Madotine 10mg Tablet (Paroxetine): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Thoughts of harming yourself or others
- Agitation, hallucinations, fever, rapid heart rate, muscle stiffness (serotonin syndrome)
- Unusual bleeding or bruising
- Severe headache, confusion, weakness, or seizures (hyponatremia)
- Eye pain, vision changes, or swelling around the eyes (angle-closure glaucoma)
- Difficulty breathing, swelling of face, lips, or throat (allergic reaction)
- Chest pain, palpitations, or fainting
- Yellowing of skin or eyes, dark urine, or abdominal pain (liver problems)
If experiencing severe symptoms, call emergency services immediately.
What is raxit 10mg tablet used for?
This medicine contains Paroxetine 10mg, an SSRI antidepressant used to treat depression, anxiety disorders, OCD, and PTSD. It works by increasing serotonin levels in the brain. It is taken orally once daily, usually in the morning. Do not stop abruptly.
- Generic Name: Paroxetine (10mg)
- Manufacturer: Sun Pharmaceutical Industries Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 raxit 10mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पैरोक्सेटीन 10mg टैबलेट के रूप में उपलब्ध है और मुख्य रूप से अवसाद (डिप्रेशन), चिंता विकार, ऑब्सेसिव-कंपल्सिव डिसऑर्डर (OCD), पैनिक डिसऑर्डर, सोशल एंग्जायटी डिसऑर्डर, और पोस्ट-ट्रॉमेटिक स्ट्रेस डिसऑर्डर (PTSD) के इलाज के लिए इस्तेमाल की जाती है। यह दवा मस्तिष्क में सेरोटोनिन नामक रसायन के स्तर को बढ़ाकर मूड को बेहतर बनाती है और चिंता को कम करती है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए। इसे रोज एक बार लिया जाता है, आमतौर पर सुबह के समय। इसे अचानक बंद न करें, क्योंकि इससे withdrawal symptoms हो सकते हैं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, नींद आना, चक्कर आना, अनिद्रा, पसीना आना, मुंह सूखना, कब्ज, दस्त, भूख में कमी, और यौन समस्याएं शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभावों में सेरोटोनिन सिंड्रोम, रक्तस्राव का खतरा, सोडियम की कमी, और आत्महत्या के विचार शामिल हैं। अगर आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, सीने में दर्द, तेज सिरदर्द, या असामान्य रक्तस्राव हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक को अपने आप न बदलें और न ही अचानक बंद करें। यह दवा नींद या चक्कर का कारण बन सकती है, इसलिए जब तक आपको इसका असर पता न चल जाए, वाहन चलाने या भारी मशीनरी चलाने से बचें। इस दवा के साथ शराब न लें। अगर आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं, तो अपने डॉक्टर को बताएं। अगर आप MAOI दवाएं ले रहे हैं या पिछले 14 दिनों में ली हैं, तो यह दवा न लें। इस दवा को कमरे के तापमान पर, नमी और गर्मी से दूर रखें। बच्चों की पहुंच से दूर रखें।
💊 raxit 10mg tablet Uses & Benefits
[{"condition":"Major Depressive Disorder","description":"This medicine helps relieve symptoms of depression such as persistent sadness, loss of interest, and fatigue.","evidence":"Well-established"},{"condition":"Obsessive-Compulsive Disorder","description":"Reduces the frequency and intensity of intrusive thoughts and repetitive behaviors.","evidence":"Well-established"},{"condition":"Panic Disorder","description":"Decreases the frequency and severity of panic attacks and reduces anticipatory anxiety.","evidence":"Well-established"},{"condition":"Social Anxiety Disorder","description":"Helps reduce excessive fear and avoidance of social situations.","evidence":"Well-established"},{"condition":"Generalized Anxiety Disorder","description":"Reduces chronic, excessive worry and tension.","evidence":"Well-established"},{"condition":"Post-Traumatic Stress Disorder","description":"Helps manage symptoms such as flashbacks, avoidance, and hyperarousal.","evidence":"Well-established"},{"condition":"Premenstrual Dysphoric Disorder","description":"Reduces mood swings, irritability, and other premenstrual symptoms.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Premature Ejaculation","description":"Sometimes prescribed off-label to delay ejaculation due to SSRI effects on sexual function.","evidence":"Moderate"},{"condition":"Hot Flashes","description":"May be used off-label to reduce hot flashes in menopausal women.","evidence":"Limited"},{"condition":"Irritable Bowel Syndrome","description":"Occasionally used off-label for IBS-related anxiety and gut-brain axis modulation.","evidence":"Limited"}]
Primary treatment for: Major Depressive Disorder
Also treats: Obsessive-Compulsive Disorder, Panic Disorder, Social Anxiety Disorder, Generalized Anxiety Disorder, Post-Traumatic Stress Disorder, Premenstrual Dysphoric Disorder
📋 Drug Information
| Generic Name(s) | Paroxetine (10mg) |
| Brand Name | raxit 10mg tablet |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Selective Seretonin Reuptake inhibitors (SSRIs) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct sunlight. Keep in the original container, tightly closed. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine selectively inhibits the reuptake of serotonin (5-hydroxytryptamine, 5-HT) at the presynaptic neuronal membrane. By blocking the serotonin transporter (SERT), it increases the concentration of serotonin in the synaptic cleft, enhancing serotonergic neurotransmission. This action is believed to underlie its therapeutic effects in depression, anxiety, and related disorders. Paroxetine has minimal affinity for norepinephrine and dopamine reuptake pumps, making it a potent and selective SSRI. It also has mild anticholinergic properties compared to some other SSRIs.
Mechanism Steps
💡 How to Take raxit 10mg tablet
Strength: Immediate-release tablet, 10 mg
Dosage Information
| Adult Dosage | The usual starting dose of this medicine for adults is 20 mg once daily, typically taken in the morning. For some conditions, the dose may be started at 10 mg once daily and increased gradually. The maximum recommended dose is 50-60 mg per day depending on the indication. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to treatment. Do not adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. The starting dose should be lower (e.g., 10 mg once daily) and titrated slowly. Monitor for hyponatremia and falls. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with severe renal impairment (creatinine clearance <30 mL/min), the dose should be reduced. The starting dose may be 10 mg once daily, with a maximum of 40 mg per day. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with hepatic impairment, the dose should be reduced. The starting dose may be 10 mg once daily, with a maximum of 40 mg per day. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | 50-60 mg per day depending on the indication, as determined by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of raxit 10mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Warfarin | Major | |
| NSAIDs | Major | |
| Triptans | Major | |
| CYP2D6 Inhibitors | Moderate | |
| TCAs | Moderate | |
| Diuretics | Moderate | |
| Alcohol | Moderate | |
| Antacids | Minor | |
| Cimetidine | Minor |
🚨 Major Interactions
- Monoamine Oxidase Inhibitors (MAOIs)
- Thioridazine
- Pimozide
- Warfarin
- NSAIDs, Aspirin
- Triptans
- Linezolid
- Methylene Blue
⚡ Moderate Interactions
- CYP2D6 Inhibitors (e.g., Quinidine, Fluoxetine)
- Tricyclic Antidepressants (TCAs)
- Anticoagulants (e.g., Heparin)
- Diuretics
- Alcohol
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase drowsiness, dizziness, and impair judgment and motor skills. It may also worsen depression and anxiety symptoms.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Paroxetine or any component of the formulation","Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping an MAOI","Concurrent use with thioridazine or pimozide","Uncontrolled narrow-angle glaucoma","Pregnancy (Category D) unless benefit outweighs risk"]
⚠️ Warnings & Precautions
["Increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults, especially during initial treatment.","Serotonin syndrome may occur with concomitant use of other serotonergic drugs.","Increased risk of bleeding, especially when used with NSAIDs, aspirin, or anticoagulants.","Hyponatremia may occur, particularly in elderly patients and those on diuretics.","May impair physical and mental abilities; avoid driving or operating machinery until effects are known.","Do not stop abruptly; taper gradually to avoid discontinuation syndrome.","Use with caution in patients with a history of mania or bipolar disorder.","May increase the risk of angle-closure glaucoma.","Use with caution in patients with hepatic or renal impairment.","May cause sexual dysfunction; discuss with your doctor if concerned."]
🤱 Lactation Safety
This medicine is excreted in human breast milk. Caution should be exercised when administered to a nursing woman. The benefits of breastfeeding should be weighed against the potential risks to the infant. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose of this medicine may cause symptoms such as nausea, vomiting, drowsiness, tachycardia, tremor, and in severe cases, serotonin syndrome, seizures, and cardiac arrhythmias. There is no specific antidote. Treatment should be symptomatic and supportive. Gastric lavage may be considered if ingestion is recent. Monitor vital signs, cardiac rhythm, and mental status. Contact a poison control center or emergency services immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop suddenly without medical advice. This medicine may cause drowsiness or dizziness; avoid driving or operating heavy machinery until you know how it affects you. Avoid alcohol while taking this medicine, as it can worsen side effects. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not take this medicine if you are taking an MAOI or have taken one in the last 14 days. Keep all follow-up appointments and report any new or worsening symptoms, especially mood changes or suicidal thoughts. Store this medicine at room temperature away from moisture and heat. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at increased risk of hyponatremia, falls, and fractures. Start with a lower dose (10 mg daily) and titrate slowly. Monitor sodium levels and renal function regularly. Avoid concomitant use with diuretics if possible.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before conception. This medicine is classified as Pregnancy Category D and may pose risks to the fetus. Your doctor may consider switching to a safer alternative or tapering off the medication. Do not stop abruptly without medical guidance.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with certain anesthetic agents and increase the risk of serotonin syndrome. Your doctor may advise temporary dose adjustment or monitoring.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may increase bleeding risk during dental procedures, especially if you are also taking NSAIDs or blood thinners. Your dentist may take extra precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness or dizziness, especially when starting treatment or changing doses. Avoid strenuous exercise or activities requiring alertness until you know how it affects you. Stay hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness, dizziness, or difficulty concentrating, especially during the first few weeks. Avoid driving or operating heavy machinery until you know how it affects you. It may take several weeks to feel the full benefits, so be patient with your work performance. Communicate with your employer if you need accommodations.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or wish to discontinue, your doctor will guide you through a gradual taper to avoid withdrawal symptoms. Stopping abruptly can cause dizziness, nausea, headache, and irritability.
📅 Long-Term Use Effects
Long-term use of this medicine may be necessary for chronic conditions like depression and anxiety. Regular monitoring for side effects, mood changes, and metabolic parameters is recommended. Some patients may experience weight gain, sexual dysfunction, or emotional blunting. Do not stop long-term use without medical advice. Periodic review of the need for continued treatment is advised.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A type of talk therapy that can be as effective as medication for mild to moderate depression and anxiety.
Evidence: Well-establishedAerobic exercise can boost mood and reduce anxiety symptoms.
Evidence: Well-establishedCan help manage stress and improve emotional regulation.
Evidence: ModerateMay have a modest benefit in depression, but not a replacement for medication.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medications you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, adjust your dosing schedule gradually; consult your doctor for specific advice. Store at room temperature and avoid leaving it in a hot car. Check customs regulations for controlled substances before traveling internationally. Carry enough supply for your entire trip and a few extra days in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine may start working within 1-2 weeks, but full therapeutic effects usually take 4-6 weeks. Be patient and continue as prescribed.
A: No, stopping abruptly can cause withdrawal symptoms such as dizziness, nausea, and irritability. Always consult your doctor for a gradual taper.
A: If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine is classified as Pregnancy Category D, meaning there is evidence of risk to the fetus. Consult your doctor if you are pregnant or planning to become pregnant.
A: It is best to avoid alcohol as it can increase drowsiness, dizziness, and impair judgment.
A: Some people may experience weight changes. Monitor your weight and discuss with your doctor if concerned.
A: Sexual dysfunction is a common side effect of SSRIs. Discuss with your doctor if this is bothersome; dose adjustment or alternative may be considered.
A: Store at room temperature between 15°C and 30°C, away from moisture, heat, and direct sunlight. Keep in the original container.
🤔 Common Patient Concerns
🔄 Substitutes for raxit 10mg tablet
View AllAlternative brands with exact same active ingredient:
-
prx 10mg tabletSunrise Remedies Pvt Ltd ₹46.88 28.6% CHEAPER
-
madotine 10mg tabletMaiden Pharmaceutical Ltd ₹65.63 SAME PRICE
-
pxt 10mg tabletDr. Johns Laboratories Pvt Ltd ₹68.42 4.3% COSTLIER
-
parotin 10mg tabletAronex Life Sciences Pvt Ltd ₹68.47 4.3% COSTLIER
-
oxitine pr 10mg tabletPsycormedies ₹69.19 5.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is addictive.
Fact: This medicine is not addictive in the traditional sense, but it can cause dependence and withdrawal symptoms if stopped abruptly. It should be tapered gradually under medical supervision. - Myth: This medicine works immediately.
Fact: This medicine may take 1-2 weeks to start working and 4-6 weeks for full therapeutic effects. - Myth: I can stop taking this medicine once I feel better.
Fact: You should continue taking this medicine for as long as your doctor recommends, even if you feel better, to prevent relapse. Stopping abruptly can cause withdrawal symptoms. - Myth: This medicine will change my personality.
Fact: This medicine is intended to treat your symptoms and help you feel more like yourself, not to change your personality.
🔄 Alternative Options
Generic Alternatives
- Paroxetine 10mg Tablet
Brand Alternatives
- Paxil
- Seroxat
- Pexeva