prugain drops honey - Hydroxyzine (10mg/5ml) medicine

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🏭 Hermes Therapeutics Pvt Ltd. 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 17, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for allergic pruritus and anxiety.
Reviewed by
SaathiMed Expert Panel | Oct 17, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is prugain drops honey used for?

This medicine is an antihistamine syrup containing hydroxyzine, used to treat itching from allergies and to relieve anxiety. It works by blocking histamine receptors and causing sedation.

  • Generic Name: Hydroxyzine (10mg/5ml)
  • Manufacturer: Hermes Therapeutics Pvt Ltd.
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 prugain drops honey के बारे में (Hindi Summary)

उपयोग: यह दवा हाइड्रोक्सीज़िन नामक एंटीहिस्टामाइन का सिरप है, जिसका उपयोग एलर्जी के कारण होने वाली खुजली, चकत्ते, और सूजन को कम करने के लिए किया जाता है। यह चिंता और तनाव को कम करने में भी मदद करती है और कभी-कभी नींद न आने की समस्या में भी दी जाती है। यह दवा दिमाग में हिस्टामाइन रिसेप्टर्स को ब्लॉक करके काम करती है, जिससे एलर्जी के लक्षण कम होते हैं और नींद आती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, मुँह सूखना, सिरदर्द और थकान शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन दिल की धड़कन अनियमित होना, दौरे पड़ना, या गंभीर एलर्जी हो सकती है। अगर आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: यह दवा लेने से नींद आ सकती है, इसलिए गाड़ी चलाने या मशीन चलाने से बचें। शराब का सेवन न करें क्योंकि इससे नींद और बढ़ सकती है। अगर आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं, तो डॉक्टर को बताएं। डॉक्टर की सलाह के बिना दवा बंद न करें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 prugain drops honey Uses & Benefits

[{"condition":"Allergic pruritus","description":"Relieves itching associated with allergic skin conditions such as urticaria and eczema.","evidence":"Well-established"},{"condition":"Anxiety","description":"Used for the short-term management of anxiety and tension.","evidence":"Well-established"},{"condition":"Preoperative sedation","description":"Used to produce sedation before surgical procedures.","evidence":"Well-established"},{"condition":"Insomnia","description":"Sometimes used as a short-term sleep aid due to its sedative properties.","evidence":"Limited"}]

Off-label uses: [{"condition":"Nausea and vomiting","description":"Occasionally used off-label for its antiemetic effects.","evidence":"Limited"},{"condition":"Motion sickness","description":"May be used off-label to prevent motion sickness.","evidence":"Limited"}]

Primary treatment for: Allergic pruritus

Also treats: Anxiety, Insomnia, Preoperative sedation

📋 Drug Information

Generic Name(s)Hydroxyzine (10mg/5ml)
Brand Nameprugain drops honey
ManufacturerHermes Therapeutics Pvt Ltd.
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassH1 Antihistaminics (First Generation)
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep the bottle tightly closed when not in use.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Avoid driving or operating machinery until you know how this medicine affects you.
3
Do not drink alcohol while taking this medicine.
4
Take the lowest effective dose for the shortest duration possible.
5
Consult your doctor if symptoms persist beyond 7 days.
6
Report any unusual heart palpitations or fainting immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

❌
Chronic joint pain
This medicine is not primarily used for joint pain.
Not Primary
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
✅
Itching
This medicine is commonly prescribed for allergic itching.
Likely Use
✅
Anxiety
This medicine is used for short-term anxiety relief.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionHydroxyzine is rapidly absorbed from the gastrointestinal tract after oral administration. The syrup formulation is designed for quick absorption, with peak plasma concentrations typically reached within 2 hours.
DistributionHydroxyzine is widely distributed throughout the body, including the central nervous system. It crosses the blood-brain barrier and the placenta.
Protein BindingApproximately 93% of hydroxyzine is bound to plasma proteins.
MetabolismHydroxyzine is extensively metabolized in the liver, primarily through oxidation and conjugation. The main metabolite is cetirizine, which is a active antihistamine.
Half-LifeThe elimination half-life of hydroxyzine is approximately 20 hours in adults, but it may be prolonged in elderly patients and those with hepatic impairment.
ExcretionHydroxyzine and its metabolites are primarily excreted in the urine and feces.
BioavailabilityThe oral bioavailability of hydroxyzine is approximately 80%.
Onset of ActionSedative effects typically begin within 30 to 60 minutes after oral administration.
Peak Plasma TimePeak plasma concentrations are reached within 2 hours after oral administration.
Duration of ActionThe sedative and antihistamine effects of hydroxyzine usually last for 4 to 6 hours, but may be longer in some individuals.

How It Works

Hydroxyzine is a first-generation antihistamine that works by competitively blocking histamine H1 receptors in the central nervous system and peripheral tissues. This action prevents histamine from binding to its receptors, thereby reducing allergic responses such as itching, sneezing, and runny nose. Additionally, hydroxyzine has anticholinergic and sedative effects, which contribute to its use in anxiety and as a sleep aid.

Mechanism Steps

1
Histamine H1 receptor blockade: Hydroxyzine binds to histamine H1 receptors in the brain and peripheral tissues, preventing histamine from exerting its effects.
2
Reduction of allergic symptoms: By blocking H1 receptors, hydroxyzine reduces itching, swelling, and other allergic responses.
3
Central nervous system depression: Hydroxyzine crosses the blood-brain barrier and causes sedation by blocking central H1 receptors and possibly other neurotransmitter systems.
4
Anticholinergic effects: Hydroxyzine also has anticholinergic properties, which can cause dry mouth, blurred vision, and constipation.

💡 How to Take prugain drops honey

Strength: Each 5 ml of syrup contains 10 mg of hydroxyzine.

1Shake the bottle well before each use.
2Measure the dose accurately using the measuring cup or spoon provided.
3Take this medicine with or without food, but taking it with food may reduce stomach upset.
4Swallow the syrup directly; do not mix with other liquids unless instructed by your doctor.
5Follow your doctor's instructions regarding the frequency and duration of treatment.

Dosage Information

Adult DosageThe usual adult dose of this medicine for allergic pruritus is 25 mg to 100 mg taken 3 to 4 times daily. For anxiety, the dose is typically 50 mg to 100 mg four times daily. For preoperative sedation, 50 mg to 100 mg is given the night before and on the morning of surgery. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosageFor children over 6 years, the usual dose for allergic pruritus is 25 mg to 50 mg daily in divided doses. For children under 6 years, the dose is 50 mg daily in divided doses. Pediatric dosing is not established from available information for all indications. Consult a pediatrician.
Elderly DosageElderly patients are more sensitive to the sedative and anticholinergic effects of hydroxyzine. Start with a lower dose and titrate slowly. The maximum daily dose should not exceed 50 mg in elderly patients.
Renal ImpairmentIn patients with renal impairment, dose reduction may be necessary. Monitor for increased side effects. Consult a clinician for individualized dosing.
Hepatic ImpairmentIn patients with hepatic impairment, dose reduction is recommended due to reduced metabolism. Use with caution and monitor for adverse effects.
Maximum Daily DoseThe maximum recommended daily dose for adults is 600 mg per day in divided doses for anxiety, but doses above 100 mg per day are rarely used. For allergic conditions, the maximum is 300 mg per day.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of prugain drops honey

✅ Common Side Effects

Drowsiness (Common (10-20%))
Avoid driving or operating machinery. If drowsiness persists, consult your doctor.
Dry mouth (Common (5-10%))
Sip water frequently or chew sugarless gum. Consult doctor if severe.
Headache (Common (5-10%))
Usually resolves on its own. If persistent, consult your doctor.
Fatigue (Common (5-10%))
Get adequate rest. If fatigue interferes with daily activities, consult your doctor.

🚨 Serious Side Effects

QT interval prolongation (Rare (<0.1%))
Seek immediate medical attention if you experience palpitations, dizziness, or fainting.
Seizures (Rare (<0.1%))
Call emergency services if a seizure occurs.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek emergency medical help if you experience swelling of face, lips, throat, or difficulty breathing.

⚠️ Rare Side Effects

Blood dyscrasias
Report any unusual bruising, bleeding, or signs of infection to your doctor.
Liver dysfunction
Report yellowing of skin or eyes, dark urine, or abdominal pain to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
CNS depressants Major
MAO inhibitors Major
Anticholinergics Moderate
QT-prolonging drugs Moderate
Alcohol Major

🚨 Major Interactions

  • CNS depressants (e.g., opioids, benzodiazepines, alcohol)
  • MAO inhibitors

⚡ Moderate Interactions

  • Anticholinergic drugs (e.g., atropine, benztropine)
  • QT-prolonging drugs (e.g., amiodarone, sotalol)

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine because it can significantly increase drowsiness, dizziness, and impair your ability to think and react quickly. Combining alcohol with hydroxyzine can also increase the risk of respiratory depression.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to hydroxyzine or any component of the formulation","History of prolonged QT interval or congenital long QT syndrome","Severe hepatic impairment","Concurrent use with MAO inhibitors"]

⚠️ Warnings & Precautions

["May impair mental and physical abilities required for driving or operating machinery.","Avoid alcohol and other CNS depressants.","Use with caution in patients with asthma, glaucoma, or urinary retention.","May cause anticholinergic effects; use with caution in elderly.","Not recommended for long-term use without medical supervision."]

🤱 Lactation Safety

Hydroxyzine is excreted in breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

💊 Overdose Management

Overdose of hydroxyzine may cause severe drowsiness, seizures, respiratory depression, and cardiac arrhythmias. Treatment is supportive and symptomatic. There is no specific antidote. If overdose is suspected, seek emergency medical attention immediately.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

This medicine can cause significant drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. Do not consume alcohol while taking this medicine as it can increase drowsiness and impair your ability to think clearly. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not stop taking this medicine abruptly without consulting your doctor, especially if you have been using it for a long time. Keep this medicine out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the sedative and anticholinergic effects of this medicine. Start with a lower dose and monitor closely for confusion, falls, and urinary retention.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. Hydroxyzine may not be suitable during pregnancy.

🏥 Post-Surgery Considerations

This medicine may be used for preoperative sedation. After surgery, it may increase drowsiness and delay recovery. Follow your doctor's instructions.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it can cause dry mouth and increase the risk of dental problems. It may also interact with sedatives used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming.
😴
Practice good posture.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep.

🏋️ Exercise Considerations

This medicine can cause drowsiness and dizziness. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated

💼 Impact on Daily Work & Life

This medicine can cause significant drowsiness, which may affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is advisable to take it at bedtime if possible.

🛑 When to Stop This Medicine

Do not stop taking this medicine abruptly without consulting your doctor, especially if you have been using it for a long time. Your doctor will advise you on how to taper the dose gradually.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to tolerance, dependence, and anticholinergic side effects. Regular monitoring of liver and kidney function is advised. It is not recommended for prolonged use without medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain.

Evidence: Well-established
Cognitive behavioral therapy

Effective for anxiety management.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while taking this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from light and moisture. If crossing time zones, adjust the dosing schedule as advised by your doctor. Check local customs regulations regarding carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with chronic hives
Started this medicine as prescribed for itching. Within a few days, the itching reduced significantly. She was advised to take it at night to avoid daytime drowsiness.
💡 Lesson: Taking this medicine at bedtime can help manage daytime drowsiness while still providing relief.
👤 A 60-year-old man with anxiety
Was prescribed this medicine for short-term anxiety. He experienced dry mouth and drowsiness initially, but these side effects diminished after a week. He was advised not to drive until he knew how the medicine affected him.
💡 Lesson: Side effects often improve with continued use, but caution is needed with activities requiring alertness.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30 to 60 minutes after taking a dose.

Q: Can I take this medicine every day?

A: This medicine is generally prescribed for short-term use. Consult your doctor before taking it daily for extended periods.

Q: Is it safe for children?

A: This medicine can be used in children over 6 years under medical supervision. The dose is adjusted based on age and weight.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for prugain drops honey

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is safe to take with alcohol.
    Fact: No, alcohol increases the sedative effects and can be dangerous.
  • Myth: This medicine is not habit-forming.
    Fact: Hydroxyzine has a low potential for dependence, but it can cause dependence if misused.

🔄 Alternative Options

Generic Alternatives

  • Hydroxyzine hydrochloride syrup

Brand Alternatives

  • Atarax
  • Vistaril

📊 Comparison with Similar Medicines

[{"medicine":"Hydroxyzine","class":"First-generation antihistamine","sedation":"High","duration":"4-6 hours"},{"medicine":"Diphenhydramine","class":"First-generation antihistamine","sedation":"High","duration":"4-6 hours"},{"medicine":"Cetirizine","class":"Second-generation antihistamine","sedation":"Low","duration":"24 hours"}]

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