ranispas ac 10mg/150mg tablet - Dicyclomine (10mg) + Ranitidine (150mg) medicine

Actispas-R Tablet: Complete Information

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🏭 Mankind Pharma Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for individual components; limited for the fixed-dose combination.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Fast or irregular heartbeat
  • Severe abdominal pain
  • Confusion or hallucinations
  • Difficulty urinating
  • Blood in stool or vomit
  • Yellowing of skin or eyes
  • Severe allergic reaction (rash, swelling, difficulty breathing)

If experiencing severe symptoms, call emergency services immediately.

What is ranispas ac 10mg/150mg tablet used for?

This medicine is a combination of dicyclomine (an antispasmodic) and ranitidine (an acid reducer) used to treat abdominal cramps and acid-related stomach problems. It is taken orally, usually two to four times daily, and should be used only under medical supervision.

  • Generic Name: Dicyclomine (10mg) + Ranitidine (150mg)
  • Manufacturer: Mankind Pharma Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 ranispas ac 10mg/150mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा पेट की ऐंठन, गैस, एसिडिटी और पेट दर्द में राहत देने के लिए इस्तेमाल की जाती है। इसमें डाइसाइक्लोमिन और रैनिटिडीन दो दवाएं होती हैं। डाइसाइक्लोमिन पेट की मांसपेशियों को आराम देती है और रैनिटिडीन पेट में एसिड बनना कम करती है। यह दवा इरिटेबल बाउल सिंड्रोम, अल्सर और गैस्ट्राइटिस में भी फायदेमंद होती है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए।

साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में मुंह सूखना, धुंधला दिखना, नींद आना, कब्ज और जी मिचलाना शामिल हैं। कभी-कभी दिल की धड़कन तेज हो सकती है या पेशाब करने में दिक्कत हो सकती है। अगर कोई भी परेशानी लगातार बनी रहे तो डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे चबाएं नहीं, पूरा निगल लें। दवा लेने के बाद नींद या चक्कर आ सकते हैं, इसलिए गाड़ी चलाने से बचें। शराब न पिएं। अगर आपको ग्लूकोमा, दिल की बीमारी, किडनी या लिवर की समस्या है तो डॉक्टर को बताएं। बच्चों को बिना डॉक्टर की सलाह के न दें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 ranispas ac 10mg/150mg tablet Uses & Benefits

[{"condition":"Irritable bowel syndrome (IBS)","description":"Helps relieve abdominal cramps and spasms associated with IBS, while ranitidine reduces accompanying acid symptoms.","evidence":"Moderate"},{"condition":"Peptic ulcer disease","description":"Ranitidine reduces gastric acid secretion, aiding ulcer healing, and dicyclomine relieves associated spasmodic pain.","evidence":"Moderate"},{"condition":"Gastritis","description":"Provides symptomatic relief from stomach inflammation by reducing acid and easing muscle spasms.","evidence":"Limited"},{"condition":"Gastrointestinal spasms","description":"Dicyclomine directly relaxes smooth muscle to reduce cramping and pain.","evidence":"Well-established for dicyclomine component"}]

Off-label uses: [{"condition":"Functional dyspepsia","description":"Sometimes used to relieve upper abdominal discomfort and bloating not explained by organic disease.","evidence":"Limited"},{"condition":"Biliary colic","description":"May be used off-label to ease pain from bile duct spasms, but evidence is weak.","evidence":"Insufficient"}]

Primary treatment for: Irritable bowel syndrome

Also treats: Peptic ulcer disease, Gastritis, Gastrointestinal spasms

📋 Drug Information

Generic Name(s)Dicyclomine (10mg) + Ranitidine (150mg)
Brand Nameranispas ac 10mg/150mg tablet
ManufacturerMankind Pharma Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Avoid driving or operating machinery if you feel drowsy.
3
Do not drink alcohol while taking this medicine.
4
Stay well hydrated to help with dry mouth and constipation.
5
Report any fast heartbeat, confusion, or difficulty urinating immediately.
6
Do not use for more than 7 days without consulting your doctor.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Abdominal cramps
This medicine is commonly prescribed for this.
Likely Use
Acid indigestion
Ranitidine component reduces acid.
Likely Use
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDicyclomine is well absorbed from the gastrointestinal tract. Ranitidine is rapidly absorbed after oral administration, with bioavailability of about 50%. Food does not significantly affect the absorption of either component.
DistributionDicyclomine is widely distributed in body tissues, including the gastrointestinal tract. Ranitidine distributes widely, including into breast milk and cerebrospinal fluid. Protein binding is moderate for both.
Protein BindingDicyclomine: approximately 80% bound to plasma proteins. Ranitidine: approximately 15% bound to plasma proteins.
MetabolismDicyclomine is extensively metabolized in the liver. Ranitidine undergoes some hepatic metabolism, but a significant portion is excreted unchanged in urine.
Half-LifeDicyclomine: approximately 1.8 hours. Ranitidine: approximately 2.5 to 3 hours.
ExcretionDicyclomine is excreted mainly in urine and feces as metabolites. Ranitidine is excreted primarily unchanged in urine.
BioavailabilityDicyclomine: approximately 50% to 60%. Ranitidine: approximately 50%.
Onset of ActionDicyclomine: within 1 to 2 hours. Ranitidine: within 1 hour.
Peak Plasma TimeDicyclomine: 1 to 2 hours. Ranitidine: 1 to 3 hours.
Duration of ActionDicyclomine: 4 to 6 hours. Ranitidine: up to 12 hours for acid suppression.

How It Works

This medicine combines two active ingredients with complementary actions. Dicyclomine blocks muscarinic acetylcholine receptors on smooth muscle cells in the gastrointestinal tract, reducing muscle contractions and spasms. Ranitidine competitively blocks histamine H2 receptors on gastric parietal cells, decreasing both basal and stimulated gastric acid secretion. Together, they relieve cramping and reduce acid-related irritation.

Mechanism Steps

1
Dicyclomine blocks muscarinic receptors: Dicyclomine binds to muscarinic receptors on gastrointestinal smooth muscle, preventing acetylcholine from stimulating contractions.
2
Reduced smooth muscle spasm: This blockade leads to relaxation of the gut wall, easing cramps and spasms.
3
Ranitidine blocks H2 receptors: Ranitidine competes with histamine at H2 receptors on parietal cells in the stomach.
4
Decreased gastric acid secretion: This reduces the production of stomach acid, helping to protect the stomach lining and relieve acid-related symptoms.

💡 How to Take ranispas ac 10mg/150mg tablet

Strength: Tablet containing dicyclomine 10 mg and ranitidine 150 mg.

1Swallow the tablet whole with a glass of water.
2Take with food to reduce stomach upset.
3Do not crush or chew the tablet.
4Take at the same times each day.
5Follow your doctor's instructions exactly.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally two to four times daily, as prescribed by your doctor. The exact dose and frequency depend on your condition and response to treatment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to anticholinergic effects. Use with caution and lower doses may be appropriate. Dose must be individualized by a qualified clinician.
Renal ImpairmentRanitidine dose should be reduced in patients with renal impairment. Dicyclomine should be used with caution. Consult your doctor for dose adjustment.
Hepatic ImpairmentUse with caution in hepatic impairment. Dose adjustment may be necessary. Consult your doctor.
Maximum Daily DoseThe maximum recommended daily dose is 4 tablets (dicyclomine 40 mg and ranitidine 600 mg) in divided doses, but this must be confirmed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases drowsiness and stomach irritation.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of ranispas ac 10mg/150mg tablet

✅ Common Side Effects

Dry mouth (Common (10-20%))
Sip water, chew sugar-free gum, or use saliva substitutes. Consult doctor if severe.
Drowsiness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Blurred vision (Common (5-10%))
Usually temporary. Do not drive if vision is affected. Report if persistent.
Constipation (Common (5-10%))
Increase fiber and fluid intake. Consult doctor if it persists.
Nausea (Common (5-10%))
Take with food. Consult doctor if vomiting occurs.

🚨 Serious Side Effects

Fast or irregular heartbeat (Rare (<0.1%))
Seek immediate medical attention.
Confusion or hallucinations (Rare (<0.1%))
Stop the medicine and contact your doctor immediately.
Difficulty urinating (Rare (<0.1%))
Consult a doctor promptly.
Severe abdominal pain (Rare (<0.1%))
Seek immediate medical evaluation.

⚠️ Rare Side Effects

Anaphylaxis
Call emergency services immediately.
Liver enzyme elevation
Report jaundice or dark urine to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Atropine Major
Metformin Moderate
Warfarin Moderate
Antacids Minor

🚨 Major Interactions

  • Ketoconazole
  • Atropine

⚡ Moderate Interactions

  • Metformin
  • Warfarin

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine. It can worsen drowsiness, dizziness, and stomach irritation, and may increase the risk of liver problems.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Glaucoma","Myasthenia gravis","Severe ulcerative colitis","Toxic megacolon","Urinary retention","Severe liver disease","Known hypersensitivity to dicyclomine or ranitidine"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving.","Use with caution in elderly due to increased risk of confusion.","Not recommended for children without specialist advice.","Avoid in patients with obstructive uropathy.","May worsen gastroesophageal reflux."]

🤱 Lactation Safety

Dicyclomine and ranitidine are excreted in breast milk. Use with caution and only if clearly needed. Consult your doctor.

💊 Overdose Management

Overdose may cause severe anticholinergic symptoms such as dry mouth, flushing, tachycardia, urinary retention, and confusion. Seek immediate medical attention. Treatment is supportive and symptomatic.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the tablet unless your doctor advises otherwise. Avoid driving or operating heavy machinery if you feel dizzy or drowsy. Do not drink alcohol while taking this medicine, as it can worsen drowsiness and stomach irritation. Inform your doctor if you have glaucoma, heart problems, kidney or liver disease, or difficulty passing urine. Do not use this medicine for longer than recommended without medical review. Keep out of reach of children and store in a cool, dry place.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more prone to anticholinergic side effects like confusion, dry mouth, and urinary retention. Use with caution and lower doses may be needed.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before taking this medicine. The safety profile is not well established, and alternative treatments may be considered.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist if you are taking this medicine before surgery. It may interact with anesthetic agents and affect heart rate.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it can cause dry mouth and may interact with certain dental anesthetics.

💚 Lifestyle Tips for Better Results

🏃
Eat small, frequent meals to reduce acid production.
🥗
Avoid spicy, oily, and acidic foods.
😴
Manage stress through relaxation techniques.
💧
Get regular exercise to improve digestion.
🧘
Avoid smoking and alcohol.
🌞
Stay hydrated throughout the day.

🏋️ Exercise Considerations

Avoid strenuous exercise if you feel dizzy or drowsy. Light activities like walking are generally safe. Consult your doctor before starting any new exercise routine.

🥗 Diet Recommendations

Include fiber-rich foods to prevent constipation.
Avoid caffeine and carbonated drinks.
Eat bland, easily digestible foods.
Stay well hydrated.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness and blurred vision, affecting your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. Office work is usually fine.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience severe side effects, contact your doctor immediately. Your doctor will advise on tapering or stopping based on your condition.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to persistent dry mouth, constipation, and rarely, liver enzyme changes. Regular monitoring by your doctor is advised if used for more than a few weeks. Do not continue without medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Dietary changes

Avoiding trigger foods can reduce symptoms of IBS and acid reflux.

Evidence: Well-established
Stress management

Yoga, meditation, and counseling can help reduce stress-related GI symptoms.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No known interactions with vaccines. Continue routine vaccinations as advised by your doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing times gradually as advised by your doctor. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with IBS
She experienced frequent abdominal cramps and bloating. Her doctor prescribed this medicine. After taking it regularly with meals, her cramps reduced significantly within a week. She also increased her water intake to manage dry mouth.
💡 Lesson: Taking the medicine with food and staying hydrated improves tolerability.
👤 A 50-year-old man with peptic ulcer
He had burning stomach pain and was prescribed this medicine. He noticed relief in acid symptoms within a few days. He was advised to avoid alcohol and spicy food, which helped further.
💡 Lesson: Lifestyle modifications along with medicine enhance recovery.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Dicyclomine starts working within 1-2 hours, and ranitidine within 1 hour. You may feel relief from cramps and acid symptoms within a few hours.

Q: Can I take it on an empty stomach?

A: It is best taken with food to reduce stomach upset.

Q: Is it safe during pregnancy?

A: Consult your doctor. The safety profile is not well established, and use only if clearly needed.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for ranispas ac 10mg/150mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Actispas-R can be taken for any stomach pain.
    Fact: It is specific for spasms and acid-related conditions; other causes of stomach pain need different treatment.
  • Myth: It is safe to take Actispas-R daily without a doctor's advice.
    Fact: Prolonged use requires medical supervision due to potential side effects.

🔄 Alternative Options

Generic Alternatives

  • Dicyclomine + Ranitidine tablets from other manufacturers

Brand Alternatives

  • Actispas-R
  • Other brands containing dicyclomine and ranitidine

📊 Comparison with Similar Medicines

[{"medicine":"Actispas-R","composition":"Dicyclomine 10 mg + Ranitidine 150 mg","primary_use":"IBS, peptic ulcer, gastritis"},{"medicine":"Dicyclomine alone","composition":"Dicyclomine 10 mg","primary_use":"GI spasms"},{"medicine":"Ranitidine alone","composition":"Ranitidine 150 mg","primary_use":"Acid reduction"}]

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