Rasburnat Injection (Rasburicase 1.5 mg): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Swelling of the face, lips, tongue, or throat
- Sudden drop in blood pressure or fainting
- Dark or reddish urine, which may indicate haemolysis
- Yellowing of the skin or eyes (jaundice)
- Bluish discolouration of lips or skin
- Severe rash with blisters or peeling skin
- Decreased urine output or swelling in the legs
- Chest pain or irregular heartbeat
- Confusion or seizures
If experiencing severe symptoms, call emergency services immediately.
What is rascas 1.5mg injection used for?
This medicine contains rasburicase, an enzyme that rapidly breaks down uric acid in the blood. It is used to treat or prevent tumour lysis syndrome, a serious complication of cancer treatment that can damage the kidneys. It is given as an intravenous infusion in a hospital setting.
- Generic Name: Rasburicase (1.5mg)
- Manufacturer: Sayre Therapeutics Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 rascas 1.5mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा रासब्यूरिकेज 1.5 मिलीग्राम इंजेक्शन के रूप में उपलब्ध है और इसे डॉक्टर की देखरेख में नस के माध्यम से दिया जाता है। इसका मुख्य उपयोग ट्यूमर लाइसिस सिंड्रोम के इलाज और रोकथाम के लिए किया जाता है, जो कैंसर के इलाज के दौरान होने वाली एक गंभीर समस्या है। इस स्थिति में शरीर में यूरिक एसिड का स्तर बहुत तेजी से बढ़ जाता है, जिससे किडनी को नुकसान हो सकता है। यह दवा यूरिक एसिड को जल्दी से तोड़कर उसे शरीर से बाहर निकालने में मदद करती है और किडनी की सुरक्षा करती है। यह दवा केवल अस्पताल में ही दी जाती है और इसे घर पर स्वयं नहीं लगाया जा सकता।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में बुखार, सिरदर्द, जी मिचलाना, उल्टी, पेट दर्द, दस्त और त्वचा पर चकत्ते शामिल हैं। कुछ मरीजों में रक्तचाप कम हो सकता है, दिल की धड़कन तेज हो सकती है, या हाथ-पैरों में सूजन आ सकती है। गंभीर दुष्प्रभावों में एलर्जी की तीव्र प्रतिक्रिया, लाल रक्त कोशिकाओं का टूटना, और मेथेमोग्लोबिनेमिया शामिल हैं। अगर सांस लेने में तकलीफ, चेहरे या गले में सूजन, या त्वचा पर गंभीर दाने दिखें तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल योग्य डॉक्टर या स्वास्थ्यकर्मी द्वारा अस्पताल में ही दी जानी चाहिए। इसे घर पर स्वयं न लगाएं। इस दवा को लेने से पहले अपने डॉक्टर को बताएं कि आपको जी6पीडी की कमी, अस्थमा, एलर्जी, किडनी की समस्या है या आप गर्भवती या स्तनपान करा रही हैं। इलाज के दौरान डॉक्टर आपके यूरिक एसिड लेवल, किडनी फंक्शन और ब्लड काउंट की निगरानी करेंगे। कोई भी नई दवा लेने से पहले डॉक्टर से सलाह लें।
💊 rascas 1.5mg injection Uses & Benefits
[{"condition":"Tumour lysis syndrome (treatment)","description":"This medicine is used to rapidly lower high uric acid levels in patients who develop tumour lysis syndrome during chemotherapy for blood cancers such as leukaemia and lymphoma.","evidence":"Well-established"},{"condition":"Tumour lysis syndrome (prevention)","description":"It is given before or during chemotherapy in patients at high risk of tumour lysis syndrome to prevent dangerous rises in uric acid and kidney damage.","evidence":"Well-established"},{"condition":"Hyperuricaemia associated with malignancy","description":"This medicine helps control severely elevated uric acid levels in patients with cancers that produce high uric acid, especially when other treatments are not suitable.","evidence":"Established"}]
Off-label uses: [{"condition":"Gout flare with severe hyperuricaemia","description":"In rare cases, this medicine may be considered for extremely high uric acid levels in gout when standard treatments are ineffective or contraindicated, but this is not a routine use.","evidence":"Limited"},{"condition":"Prevention of contrast-induced nephropathy","description":"Some small studies have explored the use of this medicine to protect kidneys from contrast dye, but evidence is not strong enough for routine recommendation.","evidence":"Limited"}]
Primary treatment for: Tumour lysis syndrome
Also treats: Hyperuricaemia associated with malignancy, Acute kidney injury due to uric acid nephropathy
📋 Drug Information
| Generic Name(s) | Rasburicase (1.5mg) |
| Brand Name | rascas 1.5mg injection |
| Manufacturer | Sayre Therapeutics Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | Uricolytic agent- Chemotherapy |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store this medicine in a refrigerator at 2°C to 8°C. Do not freeze. Protect from light. Once reconstituted, the solution should be used immediately or stored as directed by the pharmacist. Keep out of reach of children. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture when stored under recommended conditions. Refer to the product label for the exact expiry date. |
| WHO Guideline | Not established from the available information. Guidelines from oncology societies recommend rasburicase for the management of tumour lysis syndrome in high-risk patients, but specific WHO recommendations are not available. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by providing a recombinant form of the enzyme urate oxidase, also called rasburicase. Urate oxidase is normally present in many mammals but not in humans. This enzyme catalyses the oxidation of uric acid into allantoin, a substance that is much more soluble in water and is easily excreted by the kidneys. By rapidly converting uric acid to allantoin, this medicine lowers blood uric acid levels within hours, preventing uric acid crystals from forming in the kidneys and other tissues. This helps protect kidney function and reduces the risk of acute kidney injury caused by tumour lysis syndrome.
Mechanism Steps
💡 How to Take rascas 1.5mg injection
Strength: This medicine is available as a lyophilised powder for injection containing rasburicase 1.5 mg per vial. It is reconstituted with the provided diluent before intravenous infusion.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 0.2 mg/kg as a single daily dose, given as an intravenous infusion over 30 minutes. The dose may be repeated daily for up to 5 days based on uric acid levels and clinical response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and the severity of hyperuricaemia. Do not self-administer. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. In clinical practice, the dose is often 0.2 mg/kg as a single daily intravenous infusion, but this must be determined by a pediatric oncologist. |
| Elderly Dosage | There are no specific dose adjustments for elderly patients based on age alone. However, elderly patients may have reduced kidney function and are more prone to dehydration and electrolyte imbalances. Dose must be individualized by a qualified clinician based on renal function and overall health status. |
| Renal Impairment | No specific dose adjustment is recommended for patients with renal impairment. However, because this medicine is used to prevent or treat kidney damage from tumour lysis syndrome, kidney function should be monitored closely. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No specific dose adjustment is recommended for patients with hepatic impairment. Dose must be individualized by a qualified clinician based on the patient's overall condition. |
| Maximum Daily Dose | The maximum recommended daily dose is 0.2 mg/kg. Doses above this are not recommended. Dose must be individualized by a qualified clinician. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of rascas 1.5mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Allopurinol | Moderate | |
| Febuxostat | Moderate | |
| Pegloticase | Major | |
| NSAIDs | Moderate | |
| Aminoglycosides | Moderate | |
| Amphotericin B | Moderate | |
| Live vaccines | Moderate | |
| Antihistamines | Minor | |
| Corticosteroids | Minor | |
| Warfarin | Minor |
🚨 Major Interactions
- Other uric acid-lowering agents (e.g., allopurinol, febuxostat)
- Pegylated uricase (pegloticase)
⚡ Moderate Interactions
- Nephrotoxic drugs (e.g., NSAIDs, aminoglycosides, amphotericin B)
- Vaccines (live)
🍷 Alcohol Interaction
There is no known direct interaction between this medicine and alcohol. However, alcohol can worsen dehydration and kidney stress, which may increase the risk of complications in patients with tumour lysis syndrome. It is best to avoid alcohol during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to rasburicase or any of its components","Glucose-6-phosphate dehydrogenase (G6PD) deficiency","History of severe allergic reaction to rasburicase or other uricases","Pregnancy (unless clearly needed and benefits outweigh risks)","Breastfeeding (unless benefits outweigh risks)"]
⚠️ Warnings & Precautions
["This medicine must be given by a healthcare professional in a setting equipped to manage anaphylaxis.","Patients should be screened for G6PD deficiency before receiving this medicine.","Monitor for signs of haemolysis, especially in patients with G6PD deficiency.","Use with caution in patients with asthma or a history of allergic reactions.","Blood samples for uric acid measurement must be collected in chilled tubes and analysed promptly to avoid falsely low results.","Do not use this medicine for routine treatment of gout or asymptomatic hyperuricaemia.","Repeated courses may lead to antibody formation and reduced efficacy or increased allergic reactions."]
🤱 Lactation Safety
It is not known whether rasburicase is excreted in human breast milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of overdose, treatment should be symptomatic and supportive. Monitor vital signs, kidney function, and blood counts. Contact a poison control centre or emergency department immediately if an overdose is suspected.
⏰ Missed Dose
This medicine is given by a healthcare professional in a hospital or clinic. If you miss an appointment for your dose, contact your doctor or clinic as soon as possible to reschedule. Do not attempt to self-administer a missed dose.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a hospital or clinic setting. Do not attempt to self-administer this injection. Before receiving this medicine, tell your doctor if you have glucose-6-phosphate dehydrogenase deficiency, asthma, allergies, kidney problems, or if you are pregnant or breastfeeding. Your doctor will monitor your blood uric acid levels, kidney function, and blood counts during treatment. Avoid taking any other medicines, including over-the-counter products, without informing your doctor. If you notice any signs of an allergic reaction such as rash, itching, swelling, or difficulty breathing, seek immediate medical help. Do not drive or operate heavy machinery immediately after receiving this medicine, as it may cause dizziness or low blood pressure.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced kidney function and are more susceptible to dehydration and electrolyte imbalances. They should be monitored closely for kidney function and signs of allergic reactions. Dose adjustments are not based on age alone but on overall health and renal function.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before receiving this medicine. It should be used during pregnancy only if clearly needed. Effective contraception is recommended during treatment for both men and women.
🏥 Post-Surgery Considerations
There are no specific restrictions after surgery, but inform your surgeon and anesthesiologist if you have received this medicine recently. It may affect kidney function and blood counts, which can influence surgical planning and recovery.
🦷 Dental Procedures
Inform your dentist if you are receiving or have recently received this medicine. There is no direct interaction with dental procedures, but your overall medical condition and kidney function should be considered before any dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting immediately after receiving this medicine, as it may cause dizziness or low blood pressure. Light activities like walking are generally safe once you feel well. Consult your doctor before resuming your regular exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so you will need to take time off work for treatment and monitoring. You may feel tired or dizzy after the infusion, so avoid driving or operating heavy machinery for at least 24 hours. Most patients can resume normal activities within a day or two after treatment, depending on their overall condition.
🛑 When to Stop This Medicine
This medicine is stopped when your uric acid levels are controlled and the risk of tumour lysis syndrome has passed, as determined by your doctor. Do not stop treatment on your own. If you experience severe side effects, your doctor may decide to stop the medicine or adjust the dose.
📅 Long-Term Use Effects
This medicine is usually given for a short duration, typically up to 5 days. Long-term effects are not well studied because it is not intended for chronic use. Repeated courses may lead to the development of antibodies that can reduce its effectiveness and increase the risk of allergic reactions. Patients who receive this medicine should be monitored for kidney function and blood counts during and after treatment. There is no known risk of long-term organ damage when used as recommended.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
An oral medicine that reduces uric acid production. It is used for prevention but works more slowly than rasburicase.
Evidence: Well-establishedAn oral medicine similar to allopurinol, used for chronic management of hyperuricaemia.
Evidence: Well-establishedSupportive measures to help flush out uric acid and prevent crystal formation in the kidneys.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions reported with this medicine. However, patients with cancer may have weakened immune systems, and live vaccines should be avoided during treatment. Discuss vaccination timing with your oncologist.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2°C to 8°C.
❌ DON'T
Do not freeze the product.
✅ DO
Protect from light by keeping it in the original carton.
❌ DON'T
Do not expose to direct sunlight.
✅ DO
Keep out of reach of children.
❌ DON'T
Do not store at room temperature for prolonged periods.
✅ DO
Use reconstituted solution immediately as directed by the pharmacist.
❌ DON'T
Do not use if the solution is discoloured or contains particles.
✈️ Traveling with This Medicine
This medicine is given in a hospital setting and is not typically self-administered during travel. If you need to travel for treatment, carry a copy of your prescription and medical records. The medicine should be stored in a refrigerator at 2°C to 8°C and protected from light. When travelling, use a cool pack and insulated bag to maintain the cold chain. Inform airport security about your medical condition and carry a doctor's letter. Customs may require documentation for injectable medicines, so check the regulations of your destination country in advance.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering uric acid levels within 4 to 6 hours after the infusion. Your doctor will monitor your blood levels to see how well it is working.
A: No, this medicine must be given in a hospital or clinic setting by a healthcare professional because it can cause serious allergic reactions that require immediate medical attention.
A: Tell your doctor or nurse immediately if you notice any side effects, especially difficulty breathing, rash, swelling, or dark urine. Most side effects are manageable with supportive care.
A: This medicine can be used in children, but the dose must be determined by a pediatric oncologist. It is not for self-administration.
A: This medicine should be used during pregnancy only if clearly needed. Discuss the risks and benefits with your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for rascas 1.5mg injection
View AllAlternative brands with exact same active ingredient:
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rasuric 1.5mg injectionAureate Healthcare Pvt Ltd ₹6,679.69 28.9% CHEAPER
-
rasbelon injectionCelon Laboratories Ltd ₹7,593.00 19.2% CHEAPER
-
rasburnat injectionNatco Pharma Ltd ₹8,250.00 12.2% CHEAPER
-
rasby injectionIntas Pharmaceuticals Ltd ₹8,250.00 12.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Rasburicase can be taken as a tablet.
Fact: This medicine is only available as an intravenous injection and must be given by a healthcare professional. - Myth: Rasburicase is a painkiller.
Fact: This medicine is not a painkiller. It is an enzyme that lowers uric acid levels. - Myth: Rasburicase can be used for routine gout treatment.
Fact: This medicine is reserved for serious conditions like tumour lysis syndrome and is not used for routine gout. - Myth: Rasburicase is safe for everyone.
Fact: It is not safe for people with G6PD deficiency or those allergic to it.