingredient, Sevelamer, travels through the stomach and intestines without being absorbed into the bloodstream. In the gut, it binds to phosphate from the food you have eaten. This binding forms a large, insoluble complex that cannot cross the intestinal wall, so the phosphate is carried out of the body in the stool instead of being taken up into the blood. Because it does not contain calcium or aluminium, it does not add to the body's mineral load. By reducing phosphate absorption, this medicine helps lower serum phosphate levels, which in turn reduces the risk of phosphate depositing in blood vessels, heart valves, and soft tissues, and helps prevent bone disease associated with kidney failure.
Mechanism Steps
💡 How to Take renvela 800mg sachet
Strength: This medicine is available as an 800 mg immediate-release tablet for oral use.
Dosage Information
| Adult Dosage | The usual starting dose for adults is 800 mg to 1600 mg taken with each meal, three times a day, but the exact dose depends on your blood phosphate level, your diet, and whether you are on dialysis. Your doctor will adjust the dose every two to four weeks based on your phosphate levels until they are controlled. The maximum daily dose is usually 2400 mg per meal, but this must be decided by your kidney specialist. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Always take this medicine with food and a full glass of water. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician or pediatric kidney specialist for guidance. |
| Elderly Dosage | Older adults can take this medicine, but they may be more sensitive to stomach and bowel side effects such as constipation. The dose is the same as for other adults but should be adjusted carefully based on kidney function, phosphate levels, and overall health. Regular monitoring is especially important in this age group. |
| Renal Impairment | This medicine is used in people with kidney disease, including those on dialysis. No specific dose reduction is required for kidney impairment because the medicine is not absorbed. However, the dose must be adjusted based on your serum phosphate levels and your dialysis schedule. Your doctor will monitor you closely. |
| Hepatic Impairment | No specific dose adjustment is required for liver impairment because this medicine is not absorbed and does not undergo liver metabolism. However, your doctor will monitor your overall health and adjust the dose based on your phosphate levels. |
| Maximum Daily Dose | The maximum daily dose is usually 2400 mg per meal, but this must be determined by your kidney specialist based on your phosphate levels and tolerance. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of renvela 800mg sachet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ciprofloxacin | Major | |
| Levothyroxine | Major | |
| Tacrolimus | Major | |
| Mycophenolate mofetil | Major | |
| Warfarin | Moderate | |
| Digoxin | Moderate | |
| Metformin | Moderate | |
| Aspirin | Moderate | |
| Calcium supplements | Minor | |
| Iron supplements | Minor |
🚨 Major Interactions
- Ciprofloxacin
- Levothyroxine
- Tacrolimus
- Mycophenolate mofetil
⚡ Moderate Interactions
- Warfarin
- Digoxin
- Metformin
- Aspirin
🍷 Alcohol Interaction
There is no direct interaction between this medicine and alcohol because the medicine is not absorbed into the bloodstream. However, alcohol can worsen dehydration, stomach irritation, and liver problems, and it may interfere with your kidney diet and overall health. It is best to avoid alcohol or limit it strictly as advised by your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to Sevelamer or any ingredient in this medicine","Bowel obstruction","Severe constipation or history of severe gastrointestinal motility problems","History of major gastrointestinal surgery that increases risk of obstruction","Low phosphate levels (hypophosphatemia)"]
⚠️ Warnings & Precautions
["Take this medicine with meals; it will not work if taken on an empty stomach.","Swallow the tablet whole; do not crush or chew unless advised by your doctor.","This medicine can reduce the absorption of other medicines; separate doses as directed.","Tell your doctor if you have a history of bowel obstruction, severe constipation, or stomach surgery.","Your doctor will monitor your vitamin and mineral levels during long-term use.","Do not use this medicine to treat high phosphate without a doctor's supervision.","If you are pregnant or breastfeeding, discuss with your doctor before use.","Keep all follow-up appointments and blood tests.","Do not share this medicine with others.","Report any severe stomach pain, vomiting, or blood in stool immediately."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Because it is not absorbed into the bloodstream, the amount reaching breast milk is expected to be negligible. However, you should consult your doctor before breastfeeding while taking this medicine, especially if your baby has kidney problems or other health issues.
💊 Overdose Management
Overdose with this medicine is unlikely to cause serious harm because it is not absorbed into the bloodstream. However, taking too much may cause severe stomach upset, constipation, or diarrhoea. If you suspect an overdose, contact your doctor or a poison control centre immediately. Treatment is supportive, and your doctor may monitor your phosphate and electrolyte levels. Do not try to make yourself vomit unless told to do so by a medical professional.
⏰ Missed Dose
If you miss a dose with a meal, take it with your next meal if it is almost time. If it is more than half the time until your next meal, skip the missed dose and continue with your regular schedule. Never take two doses at once to make up for a missed dose. If you are unsure, contact your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed, always with meals or immediately before eating, because it only binds phosphate from food. Swallow the tablet whole with a full glass of water; do not crush, chew, or break it unless your doctor or pharmacist tells you it is safe to do so. Do not skip meals while taking this medicine, as it will not work without food. Keep all your blood tests, especially phosphate, calcium, and vitamin levels, because your dose may need to be adjusted. Tell your doctor if you have severe constipation, bowel problems, or a history of stomach or intestinal surgery. This medicine can reduce the absorption of some other medicines, so take other oral medicines either one hour before or three hours after this medicine, unless your doctor advises otherwise. Do not start any new medicine, vitamin, or herbal supplement without asking your kidney team. If you are pregnant, planning pregnancy, or breastfeeding, talk to your doctor before using this medicine. Do not share this medicine with anyone else, even if they have similar symptoms. Store it in a cool, dry place away from direct sunlight and out of reach of children. If you miss a dose with a meal, take it with your next meal if it is almost time, but never take two doses at once to make up for a missed one. Contact your doctor immediately if you experience severe stomach pain, persistent vomiting, or signs of an allergic reaction.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may be more prone to constipation and dehydration while taking this medicine. They should drink enough fluids as advised by their doctor and report any changes in bowel habits. The dose is the same as for other adults but should be adjusted based on kidney function and phosphate levels. Regular monitoring is especially important in this age group.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, talk to your kidney specialist and obstetrician before conception. This medicine should be used during pregnancy only if clearly needed. Your doctor will weigh the benefits of controlling phosphate against any potential risks to the baby. Good control of phosphate before and during pregnancy is important for both mother and baby.
🏥 Post-Surgery Considerations
If you are going to have surgery, tell your surgeon and anaesthesiologist that you are taking this medicine. It may need to be stopped temporarily if you cannot eat, because it must be taken with food. Your doctor will advise you on when to restart it. It does not usually affect wound healing or surgical outcomes.
🦷 Dental Procedures
This medicine is not expected to cause problems during dental procedures. However, tell your dentist about all medicines you take, including this one. If you need to take antibiotics or painkillers after a dental procedure, ask your doctor or pharmacist about timing, as this medicine can affect the absorption of some medicines.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine is not expected to affect your ability to exercise. However, if you have kidney disease, you should follow your doctor's advice about the type and amount of exercise that is safe for you. Avoid heavy lifting or strenuous activity if you have bone disease or are at risk of fractures. Stay hydrated during exercise, but follow your fluid restrictions if you are on dialysis.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is not expected to affect your ability to work or drive. However, if you experience dizziness, fatigue, or stomach upset, use caution when driving or operating machinery. You may need to plan your meals and doses around your work schedule. Talk to your employer about any accommodations you may need for dialysis or medical appointments.
🛑 When to Stop This Medicine
Do not stop taking this medicine without talking to your doctor. It is usually a long-term treatment for kidney disease. If you experience severe side effects such as bowel obstruction, severe allergic reaction, or persistent vomiting, your doctor may advise you to stop. Always consult your kidney specialist before making any changes.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe and is often necessary for people with chronic kidney disease. The main concern is that it can reduce the absorption of certain vitamins, including vitamins A, D, E, and K, and minerals like zinc and folic acid. Your doctor will monitor your blood levels regularly and may recommend supplements. It may also cause ongoing gastrointestinal symptoms like constipation or bloating. Long-term use does not harm the kidneys or liver. Regular follow-up with your kidney team is important to adjust the dose and check for any complications.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Limiting high-phosphate foods can help lower phosphate levels, but it is often not enough alone in advanced kidney disease.
Evidence: Well-establishedMedicines like calcium acetate can also bind phosphate, but they may cause high calcium levels.
Evidence: Well-establishedOther options like lanthanum carbonate are available for patients who cannot take calcium or Sevelamer.
Evidence: Well-establishedEnsuring adequate dialysis can help remove some phosphate, but it does not replace phosphate binders.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, people with chronic kidney disease should stay up to date with recommended vaccines, including influenza, COVID-19, pneumococcal, and hepatitis B vaccines, as advised by their doctor. This medicine does not affect vaccine effectiveness.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless specifically instructed
✅ DO
Keep in the original container, tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children and pets
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with the prescription label clearly visible. Bring enough supply for your entire trip, plus extra in case of delays. Keep a copy of your prescription and a letter from your doctor explaining that you need this medicine for a chronic condition. Store it in your hand luggage, away from direct sunlight and extreme temperatures. If you are crossing time zones, continue taking this medicine with your meals according to local meal times, as it must be taken with food. Check the customs rules of your destination for carrying prescription medicines. If you are on dialysis, arrange your dialysis sessions in advance and inform the dialysis centre about your medicine.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working with the first dose taken with food, but it may take several days to weeks of consistent use before your blood phosphate levels show a clear improvement. Your doctor will check your levels regularly and adjust the dose.
A: No. This medicine must be taken with food or immediately before eating. It only binds phosphate from the food you eat, so it will not work on an empty stomach.
A: If you miss a dose with a meal, take it with your next meal if it is almost time. If it is more than half the time until your next meal, skip the missed dose. Never take two doses at once.
A: This medicine can reduce the absorption of some other medicines. Take other oral medicines at least 1 hour before or 3 hours after this medicine, unless your doctor advises otherwise. Always tell your doctor about all medicines you take.
A: Yes, it is often used long-term in kidney disease. However, it can lower levels of some vitamins, so your doctor will monitor your blood levels and may recommend supplements. Do not stop it without talking to your doctor.
A: No. You should not stop this medicine without talking to your doctor. Phosphate levels can rise again if you stop, and long-term control is important to protect your heart and bones.
🤔 Common Patient Concerns
🔄 Substitutes for renvela 800mg sachet
View AllAlternative brands with exact same active ingredient:
-
Sevcar 800mg GranulesEmcure Pharmaceuticals Ltd ₹50.00 8.7% COSTLIER
-
davaindia sevelamer 800mg tablet dtDavaindia Generic Pharmacy ₹100.00 117.4% COSTLIER
-
forsemer 800mg tabletMicro Labs Ltd ₹177.19 285.2% COSTLIER
-
phoscut 800 tabletSteadfast Medishield Pvt Ltd ₹182.81 297.4% COSTLIER
-
sevgia 800mg tabletHygeia Pharmaceuticals ₹214.69 366.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure kidney disease.
Fact: This medicine does not cure kidney disease. It only helps control phosphate levels, which is one part of managing kidney disease. - Myth: You can take this medicine on an empty stomach.
Fact: This medicine must be taken with food to work. It binds phosphate from the food you eat. - Myth: This medicine is the same as calcium supplements.
Fact: This medicine does not contain calcium. It is a different type of phosphate binder that does not add calcium to your body. - Myth: Once your phosphate is normal, you can stop this medicine.
Fact: You should not stop this medicine without talking to your doctor. Phosphate levels can rise again if you stop, and long-term control is important.
🔄 Alternative Options
Generic Alternatives
- Sevelamer carbonate
- Sevelamer hydrochloride
Brand Alternatives
- Acutrol 800 Tablet